Abstract:
:Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at least one further new group; the hypothesis of a fla gene which specifies only an RNA structural component of a flagellum-synthesizing basal apparatus is disproven for the corresponding genes. Hfr and transductional crosses confirmed gene assignments from complementation and indicated that flaM and another new fla locus map near H1. A small minority of motile bacteria were detectable in many of the amber fla mutants. In groups A and F some pairs of amber fla mutants complemented each other, and perhaps each of these groups corresponds to more than one structural gene. The suppressed derivatives of a mutant with an amber mutation in H1 made flagella morphologically and serologically indistinguishable from wild-type flagella. A slow-spreading but flagellate mutant showed mainly non-translational motility in broth, and in a viscous medium the bacteria reversed very frequently; its amber mutation, probably near H1, is inferred to cause a defect in chemotaxis, so that the bacteria give the avoidance reaction continuously.
journal_name
Geneticsjournal_title
Geneticsauthors
Vary PS,Stocker BAsubject
Has Abstractpub_date
1973-02-01 00:00:00pages
229-45issue
2eissn
0016-6731issn
1943-2631journal_volume
73pub_type
杂志文章相关文献
GENETICS文献大全abstract::According to the ratchet mechanism hypothesis, deleterious mutations should accumulate in clonal genomes of unisexual fish of the genus Poeciliopsis. This study defines one such mutant, a silent carboxylesterase allele (ES-5 degrees) which is found in the heterozygous condition in a particular population of P. monacha...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-02-01 00:00:00
abstract::This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screeni...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The formation of the Aspergillus nidulans fruiting body is affected by a number of genetic and environmental factors. Here, the nsdC (never in sexual development) gene-encoding a putative transcription factor carrying a novel type of zinc-finger DNA-binding domain consisting of two C(2)H(2)'s and a C(2)HC motif that a...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101667
更新日期:2009-07-01 00:00:00
abstract::We present here a molecular analysis of the region surrounding the structural gene encoding alcohol dehydrogenase (Adh) in 47 lines of Drosophila melanogaster that have each accumulated mutations for 300 generations. While these lines show a significant increase in variation of alcohol dehydrogenase enzyme activity co...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Male Drosophila heterozygous for an SD-bearing second chromosome and a normal homolog preferentially transmit the SD chromosome to their offspring. The distorted transmission involves the induced dysfunction of the sperm that receive the SD+ chromosome. The loci on the SD chromosome responsible for causing distortion ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::A multivariate quantitative genetic model is analyzed that is based on the assumption that the genetic variation at a locus j primarily influences an underlying physiological variable yj, while influence on the genotypic values is determined by a kind of "developmental function" which is not changed by mutations at th...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) are used widely for detecting quantitative trait loci, or for searching for causal variants of diseases. Nevertheless, structural variations such as copy-number variants (CNVs) represent a large part of natural genetic diversity, and contribute significantly to trait variation. N...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302881
更新日期:2020-03-01 00:00:00
abstract::Yip1p is the first identified Rab-interacting membrane protein and the founder member of the YIP1 family, with both orthologs and paralogs found in all eukaryotic genomes. The exact role of Yip1p is unclear; YIP1 is an essential gene and defective alleles severely disrupt membrane transport and inhibit ER vesicle budd...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.032888
更新日期:2004-12-01 00:00:00
abstract::Functional analyses of the Arabidopsis genome require analysis of the gametophytic generation, since approximately 10% of the genes are expressed in the male gametophyte and approximately 9% in the female gametophyte. Here we describe the genetic and molecular characterization of 67 Ds insertion lines that show reduce...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.090852
更新日期:2009-04-01 00:00:00
abstract::There are two distinct reasons for making comparisons of genetic variation for quantitative characters. The first is to compare evolvabilities, or ability to respond to selection, and the second is to make inferences about the forces that maintain genetic variability. Measures of variation that are standardized by the...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::Plants with mutations in one of three maize genes, mop1, rmr1, and rmr2, are defective in paramutation, an allele-specific interaction that leads to meiotically heritable chromatin changes. Experiments reported here demonstrate that these genes are required to maintain the transcriptional silencing of two different tr...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.058669
更新日期:2006-07-01 00:00:00
abstract::Cornell Control White Leghorn chicks were grown in a common environment to five weeks of age and selected for fast and slow gain in body weight from five to nine weeks of age at two temperatures, 21.1 degrees (cold) and 32.2 degrees (hot), during which time a constant 50% relative humidity was maintained. All lines we...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract::We report the results of a genetic screen designed to identify transcriptional coregulators of yeast heat-shock factor (HSF). This sequence-specific activator is required to stimulate both basal and induced transcription; however, the identity of factors that collaborate with HSF in governing noninduced heat-shock gen...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.052738
更新日期:2006-04-01 00:00:00
abstract::All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.112.147207
更新日期:2013-03-01 00:00:00
abstract::Microarray experiments have been used recently in genetical genomics studies, as an additional tool to understand the genetic mechanisms governing variation in complex traits, such as for estimating heritabilities of mRNA transcript abundances, for mapping expression quantitative trait loci, and for inferring regulato...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.106.057281
更新日期:2006-10-01 00:00:00
abstract::The cdc19+ gene encodes an essential member of the MCM family of replication proteins in Schizosaccharomyces pombe. We have examined the structure and function of the Cdc19p protein using molecular and genetic approaches. We find that overproduction of wild-type Cdc19p in wild-type cells has no effect, but cdc19-P1 mu...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::The Pif1 family of DNA helicases is conserved from yeast to humans. Although the helicase domains of family members are well conserved, the amino termini of these proteins are not. The Saccharomyces cerevisiae genome encodes two Pif1 family members, Rrm3p and Pif1p, that have very different functions. To determine if ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.028035
更新日期:2004-11-01 00:00:00
abstract::Restriction site-associated DNA sequencing or genotyping-by-sequencing (GBS) approaches allow for rapid and cost-effective discovery and genotyping of thousands of single-nucleotide polymorphisms (SNPs) in multiple individuals. However, rigorous quality control practices are needed to avoid high levels of error and bi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.169052
更新日期:2014-11-01 00:00:00
abstract::Using a new model of isoalleles, extensive Monte Carlo experiments were performed to examine the pattern of allelic distribution in a finite population. In this model it was assumed that the set of allelic states is represented by discrete points on a one-dimensional lattice and that change of state by mutation occurs...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-03-01 00:00:00
abstract::Heterozygotes for three long inversions on chromosome 1 were analyzed by serial reconstruction from electron micrographs. Measurements of loop lengths at different meiotic prophase substages revealed that the homologous synapsis of the inverted region was gradually replaced by nonhomologous synapsis as loops were elim...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::Interspecific hybridization in the genus Mus results in male sterility and X-linked placental dysplasia. We have generated several congenic laboratory mouse lines (Mus musculus) in which different parts of the maternal X chromosome were derived from M. spretus. A strict positive correlation between placental weight an...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::The determination of segment identity in Drosophila melanogaster appears to be controlled by a small number of genes. In order to identity new components in the process, we have systematically screened the autosomal complement for loci that show a dosage-dependent interaction with mutations in previously characterized...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::The homeotic genes of the Drosophila bithorax complex are controlled by a large cis-regulatory region that ensures their segmentally restricted pattern of expression. A deletion that removes the Frontabdominal-7 cis-regulatory region (Fab-7') dominantly transforms parasegment 11 into parasegment 12. Previous studies s...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::The small heat-shock proteins have undergone a tremendous diversification in plants; whereas only a single small heat-shock protein is found in fungi and many animals, over 20 different small heat-shock proteins are found in higher plants. The small heat-shock proteins in plants have diversified in both sequence and c...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Haplotype variation in 9.7 kb of genomic DNA sequence from the human lipoprotein lipase (LPL) gene was scored in three populations: African-Americans from Jackson, Mississippi (24 individuals), Finns from North Karelia, Finland (24), and non-Hispanic whites from Rochester, Minnesota (23). Earlier analyses had indicate...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and mapped two of the mu...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.092775
更新日期:2008-12-01 00:00:00
abstract::Selection during evolution, whether natural or artificial, acts through the phenotype. For multifaceted phenotypes such as plant and inflorescence architecture, the underlying genetic architecture is comprised of a complex network of interacting genes rather than single genes that act independently to determine the tr...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.300071
更新日期:2017-10-01 00:00:00
abstract::We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering approximately 77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element insertions, we have generated 655 new deletions and verifi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.076216
更新日期:2007-09-01 00:00:00
abstract::Serrate (Ser) is an essential gene in Drosophila melanogaster best known for the Ser dominant (SerD) allele and its effects on wing development. Animals heterozygous or homozygous for SerD are viable and exhibit loss of wing margin tissue and associated bristles and hairs. The Beaded of Goldschmidt (BdG) allele of Ser...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00