A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.

abstract：:Protein kinases mediate much of the signal transduction in eukaryotic cells and defects in kinase function are associated with a variety of human diseases. To understand and correct these defects, we will need to identify the physiologically relevant substrates of these enzymes. The work presented here describes a nov...

journal_title：Genetics

authors： Deminoff SJ,Howard SC,Hester A,Warner S,Herman PK

更新日期：2006-08-01 00:00:00

abstract：:Understanding the initiation of meiosis and the relationship of this event with other key cytogenetic processes are major goals in studying the genetic control of meiosis in higher plants. Our genetic and structural analysis of two mutant alleles of the ameiotic1 gene (am1 and am1-praI) suggest that this locus plays a...

journal_title：Genetics

authors： Golubovskaya I,Grebennikova ZK,Avalkina NA,Sheridan WF

更新日期：1993-12-01 00:00:00

abstract：:With the rise of both the number and the complexity of traits of interest, control of the false discovery rate (FDR) in genetic association studies has become an increasingly appealing and accepted target for multiple comparison adjustment. While a number of robust FDR-controlling strategies exist, the nature of this ...

journal_title：Genetics

authors： Brzyski D,Peterson CB,Sobczyk P,Candès EJ,Bogdan M,Sabatti C

更新日期：2017-01-01 00:00:00

abstract：:In mismatch repair (MMR), members of the MLH gene family have been proposed to act as key molecular matchmakers to coordinate mismatch recognition with downstream repair functions that result in mispair excision. Two members of this gene family, MLH1 and MLH3, have also been implicated in meiotic crossing over. These ...

journal_title：Genetics

authors： Argueso JL,Smith D,Yi J,Waase M,Sarin S,Alani E

更新日期：2002-03-01 00:00:00

abstract：:The Drosophila melanogaster Gld gene has multiple and diverse developmental and physiological functions. We report herein that interactions among proximal promoter elements and a cluster of intronically located enhancers and silencers specify the complex regulation of Gld that underlies its diverse functions. Gld expr...

journal_title：Genetics

authors： Keplinger BL,Guo X,Quine J,Feng Y,Cavener DR

更新日期：2001-02-01 00:00:00

abstract：:Recombination of phage lambda attachment sites occurs by sequential exchange of the DNA strands at two specific locations. The first exchange produces a Holliday structure, and the second resolves it to recombinant products. Heterology for base substitution mutations in the region between the two strand exchange point...

journal_title：Genetics

authors： Bauer CE,Gardner JF,Gumport RI,Weisberg RA

更新日期：1989-08-01 00:00:00

abstract：:Precocious entry into S phase due to overproduction of G1 regulators can cause genomic instability. The mechanisms of this phenomenon are largely unknown. We explored the consequences of precocious S phase in yeast by overproducing a deregulated form of Swi4 (Swi4-t). Swi4 is a late G1-specific transcriptional activat...

journal_title：Genetics

authors： Sidorova JM,Breeden LL

更新日期：2002-01-01 00:00:00

abstract：:We have tested the hypothesis that genetic differences among conspecific populations may result in diverse responses to selection, using natural populations of Drosophila melanogaster. Selection for ethanol tolerance in a tube measuring knockdown resistance was imposed on five West Coast populations. In 24 generations...

journal_title：Genetics

authors： Cohan FM,Hoffmann AA

更新日期：1986-09-01 00:00:00

abstract：:The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...

journal_title：Genetics

authors： Malpica JM,Vassallo JM,Frías A,Fuentes-Bol F

更新日期：1987-01-01 00:00:00

abstract：:We examine the efficiency of different genotyping and phenotyping strategies in inbred line crosses from an information perspective. This provides a mathematical framework for the statistical aspects of QTL experimental design, while guiding our intuition. Our central result is a simple formula that quantifies the fra...

journal_title：Genetics

authors： Sen S,Satagopan JM,Churchill GA

更新日期：2005-05-01 00:00:00

abstract：:In Saccharomyces cerevisiae, silencers flanking the HML and HMR loci initiate the establishment of transcriptional silencing. We demonstrate that the activity of a silencer pertaining to its potency and directionality is dependent on its genomic position. The context of the HML-E silencer is more permissive to silence...

journal_title：Genetics

authors： Zou Y,Yu Q,Chiu YH,Bi X

更新日期：2006-09-01 00:00:00

abstract：:A major challenge in undergraduate life science curricula is the continual evaluation and development of courses that reflect the constantly shifting face of contemporary biological research. Synthetic biology offers an excellent framework within which students may participate in cutting-edge interdisciplinary researc...

journal_title：Genetics

authors： Dymond JS,Scheifele LZ,Richardson S,Lee P,Chandrasegaran S,Bader JS,Boeke JD

更新日期：2009-01-01 00:00:00

abstract：:T (Texas) cytoplasm is associated with a mitochondrial disruption that is phenotypically expressed during microsporogenesis resulting in male sterility. Restoration of pollen fertility in T-cytoplasm maize is controlled by dominant alleles at two unlinked, complementary, nuclear-encoded genes, rf1 and rf2. As a first ...

journal_title：Genetics

authors： Schnable PS,Wise RP

更新日期：1994-03-01 00:00:00

abstract：:Vertebrate retrotransposons have been used extensively for phylogenetic analyses and studies of molecular evolution. Information can be obtained from specific inserts either by comparing sequence differences that have accumulated over time in orthologous copies of that insert or by determining the presence or absence ...

journal_title：Genetics

authors： Cantrell MA,Filanoski BJ,Ingermann AR,Olsson K,DiLuglio N,Lister Z,Wichman HA

更新日期：2001-06-01 00:00:00

abstract：:The Caenorhabditis elegans pRb ortholog, LIN-35, functions in a wide range of cellular and developmental processes. This includes a role of LIN-35 in nutrient utilization by the intestine, which it carries out redundantly with SLR-2, a zinc-finger protein. This and other redundant functions of LIN-35 were identified i...

journal_title：Genetics

authors： Polley SR,Fay DS

更新日期：2012-08-01 00:00:00

abstract：:If multiple linked polymorphisms are under natural selection, then conflicts arise and the efficiency of natural selection is hindered relative to the case of no linkage. This simple interaction between linkage and natural selection creates an opportunity for mutations that raise the level of recombination to increase...

journal_title：Genetics

authors： Hey J

更新日期：1998-08-01 00:00:00

abstract：:The T-box genes comprise an ancient family of putative transcription factors conserved across species as divergent as Mus musculus and Caenorhabditis elegans. All T-box gene products are characterized by a novel 174-186-amino acid DNA binding domain called the T-box that was first discovered in the polypeptide product...

journal_title：Genetics

authors： Agulnik SI,Garvey N,Hancock S,Ruvinsky I,Chapman DL,Agulnik I,Bollag R,Papaioannou V,Silver LM

更新日期：1996-09-01 00:00:00

abstract：:The neutral rate of allelic substitution is analyzed for a class-structured population subject to a stationary stochastic demographic process. The substitution rate is shown to be generally equal to the effective mutation rate, and under overlapping generations it can be expressed as the effective mutation rate in new...

journal_title：Genetics

authors： Lehmann L

更新日期：2014-05-01 00:00:00

abstract：:Low-coverage next-generation sequencing methodologies are routinely employed to genotype large populations. Missing data in these populations manifest both as missing markers and markers with incomplete allele recovery. False homozygous calls at heterozygous sites resulting from incomplete allele recovery confound man...

journal_title：Genetics

authors： Fragoso CA,Heffelfinger C,Zhao H,Dellaporta SL

更新日期：2016-02-01 00:00:00

abstract：:Ten mutations are described that transform genotypic hermaphrodites of the nematode Caenorhabditis elegans into phenotypic males. These fall into three autosomal complementation groups, termed tra-1, tra-2, and tra-3. Two alleles of tra-1 produce almost complete transformation, to a fertile male phenotype; such transf...

journal_title：Genetics

authors： Hodgkin JA,Brenner S

更新日期：1977-06-01 00:00:00

abstract：:Methods for inference and interpretation of evolutionary quantitative genetic parameters, and for prediction of the response to selection, are best developed for traits with normal distributions. Many traits of evolutionary interest, including many life history and behavioral traits, have inherently nonnormal distribu...

journal_title：Genetics

authors： de Villemereuil P,Schielzeth H,Nakagawa S,Morrissey M

更新日期：2016-11-01 00:00:00

abstract：:Clustering individuals to subpopulations based on genetic data has become commonplace in many genetic studies. Inference about population structure is most often done by applying model-based approaches, aided by visualization using distance-based approaches such as multidimensional scaling. While existing distance-bas...

journal_title：Genetics

authors： Greenbaum G,Templeton AR,Bar-David S

更新日期：2016-04-01 00:00:00

abstract：:Although neurons are highly polarized, how neuronal polarity is generated remains poorly understood. An evolutionarily conserved inositol-producing enzyme myo-inositol monophosphatase (IMPase) is essential for polarized localization of synaptic molecules in Caenorhabditis elegans and can be inhibited by lithium, a dru...

journal_title：Genetics

authors： Kimata T,Tanizawa Y,Can Y,Ikeda S,Kuhara A,Mori I

更新日期：2012-06-01 00:00:00

abstract：:It has been hypothesized that the ratio of X-linked to autosomal sequence diversity is influenced by unequal sex ratios in Drosophila melanogaster populations. We conducted a genome scan of single nucleotide polymorphism (SNP) of 378 autosomal loci in a derived European population and of a subset of 53 loci in an ance...

journal_title：Genetics

authors： Hutter S,Li H,Beisswanger S,De Lorenzo D,Stephan W

更新日期：2007-09-01 00:00:00

abstract：:Competition among domesticated plants or animals can have a dramatic negative impact on yield of a stand or farm. The usual quantitative genetic model ignores these competitive interactions and could result in seriously incorrect breeding decisions and acerbate animal well-being. A general solution to this problem is ...

journal_title：Genetics

authors： Muir WM

更新日期：2005-07-01 00:00:00

abstract：:Presynaptic association of homologous chromosomes is a prerequisite to the sequence of events that lead to chiasma formation. This association of homologous chromosomes, as entire units, occurs with probability a, and chiasma formation occurs independently in opposite chromosome arms with probability c. a and c have b...

journal_title：Genetics

authors： Driscoll CJ,Bielig LM,Darvey NL

更新日期：1979-04-01 00:00:00

abstract：:Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at leas...

journal_title：Genetics

authors： Vary PS,Stocker BA

更新日期：1973-02-01 00:00:00

abstract：:Gene duplication is arguably the most significant source of new functional genetic material. A better understanding of the processes that lead to the stable incorporation of gene duplications into the genome is important both because it relates to interspecific differences in genome composition and because it can shed...

journal_title：Genetics

authors： Proulx SR

更新日期：2012-02-01 00:00:00

abstract：:We study a situation that arises in the somatic evolution of cancer. Consider a finite population of replicating cells and a sequence of mutations: type 0 can mutate to type 1, which can mutate to type 2. There is no back mutation. We start with a homogeneous population of type 0. Mutants of type 1 emerge and either b...

journal_title：Genetics

authors： Iwasa Y,Michor F,Nowak MA

更新日期：2004-03-01 00:00:00

abstract：:A general method is proposed for calculating approximate thresholds of interval mapping tests for quantitative trait loci (QTL) detection. Simulation results show that this method, when applied to backcross and F2 populations, gives good approximations and is useful for any situation. Programs which calculate these th...

journal_title：Genetics

authors： Rebaï A,Goffinet B,Mangin B

更新日期：1994-09-01 00:00:00