Abstract:
:The replication of the rDNA complement of only one nucleolus organizer region during polytene chromosome formation (replicative dominance) was initially observed in Drosophila melanogaster. Here we demonstrate replicative dominance in Drosophila simulans and D. melanogaster/D. simulans interspecific hybrids. A second nucleolar phenomenon, nucleolar dominance, is observed in the diploid tissue of interspecific hybrids. In this case only one of two nucleolus organizer regions forms a nucleolus. However, reorganizations of the X chromosome heterochromatin which eliminate nucleolar dominance have no apparent effect on the expression of replicative dominance. These observations lead us to conclude that nucleolar dominance and replicative dominance are operationally separable functions influencing the rDNAs, and may be determined by differing regulatory events.
journal_name
Geneticsjournal_title
Geneticsauthors
Goodrich-Young C,Krider HMsubject
Has Abstractpub_date
1989-10-01 00:00:00pages
349-58issue
2eissn
0016-6731issn
1943-2631journal_volume
123pub_type
杂志文章相关文献
GENETICS文献大全abstract::Primary cilia have essential roles in transducing signals in eukaryotes. At their core is the ciliary axoneme, a microtubule-based structure that defines cilium morphology and provides a substrate for intraflagellar transport. However, the extent to which axonemal microtubules are specialized for sensory cilium functi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.116996
更新日期:2010-07-01 00:00:00
abstract::The three-dimensional organization of polytene chromosomes within nuclei containing rearranged X chromosomes was examined in male Drosophila melanogaster. Salivary glands of third instar larvae containing either an inverted X chromosome (YSX.YL, In(1)EN/O) or a ring X chromosome (R(1) 2/BSYy+) were fixed, embedded, an...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::The Thomas Hunt Morgan Medal is awarded to an individual Genetics Society of America member for lifetime achievement in the field of genetics. It recognizes the full body of work of an exceptional geneticist. The 2016 recipient is Nancy Kleckner, who has made many significant contributions to our understanding of chro...
journal_title:Genetics
pub_type: 历史文章,杂志文章
doi:10.1534/genetics.116.197608
更新日期:2016-12-01 00:00:00
abstract::A correlation between diversity levels and rates of recombination is predicted both by models of positive selection, such as hitchhiking associated with the rapid fixation of advantageous mutations, and by models of purifying selection against strongly deleterious mutations (commonly referred to as "background selecti...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::Microsatellites have been widely used as tools for population studies. However, inference about population processes relies on the specification of mutation parameters that are largely unknown and likely to differ across loci. Here, we use data on somatic mutations to investigate the mutation process at 14 tetranucleo...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the post...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.117.300167
更新日期:2018-06-01 00:00:00
abstract::The three mammalian D-type cyclins are thought to promote progression through the G1 phase of the cell cycle as regulatory subunits of cyclin-dependent kinase 4 and 6. In addition, they have been proposed to control the activity of various transcription factors without a partner kinase. Here we describe phenotypic con...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.027417
更新日期:2004-10-01 00:00:00
abstract::To understand the role of Los1p in pre-tRNA splicing, we sought los1 multicopy suppressors. We found SOL1 that suppresses both point and null LOS1 mutations. Since, when fused to the Ga14p DNA-binding domain, Los1p activates transcription, we tested whether Los1p regulates SOL1. We found that las1 mutants have deplete...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::The ability of autonomously replicating plasmids to recombine in mammalian cells was investigated. Two deletion plasmids of the eukaryotic-prokaryotic shuttle vector pSV2neo were cotransfected into transformed monkey COS cells. Examination of the low molecular weight DNA isolated after 48 hr of incubation revealed tha...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1985-10-01 00:00:00
abstract::Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-08-01 00:00:00
abstract::In this article, we utilize stochastic search variable selection methodology to develop a Bayesian method for identifying multiple quantitative trait loci (QTL) for complex traits in experimental designs. The proposed procedure entails embedding multiple regression in a hierarchical normal mixture model, where latent ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::In mismatch repair (MMR), members of the MLH gene family have been proposed to act as key molecular matchmakers to coordinate mismatch recognition with downstream repair functions that result in mispair excision. Two members of this gene family, MLH1 and MLH3, have also been implicated in meiotic crossing over. These ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.166769
更新日期:2014-09-01 00:00:00
abstract::Translocation induced in the immature oocyte, in meiotic prophase, affects division I orientation and segregation, the usual result being that the two halves of translocations are directed to opposite poles. Since interchange is usually (if not exclusively) between chromatids, this is to be expected from the creation ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-09-01 00:00:00
abstract::Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.166.2.807
更新日期:2004-02-01 00:00:00
abstract::The DC2 gene was isolated previously on the basis of sequence similarity to DC0, the major Drosophila protein kinase A (PKA) catalytic subunit gene. We show here that the 67-kD Drosophila DC2 protein behaves as a PKA catalytic subunit in vitro. DC2 is transcribed in mesodermal anlagen of early embryos. This expression...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::The construction in bacteriophage lambda of a set of long DNA palindromes with paired changes in the central sequence is described. Identical palindrome centers were previously used by others to test the S-type model for cruciform extrusion in vitro. Long DNA palindromes prevent the propagation of carrier phage lambda...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Data for Apis mellifera indicate that the P-3 proteins and one esterase enzyme are controlled by two genes, P-3 and Est, with two alleles each. The frequency of the P-3 alleles is different in the two subspecies (adansonii and ligustica), that for P-3(F) in Italian bees being 46.9% and in African 0.5%. The frequency o...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-12-01 00:00:00
abstract::We present a Bayesian method for characterizing the mating system of populations reproducing through a mixture of self-fertilization and random outcrossing. Our method uses patterns of genetic variation across the genome as a basis for inference about reproduction under pure hermaphroditism, gynodioecy, and a model de...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.179093
更新日期:2015-11-01 00:00:00
abstract::In Drosophila melanogaster, the endogenous retrovirus gypsy is repressed by the functional alleles (restrictive) of an as-yet-uncloned heterochromatic gene called flamenco. Using gypsy-lacZ transcriptional fusions, we show here that this repression takes place not only in the follicle cells of restrictive ovaries, as ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.166.3.1313
更新日期:2004-03-01 00:00:00
abstract::Sixty independent UGA suppressors of Saccharomyces cerevisiae have been studied. They are dominant and are divided into 16 groups (loci) by recombination. Suppressors representing these loci are divided into two classes by action spectra; four in class 1 (a broad action spectrum) and 12 in class 2 (a narrow action spe...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::At least six nuclear loci are responsible for the genetic control of malate dehydrogenase (L-malate: NAD oxidoreductase; EC 1.1.1.37; MDH) in coleoptiles of maize. Three independently segregating loci (Mdh1, Mdh2, Mdh3) govern the production of MDH isozymes resistant to inactivation by ascorbic acid and found largely ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Several human pathogens (e.g., Bacillus anthracis, Yersinia pestis, Bordetella pertussis, Plasmodium falciparum, and Mycobacterium tuberculosis) have very restricted unselected allelic variation in structural genes, which hinders study of the genetic relationships among strains and strain-trait correlations. To addres...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::An analysis of the effects of spontaneous mutations affecting age-specific mortality was conducted using 29 lines of Drosophila melanogaster that had accumulated spontaneous mutations for 19 generations. Divergence among the lines was used to estimate the mutational variance for weekly mortality rates and the covarian...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::In Arabidopsis thaliana, DICER-LIKE 1 and DICER-LIKE 3 are involved in the generation of small RNAs. Double mutants between dicer-like 1 and dicer-like 3 exhibit a delay in flowering that is caused by increased expression of the floral repressor FLOWERING LOCUS C. This delayed-flowering phenotype is similar to that of...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.070649
更新日期:2007-06-01 00:00:00
abstract::Two sets of overlapping experiments were conducted to examine recombination and spontaneous mutation events within clusters of resistance genes in lettuce. Multiple generations were screened for recombinants using PCR-based markers flanking Dm3. The Dm3 region is not highly recombinagenic, exhibiting a recombination f...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::We estimated DNA sequence variation in a 5.7-kb fragment of the furrowed (fw) gene region within and between four populations of Drosophila ananassae; fw is located in a chromosomal region of very low recombination. We analyzed gene flow between these four populations along a latitudinal transect on the Indian subcont...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::The TATA-binding protein (TBP) is composed of a highly conserved core domain sufficient for TATA-element binding and preinitiation complex formation as well as a highly divergent N-terminal region that is dispensable for yeast cell viability. In vitro, removal of the N-terminal region domain enhances TBP-TATA associat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::Two-dimensional paper chromatography was performed on methanol extracts of leaves of hexaploid bread wheat, Triticum aestivum L. em. Thell. cultivar Chinese Spring, and of the available nullisomic-tetrasomic compensating lines, the tetrasomic lines and the ditelocentric lines. The chromatograms had 27 spots identified...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1983-02-01 00:00:00
abstract::Four species of the Hawaiian Drosophila planitibia subgroup which are homosequential in their polytene chromosomes are resident on the islands of Molokai, Maui and Hawaii. Comparisons of DNA sequence divergence in these four have been made by hybridization of total single-copy radiolabeled tracer DNA from each of the ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00