A collection of Ds insertional mutants associated with defects in male gametophyte development and function in Arabidopsis thaliana.

Abstract:

:Functional analyses of the Arabidopsis genome require analysis of the gametophytic generation, since approximately 10% of the genes are expressed in the male gametophyte and approximately 9% in the female gametophyte. Here we describe the genetic and molecular characterization of 67 Ds insertion lines that show reduced transmission through the male gametophyte. About half of these mutations are male gametophytic-specific mutations, while the others also affect female transmission. Genomic sequences flanking both sides of the Ds element were recovered for 39 lines; for 16 the Ds elements were inserted in or close to coding regions, while 7 were located in intergenic/unannotated regions of the genome. For the remaining 16 lines, chromosomal rearrangements such as translocations or deletions, ranging between 30 and 500 kb, were associated with the transposition event. The mutants were classified into five groups according to the developmental processes affected; these ranged from defects in early stages of gametogenesis to later defects affecting pollen germination, pollen tube growth, polarity or guidance, or pollen tube-embryo sac interactions or fertilization. The isolated mutants carry Ds insertions in genes with diverse biological functions and potentially specify new functions for several unannotated or unknown proteins.

journal_name

Genetics

journal_title

Genetics

authors

Boavida LC,Shuai B,Yu HJ,Pagnussat GC,Sundaresan V,McCormick S

doi

10.1534/genetics.108.090852

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1369-85

issue

4

eissn

0016-6731

issn

1943-2631

pii

genetics.108.090852

journal_volume

181

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Roles for the Histone Modifying and Exchange Complex NuA4 in Cell Cycle Progression in Drosophila melanogaster.

    abstract::Robust and synchronous repression of E2F-dependent gene expression is critical to the proper timing of cell cycle exit when cells transition to a postmitotic state. Previously NuA4 was suggested to act as a barrier to proliferation in Drosophila by repressing E2F-dependent gene expression. Here we show that NuA4 activ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.188581

    authors: Flegel K,Grushko O,Bolin K,Griggs E,Buttitta L

    更新日期:2016-07-01 00:00:00

  • Identification of genomic regions that interact with a viable allele of the Drosophila protein tyrosine phosphatase corkscrew.

    abstract::Signaling by receptor tyrosine kinases (RTKs) is critical for a multitude of developmental decisions and processes. Among the molecules known to transduce the RTK-generated signal is the nonreceptor protein tyrosine phosphatase Corkscrew (Csw). Previously, Csw has been demonstrated to function throughout the Drosophil...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Firth L,Manchester J,Lorenzen JA,Baron M,Perkins LA

    更新日期:2000-10-01 00:00:00

  • Stochastic tunnels in evolutionary dynamics.

    abstract::We study a situation that arises in the somatic evolution of cancer. Consider a finite population of replicating cells and a sequence of mutations: type 0 can mutate to type 1, which can mutate to type 2. There is no back mutation. We start with a homogeneous population of type 0. Mutants of type 1 emerge and either b...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.166.3.1571

    authors: Iwasa Y,Michor F,Nowak MA

    更新日期:2004-03-01 00:00:00

  • Chromosomal location of genes controlling flavonoid production in hexaploid wheat.

    abstract::Two-dimensional paper chromatography was performed on methanol extracts of leaves of hexaploid bread wheat, Triticum aestivum L. em. Thell. cultivar Chinese Spring, and of the available nullisomic-tetrasomic compensating lines, the tetrasomic lines and the ditelocentric lines. The chromatograms had 27 spots identified...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Neuman PR,Waines JG,Hilu KW,Barnhart D

    更新日期:1983-02-01 00:00:00

  • Drosophila-host genetic control of susceptibility to Drosophila C virus.

    abstract::Interactions between Drosophila C virus (DCV) and its natural host, Drosophila melanogaster, were investigated using 15 geographical population samples infected by intraabdominal inoculation. These strains derived from natural populations of D. melanogaster differed in susceptibility to the DCVc. One strain was "parti...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Thomas-Orillard M,Jeune B,Cusset G

    更新日期:1995-08-01 00:00:00

  • hairy: A quantitative trait locus for drosophila sensory bristle number.

    abstract::Advances in medicine, agriculture, and an understanding of evolution depend on resolving the genetic architecture of quantitative traits, which is challenging since variation for complex traits is caused by multiple interacting quantitative trait loci (QTL) with small and conditional effects. Here, we show that the ke...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Robin C,Lyman RF,Long AD,Langley CH,Mackay TF

    更新日期:2002-09-01 00:00:00

  • Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.

    abstract::Immature spermatids from Caenorhabditis elegans are stimulated by an external activation signal to reorganize their membranes and cytoskeleton to form crawling spermatozoa. This rapid maturation, termed spermiogenesis, occurs without any new gene expression. To better understand this signal transduction pathway, we is...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Muhlrad PJ,Ward S

    更新日期:2002-05-01 00:00:00

  • Genetic control of horizontal virus transmission in the chestnut blight fungus, Cryphonectria parasitica.

    abstract::Vegetative incompatibility in fungi has long been known to reduce the transmission of viruses between individuals, but the barrier to transmission is incomplete. In replicated laboratory assays, we showed conclusively that the transmission of viruses between individuals of the chestnut blight fungus Cryphonectria para...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Cortesi P,McCulloch CE,Song H,Lin H,Milgroom MG

    更新日期:2001-09-01 00:00:00

  • Mutation at the am locus of Neurospora crassa.

    abstract::Forty-eight new mutations at the am locus of Neurospora crassa have been characterized. Nineteen mutations were induced by UV; of these, eight were missense, two were frameshifts, two were nonsense, three were deletions and four were unidentified. Twenty-nine mutations were induced with nitrous acid; of these, twenty-...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kinsey JA,Hung BS

    更新日期:1981-11-01 00:00:00

  • A Distinct type of heterochromatin within Drosophila melanogaster chromosome 4.

    abstract::Studies of transcriptional gene silencing in Drosophila melanogaster suggest that most of chromosome 4 resembles pericentric heterochromatin. However, some modifiers of position-effect variegation, including chromosome 4 dosage and loss of SU(VAR)3-9, have different effects on silencing in pericentric vs. distal arm c...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.066407

    authors: Haynes KA,Gracheva E,Elgin SC

    更新日期:2007-03-01 00:00:00

  • Marker-dependent recombination in T4 bacteriophage. III. Structural prerequisites for marker discrimination.

    abstract::Distance- as well as marker-dependence of genetic recombination of bacteriophage T4 was studied in crosses between rIIB mutants with known base sequences. The notion of a "basic recombination," which is the recombination within distances shorter than hybrid DNA length in the absence of mismatch repair and any marker e...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shcherbakov VP,Plugina LA

    更新日期:1991-08-01 00:00:00

  • Molecular zoogeography of freshwater fishes in the southeastern United States.

    abstract::Restriction fragment length polymorphisms in mitochondrial DNA (mtDNA) were used to reconstruct evolutionary relationships of conspecific populations in four species of freshwater fish-Amia calva, Lepomis punctatus, L. gulosus, and L. microlophus. A suite of 14-17 endonucleases was employed to assay mtDNAs from 305 sp...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bermingham E,Avise JC

    更新日期:1986-08-01 00:00:00

  • Mitochondrial genome maintenance: roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae.

    abstract::Mitochondrial DNA (mtDNA) deletions are associated with sporadic and inherited diseases and age-associated neurodegenerative disorders. Approximately 85% of mtDNA deletions identified in humans are flanked by short directly repeated sequences; however, mechanisms by which these deletions arise are unknown. A limitatio...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.138214

    authors: Kalifa L,Quintana DF,Schiraldi LK,Phadnis N,Coles GL,Sia RA,Sia EA

    更新日期:2012-03-01 00:00:00

  • Genetic and molecular characterization of suppressors of SIR4 mutations in Saccharomyces cerevisiae.

    abstract::In order to learn more about other proteins that may be involved in repression of HML and HMR in Saccharomyces cerevisiae, extragenic suppressor mutations were identified that could restore repression in cells defective in SIR4, a gene required for function of the silencer elements flanking HML and HMR. These suppress...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Schnell R,D'Ari L,Foss M,Goodman D,Rine J

    更新日期:1989-05-01 00:00:00

  • Sequencing complex diseases With HapMap.

    abstract::Determining the patterns of DNA sequence variation in the human genome is a useful first step toward identifying the genetic basis of a common disease. A haplotype map (HapMap), aimed at describing these variation patterns across the entire genome, has been recently developed by the International HapMap Consortium. In...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.029603

    authors: Liu T,Johnson JA,Casella G,Wu R

    更新日期:2004-09-01 00:00:00

  • An inbreeding model of associative overdominance during a population bottleneck.

    abstract::Associative overdominance, the fitness difference between heterozygotes and homozygotes at a neutral locus, is classically described using two categories of models: linkage disequilibrium in small populations or identity disequilibrium in infinite, partially selfing populations. In both cases, only equilibrium situati...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bierne N,Tsitrone A,David P

    更新日期:2000-08-01 00:00:00

  • The isolation of mms- and histidine-sensitive mutants in Neurospora crassa.

    abstract::A simple method of replica plating has been used to isolate mutants of Neurospora crassa that have increased sensitivity to methyl methanesulfonate (MMS) and/or to histidine. Twelve mutants with increased sensitivity to MMS and one mutant with increased sensitivity to histidine showed Mendelian segregation of the muta...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Delange AM,Mishra NC

    更新日期:1981-02-01 00:00:00

  • Mapping quantitative trait loci for expression abundance.

    abstract::Mendelian loci that control the expression levels of transcripts are called expression quantitative trait loci (eQTL). When mapping eQTL, we often deal with thousands of expression traits simultaneously, which complicates the statistical model and data analysis. Two simple approaches may be taken in eQTL analysis: (1)...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.065599

    authors: Jia Z,Xu S

    更新日期:2007-05-01 00:00:00

  • A selfish gene governing pollen-pistil compatibility confers reproductive isolation between maize relatives.

    abstract::Some populations of maize's closest relatives, the annual teosintes of Mexico, are unreceptive to maize pollen. When present in the pistil (silk and ovary) a number of maize genes discriminate against or exclude pollen not carrying the same allele. An analogous gene Tcb1-s was found in some teosinte populations but no...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.048645

    authors: Kermicle JL

    更新日期:2006-01-01 00:00:00

  • Microsatellite mutations and inferences about human demography.

    abstract::Microsatellites have been widely used as tools for population studies. However, inference about population processes relies on the specification of mutation parameters that are largely unknown and likely to differ across loci. Here, we use data on somatic mutations to investigate the mutation process at 14 tetranucleo...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Gonser R,Donnelly P,Nicholson G,Di Rienzo A

    更新日期:2000-04-01 00:00:00

  • Interactions of liguleless1 and liguleless2 function during ligule induction in maize.

    abstract::The maize ligule is an adaxial membranous structure on the leaf that develops at the boundary of the sheath and blade. The ligule and the associated auricle are dispensable structures, amenable to genetic manipulation. We present here a genetic analysis of liguleless1 (lg1) and liguleless2 (lg2), the two genes known t...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Harper L,Freeling M

    更新日期:1996-12-01 00:00:00

  • Wolbachia infection and cytoplasmic incompatibility in Drosophila species.

    abstract::Forty-one stocks from 30 Drosophila species were surveyed for Wolbachia infection using PCR technology. D. sechellia and two strains of D. auraria were found to be infected and were tested for the expression of cytoplasmic incompatibility, along with D. ananassae and D. melanogaster strains, which are already known to...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bourtzis K,Nirgianaki A,Markakis G,Savakis C

    更新日期:1996-11-01 00:00:00

  • Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing.

    abstract::Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.084384

    authors: Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

    更新日期:2008-06-01 00:00:00

  • Punctuated Aneuploidization of the Budding Yeast Genome.

    abstract::Remarkably complex patterns of aneuploidy have been observed in the genomes of many eukaryotic cell types, ranging from brewing yeasts to tumor cells. Such aberrant karyotypes are generally thought to take shape progressively over many generations, but evidence also suggests that genomes may undergo faster modes of ev...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.120.303536

    authors: Heasley LR,Watson RA,Argueso JL

    更新日期:2020-09-01 00:00:00

  • Overdominant epistatic loci are the primary genetic basis of inbreeding depression and heterosis in rice. II. Grain yield components.

    abstract::The genetic basis underlying inbreeding depression and heterosis for three grain yield components of rice was investigated in five interrelated mapping populations using a complete RFLP linkage map, replicated phenotyping, and the mixed model approach. The populations included 254 F(10) recombinant inbred lines (RILs)...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Luo LJ,Li ZK,Mei HW,Shu QY,Tabien R,Zhong DB,Ying CS,Stansel JW,Khush GS,Paterson AH

    更新日期:2001-08-01 00:00:00

  • The neutral coalescent process for recent gene duplications and copy-number variants.

    abstract::I describe a method for simulating samples from gene families of size two under a neutral coalescent process, for the case where the duplicate gene either has fixed recently in the population or is still segregating. When a duplicate locus has recently fixed by genetic drift, diversity in the new gene is expected to b...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.074948

    authors: Thornton KR

    更新日期:2007-10-01 00:00:00

  • A Bayesian multilocus association method: allowing for higher-order interaction in association studies.

    abstract::For most common diseases with heritable components, not a single or a few single-nucleotide polymorphisms (SNPs) explain most of the variance for these disorders. Instead, much of the variance may be caused by interactions (epistasis) among multiple SNPs or interactions with environmental conditions. We present a new ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.071696

    authors: Albrechtsen A,Castella S,Andersen G,Hansen T,Pedersen O,Nielsen R

    更新日期:2007-06-01 00:00:00

  • Spt3 plays opposite roles in filamentous growth in Saccharomyces cerevisiae and Candida albicans and is required for C. albicans virulence.

    abstract::Spt3 of Saccharomyces cerevisiae is required for the normal transcription of many genes in vivo. Past studies have shown that Spt3 is required for both mating and sporulation, two events that initiate when cells are at G(1)/START. We now show that Spt3 is needed for two other events that begin at G(1)/START, diploid f...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Laprade L,Boyartchuk VL,Dietrich WF,Winston F

    更新日期:2002-06-01 00:00:00

  • Nucleolar dominance and replicative dominance in Drosophila interspecific hybrids.

    abstract::The replication of the rDNA complement of only one nucleolus organizer region during polytene chromosome formation (replicative dominance) was initially observed in Drosophila melanogaster. Here we demonstrate replicative dominance in Drosophila simulans and D. melanogaster/D. simulans interspecific hybrids. A second ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Goodrich-Young C,Krider HM

    更新日期:1989-10-01 00:00:00

  • The colinearity of the Sh2/A1 orthologous region in rice, sorghum and maize is interrupted and accompanied by genome expansion in the triticeae.

    abstract::The Sh2/A1 orthologous region of maize, rice, and sorghum contains five genes in the order Sh2, X1, X2, and two A1 homologs in tandem duplication. The Sh2 and A1 homologs are separated by approximately 20 kb in rice and sorghum and by approximately 140 kb in maize. We analyzed the fate of the Sh2/A1 region in large-ge...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Li W,Gill BS

    更新日期:2002-03-01 00:00:00