Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences.

abstract：:Drosophila melanogaster males deficient for the crystal (cry) locus of the Y chromosome that carry between 15 and 60 copies of the X-linked Stellate (Ste) gene are semisterile, have elevated levels of nondisjunction, produce distorted sperm genotype ratios (meiotic drive), and evince hyperactive transcription of Ste i...

journal_title：Genetics

authors： Belloni M,Tritto P,Bozzetti MP,Palumbo G,Robbins LG

更新日期：2002-08-01 00:00:00

abstract：:Protein kinases mediate much of the signal transduction in eukaryotic cells and defects in kinase function are associated with a variety of human diseases. To understand and correct these defects, we will need to identify the physiologically relevant substrates of these enzymes. The work presented here describes a nov...

journal_title：Genetics

authors： Deminoff SJ,Howard SC,Hester A,Warner S,Herman PK

更新日期：2006-08-01 00:00:00

abstract：:Mutation frequency and specificity were determined as a function of age in nuclear DNA from liver, bladder, and brain of Big Blue lacI transgenic mice aged 1.5-25 months. Mutations accumulated with age in liver and accumulated more rapidly in bladder. In the brain a small initial increase in mutation frequency was obs...

journal_title：Genetics

authors： Stuart GR,Oda Y,de Boer JG,Glickman BW

更新日期：2000-03-01 00:00:00

abstract：:Using a new model of isoalleles, extensive Monte Carlo experiments were performed to examine the pattern of allelic distribution in a finite population. In this model it was assumed that the set of allelic states is represented by discrete points on a one-dimensional lattice and that change of state by mutation occurs...

journal_title：Genetics

authors： Ohta T,Kimura M

更新日期：1974-03-01 00:00:00

abstract：:Dis3 encodes a conserved RNase that degrades or processes all RNA species via an N-terminal PilT N terminus (PIN) domain and C-terminal RNB domain that harbor, respectively, endonuclease activity and 3'-5' exonuclease activity. In Schizosaccharomyces pombe, dis3 mutations cause chromosome missegregation and failure in...

journal_title：Genetics

authors： Snee MJ,Wilson WC,Zhu Y,Chen SY,Wilson BA,Kseib C,O'Neal J,Mahajan N,Tomasson MH,Arur S,Skeath JB

更新日期：2016-06-01 00:00:00

abstract：:Adaptation from de novo mutation can produce so-called soft selective sweeps, where adaptive alleles of independent mutational origin sweep through the population at the same time. Population genetic theory predicts that such soft sweeps should be likely if the product of the population size and the mutation rate towa...

journal_title：Genetics

authors： Wilson BA,Petrov DA,Messer PW

更新日期：2014-10-01 00:00:00

abstract：:Two closely related bacteriophage, varphiCr30 and varphiCr35, are the first bacteriophage shown to mediate generalized transduction in Caulobacter crescentus. Unlike most other transducing phage, they are virulent and do not form any sort of lysogenic relationship with their host. However, they are rather inefficient ...

journal_title：Genetics

authors： Ely B,Johnson RC

更新日期：1977-11-01 00:00:00

abstract：:A genetic strategy identified Salmonella typhimurium strains carrying large (> 40 kb) Tn 10-catalyzed inversions; the inverted segments were characterized by XbaI digestion and pulsed field gel electrophoresis. Two size classes of large inversions were found. More than half of the inversions extended 40-80 kb either c...

journal_title：Genetics

authors： Krug PJ,Gileski AZ,Code RJ,Torjussen A,Schmid MB

更新日期：1994-03-01 00:00:00

abstract：:Naturally transformable bacteria acquire chromosomal DNA from related species at lower frequencies than from cognate DNA sources. To determine how genome location affects heterogamic transformation in bacteria, we inserted an nptI marker into random chromosome locations in 19 different strains of the Acinetobacter gen...

journal_title：Genetics

authors： Ray JL,Harms K,Wikmark OG,Starikova I,Johnsen PJ,Nielsen KM

更新日期：2009-08-01 00:00:00

abstract：:The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

journal_title：Genetics

authors： Wagner M,Briza P,Pierce M,Winter E

更新日期：1999-04-01 00:00:00

abstract：:Correlation and regression analyses indicate that isofemale strains extracted from a population of the parasitic wasp, Nasonia vitripennis, differ in the fit of their second sex ratios (those produced in previously parasitized hosts) to the predictions of the theory of optimal facultative sex ratio adjustment. Under t...

journal_title：Genetics

authors： Orzack SH

更新日期：1990-02-01 00:00:00

abstract：:Nonallelic gene conversion has been proposed as a major force in homogenizing the sequences of paralogous genes. In this work, we investigate the extent and characteristics of gene conversion among gene families in nine species of the genus Drosophila. We carried out a genome-wide study of 2855 gene families (includin...

journal_title：Genetics

authors： Casola C,Ganote CL,Hahn MW

更新日期：2010-05-01 00:00:00

abstract：:The distinction between deleterious, neutral, and adaptive mutations is a fundamental problem in the study of molecular evolution. Two significant quantities are the fraction of DNA variation in natural populations that is deleterious and destined to be eliminated and the fraction of fixed differences between species ...

journal_title：Genetics

authors： Fay JC,Wyckoff GJ,Wu CI

更新日期：2001-07-01 00:00:00

abstract：:Resident gut bacteria are constantly influencing the immune system, yet the role of the immune system in shaping microbiota composition during an organism's life span has remained unclear. Experiments in mice have been inconclusive due to differences in husbandry schemes that led to conflicting results. We used Drosop...

journal_title：Genetics

authors： Mistry R,Kounatidis I,Ligoxygakis P

更新日期：2017-06-01 00:00:00

abstract：:Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behin...

journal_title：Genetics

authors： Myster SH,Wang F,Cavallo R,Christian W,Bhotika S,Anderson CT,Peifer M

更新日期：2004-02-01 00:00:00

abstract：:Establishing durable disease resistance in agricultural crops, where much of the plant defense is provided through effector-R gene interactions, is complicated by the ability of pathogens to overcome R gene resistance by losing the corresponding effector gene. Many proposed methods to maintain disease resistance in th...

journal_title：Genetics

authors： Wichmann G,Bergelson J

更新日期：2004-02-01 00:00:00

abstract：:The morphogenetic pathway of bacteriophage phi X 174 was investigated in rep mutant hosts that specifically block stage III single-stranded DNA synthesis. The defects conferred by the mutant rep protein most likely affect the formation or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediat...

journal_title：Genetics

authors： Ekechukwu MC,Oberste DJ,Fane BA

更新日期：1995-08-01 00:00:00

abstract：:Nonautonomous inductive signals from the soma and autonomous signals due to a 2X karyotype determine the sex of Drosophila melanogaster germ cells. These two signals have partially overlapping influences on downstream sex determination genes. The upstream OVO-B transcription factor is required for the viability of 2X ...

journal_title：Genetics

authors： Andrews J,Oliver B

更新日期：2002-02-01 00:00:00

abstract：:Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity o...

journal_title：Genetics

authors： Drummond-Barbosa D

更新日期：2008-12-01 00:00:00

abstract：:In Saccharomyces cerevisiae, genes located at the telomeres and the HM loci are subject to transcriptional silencing. Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing when targeted to a silencer-defective HMR locus. ...

journal_title：Genetics

authors： Andrulis ED,Zappulla DC,Alexieva-Botcheva K,Evangelista C,Sternglanz R

更新日期：2004-01-01 00:00:00

abstract：:DNA sequence analysis and genetic mapping of loci from mating-type-specific chromosomes of the smut fungus Microbotryum violaceum demonstrated that the nonrecombining mating-type-specific region in this species comprises approximately 25% ( approximately 1 Mb) of the chromosome length. Divergence between homologous ma...

journal_title：Genetics

authors： Votintseva AA,Filatov DA

更新日期：2009-08-01 00:00:00

abstract：:Restorer-of-fertility (Rf) alleles for S-type cytoplasmic male sterility (CMS-S) are prevalent in Mexican races of maize and teosinte. Forty-five Rf alleles from 26 races of maize and 6 Rf alleles from different accessions of teosinte were found to be homozygous viable, consistent with the hypothesis that they are nat...

journal_title：Genetics

authors： Gabay-Laughnan S,Chase CD,Ortega VM,Zhao L

更新日期：2004-02-01 00:00:00

abstract：:One of the key factors contributing to the success of a quantitative trait locus (QTL) mapping experiment is the precision with which QTL positions can be estimated. We show, using simulations, that QTL mapping precision for an experimental cross can be increased by the use of a genotypically selected sample of indivi...

journal_title：Genetics

authors： Xu Z,Zou F,Vision TJ

更新日期：2005-05-01 00:00:00

abstract：:Likelihood-based parentage inference depends on the distribution of a likelihood-ratio statistic, which, in most cases of interest, cannot be exactly determined, but only approximated by Monte Carlo simulation. We provide importance-sampling algorithms for efficiently approximating very small tail probabilities in the...

journal_title：Genetics

authors： Anderson EC,Garza JC

更新日期：2006-04-01 00:00:00

abstract：:We describe a method for co-estimating r = C/mu (where C is the per-site recombination rate and mu is the per-site neutral mutation rate) and Theta = 4N(e)mu (where N(e) is the effective population size) from a population sample of molecular data. The technique is Metropolis-Hastings sampling: we explore a large numbe...

journal_title：Genetics

authors： Kuhner MK,Yamato J,Felsenstein J

更新日期：2000-11-01 00:00:00

abstract：:We have used mutational and revertant analysis to study the elements of the 54-nucleotide COX2 5'-untranslated leader involved in translation initiation in yeast mitochondria and in activation by the COX2 translational activator. Pet111p. We generated a collection of mutants with substitutions spanning the entire COX2...

journal_title：Genetics

authors： Dunstan HM,Green-Willms NS,Fox TD

更新日期：1997-09-01 00:00:00

abstract：:The type and frequency of simple sequence repeats (SSRs) in plant genomes was investigated using the expanding quantity of DNA sequence data deposited in public databases. In Arabidopsis, 306 genomic DNA sequences longer than 10 kb and 36,199 EST sequences were searched for all possible mono- to pentanucleotide repeat...

journal_title：Genetics

authors： Cardle L,Ramsay L,Milbourne D,Macaulay M,Marshall D,Waugh R

更新日期：2000-10-01 00:00:00

abstract：:The three mammalian D-type cyclins are thought to promote progression through the G1 phase of the cell cycle as regulatory subunits of cyclin-dependent kinase 4 and 6. In addition, they have been proposed to control the activity of various transcription factors without a partner kinase. Here we describe phenotypic con...

journal_title：Genetics

authors： Emmerich J,Meyer CA,de la Cruz AF,Edgar BA,Lehner CF

更新日期：2004-10-01 00:00:00

abstract：:In contrast to our growing understanding of patterns of additive genetic variance in single- and multi-trait combinations, the relative contribution of nonadditive genetic variance, particularly dominance variance, to multivariate phenotypes is largely unknown. While mechanisms for the evolution of dominance genetic v...

journal_title：Genetics

authors： Sztepanacz JL,Blows MW

更新日期：2015-05-01 00:00:00

abstract：:Bacteriophages are the most abundant biological entities in our biosphere, characterized by their hyperplasticity, mosaic composition, and the many unknown functions (ORFans) encoded by their immense genetic repertoire. These genes are potentially maintained by the bacteriophage to allow efficient propagation on hosts...

journal_title：Genetics

authors： Ang D,Georgopoulos C

更新日期：2012-03-01 00:00:00