Mapping quantitative trait loci for longitudinal traits in line crosses.

abstract：:This article focuses on conducting global testing for association between a binary trait and a set of rare variants (RVs), although its application can be much broader to other types of traits, common variants (CVs), and gene set or pathway analysis. We show that many of the existing tests have deteriorating performan...

journal_title：Genetics

authors： Pan W,Kim J,Zhang Y,Shen X,Wei P

更新日期：2014-08-01 00:00:00

abstract：:Germ cell specification as sperm or oocyte is an ancient cell fate decision, but its molecular regulation is poorly understood. In Caenorhabditis elegans, the FOG-1 and FOG-3 proteins behave genetically as terminal regulators of sperm fate specification. Both are homologous to well-established RNA regulators, suggesti...

journal_title：Genetics

authors： Noble DC,Aoki ST,Ortiz MA,Kim KW,Verheyden JM,Kimble J

更新日期：2016-01-01 00:00:00

abstract：:beta-Alanine synthase (EC 3.5.1.6), which catalyzes the final step of pyrimidine catabolism, has only been characterized in mammals. A Saccharomyces kluyveri pyd3 mutant that is unable to grow on N-carbamyl-beta-alanine as the sole nitrogen source and exhibits diminished beta-alanine synthase activity was used to clon...

journal_title：Genetics

authors： Gojković Z,Sandrini MP,Piskur J

更新日期：2001-07-01 00:00:00

abstract：:Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments on accumulation of mutations on protected second chromosomes. A model of equal mutant effects gives a poor fit to the data ...

journal_title：Genetics

authors： Keightley PD

更新日期：1994-12-01 00:00:00

abstract：:The percentage of crossovers is consistently higher in plants hypoploid for six B-A translocations when crossed as males than when crossed as females; in most instances, this excess of male crossing over exceeds that found in control crosses (involving normal chromosomes). Thus, there seems to be something about the h...

journal_title：Genetics

authors： Robertson DS

更新日期：1984-05-01 00:00:00

abstract：:The bovine Growth Hormone gene (bGH) is an attractive candidate gene for milk production in cattle. Single-strand conformation polymorphisms at bGH were identified and used to define haplotype configurations at this gene in the Israeli Holstein dairy cattle population (Bos taurus) and in the parent animals of the Inte...

journal_title：Genetics

authors： Lagziel A,Lipkin E,Soller M

更新日期：1996-03-01 00:00:00

abstract：:We provide a genetic analysis of the meiotic drive system on maize abnormal chromosome 10 (Ab10) that causes preferential segregation of specific chromosomal regions to the reproductive megaspore. The data indicate that at least four chromosomal regions contribute to meiotic drive, each providing distinct functions th...

journal_title：Genetics

authors： Hiatt EN,Dawe RK

更新日期：2003-06-01 00:00:00

abstract：:Mutations in the SPT10 and SPT21 genes were originally isolated as suppressors of Ty and LTR (delta) insertion mutations in Saccharomyces cerevisiae, and the genes were shown to be required for normal transcription at a number of loci in yeast. Now we have cloned, sequenced, mapped and mutagenized SPT10 and SPT21. Sin...

journal_title：Genetics

authors： Natsoulis G,Winston F,Boeke JD

更新日期：1994-01-01 00:00:00

abstract：:Gene duplication is arguably the most significant source of new functional genetic material. A better understanding of the processes that lead to the stable incorporation of gene duplications into the genome is important both because it relates to interspecific differences in genome composition and because it can shed...

journal_title：Genetics

authors： Proulx SR

更新日期：2012-02-01 00:00:00

abstract：:We have initiated an analysis of protein kinase A (PKA) in Drosophila using transgenic techniques to modulate PKA activity in specific tissues during development. We have constructed GAL4/UAS-regulated transgenes in active and mutant forms that encode PKAc, the catalytic subunit of PKA, and PKI(1-31), a competitive in...

journal_title：Genetics

authors： Kiger JA Jr,Eklund JL,Younger SH,O'Kane CJ

更新日期：1999-05-01 00:00:00

abstract：:The genotypes of three color mutants in goldfish: a depigmentation character of larval melanophores, albinism and a recessive-transparent character, were analyzed by crossing experiments. The depigmentation character in the common goldfish is controlled by two dominant multiple genes, Dp1 and Dp2, and only fish with d...

journal_title：Genetics

authors： Kajishima T

更新日期：1977-05-01 00:00:00

abstract：:At least six nuclear loci are responsible for the genetic control of malate dehydrogenase (L-malate: NAD oxidoreductase; EC 1.1.1.37; MDH) in coleoptiles of maize. Three independently segregating loci (Mdh1, Mdh2, Mdh3) govern the production of MDH isozymes resistant to inactivation by ascorbic acid and found largely ...

journal_title：Genetics

authors： Goodman MM,Stuber CW,Lee CN,Johnson FM

更新日期：1980-01-01 00:00:00

abstract：:The mitochondrial genotype of all F(1) female offspring (426 individuals) of a single Drosophila mauritiana female, heteroplasmic for two types of mtDNA (a short and a long genome), was established. All descendants were heteroplasmic. The earliest eggs laid by this female show the cytoplasmic genetic structure of ovar...

journal_title：Genetics

authors： Solignac M,Génermont J,Monnerot M,Mounolou JC

更新日期：1987-12-01 00:00:00

abstract：:A technique has been perfected for enabling good microscope preparations to be obtained from the larval ganglia of Drosophila melanogaster. This system was then tested with X-rays and an extensive series of data was obtained on the chromosome aberrations induced in the various stages of the cell cycle.-The analysis of...

journal_title：Genetics

authors： Gatti M,Tanzarella C,Olivieri G

更新日期：1974-08-01 00:00:00

abstract：:Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations...

journal_title：Genetics

authors： Alcazar RM,Lin R,Fire AZ

更新日期：2008-11-01 00:00:00

abstract：:Transmission ratio distortion (TRD) is the departure from the expected genotypic frequencies under Mendelian inheritance. This departure can be due to multiple physiological mechanisms during gametogenesis, fertilization, fetal and embryonic development, and early neonatal life. Although a few TRD loci have been repor...

journal_title：Genetics

authors： Casellas J,Gularte RJ,Farber CR,Varona L,Mehrabian M,Schadt EE,Lusis AJ,Attie AD,Yandell BS,Medrano JF

更新日期：2012-05-01 00:00:00

abstract：:Regulation of cytoskeletal structure and dynamics is essential for multiple aspects of cellular behavior, yet there is much to learn about the molecular machinery underlying the coordination between the cytoskeleton and its effector systems. One group of proteins that regulate microtubule behavior and its interaction ...

journal_title：Genetics

authors： Lowery LA,Lee H,Lu C,Murphy R,Obar RA,Zhai B,Schedl M,Van Vactor D,Zhan Y

更新日期：2010-08-01 00:00:00

abstract：:Whereas nonlinear relationships between genes are acknowledged, there exist only a few methods for estimating nonlinear gene coexpression networks or gene regulatory networks (GCNs/GRNs) with common deficiencies. These methods often consider only pairwise associations between genes, and are, therefore, poorly capable ...

journal_title：Genetics

authors： Kontio JAJ,Rinta-Aho MJ,Sillanpää MJ

更新日期：2020-07-01 00:00:00

abstract：:The DC2 gene was isolated previously on the basis of sequence similarity to DC0, the major Drosophila protein kinase A (PKA) catalytic subunit gene. We show here that the 67-kD Drosophila DC2 protein behaves as a PKA catalytic subunit in vitro. DC2 is transcribed in mesodermal anlagen of early embryos. This expression...

journal_title：Genetics

authors： Meléndez A,Li W,Kalderon D

更新日期：1995-12-01 00:00:00

abstract：:We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX). In addition we show that recessive...

journal_title：Genetics

authors： Meneely PM,Wood WB

更新日期：1987-09-01 00:00:00

abstract：:RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) in Drosophila cells are currently being performed and emphasize the strengths and weaknesses of the...

journal_title：Genetics

authors： Perrimon N,Mathey-Prevot B

更新日期：2007-01-01 00:00:00

abstract：:Very few mutations derived from Mutator maize lines have been studied at the molecular level. The variety of Mu elements that can induce mutations, the relative frequency of mutant induction by insertion of a given class of Mu elements or by a Mu-induced genomic rearrangement, a possible intragenic insertion site spec...

journal_title：Genetics

authors： Brown WE,Robertson DS,Bennetzen JL

更新日期：1989-06-01 00:00:00

abstract：:In its hypermutable state, an unstable singed allele, sn(w), mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of sn(w) is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property cal...

journal_title：Genetics

authors： Engels WR

更新日期：1981-07-01 00:00:00

abstract：:Predicting the chromosomal location of mapped markers has been difficult because linkage maps do not reveal differences in crossover frequencies along the physical structure of chromosomes. Here we combine a physical crossover map based on the distribution of recombination nodules (RNs) on Solanum lycopersicum (tomato...

journal_title：Genetics

authors： Chang SB,Anderson LK,Sherman JD,Royer SM,Stack SM

更新日期：2007-08-01 00:00:00

abstract：:An extending axon growth cone is subjected to attractant and repellent cues. It is not clear how these growth cones discriminate the two opposing forces and select their projection paths. Here, we report that in the Drosophila nerve cord the growth cones of longitudinal tracts are subjected to attraction by the Netrin...

journal_title：Genetics

authors： Bhat KM

更新日期：2005-05-01 00:00:00

abstract：:Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, de...

journal_title：Genetics

authors： Hartl TA,Ni J,Cao J,Suyama KL,Patchett S,Bussiere C,Gui DY,Tang S,Kaplan DD,Fish M,Johnson AW,Scott MP

更新日期：2013-05-01 00:00:00

abstract：:A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly distributed. It was r...

journal_title：Genetics

authors： Shiina T,Ota M,Shimizu S,Katsuyama Y,Hashimoto N,Takasu M,Anzai T,Kulski JK,Kikkawa E,Naruse T,Kimura N,Yanagiya K,Watanabe A,Hosomichi K,Kohara S,Iwamoto C,Umehara Y,Meyer A,Wanner V,Sano K,Macquin C,Ikeo K,T

更新日期：2006-07-01 00:00:00

abstract：:The centromere is essential for proper segregation and inheritance of genetic information. Centromeres are generally regulated to occur exactly once per chromosome; failure to do so leads to chromosome loss or damage and loss of linked genetic material. The mechanism for faithful regulation of centromere activity and ...

journal_title：Genetics

authors： Maggert KA,Karpen GH

更新日期：2001-08-01 00:00:00

abstract：:Using the biological species definition, yeasts of the genus Saccharomyces sensu stricto comprise six species and one natural hybrid. Previous work has shown that reproductive isolation between the species is due primarily to sequence divergence acted upon by the mismatch repair system and not due to major gene differ...

journal_title：Genetics

authors： Liti G,Barton DB,Louis EJ

更新日期：2006-10-01 00:00:00

abstract：:Mutation of the two homothallic genes, HML alpha/HMLa and HMRa/HMR alpha, in homothallic strains of Saccharomyces cerevisiae was studied. Of 11 mutants of the HML alpha gene, eight were due to a phenotypic mutation from HML alpha to HMLa, i.e., a mutation causing a change in function of the original HML allele to that...

journal_title：Genetics

authors： Oshima T,Takano I

更新日期：1980-04-01 00:00:00