Estimation of linkage in the presence of multiplicative viability effects.

Abstract:

:Log-linear analysis of contingency tables is applied to trihybrid backcross data to estimate linkage and viability. Whereas nonadditive viability differences perturb recombination estimates in the classical analysis, this statistical procedure yields maximum likelihood crossover frequency estimates in the presence of multiplicative viability effects. Other advantages of this method include: (1) estimation of viability effects of gene substitution at each locus, (2) estimation of asymptotic confidence intervals on recombination frequencies and viabilities, and (3) it tests the null hypothesis of no interference and no viability interactions. Extensions to cover more loci and to allow certain kinds of epistasis are easily made. Relative merits of the proposed and classical methods are discussed.

journal_name

Genetics

journal_title

Genetics

authors

Clark AG

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

157-68

issue

1

eissn

0016-6731

issn

1943-2631

journal_volume

99

pub_type

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