Abstract:
:The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more paralogs than haplosufficient genes in the human genome. However, the previous analysis incorrectly assumed that the presence of dominant abnormal alleles of a human gene means that the gene is haploinsufficient, ignoring the fact that many dominant abnormal alleles arise from gain-of-function mutations. Here we show in both humans and yeast that haploinsufficient genes generally do not duplicate more frequently than haplosufficient genes. Yeast haploinsufficient genes do exhibit enhanced retention after whole-genome duplication compared to haplosufficient genes if they encode members of stable protein complexes, but the same phenomenon is absent if the genes do not encode protein complex members, suggesting that the dosage balance effect rather than the dosage effect is the underlying cause of the phenomenon. On the basis of these and other results, we conclude that selection for higher gene dosage does not play a major role in driving the fixation of duplication genes.
journal_name
Geneticsjournal_title
Geneticsauthors
Qian W,Zhang Jdoi
10.1534/genetics.108.090936subject
Has Abstractpub_date
2008-08-01 00:00:00pages
2319-24issue
4eissn
0016-6731issn
1943-2631pii
genetics.108.090936journal_volume
179pub_type
杂志文章相关文献
GENETICS文献大全abstract::Immunosenescence, the age-related decline in immune system function, is a general hallmark of aging. While much is known about the cellular and physiological changes that accompany immunosenescence, we know little about the genetic influences on this phenomenon. In this study we combined age-specific measurements of b...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.140640
更新日期:2012-07-01 00:00:00
abstract::doublesex (dsx) is unusual among the known sex-determination genes of Drosophila melanogaster in that functional homologs are found in distantly related species. In flies, dsx occupies a position near the bottom of the sex determination hierarchy. It is expressed in male- and female-specific forms and these proteins f...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Germ cell specification as sperm or oocyte is an ancient cell fate decision, but its molecular regulation is poorly understood. In Caenorhabditis elegans, the FOG-1 and FOG-3 proteins behave genetically as terminal regulators of sperm fate specification. Both are homologous to well-established RNA regulators, suggesti...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.182592
更新日期:2016-01-01 00:00:00
abstract::The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on the Bos taurus lineage, an impo...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.039040
更新日期:2005-07-01 00:00:00
abstract::Statistical associations between phenotypic traits often result from shared developmental processes and include both covariation between the trait values and more complex associations between higher moments of the joint distribution of traits. In this article, an analytical technique for calculating the covariance bet...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.166.1.513
更新日期:2004-01-01 00:00:00
abstract::Chromosome 1A(m) of Triticum monococcum is closely homeologous to T. aestivum chromosome 1A but recombines with it little in the presence of the wheat suppressor of homeologous chromosome pairing, Ph1. In the absence of Ph1, the two chromosomes recombine as if they were completely homologous. Chromosomes having either...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::Triose phosphate isomerase (TPI) deficiency glycolytic enzymopathy is a progressive neurodegenerative condition that remains poorly understood. The disease is caused exclusively by specific missense mutations affecting the TPI protein and clinically features hemolytic anemia, adult-onset neurological impairment, degen...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.087551
更新日期:2008-06-01 00:00:00
abstract::Genome-wide association studies (GWAS) have been widely used for identifying common variants associated with complex diseases. Despite remarkable success in uncovering many risk variants and providing novel insights into disease biology, genetic variants identified to date fail to explain the vast majority of the heri...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.185009
更新日期:2016-03-01 00:00:00
abstract::In eukaryotic cells, checkpoint pathways arrest cell-cycle progression if a particular event has failed to complete appropriately or if an important intracellular structure is defective or damaged. Saccharomyces cerevisiae strains that lack the SFP1 gene fail to arrest at the G2 DNA-damage checkpoint in response to ge...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::We have created a resource to rapidly map genetic traits to specific chromosomes in yeast. This mapping is done using a set of 16 yeast strains each containing a different chromosome with a conditionally functional centromere. Conditional centromere function is achieved by integration of a GAL1 promoter in cis to cent...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.087999
更新日期:2008-12-01 00:00:00
abstract::The three-dimensional (3D) organization of chromosomes can influence transcription. However, the frequency and magnitude of these effects remain debated. To determine how changes in chromosome positioning affect transcription across thousands of genes with minimal perturbation, we characterized nuclear organization an...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302978
更新日期:2020-03-01 00:00:00
abstract::In Drosophila and other insects egg production is related to the nutrients available. Somehow the nutritional status of the environment is translated into hormonal signs that can be "read" by each individual egg chamber, influencing the decision to either develop into an egg or die. We have shown that BR-C is a contro...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.103.024323
更新日期:2004-08-01 00:00:00
abstract::Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, m...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.122754
更新日期:2011-01-01 00:00:00
abstract::Data for Apis mellifera indicate that the P-3 proteins and one esterase enzyme are controlled by two genes, P-3 and Est, with two alleles each. The frequency of the P-3 alleles is different in the two subspecies (adansonii and ligustica), that for P-3(F) in Italian bees being 46.9% and in African 0.5%. The frequency o...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1972-12-01 00:00:00
abstract::While evolution of coding sequences has been intensively studied, diversification of noncoding regulatory regions remains poorly understood. In this study, we investigated the molecular evolution of an enhancer region located 5 kb upstream of the transcription start site of the maize pericarp color1 (p1) gene. The p1 ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.053942
更新日期:2006-10-01 00:00:00
abstract::Availability of animal protein for human consumption is very low in the developing countries mainly because of low productivity of existing livestock; ways and means to improve productivity through breeding are discussed and some basic issues requiring further research pointed out. ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-09-01 00:00:00
abstract::The spatial model of Levene (1953) was examined in a finite population and compared to a temporal model. The spatial model was much more effective in retaining genetic variation in a finite population. Furthermore, the haploid spatial model was more effective in retaining genetic variation than the analogous diploid a...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1978-06-01 00:00:00
abstract::Although most living organisms reproduce sexually, some have developed a uniparental reproduction where the embryo usually derives from the female parent. A unique case of paternal apomixis in plants has been recently reported in Cupressus dupreziana, an endangered Mediterranean conifer. This species produces unreduce...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.080572
更新日期:2008-01-01 00:00:00
abstract::Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.300139
更新日期:2017-10-01 00:00:00
abstract::Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::The MITF protein is a member of the MYC family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors and is most closely related to the TFE3, TFEC, and TFEB proteins. In the mouse, MITF is required for the development of several different cell types, including the retinal pigment epithelial (RPE) c...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.167.1.233
更新日期:2004-05-01 00:00:00
abstract::There are two naturally occurring functional alleles of the recombination hotspot cog, which is located 3.5 kb from the his-3 locus of Neurospora crassa. The presence of the cog+ allele in a cross significantly increases recombination in the his-3 region compared to a cross homozygous for the cog allele. Data obtained...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.103.025080
更新日期:2004-07-01 00:00:00
abstract::Genome-wide association mapping is a popular method for using natural variation within a species to generate a genotype-phenotype map. Statistical association between an allele at a locus and the trait in question is used as evidence that variation at the locus is responsible for variation of the trait. Indirect assoc...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.121665
更新日期:2010-11-01 00:00:00
abstract::An exact sampling formula for a Wright-Fisher population of fixed size N under the infinitely many neutral alleles model is deduced. This extends the Ewens formula for the configuration of a random sample to the case where the sample is drawn from a population of small size, that is, without the usual large-N and smal...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.077644
更新日期:2007-10-01 00:00:00
abstract::A simple two-locus gene conversion model is considered to investigate the amounts of DNA variation and linkage disequilibrium in small multigene families. The exact solutions for the expectations and variances of the amounts of variation within and between two loci are obtained. It is shown that gene conversion increa...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::Recessive mutations in three autosomal genes, him-1, him-5 and him-8, cause high levels of X chromosome nondisjunction in hermaphrodites of Caenorhabditis elegans, with no comparable effect on autosomal disjunction. Each of the mutants has reduced levels of X chromosome recombination, correlating with the increase in ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The 73AD salivary chromosome region of Drosophila melanogaster was subjected to mutational analysis in order to (1) generate a collection of chromosome breakpoints that would allow a correlation between the genetic, cytological and molecular maps of the region and (2) define the number and gross organization of comple...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::The GAL4 protein of Saccharomyces cerevisiae binds to DNA upstream of each of six genes and stimulates their transcription. To locate regions of the protein responsible for these processes, we identified and characterized 88 gal4 mutations selected in vivo to reduce the ability to GAL4 protein to activate transcriptio...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the widely conserved histone variant CENP-A. Mutations in kinetochore proteins of the fission yeast Schizosaccharomyces pom...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.300183
更新日期:2017-10-01 00:00:00
abstract::Individuals within a species vary in their responses to a wide range of stimuli, partly as a result of differences in their genetic makeup. Relatively little is known about the genetic and neuronal mechanisms contributing to diversity of behavior in natural populations. By studying intraspecies variation in innate avo...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.178491
更新日期:2015-08-01 00:00:00