A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae.

abstract：:Following transformation of a Drosophila melanogaster true M strain with an autonomous P element, six lines were established and monitored for their molecular and phenotypic properties during a 4-yr period. The number of P elements increased with time in all the lines but the rate of increase differed among lines. Fur...

journal_title：Genetics

authors： Daniels SB,Clark SH,Kidwell MG,Chovnick A

更新日期：1987-04-01 00:00:00

abstract：:To study the interdependence of Gcr1p and Rap1p, we prepared a series of synthetic regulatory sequences that contained various numbers and combinations of CT-boxes (Gcr1p-binding sites) and RPG-boxes (Rap1p-binding sites). The ability of the synthetic oligonucleotides to function as regulatory sequences was tested usi...

journal_title：Genetics

authors： Uemura H,Koshio M,Inoue Y,Lopez MC,Baker HV

更新日期：1997-10-01 00:00:00

abstract：:Previous models suggested that regulation of telomere length in Saccharomyces cerevisiae by Tel1(ATM) and Mec1(ATR) would parallel the established pathways regulating the DNA damage response. Here, we provide evidence that telomere length regulation differs from the DNA damage response in both the Tel1 and Mec1 pathwa...

journal_title：Genetics

authors： Keener R,Connelly CJ,Greider CW

更新日期：2019-12-01 00:00:00

abstract：:The external genitalia are some of the most rapidly evolving morphological structures in insects. The posterior lobe of the male genital arch shows striking differences in both size and shape among closely related species of the Drosophila melanogaster species subgroup. Here, we dissect the genetic basis of posterior ...

journal_title：Genetics

authors： Masly JP,Dalton JE,Srivastava S,Chen L,Arbeitman MN

更新日期：2011-09-01 00:00:00

abstract：:We present here a molecular analysis of the region surrounding the structural gene encoding alcohol dehydrogenase (Adh) in 47 lines of Drosophila melanogaster that have each accumulated mutations for 300 generations. While these lines show a significant increase in variation of alcohol dehydrogenase enzyme activity co...

journal_title：Genetics

authors： Aquadro CF,Tachida H,Langley CH,Harada K,Mukai T

更新日期：1990-12-01 00:00:00

abstract：:Hybridization between related species results in the formation of an allopolyploid with multiple subgenomes. These subgenomes will each contain complete, yet evolutionarily divergent, sets of genes. Like a diploid hybrid, allopolyploids will have two versions, or homeoalleles, for every gene. Partial functional redund...

journal_title：Genetics

authors： Santantonio N,Jannink JL,Sorrells M

更新日期：2019-03-01 00:00:00

abstract：:Nonrandom associations between alleles at different loci can be tested for using Fisher's exact test. Extensive simulations show that there is a substantial probability of obtaining significant nonrandom associations between closely or completely linked polymorphic neutral loci in a population of constant size at equi...

journal_title：Genetics

authors： Slatkin M

更新日期：1994-05-01 00:00:00

abstract：:Some mutant strains of the filamentous fungus Podospora anserina spontaneously present a growth impairment, which has been called Crippled Growth (CG). CG is caused by a cytoplasmic and infectious factor, C. C is efficiently transmitted during mitosis but is not transmitted to the progeny after sexual crosses. C is in...

journal_title：Genetics

authors： Silar P,Haedens V,Rossignol M,Lalucque H

更新日期：1999-01-01 00:00:00

abstract：:Phylogenetic analyses of non-LTR retrotransposons suggest that all elements can be divided into 11 lineages. The 3 oldest lineages show target site specificity for unique locations in the genome and encode an endonuclease with an active site similar to certain restriction enzymes. The more "modern" non-LTR lineages po...

journal_title：Genetics

authors： Malik HS,Eickbush TH

更新日期：2000-01-01 00:00:00

abstract：:The availability of genomewide dense markers brings opportunities and challenges to breeding programs. An important question concerns the ways in which dense markers and pedigrees, together with phenotypic records, should be used to arrive at predictions of genetic values for complex traits. If a large number of marke...

journal_title：Genetics

authors： de los Campos G,Naya H,Gianola D,Crossa J,Legarra A,Manfredi E,Weigel K,Cotes JM

更新日期：2009-05-01 00:00:00

abstract：:Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected under neutral evolution and described statistically by Kingman's...

journal_title：Genetics

authors： Dayarian A,Shraiman BI

更新日期：2014-07-01 00:00:00

abstract：:Gene targeting techniques have led to the phenotypic characterization of numerous genes; however, many genes show minimal to no phenotypic consequences when disrupted, despite many having highly conserved sequences. The standard explanation for these findings is functional redundancy. A competing hypothesis is that th...

journal_title：Genetics

authors： Ruff JS,Saffarini RB,Ramoz LL,Morrison LC,Baker S,Laverty SM,Tvrdik P,Potts WK

更新日期：2015-10-01 00:00:00

abstract：:Gene expression in Anopheles gambiae shows a deficiency of testis-expressed genes on the X chromosome associated with an excessive movement of retrogene duplication. We suggest that the degeneration of sex chromosomes in this monandrous species is likely the result of pressures from X inactivation, dosage compensation...

journal_title：Genetics

authors： Baker DA,Russell S

更新日期：2011-11-01 00:00:00

abstract：:Immature spermatids from Caenorhabditis elegans are stimulated by an external activation signal to reorganize their membranes and cytoskeleton to form crawling spermatozoa. This rapid maturation, termed spermiogenesis, occurs without any new gene expression. To better understand this signal transduction pathway, we is...

journal_title：Genetics

authors： Muhlrad PJ,Ward S

更新日期：2002-05-01 00:00:00

abstract：:We have isolated and characterized deletions arising within a P transposon, P[hswa], in the presence of P transposase. P[hswa] carries white-apricot (wa) sequences, including a complete copia element, under the control of an hsp70 promoter, and resembles the original wa allele in eye color phenotype. In the presence o...

journal_title：Genetics

authors： Kurkulos M,Weinberg JM,Roy D,Mount SM

更新日期：1994-03-01 00:00:00

abstract：:We formalize the use of allele frequency and geographic information for the construction of gene trees at the intraspecific level and extend the concept of evolutionary parsimony to molecular variance parsimony. The central principle is to consider a particular gene tree as a variable to be optimized in the estimation...

journal_title：Genetics

authors： Excoffier L,Smouse PE

更新日期：1994-01-01 00:00:00

abstract：:Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the widely conserved histone variant CENP-A. Mutations in kinetochore proteins of the fission yeast Schizosaccharomyces pom...

journal_title：Genetics

authors： Gao C,Langbein L,Kamal F,George AA,Walworth NC

更新日期：2017-10-01 00:00:00

abstract：:Molecular heterogeneity in human breast cancer has challenged diagnosis, prognosis, and clinical treatment. It is well known that molecular subtypes of breast tumors are associated with significant differences in prognosis and survival. Assuming that the differences are attributed to subtype-specific pathways, we then...

journal_title：Genetics

authors： Li R,Campos J,Iida J

更新日期：2015-12-01 00:00:00

abstract：:Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...

journal_title：Genetics

authors： Cutter AD,Agrawal AF

更新日期：2010-06-01 00:00:00

abstract：:RNA editing refers to post-transcriptional processes that alter the base sequence of RNA. Recently, hundreds of new RNA editing targets have been reported. However, the mechanisms that determine the specificity and degree of editing are not well understood. We examined quantitative variation of site-specific editing i...

journal_title：Genetics

authors： Gu T,Gatti DM,Srivastava A,Snyder EM,Raghupathy N,Simecek P,Svenson KL,Dotu I,Chuang JH,Keller MP,Attie AD,Braun RE,Churchill GA

更新日期：2016-02-01 00:00:00

abstract：:Several quantitative trait loci (QTL) mapping strategies can successfully identify major-effect loci, but often have poor success detecting loci with minor effects, potentially due to the confounding effects of major loci, epistasis, and limited sample sizes. To overcome such difficulties, we used a targeted backcross...

journal_title：Genetics

authors： Sinha H,David L,Pascon RC,Clauder-Münster S,Krishnakumar S,Nguyen M,Shi G,Dean J,Davis RW,Oefner PJ,McCusker JH,Steinmetz LM

更新日期：2008-11-01 00:00:00

abstract：:Translation of the chloroplast psbC mRNA in the unicellular eukaryotic alga Chlamydomonas reinhardtii is controlled by interactions between its 547-base 5' untranslated region and the products of the nuclear loci TBC1, TBC2, and possibly TBC3. In this study, a series of site-directed mutations in this region was gener...

journal_title：Genetics

authors： Zerges W,Auchincloss AH,Rochaix JD

更新日期：2003-03-01 00:00:00

abstract：:Chromatin is organized and compacted in the nucleus through the association of histones and other proteins, which together control genomic activity. Two broad types of chromatin can be distinguished: euchromatin, which is generally transcriptionally active, and heterochromatin, which is repressed. Here we examine the ...

journal_title：Genetics

authors： Ahringer J,Gasser SM

更新日期：2018-02-01 00:00:00

abstract：:The forest tent caterpillar is polymorphic for two melanic genes affecting wing color of moths. These are the first genetically determined morphological traits reported for the genus. Dark (D) is a sex-limited, autosomal dominant with a phenotype of dark brown males. Frequencies in population samples varied from 8 to ...

journal_title：Genetics

authors： Lorimer N

更新日期：1979-06-01 00:00:00

abstract：:Much recent work in the theoretical study of adaptation has focused on the so-called strong selection-weak mutation (SSWM) limit, wherein adaptation is due to new mutations of definite selective advantage. This work, in turn, has focused on the first step (substitution) during adaptive evolution. Here we extend this t...

journal_title：Genetics

authors： Unckless RL,Orr HA

更新日期：2009-11-01 00:00:00

abstract：:Fifteen classical linkage groups were identified in two salmonid species (Salmo trutta and Salmo gairdneri) and three fertile, interspecific hybrids (S. gairdneri X Salmo clarki, Salvelinus fontinalis X Salvelinus namaycush and S. fontinalis X Salvelinus alpinus) by backcrossing multiply heterozygous individuals. Thes...

journal_title：Genetics

authors： Johnson KR,Wright JE Jr,May B

更新日期：1987-08-01 00:00:00

abstract：:Development of the Caenorhabditis elegans foregut (pharynx) is regulated by a network of proteins that includes the Retinoblastoma protein (pRb) ortholog LIN-35; the ubiquitin pathway components UBC-18 and ARI-1; and PHA-1, a cytoplasmic protein. Loss of pha-1 activity impairs pharyngeal development and body morphogen...

journal_title：Genetics

authors： Polley SR,Kuzmanov A,Kuang J,Karpel J,Lažetić V,Karina EI,Veo BL,Fay DS

更新日期：2014-01-01 00:00:00

abstract：:IS1 is one of the smallest transposable elements found in bacteria (768 bp). It contains eight overlapping open-reading-frames (ORFs) greater than 50 codons, designated insA to insG and insB'. To determine which of the ORFs actually code for proteins involved in transposition, we have introduced amber codons into each...

journal_title：Genetics

authors： Jakowec M,Prentki P,Chandler M,Galas DJ

更新日期：1988-09-01 00:00:00

abstract：:One of the most important parameters in population genetics is theta = 4Ne mu where Ne is the effective population size and mu is the rate of mutation per gene per generation. We study two related problems, using the maximum likelihood method and the theory of coalescence. One problem is the potential improvement of a...

journal_title：Genetics

authors： Fu YX,Li WH

更新日期：1993-08-01 00:00:00

abstract：:Combined with a system for identifying each of the chromosomes in a genome, visualizing the location of individual genetic loci by fluorescence in situ hybridization (FISH) would aid in assembling physical and genetic maps. Previously, large genomic clones have been successfully used as FISH probes onto somatic chromo...

journal_title：Genetics

authors： Lamb JC,Danilova T,Bauer MJ,Meyer JM,Holland JJ,Jensen MD,Birchler JA

更新日期：2007-03-01 00:00:00