Abstract：
:Condensins are evolutionarily conserved protein complexes that are required for chromosome segregation during cell division and genome organization during interphase. In Caenorhabditis elegans, a specialized condensin, which forms the core of the dosage compensation complex (DCC), binds to and represses X chromosome transcription. Here, we analyzed DCC localization and the effect of DCC depletion on histone modifications, transcription factor binding, and gene expression using chromatin immunoprecipitation sequencing and mRNA sequencing. Across the X, the DCC accumulates at accessible gene regulatory sites in active chromatin and not heterochromatin. The DCC is required for reducing the levels of activating histone modifications, including H3K4me3 and H3K27ac, but not repressive modification H3K9me3. In X-to-autosome fusion chromosomes, DCC spreading into the autosomal sequences locally reduces gene expression, thus establishing a direct link between DCC binding and repression. Together, our results indicate that DCC-mediated transcription repression is associated with a reduction in the activity of X chromosomal gene regulatory elements.
journal_name
Geneticsjournal_title
Geneticsauthors
Street LA,Morao AK,Winterkorn LH,Jiao CY,Albritton SE,Sadic M,Kramer M,Ercan Sdoi
10.1534/genetics.119.302254subject
Has Abstractpub_date
2019-07-01 00:00:00pages
729-742issue
3eissn
0016-6731issn
1943-2631pii
genetics.119.302254journal_volume
212pub_type
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