Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species.

abstract：:In this article we define and characterize the smellblind gene (sbl). We show that two mutants, sbl and olfDx9, both isolated by virtue of their olfactory phenotypes and analyzed extensively by others with respect to courtship behavior, contain mutations at a single locus. Meiotic recombination, duplication, and defic...

journal_title：Genetics

authors： Lilly M,Carlson J

更新日期：1990-02-01 00:00:00

abstract：:The consequences of asymmetric dispersion on the maintenance of an allele in a one-dimensional environmental pocket are examined. The diffusion model of migration and selection is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is further supposed that ...

journal_title：Genetics

authors： Nagylaki T

更新日期：1978-04-01 00:00:00

abstract：:To understand long terminal repeat (LTR)-retrotransposon copy number dynamics, Ty1 elements were reintroduced into a "Ty-less" Saccharomyces strain where elements had been lost by LTR-LTR recombination. Repopulated strains exhibited alterations in chromosome size that were associated with Ty1 insertions, but did not b...

journal_title：Genetics

authors： Garfinkel DJ,Nyswaner KM,Stefanisko KM,Chang C,Moore SP

更新日期：2005-04-01 00:00:00

abstract：:Considering a random mating population of finite size, the variance of the number of loci having a given gene frequency was derived under the assumption of a steady flux of mutations. The variance of average heterozygosity among populations was also derived under the same assumption. It was shown that these variances ...

journal_title：Genetics

authors： Maruyama T

更新日期：1973-02-01 00:00:00

abstract：:Amoebae of the Colonia (CL) strain, which normally produce plasmodia in clones, are shown to cross with mt3 and mt4 amoebae under appropriate conditions. Strains carrying mt3 and mt4 in a CL genetic background were constructed and used in the genetic analysis of mutants isolated in CL. ...

journal_title：Genetics

authors： Adler PN,Holt CE

更新日期：1974-12-01 00:00:00

abstract：:We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the fir...

journal_title：Genetics

authors： Tomasini M,Peischl S

更新日期：2018-07-01 00:00:00

abstract：:In vertebrates, mitotic and meiotic M phase is facilitated by the kinase Greatwall (Gwl), which phosphorylates a conserved sequence in the effector Endosulfine (Endos). Phosphorylated Endos inactivates the phosphatase PP2A/B55 to stabilize M-phase-specific phosphorylations added to many proteins by cyclin-dependent ki...

journal_title：Genetics

authors： Kim MY,Bucciarelli E,Morton DG,Williams BC,Blake-Hodek K,Pellacani C,Von Stetina JR,Hu X,Somma MP,Drummond-Barbosa D,Goldberg ML

更新日期：2012-08-01 00:00:00

abstract：:Male Drosophila heterozygous for an SD-bearing second chromosome and a normal homolog preferentially transmit the SD chromosome to their offspring. The distorted transmission involves the induced dysfunction of the sperm that receive the SD+ chromosome. The loci on the SD chromosome responsible for causing distortion ...

journal_title：Genetics

authors： Brittnacher JG,Ganetzky B

更新日期：1989-04-01 00:00:00

abstract：:The parasitoid wasp Nasonia vitripennis is an emerging model organism for developmental and behavioral genetics. It reproduces by haplodiploidy; males typically develop parthenogenetically from haploid eggs and females from fertilized diploid eggs. A polyploid mutant strain is available in which females are triploid a...

journal_title：Genetics

authors： Beukeboom LW,Kamping A

更新日期：2006-02-01 00:00:00

abstract：:Previous work showed that C. elegans gon-14 is required for gonadogenesis. Here we report that gon-14 encodes a protein with similarity to LIN-15B, a class B synMuv protein. An extensive region of GON-14 contains blocks of sequence similarity to transposases of the hAT superfamily, but key residues are not conserved, ...

journal_title：Genetics

authors： Chesney MA,Kidd AR 3rd,Kimble J

更新日期：2006-02-01 00:00:00

abstract：:Translation of the chloroplast psbC mRNA in the unicellular eukaryotic alga Chlamydomonas reinhardtii is controlled by interactions between its 547-base 5' untranslated region and the products of the nuclear loci TBC1, TBC2, and possibly TBC3. In this study, a series of site-directed mutations in this region was gener...

journal_title：Genetics

authors： Zerges W,Auchincloss AH,Rochaix JD

更新日期：2003-03-01 00:00:00

abstract：:The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection ...

journal_title：Genetics

authors： Harbison ST,Yamamoto AH,Fanara JJ,Norga KK,Mackay TF

更新日期：2004-04-01 00:00:00

abstract：:The heterotrimeric G protein Gq regulates neuronal activity through distinct downstream effector pathways. In addition to the canonical Gq effector phospholipase Cβ, the small GTPase Rho was recently identified as a conserved effector of Gq. To identify additional molecules important for Gq signaling in neurons, we pe...

journal_title：Genetics

authors： Coleman B,Topalidou I,Ailion M

更新日期：2018-06-01 00:00:00

abstract：:The SUF13 and SUF14 genes were identified among extragenic suppressors of +1 frameshift mutations. SUF13 is synonymous with MBF1, a single-copy nonessential gene coding for a POLII transcription factor. The suf13-1 mutation is a two-nucleotide deletion in the SUF13/MBF1 coding region. A suf13::TRP1 null mutant suppres...

journal_title：Genetics

authors： Hendrick JL,Wilson PG,Edelman II,Sandbaken MG,Ursic D,Culbertson MR

更新日期：2001-03-01 00:00:00

abstract：:Many heterogametic organisms adjust sex chromosome expression to accommodate differences in gene dosage. This requires selective recruitment of regulatory factors to the modulated chromosome. How these factors are localized to a chromosome with requisite accuracy is poorly understood. Drosophila melanogaster males inc...

journal_title：Genetics

authors： Deshpande N,Meller VH

更新日期：2018-08-01 00:00:00

abstract：:The back-to-back geometry of sister kinetochores is essential in preventing loss or damage of chromosomes during mitosis. Kinetochore orientation is generated in part by a process of resolving kinetochores at the centromere (centromere resolution) prior to spindle interactions. Because few of the genes required for ce...

journal_title：Genetics

authors： Stanvitch G,Moore LL

更新日期：2008-01-01 00:00:00

abstract：:The white-apricot (wa) allele differs from the wild-type white gene by the presence of the retrovirus-like transposable element copia within the transcription unit. Most RNAs derived from wa have 3' termini within this insertion, and only small amounts of structurally normal RNA are produced. The activity of wa is red...

journal_title：Genetics

authors： Peng XB,Mount SM

更新日期：1990-12-01 00:00:00

abstract：:Signaling by the second messenger inositol 1,4,5-trisphosphate is thought to affect several developmental and physiological processes. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene of Drosophila exhibit delays in molting while stronger alleles are also larval lethal. In a freshly generated set of EM...

journal_title：Genetics

authors： Joshi R,Venkatesh K,Srinivas R,Nair S,Hasan G

更新日期：2004-01-01 00:00:00

abstract：:Much of the material taken into cells by endocytosis is rapidly returned to the plasma membrane by the endocytic recycling pathway. Although recycling is vital for the correct localization of cell membrane receptors and lipids, the molecular mechanisms that regulate recycling are only partially understood. Here we sho...

journal_title：Genetics

authors： Nilsson L,Conradt B,Ruaud AF,Chen CC,Hatzold J,Bessereau JL,Grant BD,Tuck S

更新日期：2008-05-01 00:00:00

abstract：:Flowering is indicative of the transition from vegetative to reproductive phase, a critical event in the life cycle of plants. In soybean (Glycine max), a flowering quantitative trait locus, FT2, corresponding to the maturity locus E2, was detected in recombinant inbred lines (RILs) derived from the varieties "Misuzud...

journal_title：Genetics

authors： Watanabe S,Xia Z,Hideshima R,Tsubokura Y,Sato S,Yamanaka N,Takahashi R,Anai T,Tabata S,Kitamura K,Harada K

更新日期：2011-06-01 00:00:00

abstract：:Genetic material sequenced from ancient samples is revolutionizing our understanding of the recent evolutionary past. However, ancient DNA is often degraded, resulting in low coverage, error-prone sequencing. Several solutions exist to this problem, ranging from simple approach, such as selecting a read at random for ...

journal_title：Genetics

authors： Schraiber JG

更新日期：2018-01-01 00:00:00

abstract：:In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination often leads to loss of heterozygosity (LOH). Most previous studies of mitotic recombination in Saccharomyces cerevisiae have focused on a single chromosome or a single region of one chromosome at which LOH events can be selected. I...

journal_title：Genetics

authors： St Charles J,Hazkani-Covo E,Yin Y,Andersen SL,Dietrich FS,Greenwell PW,Malc E,Mieczkowski P,Petes TD

更新日期：2012-04-01 00:00:00

abstract：:The formation of dense core granules (DCGs) requires both the sorting of granule contents from other secretory proteins and a postsorting maturation process. The Tetrahymena thermophila strain SB281 fails to synthesize DCGs, and previous analysis suggested that the defect lay at or near the sorting step. Because this ...

journal_title：Genetics

authors： Bowman GR,Turkewitz AP

更新日期：2001-12-01 00:00:00

abstract：:The mutation process at microsatellite loci typically occurs at high rates and with stepwise changes in allele sizes, features that may introduce bias when using classical measures of population differentiation based on allele identity (e.g., F(ST), Nei's Ds genetic distance). Allele size-based measures of differentia...

journal_title：Genetics

authors： Hardy OJ,Charbonnel N,Fréville H,Heuertz M

更新日期：2003-04-01 00:00:00

abstract：:Genetic studies of multidimensional phenotypes can potentially link genetic variation, gene expression, and physiological data to create multi-scale models of complex traits. The challenge of reducing these data to specific hypotheses has become increasingly acute with the advent of genome-scale data resources. Multi-...

journal_title：Genetics

authors： Tyler AL,Ji B,Gatti DM,Munger SC,Churchill GA,Svenson KL,Carter GW

更新日期：2017-06-01 00:00:00

abstract：:Methods for inference and interpretation of evolutionary quantitative genetic parameters, and for prediction of the response to selection, are best developed for traits with normal distributions. Many traits of evolutionary interest, including many life history and behavioral traits, have inherently nonnormal distribu...

journal_title：Genetics

authors： de Villemereuil P,Schielzeth H,Nakagawa S,Morrissey M

更新日期：2016-11-01 00:00:00

abstract：:Combined with a system for identifying each of the chromosomes in a genome, visualizing the location of individual genetic loci by fluorescence in situ hybridization (FISH) would aid in assembling physical and genetic maps. Previously, large genomic clones have been successfully used as FISH probes onto somatic chromo...

journal_title：Genetics

authors： Lamb JC,Danilova T,Bauer MJ,Meyer JM,Holland JJ,Jensen MD,Birchler JA

更新日期：2007-03-01 00:00:00

abstract：:Four crosses were made between inbred Cannabis sativa plants with pure cannabidiol (CBD) and pure Delta-9-tetrahydrocannabinol (THC) chemotypes. All the plants belonging to the F(1)'s were analyzed by gas chromatography for cannabinoid composition and constantly found to have a mixed CBD-THC chemotype. Ten individual ...

journal_title：Genetics

authors： de Meijer EP,Bagatta M,Carboni A,Crucitti P,Moliterni VM,Ranalli P,Mandolino G

更新日期：2003-01-01 00:00:00

abstract：:Previous mathematical analyses of mutation-selection balance for metric traits assume that selection acts on the relevant loci only through the character(s) under study. Thus, they implicitly assume that all of the relevant mutation and selection parameters are estimable. A more realistic analysis must recognize that ...

journal_title：Genetics

authors： Turelli M

更新日期：1985-09-01 00:00:00

abstract：:The Acp26Aa and Acp26Ab genes that code for male accessory gland proteins are tandemly arranged in the species of the Drosophila melanogaster complex. An approximately 1.6-kb region encompassing both genes has been sequenced in 10, 24, and 18 lines from Spain, Ivory Coast, and Malawi, respectively; the previously stud...

journal_title：Genetics

authors： Aguadé M

更新日期：1998-11-01 00:00:00