Linkage relationships reflecting ancestral tetraploidy in salmonid fish.

abstract：:As a genetic mutation is passed down across generations, it distinguishes those genomes that have inherited it from those that have not, providing a glimpse of the genealogical tree relating the genomes to each other at that site. Statistical summaries of genetic variation therefore also describe the underlying geneal...

journal_title：Genetics

authors： Ralph P,Thornton K,Kelleher J

更新日期：2020-07-01 00:00:00

abstract：:The genetic effects of one generation of spermatogonial X-irradiation in rats, by a single dose of 600r in one experiment and by a fractionated dose of 450r in another, were measured in three generations of their descendants. Estimates of dominant lethal mutation rates--(2 to 3) X 10-4/gamete/r--from litter size diffe...

journal_title：Genetics

authors： Chambers JR,Chapman AB

更新日期：1977-02-01 00:00:00

abstract：:During segmentation of vertebrate embryos, somites form in accordance with a periodic pattern established by the segmentation clock. In the zebrafish (Danio rerio), the segmentation clock includes six hairy/enhancer of split-related (her/hes) genes, five of which oscillate due to negative autofeedback. The nonoscillat...

journal_title：Genetics

authors： Schwendinger-Schreck J,Kang Y,Holley SA

更新日期：2014-06-01 00:00:00

abstract：:In Saccharomyces cerevisiae, the Rad52 protein plays a role in both RAD51-dependent and RAD51-independent recombination pathways. We characterized a rad52 mutant, rad52-329, which lacks the C-terminal Rad51-interacting domain, and studied its role in RAD51-independent recombination. The rad52-329 mutant is completely ...

journal_title：Genetics

authors： Tsukamoto M,Yamashita K,Miyazaki T,Shinohara M,Shinohara A

更新日期：2003-12-01 00:00:00

abstract：:Obligate pathogenic and endosymbiotic bacteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift. We hypothesize that reduced genomes increase their functional complexity through protein multitasking, in which many genes adopt new roles to counteract gene loss. Comparisons of i...

journal_title：Genetics

authors： Kelkar YD,Ochman H

更新日期：2013-01-01 00:00:00

abstract：:Gain or loss of chromosomes resulting in aneuploidy can be important factors in cancer and adaptive evolution. Although chromosome gain is a frequent event in eukaryotes, there is limited information on its genetic control. Here we measured the rates of chromosome gain in wild-type yeast and sister chromatid cohesion ...

journal_title：Genetics

authors： Covo S,Puccia CM,Argueso JL,Gordenin DA,Resnick MA

更新日期：2014-02-01 00:00:00

abstract：:Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced t...

journal_title：Genetics

authors： LaFave MC,Varshney GK,Vemulapalli M,Mullikin JC,Burgess SM

更新日期：2014-09-01 00:00:00

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:Histone chaperones, chromatin remodelers, and histone modifying complexes play a critical role in alleviating the nucleosomal barrier for DNA-dependent processes. Here, we have examined the role of two highly conserved yeast (Saccharomyces cerevisiae) histone chaperones, facilitates chromatin transcription (FACT) and ...

journal_title：Genetics

authors： Pathak R,Singh P,Ananthakrishnan S,Adamczyk S,Schimmel O,Govind CK

更新日期：2018-07-01 00:00:00

abstract：:Aggression is a complex social behavior that is widespread in nature. To date, only a limited number of genes that affect aggression have been identified, in large part because the complexity of the phenotype makes screening difficult and time-consuming regardless of the species that is studied. We discovered that agg...

journal_title：Genetics

authors： Davis SM,Thomas AL,Liu L,Campbell IM,Dierick HA

更新日期：2018-01-01 00:00:00

abstract：:In multicellular organisms, genetic programs guide cells to adopt cell fates as tissues are formed during development, maintained in adults, and repaired after injury. Here we explore how a small molecule in the environment can switch a genetic program from one fate to another. Wild-type Caenorhabditis elegans XX adul...

journal_title：Genetics

authors： Sorokin EP,Gasch AP,Kimble J

更新日期：2014-10-01 00:00:00

abstract：:The back-to-back geometry of sister kinetochores is essential in preventing loss or damage of chromosomes during mitosis. Kinetochore orientation is generated in part by a process of resolving kinetochores at the centromere (centromere resolution) prior to spindle interactions. Because few of the genes required for ce...

journal_title：Genetics

authors： Stanvitch G,Moore LL

更新日期：2008-01-01 00:00:00

abstract：:Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation o...

journal_title：Genetics

authors： Hynes MJ,Murray SL,Khew GS,Davis MA

更新日期：2008-03-01 00:00:00

abstract：:To assess the reliability of genetic markers it is important to compare inferences that are based on them to a priori expectations. In this article we present an analysis of microsatellite variation within and among populations of island foxes (Urocyon littoralis) on California's Channel Islands. We first show that mi...

journal_title：Genetics

authors： Goldstein DB,Roemer GW,Smith DA,Reich DE,Bergman A,Wayne RK

更新日期：1999-02-01 00:00:00

abstract：:The change in the frequency of a rare mutant allele under constant sex-differentiated viability selection in an infinite, partial full-sib mating population is studied. The diplo-diploid and haplo-diploid polygynous models are considered with a Poisson distribution for the number of offspring produced by every mated f...

journal_title：Genetics

authors： Lessard S

更新日期：2005-09-01 00:00:00

abstract：:The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social ...

journal_title：Genetics

authors： Johnsson M,Henriksen R,Fogelholm J,Höglund A,Jensen P,Wright D

更新日期：2018-05-01 00:00:00

abstract：:An article by Singh and colleagues in this issue of GENETICS quantifies variation in recombination rate across a small region of the Drosophila melanogaster genome, providing an opportunity for instructors of genetics to introduce or reinforce important concepts such as recombination and recombination rate variation, ...

journal_title：Genetics

authors： Heil CS,Noor MA

更新日期：2013-06-01 00:00:00

abstract：:Gametes are produced in plants through mitotic divisions in the haploid gametophytes. We investigated the role of EXPORTIN1 (XPO1) genes during the development of both female and male gametophytes of Arabidopsis. Exportins exclude target proteins from the nucleus and are also part of a complex recruited at the kinetoc...

journal_title：Genetics

authors： Blanvillain R,Boavida LC,McCormick S,Ow DW

更新日期：2008-11-01 00:00:00

abstract：:Differential gene expression across cell types underlies development and cell physiology in multicellular organisms. Caenorhabditis elegans is a powerful, extensively used model to address these biological questions. A remaining bottleneck relates to the difficulty to obtain comprehensive tissue-specific gene transcri...

journal_title：Genetics

authors： Gómez-Saldivar G,Osuna-Luque J,Semple JI,Glauser DA,Jarriault S,Meister P

更新日期：2020-12-01 00:00:00

abstract：:We have identified a new locus involved in gibberellin (GA) signal transduction by screening for suppressors of the Arabidopsis thaliana GA biosynthetic mutant gal-3. The locus is named RGA for repressor of gal-3. Based on the recessive phenotype of the digenic rga/gal-3 mutant, the wild-type gene product of RGA is pr...

journal_title：Genetics

authors： Silverstone AL,Mak PY,Martínez EC,Sun TP

更新日期：1997-07-01 00:00:00

abstract：:We have precisely mapped and sequenced the three 5' exons of the Drosophila melanogaster Gld gene and have identified the start sites for transcription and translation. The first exon is composed of 335 nucleotides and does not contain any putative translation start codons. The second exon is separated from the first ...

journal_title：Genetics

authors： Whetten R,Organ E,Krasney P,Cox-Foster D,Cavener D

更新日期：1988-10-01 00:00:00

abstract：:A leucine, leucyl-tRNA synthetase-dependent pathway activates TorC1 kinase and its downstream stimulation of protein synthesis, a major nitrogen consumer. We previously demonstrated, however, that control of Gln3, a transcription activator of catabolic genes whose products generate the nitrogenous precursors for prote...

journal_title：Genetics

authors： Tate JJ,Rai R,Cooper TG

更新日期：2015-02-01 00:00:00

abstract：:The degree to which genomic architecture varies across space and time is central to the evolution of genomes in response to natural selection. Bulked-segregant mapping combined with pooled sequencing provides an efficient means to estimate the effect of genetic variants on quantitative traits. We develop a novel likel...

journal_title：Genetics

authors： Monnahan PJ,Kelly JK

更新日期：2017-07-01 00:00:00

abstract：:The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection ...

journal_title：Genetics

authors： Harbison ST,Yamamoto AH,Fanara JJ,Norga KK,Mackay TF

更新日期：2004-04-01 00:00:00

abstract：:An extending axon growth cone is subjected to attractant and repellent cues. It is not clear how these growth cones discriminate the two opposing forces and select their projection paths. Here, we report that in the Drosophila nerve cord the growth cones of longitudinal tracts are subjected to attraction by the Netrin...

journal_title：Genetics

authors： Bhat KM

更新日期：2005-05-01 00:00:00

abstract：:Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...

journal_title：Genetics

authors： Eustice M,Pillus L

更新日期：2014-04-01 00:00:00

abstract：:Two-dimensional paper chromatography was performed on methanol extracts of leaves of hexaploid bread wheat, Triticum aestivum L. em. Thell. cultivar Chinese Spring, and of the available nullisomic-tetrasomic compensating lines, the tetrasomic lines and the ditelocentric lines. The chromatograms had 27 spots identified...

journal_title：Genetics

authors： Neuman PR,Waines JG,Hilu KW,Barnhart D

更新日期：1983-02-01 00:00:00

abstract：:A point connecting a pair of homologous regions of DNA duplexes moves along the homology in a reaction intermediate of the homologous recombination. Formulating this movement as a random walk, we were previously successful at explaining the dependence of the recombination frequency on the homology length. Recently, th...

journal_title：Genetics

authors： Fujitani Y,Kobayashi I

更新日期：1999-12-01 00:00:00

abstract：:Data for Apis mellifera indicate that the P-3 proteins and one esterase enzyme are controlled by two genes, P-3 and Est, with two alleles each. The frequency of the P-3 alleles is different in the two subspecies (adansonii and ligustica), that for P-3(F) in Italian bees being 46.9% and in African 0.5%. The frequency o...

journal_title：Genetics

authors： Mestriner MA,Contel EP

更新日期：1972-12-01 00:00:00

abstract：:Codon usage bias in Drosophila melanogaster genes has been attributed to negative selection of those codons whose cellular tRNA abundance restricts rates of mRNA translation. Previous studies, which involved limited numbers of genes, can now be compared against analyses of the entire gene complements of 12 Drosophila ...

journal_title：Genetics

authors： Heger A,Ponting CP

更新日期：2007-11-01 00:00:00