The evolution and consequences of sex-specific reproductive variance.

abstract：:The F(1) hybrids of Nicotiana suaveolens (subgenus Petunioides, 2n = 32) and N. glutinosa (subgenus Tabacum, 2n = 24), were examined during their development, from seedlings to mature plants. It was observed that in the hybrids, there was a progressive change of dominant N. glutinosa morphological characteristics towa...

journal_title：Genetics

authors： Gupta SB,Gupta P

更新日期：1973-04-01 00:00:00

abstract：:The presence of at least ten mouse LDH-A pseudogenes was demonstrated in the genomic blot analysis, and four different processed pseudogenes have thus far been isolated and characterized. In this report, the nucleotide sequences to two different mouse lactate dehydrogenase-A processed pseudogenes, M11 and M14, were de...

journal_title：Genetics

authors： Fukasawa KM,Tanimura M,Sakai I,Sharief FS,Chung FZ,Li SS

更新日期：1987-01-01 00:00:00

abstract：:Small regulatory RNAs, such as small interfering RNAs (siRNAs) and PIWI-interacting RNAs, regulate splicing, transcription, and genome integrity in many eukaryotes. In Caenorhabditis elegans, siRNAs bind nuclear Argonautes (AGOs), which interact with homologous premessenger RNAs to recruit downstream silencing effecto...

journal_title：Genetics

authors： Wan G,Yan J,Fei Y,Pagano DJ,Kennedy S

更新日期：2020-12-01 00:00:00

abstract：:Over one-third of human genome sequence is a product of non-LTR retrotransposition. The retrotransposon that currently drives this process in humans is the highly abundant LINE-1 (L1) element. Despite the ubiquitous nature of L1's in mammals, we still lack a complete mechanistic understanding of the L1 replication cyc...

journal_title：Genetics

authors： Dong C,Poulter RT,Han JS

更新日期：2009-01-01 00:00:00

abstract：:Sexual isolating mechanisms that act before fertilization are often considered the most important genetic barriers leading to speciation in animals. While recent progress has been made toward understanding the genetic basis of the postzygotic isolating mechanisms of hybrid sterility and inviability, little is known ab...

journal_title：Genetics

authors： Moehring AJ,Li J,Schug MD,Smith SG,deAngelis M,Mackay TF,Coyne JA

更新日期：2004-07-01 00:00:00

abstract：:Dauer formation in Caenorhabditis elegans is induced by chemosensation of high levels of a constitutively secreted pheromone. Seven genes defined by mutations that confer a dauer-formation constitutive phenotype (Daf-c) can be congruently divided into two groups by any of three criteria. Group 1 genes (daf-11 and daf-...

journal_title：Genetics

authors： Thomas JH,Birnby DA,Vowels JJ

更新日期：1993-08-01 00:00:00

abstract：:Florida teosinte from Honduras and Guanajuato teosinte have most of their knobs internally located and a common inversion in the short arm of chromosome 8. Teosintes from northern Guatemala, Huixta and Monajil, have all their knobs terminally located and do not have any inversions. Therefore, Florida teosinte from Hon...

journal_title：Genetics

authors： Ting YC

更新日期：1976-08-01 00:00:00

abstract：:Biology is characterized by complex interactions between phenotypes, such as recursive and simultaneous relationships between substrates and enzymes in biochemical systems. Structural equation models (SEMs) can be used to study such relationships in multivariate analyses, e.g., with multiple traits in a quantitative g...

journal_title：Genetics

authors： Valente BD,Rosa GJ,de Los Campos G,Gianola D,Silva MA

更新日期：2010-06-01 00:00:00

abstract：:To identify the factors (selective or mutational) that affect the distribution of transposable elements (TEs) within a genome, it is necessary to compare the pattern of newly arising element insertions to the pattern of element insertions that have been fixed in a population. To do this, we analyzed the distribution o...

journal_title：Genetics

authors： Rizzon C,Martin E,Marais G,Duret L,Ségalat L,Biémont C

更新日期：2003-11-01 00:00:00

abstract：:Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at leas...

journal_title：Genetics

authors： Vary PS,Stocker BA

更新日期：1973-02-01 00:00:00

abstract：:The Duchenne muscular dystrophy (Dmd) locus lies in a region of the X chromosome that experiences a high rate of recombination and is thus expected to be relatively unaffected by the effects of selection on nearby genes. To provide a picture of nucleotide variability at a high-recombination locus in humans, we sequenc...

journal_title：Genetics

authors： Nachman MW,Crowell SL

更新日期：2000-08-01 00:00:00

abstract：:Sequence divergence among the mitochondrial (mt) DNA of nine Lycopersicon and two closely related Solanum species was estimated using the shared fragment method. A portion of each mt genome was highlighted by probing total DNA with a series of plasmid clones containing mt-specific DNA fragments from Lycopersicon penne...

journal_title：Genetics

authors： McClean PE,Hanson MR

更新日期：1986-03-01 00:00:00

abstract：:Selection of suppressor mutations that correct growth defects caused by substitutions in an RNA or protein can reveal functionally important molecular structures and interactions in living cells. This approach is particularly useful for the study of complex biological pathways involving many macromolecules, such as pr...

journal_title：Genetics

authors： Brow DA

更新日期：2019-05-01 00:00:00

abstract：:High-density genotyping of single-nucleotide polymorphisms (SNPs) enables detection of quantitative trait loci (QTL) by linkage disequilibrium (LD) mapping using LD between markers and QTL and the subsequent use of this information for marker-assisted selection (MAS). The success of LD mapping and MAS depends on the e...

journal_title：Genetics

authors： Andreescu C,Avendano S,Brown SR,Hassen A,Lamont SJ,Dekkers JC

更新日期：2007-12-01 00:00:00

abstract：:The bovine Growth Hormone gene (bGH) is an attractive candidate gene for milk production in cattle. Single-strand conformation polymorphisms at bGH were identified and used to define haplotype configurations at this gene in the Israeli Holstein dairy cattle population (Bos taurus) and in the parent animals of the Inte...

journal_title：Genetics

authors： Lagziel A,Lipkin E,Soller M

更新日期：1996-03-01 00:00:00

abstract：:I reexamine the use of isolation by distance models as a basis for the estimation of demographic parameters from measures of population subdivision. To that aim, I first provide results for values of F-statistics in one-dimensional models and coalescence times in two-dimensional models, and make more precise earlier r...

journal_title：Genetics

authors： Rousset F

更新日期：1997-04-01 00:00:00

abstract：:Laterality is believed to have genetic components, as has been deduced from family studies in humans and responses to artificial selection in mice, but these genetic components are unknown and the underlying physiological mechanisms are still a subject of dispute. We measured direction of laterality (preferential use ...

journal_title：Genetics

authors： Roubertoux PL,Le Roy I,Tordjman S,Cherfou A,Migliore-Samour D

更新日期：2003-03-01 00:00:00

abstract：:Transcriptional silencing in the budding yeast Saccharomyces cerevisiae may be linked to DNA replication and cell cycle progression. In this study, we have surveyed the effect of 41 mutations in genes with a role in replication, the cell cycle, and DNA repair on silencing at HMR. Mutations in PCNA (POL30), RF-C (CDC44...

journal_title：Genetics

authors： Ehrenhofer-Murray AE,Kamakaka RT,Rine J

更新日期：1999-11-01 00:00:00

abstract：:In altricial birds, growth rates and nestling morphology vary between broods. For natural selection to produce evolutionary change in these variables, ther must exist heritable variation. Since nestling traits are not any longer presents in parents, traditional offspring-parent regressions cannot estimate heritabiliti...

journal_title：Genetics

authors： Smith HG,Wettermark KJ

更新日期：1995-10-01 00:00:00

abstract：:Aimed at investigating the recovery of a specific mutant allele of the mating type locus (MAT) by switching a defective MAT allele, these experiments provide information bearing on several models proposed for MAT interconversion in bakers yeast, Saccharomyces cerevisiae. Hybrids between heterothallic (ho) cells carryi...

journal_title：Genetics

authors： Klar AJ,Fogel S,Radin DN

更新日期：1979-07-01 00:00:00

abstract：:Conditional cdc1(Ts) mutants of S. cerevisiae arrest with a phenotype similar to that exhibited by Mn(2+)-depleted cells. Sequence similarity between Cdc1p and a class of Mn(2+)-dependent phosphoesterases, as well as the observation that conditional cdc1(Ts) growth can be ameliorated by Mn(2+) supplement, suggests tha...

journal_title：Genetics

authors： Eguez L,Chung YS,Kuchibhatla A,Paidhungat M,Garrett S

更新日期：2004-05-01 00:00:00

abstract：:Hybrid male sterility (HMS) contributes to reproductive isolation commonly observed among house mouse (Mus musculus) subspecies, both in the wild and in laboratory crosses. Incompatibilities involving specific Prdm9 alleles and certain Chromosome (Chr) X genotypes are known determinants of fertility and HMS, and previ...

journal_title：Genetics

authors： Widmayer SJ,Handel MA,Aylor DL

更新日期：2020-10-01 00:00:00

abstract：:Methodology for mapping quantitative trait loci (QTL) has focused primarily on treating the QTL as a fixed effect. These methods differ from the usual models of genetic variation that treat genetic effects as random. Computationally expensive methods that allow QTL to be treated as random have been explicitly develope...

journal_title：Genetics

authors： Zimmer D,Mayer M,Reinsch N

更新日期：2011-01-01 00:00:00

abstract：:Microsatellite markers are extensively used to evaluate genetic diversity in natural or experimental evolving populations. Their high degree of polymorphism reflects their high mutation rates. Estimates of the mutation rates are therefore necessary when characterizing diversity in populations. As a complement to the c...

journal_title：Genetics

authors： Raquin AL,Depaulis F,Lambert A,Galic N,Brabant P,Goldringer I

更新日期：2008-08-01 00:00:00

abstract：:Hybrid incompatibility can result from gene misregulation produced by divergence in trans-acting regulatory factors and their cis-regulatory targets. However, change in trans-acting factors may be constrained by pleiotropy, which would in turn limit the evolution of incompatibility. We employed a mechanistically expli...

journal_title：Genetics

authors： Tulchinsky AY,Johnson NA,Porter AH

更新日期：2014-12-01 00:00:00

abstract：:We report the identification of bang senseless (bss), a Drosophila melanogaster mutant exhibiting seizure-like behaviors, as an allele of the paralytic (para) voltage-gated Na(+) (Na(V)) channel gene. Mutants are more prone to seizure episodes than normal flies because of a lowered seizure threshold. The bss phenotype...

journal_title：Genetics

authors： Parker L,Padilla M,Du Y,Dong K,Tanouye MA

更新日期：2011-02-01 00:00:00

abstract：:The phenomenon of heterosis describes the increased agronomic performance of heterozygous F(1) plants compared to their homozygous parental inbred plants. Heterosis is manifested during the early stages of root development in maize. The goal of this study was to identify nonadditive gene expression in primary roots of...

journal_title：Genetics

authors： Hoecker N,Keller B,Muthreich N,Chollet D,Descombes P,Piepho HP,Hochholdinger F

更新日期：2008-07-01 00:00:00

abstract：:Automated image acquisition, a custom analysis algorithm, and a distributed computing resource were used to add time as a third dimension to a quantitative trait locus (QTL) map for plant root gravitropism, a model growth response to an environmental cue. Digital images of Arabidopsis thaliana seedling roots from two ...

journal_title：Genetics

authors： Moore CR,Johnson LS,Kwak IY,Livny M,Broman KW,Spalding EP

更新日期：2013-11-01 00:00:00

abstract：:Yeast cells deficient in the transcriptional activator Imp2p are viable, but display marked hypersensitivity to a variety of oxidative agents. We now report that imp2 null mutants are also extremely sensitive to elevated levels of the monovalent ions, Na+ and Li+, as well as to the divalent ions Ca2+, Mn2+, Zn2+, and ...

journal_title：Genetics

authors： Masson JY,Ramotar D

更新日期：1998-06-01 00:00:00

abstract：:We have used a novel method to activate the DNA damage S-phase checkpoint response in Saccharomyces cerevisiae to slow lagging-strand DNA replication by exposing cells expressing a drug-sensitive DNA polymerase δ (L612M-DNA pol δ) to the inhibitory drug phosphonoacetic acid (PAA). PAA-treated pol3-L612M cells arrest a...

journal_title：Genetics

authors： Reha-Krantz LJ,Siddique MS,Murphy K,Tam A,O'Carroll M,Lou S,Schultz A,Boone C

更新日期：2011-12-01 00:00:00