Abstract:
:Translocation induced in the immature oocyte, in meiotic prophase, affects division I orientation and segregation, the usual result being that the two halves of translocations are directed to opposite poles. Since interchange is usually (if not exclusively) between chromatids, this is to be expected from the creation of illegitimate conjunctions. Good agreement is obtained between patterns of segregations deduced from recovered half-translocation bearing exceptions and the kinds of disomic gametes expected as alternative recoveries from the same division I configurations. Inferences drawn from the study of compound-X females have been found to apply as well in the case of females of normal karyotype. Numerical errors occur predominantly, possibly exclusively, in division I. The rate of induced nondisjunction of specific chromosome pairs varies in relation to the structure of the entire complement, as required if radiation-induced nondisjunction is interchange dependent, but which would be unexpected if the mechanism involved effects on individual spindle fibers, chromosomes, or chromosomal bivalents.
journal_name
Geneticsjournal_title
Geneticsauthors
Parker DR,Williamson JHsubject
Has Abstractpub_date
1974-09-01 00:00:00pages
163-71issue
1eissn
0016-6731issn
1943-2631journal_volume
78pub_type
杂志文章相关文献
GENETICS文献大全abstract::Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-function phenotypes, which cannot differentiate between separation-of-...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.147801
更新日期:2013-03-01 00:00:00
abstract::In classical "cut-and-paste" transposition, transposons are excised from donor sites and inserted at new locations. We have identified an alternative pathway in which transposition involves the 5' end of an intact Ac element and the 3' end of a nearby terminally deleted fAc (fractured Ac). The Ac and fAc elements are ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.103.026229
更新日期:2004-08-01 00:00:00
abstract::The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex of Saccharomyces cerevisiae is a multifunctional coactivator complex that has been shown to regulate transcription by distinct mechanisms. Previous results have shown that the Spt3 and Spt8 components of SAGA regulate initiation of transcription of particular genes by ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.081976
更新日期:2007-12-01 00:00:00
abstract::We have characterized the MPH1 gene from Saccharomyces cerevisiae. mph1 mutants display a spontaneous mutator phenotype. Homologs were found in archaea and in the EST libraries of Drosophila, mouse, and man. Mph1 carries the signature motifs of the DEAH family of helicases. Selected motifs were shown to be necessary f...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. While many AMD susceptibility variants have been identified, their influence on AMD progression has not been elucidated. Using data from two large clinical trials, Age-Related Eye Disease Study (AREDS) and AREDS2, we evaluat...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.196998
更新日期:2017-05-01 00:00:00
abstract::The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.090936
更新日期:2008-08-01 00:00:00
abstract::At pH 6.8, a substantial fraction of recombinant colonies obtained from conjugation with an HfrH donor contained multiple recombinant classes in a single colony (polygenotype colony). In contrast, when the conjugation was performed at pH 7.6, the number of polygenotypic colonies was drastically reduced, and the recomb...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1975-07-01 00:00:00
abstract::The gilthead sea bream (Sparus aurata L.) is a marine fish of great importance for fisheries and aquaculture. It has also a peculiar sex-determination system, being a protandrous hermaphrodite. Here we report the construction of a first-generation genetic linkage map for S. aurata, based on 204 microsatellite markers....
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.059014
更新日期:2006-10-01 00:00:00
abstract::Orientation disruptor (ord), a meiotic mutant that is recombination defective in females and disjunction defective in males and females, has been analyzed using serial section electron and light microscopy. From analysis of primary spermatocytes we have confirmed that ord males are defective in some aspect of the mech...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00
abstract::We provide a genetic analysis of the meiotic drive system on maize abnormal chromosome 10 (Ab10) that causes preferential segregation of specific chromosomal regions to the reproductive megaspore. The data indicate that at least four chromosomal regions contribute to meiotic drive, each providing distinct functions th...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::The initiation of growth cessation and dormancy represents a critical ecological and evolutionary trade-off between survival and growth in most forest trees. The most important environmental cue regulating the initiation of dormancy is a shortening of the photoperiod and phytochrome genes have been implicated in short...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.047522
更新日期:2006-03-01 00:00:00
abstract::Quantitative traits whose phenotypic values change over time are called longitudinal traits. Genetic analyses of longitudinal traits can be conducted using any of the following approaches: (1) treating the phenotypic values at different time points as repeated measurements of the same trait and analyzing the trait und...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.054775
更新日期:2006-08-01 00:00:00
abstract::As part of our investigation of disease resistance in lettuce, we generated mutants that have lost resistance to Bremia lactucae, the casual fungus of downy mildew. Using a rapid and reliable screen, we identified 16 distinct mutants of Latuca sativa that have lost activity of one of four different downy mildew resist...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Two protocols are presented that allow the selection of mutations mapping to micronuclear chromosome 5 in Tetrahymena thermophilia. One protocol involves crossing mutagenized diploid cells directly to a strain nullisomic for chromosome 5 and screening the monosomic progeny for a mutant phenotype. The second protocol f...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Catfish is the major aquaculture species in the United States. The hybrid catfish produced by crossing channel catfish females with blue catfish males exhibit a number of desirable production traits, but their mass production has been difficult. To introduce desirable genes from blue catfish into channel catfish throu...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::RNA polymerase II (RNAPII) in eukaryotic cells drives transcription of most messenger RNAs. RNAPII core enzyme is composed of 12 polypeptides where Rpb1 is the largest subunit. To further understand the mechanisms of RNAPII transcription, we isolated and characterized novel point mutants of RPB1 that are sensitive to ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.052415
更新日期:2006-04-01 00:00:00
abstract::A combination of nuclear and chloroplast simple sequence repeats (SSRs) have been used to investigate the levels and pattern of variability detected in Glycine max and G. soja genotypes. Based on the analysis of 700 soybean genotypes with 115 restriction fragment length polymorphism (RFLP) probes, 12 accessions were i...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::We describe here a new variant of transposon Tn10 especially adapted for transposon analysis of cloned yeast genes; it can equally well be used for analysis of prokaryotic genes. We have applied this element to analysis of the LEU2, RAD50, and CDC48 genes of Saccharomyces cerevisiae. This transposon, nicknamed mini-Tn...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::Population structure leads to systematic patterns in measures of mean relatedness between individuals in large genomic data sets, which are often discovered and visualized using dimension reduction techniques such as principal component analysis (PCA). Mean relatedness is an average of the relationships across locus-s...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.118.301747
更新日期:2019-01-01 00:00:00
abstract::RNA transcribed from the Saccharomyces cerevisiae retrotransposon Ty1 accumulates to a high level in mitotically growing haploid cells, yet transposition occurs at very low frequencies. The product of reverse transcription is a linear double-stranded DNA molecule that reenters the genome by either Ty1-integrase-mediat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::The bovine Growth Hormone gene (bGH) is an attractive candidate gene for milk production in cattle. Single-strand conformation polymorphisms at bGH were identified and used to define haplotype configurations at this gene in the Israeli Holstein dairy cattle population (Bos taurus) and in the parent animals of the Inte...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.071142
更新日期:2007-07-01 00:00:00
abstract::We have precisely mapped and sequenced the three 5' exons of the Drosophila melanogaster Gld gene and have identified the start sites for transcription and translation. The first exon is composed of 335 nucleotides and does not contain any putative translation start codons. The second exon is separated from the first ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Mobile P elements in Drosophila melanogaster cause hybrid dysgenesis if their mobility is not repressed. One type of repression, termed P cytotype, is a complex interaction between chromosomes carrying P elements and cytoplasm and is transmitted through the cytoplasm only of females. Another type of repression is foun...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::This paper draws attention to the formal parallelism that exists between chromosomal-loss mosaicism and mutagenically induced mosaicism in Drosophila and suggests that, although the underlying processes by which these two types of genetic mosaics are generated are very different, the more refined methodology employed ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1977-08-01 00:00:00
abstract::We have identified two Saccharomyces cerevisiae genes that, in high copy, confer resistance to Kluyveromyces lactis zymocin, an inhibitor that blocks cells in the G(1) phase of the cell cycle prior to budding and DNA replication. One gene (GRX3) encodes a glutaredoxin and is likely to act at the level of zymocin entry...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::Intron sizes show an asymmetrical distribution in a number of organisms, with a large number of "short" introns clustered around a minimal intron length and a much broader distribution of longer introns. In Drosophila melanogaster, the short intron class is centered around 61 bp. The narrow length distribution suggest...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::The inbred mouse strain, C57BL/6J, was derived from mice of the Mus musculus complex. C57BL/6J can be crossed in the laboratory with a closely related mouse species, M. spretus to produce fertile offspring; however there has been no previous evidence of gene flow between M. spretus and M. musculus in nature. Analysis ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::Properties of identity relation between genes are discussed, and a derivation of recurrent equations of identity coefficients in a random mating, diploid dioecious population is presented. Computations are run by repeated matrix multiplication. Results show that for effective population size (Ne) larger than 16 and no...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::A consensus map for loblolly pine (Pinus taeda L.) was constructed from the integration of linkage data from two unrelated three-generation outbred pedigrees. The progeny segregation data from restriction fragment length polymorphism, random amplified polymorphic DNA, and isozyme genetic markers from each pedigree wer...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00