A Distinct type of heterochromatin within Drosophila melanogaster chromosome 4.

abstract：:Y chromosome function, structure and evolution is poorly understood in many species, including the Anopheles genus of mosquitoes-an emerging model system for studying speciation that also represents the major vectors of malaria. While the Anopheline Y had previously been implicated in male mating behavior, recent data...

journal_title：Genetics

authors： Bernardini F,Galizi R,Wunderlich M,Taxiarchi C,Kranjc N,Kyrou K,Hammond A,Nolan T,Lawniczak MNK,Papathanos PA,Crisanti A,Windbichler N

更新日期：2017-10-01 00:00:00

abstract：:Repair of double-strand breaks (DSBs) in chromosomal DNA by nonhomologous end-joining (NHEJ) is not well characterized in the yeast Saccharomyces cerevisiae. Here we demonstrate that several genes associated with NHEJ perform essential functions in the repair of endonuclease-induced DSBs in vivo. Galactose-induced exp...

journal_title：Genetics

authors： Lewis LK,Westmoreland JW,Resnick MA

更新日期：1999-08-01 00:00:00

abstract：:Remarkably complex patterns of aneuploidy have been observed in the genomes of many eukaryotic cell types, ranging from brewing yeasts to tumor cells. Such aberrant karyotypes are generally thought to take shape progressively over many generations, but evidence also suggests that genomes may undergo faster modes of ev...

journal_title：Genetics

authors： Heasley LR,Watson RA,Argueso JL

更新日期：2020-09-01 00:00:00

abstract：:Genomic imprinting is well known as a regulatory property of a few specific chromosomal regions and leads to differential behavior of maternally and paternally inherited alleles. We surveyed the activity of two reporter genes in 23 independent P-element insertions on the heterochromatic Y chromosome of Drosophila mela...

journal_title：Genetics

authors： Maggert KA,Golic KG

更新日期：2002-11-01 00:00:00

abstract：:A total of 358 lys2 mutants of Saccharomyces cerevisiae have been characterized for suppressibility by the following suppressors: UAA and UAG suppressors that insert tyrosine, serine or leucine; a putative UGA suppressor; an omnipotent suppressor SUP46; and a frameshift suppressor SUF1-1. In addition, the lys2 mutants...

journal_title：Genetics

authors： Chattoo BB,Palmer E,Ono B,Sherman F

更新日期：1979-09-01 00:00:00

abstract：:Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous re...

journal_title：Genetics

authors： Singer JB,Hill AE,Nadeau JH,Lander ES

更新日期：2005-02-01 00:00:00

abstract：:Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, ...

journal_title：Genetics

authors： Hales KG,Korey CA,Larracuente AM,Roberts DM

更新日期：2015-11-01 00:00:00

abstract：:Mutations in ilvO, the operator site for operon A of the ilv region of E. coli K-12, are reported to cause a cis dominant derepression of the operon A gene products and to map between ilvC and ilvA. Studies reported here demonstrate that the F25 episome which does not carry the region between ilvC and ilvA but only il...

journal_title：Genetics

authors： Cohen BM,Jones EW

更新日期：1976-06-01 00:00:00

abstract：:The recessive mutation, hop1-1, was isolated by use of a screen designed to detect mutations defective in homologous chromosomal pairing during meiosis in Saccharomyces cerevisiae. Mutants in HOP1 displayed decreased levels of meiotic crossing over and intragenic recombination between markers on homologous chromosomes...

journal_title：Genetics

authors： Hollingsworth NM,Byers B

更新日期：1989-03-01 00:00:00

abstract：:Previously we have shown that the nucleolus organizer region (NOR) of Neurospora crassa changes size frequently during the premeiotic portion of the sexual phase. Here, we have investigated whether these changes in size originate only in specific regions of the NOR, or are distributed throughout the NOR. In two specia...

journal_title：Genetics

authors： Butler DK,Metzenberg RL

更新日期：1990-10-01 00:00:00

abstract：:Pigmentation is a rapidly evolving trait that can play important roles in mimicry, sexual selection, thermoregulation, and other adaptive processes in many groups of animals. In Drosophila, pigmentation can differ dramatically among closely related taxa, presenting a good opportunity to dissect the genetic changes und...

journal_title：Genetics

authors： Ng CS,Hamilton AM,Frank A,Barmina O,Kopp A

更新日期：2008-09-01 00:00:00

abstract：:In Arabidopsis thaliana, significant efforts to determine the extent of genomic variation between phenotypically divergent accessions are under way, but virtually nothing is known about variation at the transcription level. We used microarrays to examine variation in transcript abundance among three inbred lines and t...

journal_title：Genetics

authors： Vuylsteke M,van Eeuwijk F,Van Hummelen P,Kuiper M,Zabeau M

更新日期：2005-11-01 00:00:00

abstract：:Allorecognition is ubiquitous, or nearly so, amongst colonial invertebrates. Despite the prominent role that such phenomena have played both in evolutionary theory and in on the origin of the vertebrate immune system, unambiguous data on the transmission genetics of fusibility (i.e., the ability of two individuals to ...

journal_title：Genetics

authors： Mokady O,Buss LW

更新日期：1996-06-01 00:00:00

abstract：:In yeast meiotic recombination, alleles used as genetic markers fall into two classes as regards their fate when incorporated into heteroduplex DNA. Normal alleles are those that form heteroduplexes that are nearly always recognized and corrected by the mismatch repair system operating in meiosis. High PMS (postmeioti...

journal_title：Genetics

authors： Manivasakam P,Rosenberg SM,Hastings PJ

更新日期：1996-02-01 00:00:00

abstract：:The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient DNA polymerase γ mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, sug...

journal_title：Genetics

authors： Stumpf JD,Copeland WC

更新日期：2013-06-01 00:00:00

abstract：:A supposed sporulation-deficient mutation of Saccharomyces cerevisiae is found to affect mating in haploids and in diploids, and to be inseparable from the mating-type locus by recombination. The mutation is regarded as a defective a allele and is designated a*. This is confirmed by its dominance relations in diploids...

journal_title：Genetics

authors： Kassir Y,Simchen G

更新日期：1976-02-01 00:00:00

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:Doubly uniparental inheritance (DUI) provides an intriguing system for addressing aspects of molecular evolution and intermolecular recombination of mitochondrial DNA. For this reason, a large sequence analysis has been performed on Tapes philippinarum (Bivalvia, Veneridae), which has mitochondrial DNA heteroplasmy th...

journal_title：Genetics

authors： Passamonti M,Boore JL,Scali V

更新日期：2003-06-01 00:00:00

abstract：:Extensive length polymorphism and heteroplasmy (multiple forms within an individual) of the D-loop region are observed in mitochondrial DNA of the white sturgeon (Acipenser transmontanus). The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers o...

journal_title：Genetics

authors： Buroker NE,Brown JR,Gilbert TA,O'Hara PJ,Beckenbach AT,Thomas WK,Smith MJ

更新日期：1990-01-01 00:00:00

abstract：:The level of activity of the enzyme glucose-6-phosphate dehydrogenase was determinel in flies having seven different chromosomic constitutions. All those having an integral number of chromosomes [XAA, XXAA, XAAA, XXAAA, and XXXAAA (X=Xchromosome, A=set of autosomes)] were found to have similar units of enzyme activity...

journal_title：Genetics

authors： Maroni G,Plaut W

更新日期：1973-06-01 00:00:00

abstract：:We have isolated a new class of deletion mutants of phage lambda that extend from the prophage attachment site, att, into the gam and cIII genes. In this respect they are similar to certain of the lambda pbio transducing phage, but they differ in having a low burst size and in forming minute plaques. Lytically grown s...

journal_title：Genetics

authors： Henderson D,Weil J

更新日期：1975-02-01 00:00:00

abstract：:To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with Caenorhabditis elegans nematodes was conducted in which independently evolving lines were initiated from a low-fitness mitochondrial electron transport chain (ETC) mutant, gas-1 Following 60 generations o...

journal_title：Genetics

authors： Wernick RI,Christy SF,Howe DK,Sullins JA,Ramirez JF,Sare M,Penley MJ,Morran LT,Denver DR,Estes S

更新日期：2019-03-01 00:00:00

abstract：:A correlation between diversity levels and rates of recombination is predicted both by models of positive selection, such as hitchhiking associated with the rapid fixation of advantageous mutations, and by models of purifying selection against strongly deleterious mutations (commonly referred to as "background selecti...

journal_title：Genetics

authors： Andolfatto P,Przeworski M

更新日期：2001-06-01 00:00:00

abstract：:Divergence of the hyperthermophilic Archaea, Pyrococcus furiosus and Pyrococcus horikoshii, was assessed by analysis of complete genomic sequences of both species. The average nucleotide identity between the genomic sequences is 70-75% within ORFs. The P. furiosus genome (1.908 mbp) is 170 kbp larger than the P. horik...

journal_title：Genetics

authors： Maeder DL,Weiss RB,Dunn DM,Cherry JL,González JM,DiRuggiero J,Robb FT

更新日期：1999-08-01 00:00:00

abstract：:Putzig (Pzg) was originally identified as being an integral component of the TRF2/DREF complex in Drosophila melanogaster, thereby regulating the transcriptional activation of replication-related genes. In a DREF-independent manner, Pzg was shown to mediate Notch target gene activation. This function of Pzg entails an...

journal_title：Genetics

authors： Kugler SJ,Gehring EM,Wallkamm V,Krüger V,Nagel AC

更新日期：2011-05-01 00:00:00

abstract：:The eukaryotic cytoplasm contains a variety of ribonucleoprotein (RNP) granules in addition to the better-understood membrane-bound organelles. These granules form in response to specific stress conditions and contain a number of signaling molecules important for the control of cell growth and survival. However, relat...

journal_title：Genetics

authors： Zhang B,Shi Q,Varia SN,Xing S,Klett BM,Cook LA,Herman PK

更新日期：2016-07-01 00:00:00

abstract：:Positive selection on a new mutant allele can increase the frequencies of closely linked alleles (through hitchhiking), as well as create linkage disequilibrium between them. Because this disequilibrium is induced by the selected allele, one may be able to identify loci under selection by measuring the influence of a ...

journal_title：Genetics

authors： Grote MN,Klitz W,Thomson G

更新日期：1998-11-01 00:00:00

abstract：:The bacterium Myxococcus xanthus glides over surfaces using two different locomotive mechanisms, called S (social) and A (adventurous) motility that enable cells to move both as groups and as individuals. Neither mechanism involves flagella. The functions of these two motors are coordinated by the activity of a small ...

journal_title：Genetics

authors： Youderian P,Hartzell PL

更新日期：2007-09-01 00:00:00

abstract：:Argonaute2 (Ago2) is a rapidly evolving nuclease in the Drosophila melanogaster RNA interference (RNAi) pathway that targets viruses and transposable elements in somatic tissues. Here we reconstruct the history of Ago2 duplications across the D. obscura group and use patterns of gene expression to infer new functional...

journal_title：Genetics

authors： Lewis SH,Webster CL,Salmela H,Obbard DJ

更新日期：2016-10-01 00:00:00

abstract：:A Plasmodium-refractory strain of Anopheles gambiae melanotically encapsulates many species of Plasmodium, whereas wild-type mosquitoes are usually susceptible. This encapsulation trait can also be observed by studying the response of refractory and susceptible strains to intrathoracically injected CM-Sephadex beads. ...

journal_title：Genetics

authors： Gorman MJ,Severson DW,Cornel AJ,Collins FH,Paskewitz SM

更新日期：1997-07-01 00:00:00