Abstract：
:A major correlation has been found between the incidence of glucocorticoid-induced cleft palate and the chromosome 8 segment identified by N-acetyl transferase in mice. The resistant strain became fully susceptible while the susceptible strain became resistant when this chromosomal region, representing less than 0.7% of the genome, was transferred from one strain to the other by the construction of congenic strains. 6-Aminonicotinamide-induced cleft palate and phenytoin-induced cleft lip with or without cleft palate are also influenced by this genetic region but not as strongly. In both cases the susceptible strain became quite resistant to the teratogen-induced clefting when the N-acetyl transferase region of chromosome 8 was transferred. However, this chromosomal region does not make the resistant strain susceptible to these two teratogens.
journal_name
Geneticsjournal_title
Geneticsauthors
Karolyi J,Erickson RP,Liu S,Killewald Lsubject
Has Abstractpub_date
1990-09-01 00:00:00pages
201-5issue
1eissn
0016-6731issn
1943-2631journal_volume
126pub_type
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