Does Stellate cause meiotic drive in Drosophila melanogaster?

abstract：:Mitochondria of Neurospora crassa contain a cyanide-resistant alternative respiratory pathway in addition to the cytochrome pathway. The alternative oxidase is present only when electron flow through the cytochrome chain is restricted. Both genomic and cDNA copies for the alternative oxidase gene have been isolated an...

journal_title：Genetics

authors： Li Q,Ritzel RG,McLean LL,McIntosh L,Ko T,Bertrand H,Nargang FE

更新日期：1996-01-01 00:00:00

abstract：:Triose phosphate isomerase (TPI) deficiency glycolytic enzymopathy is a progressive neurodegenerative condition that remains poorly understood. The disease is caused exclusively by specific missense mutations affecting the TPI protein and clinically features hemolytic anemia, adult-onset neurological impairment, degen...

journal_title：Genetics

authors： Seigle JL,Celotto AM,Palladino MJ

更新日期：2008-06-01 00:00:00

abstract：:Twelve laboratory populations of recently collected Drosophila willistoni were begun with different frequencies of alleles at three enzyme loci, six populations at 25 degrees and six at 19 degrees . Periodic sampling of the populations allowed monitoring of the frequency changes in allozymes over time.-At Lap-5 (a loc...

journal_title：Genetics

authors： Powell JR

更新日期：1973-11-01 00:00:00

abstract：:Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations...

journal_title：Genetics

authors： Alcazar RM,Lin R,Fire AZ

更新日期：2008-11-01 00:00:00

abstract：:The binding of alpha-factor to its receptor (Ste2p) activates a G-protein-signaling pathway leading to conjugation of MATa cells of the budding yeast S. cerevisiae. We conducted a genetic screen to identify constitutively activating mutations in the N-terminal region of the alpha-factor receptor that includes transmem...

journal_title：Genetics

authors： Parrish W,Eilers M,Ying W,Konopka JB

更新日期：2002-02-01 00:00:00

abstract：:The consequences of a discontinuity in the migration rate and of a geographical barrier in the habitat are studied in a diffusion model of migration and selection. The treatment is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is supposed further that...

journal_title：Genetics

authors： Nagylaki T

更新日期：1976-08-01 00:00:00

abstract：:Methodology for mapping quantitative trait loci (QTL) has focused primarily on treating the QTL as a fixed effect. These methods differ from the usual models of genetic variation that treat genetic effects as random. Computationally expensive methods that allow QTL to be treated as random have been explicitly develope...

journal_title：Genetics

authors： Zimmer D,Mayer M,Reinsch N

更新日期：2011-01-01 00:00:00

abstract：:As part of our investigation of disease resistance in lettuce, we generated mutants that have lost resistance to Bremia lactucae, the casual fungus of downy mildew. Using a rapid and reliable screen, we identified 16 distinct mutants of Latuca sativa that have lost activity of one of four different downy mildew resist...

journal_title：Genetics

authors： Okubara PA,Anderson PA,Ochoa OE,Michelmore RW

更新日期：1994-07-01 00:00:00

abstract：:Bacteriophage T4 DNA metabolism is largely insulated from that of its host, although some host functions assist in the repair of T4 DNA damage. Environmental factors sometimes affect survival and mutagenesis after ultraviolet (UV) irradiation of T4, and can affect mutagenesis in many organisms. We therefore tested the...

journal_title：Genetics

authors： Smith LA,Drake JW

更新日期：1998-04-01 00:00:00

abstract：:Heterogeneous genetic divergence can accumulate across the genome when populations adapt to different habitats while still exchanging alleles. How long does diversification take and how much of the genome is affected? When divergence occurs in parallel from standing genetic variation, how often are the same haplotypes...

journal_title：Genetics

authors： Bassham S,Catchen J,Lescak E,von Hippel FA,Cresko WA

更新日期：2018-07-01 00:00:00

abstract：:Transposable elements (TEs) constitute a substantial fraction of the eukaryotic genome and, as a result, have a complex relationship with their host that is both adversarial and dependent. To minimize damage to cellular genes, TEs possess mechanisms that target integration to sequences of low importance. However, the ...

journal_title：Genetics

authors： Hickey A,Esnault C,Majumdar A,Chatterjee AG,Iben JR,McQueen PG,Yang AX,Mizuguchi T,Grewal SI,Levin HL

更新日期：2015-11-01 00:00:00

abstract：:Repair replication of DNA has been studied in first instar larvae of Drosophila melanogaster with isopycnic centrifugation techniques. Larvae were fed BUdR, FUdR, streptomycin, penicillin, and Fungazone for two to four hours prior to exposure to UV, X-rays, MMS, or EMS. Feeding was continued for four hours in the pres...

journal_title：Genetics

authors： Boyd JB,Presley JM

更新日期：1974-08-01 00:00:00

abstract：:Genomic prediction methods based on multiple markers have potential to include nonadditive effects in prediction and analysis of complex traits. However, most developments assume a Hardy-Weinberg equilibrium (HWE). Statistical approaches for genomic selection that account for dominance and epistasis in a general conte...

journal_title：Genetics

authors： Vitezica ZG,Legarra A,Toro MA,Varona L

更新日期：2017-07-01 00:00:00

abstract：:We present a two-part system for conditional FLP-out of FRT-flanked sequences in Caenorhabditis elegans to control gene activity in a spatially and/or temporally regulated manner. Using reporters, we assess the system for efficacy and demonstrate its use as a cell lineage marking tool. In addition, we construct and te...

journal_title：Genetics

authors： Voutev R,Hubbard EJ

更新日期：2008-09-01 00:00:00

abstract：:In lytic cycle crosses with Red-Gam-lambda phage, particles were examined that had undergone an Int-mediated exchange. It was assumed that this exchange dimerized the circular lambda, making it packageable. Among these Int-mediated recombinants, particles were identified that had, in addition, enjoyed a close double e...

journal_title：Genetics

authors： Stahl FW,Lieb M,Stahl MM

更新日期：1984-12-01 00:00:00

abstract：:Bisphenol A (BPA) is an organic compound to which human populations are ubiquitously exposed. Epidemiological data suggest BPA exposure might be associated with higher rates of diabetes and reproductive anomalies. Health concerns also include transgenerational consequences, but these mechanisms are crudely defined. Si...

journal_title：Genetics

authors： Branco AT,Lemos B

更新日期：2014-05-01 00:00:00

abstract：:Simple meiotic gene conversion tracts produced in wild-type females were compared with those from two meiotic mutants, mei-9 and mei-218. The positions and lengths of conversion tracts were determined by denaturing gradient gels and DNA sequencing. Conversion tracts in wild type averaged 885 base pairs in length, were...

journal_title：Genetics

authors： Curtis D,Bender W

更新日期：1991-04-01 00:00:00

abstract：:The presence of large genomic regions with suppressed recombination (SR) is a key shared property of some sex- and mating-type determining (mat) chromosomes identified to date in animals, plants, and fungi. Why such regions form and how they evolve remain central questions in evolutionary genetics. The smut fungus Mic...

journal_title：Genetics

authors： Whittle CA,Votintseva A,Ridout K,Filatov DA

更新日期：2015-03-01 00:00:00

abstract：:Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segr...

journal_title：Genetics

authors： Gould KA,Tochacek M,Schaffer BS,Reindl TM,Murrin CR,Lachel CM,VanderWoude EA,Pennington KL,Flood LA,Bynote KK,Meza JL,Newton MA,Shull JD

更新日期：2004-12-01 00:00:00

abstract：:We have studied a genome-wide set of single-nucleotide polymorphism (SNP) allele frequency measures for African-American, East Asian, and European-American samples. For this analysis we derived a simple, closed mathematical formulation for the spectrum of expected allele frequencies when the sampled populations have e...

journal_title：Genetics

authors： Marth GT,Czabarka E,Murvai J,Sherry ST

更新日期：2004-01-01 00:00:00

abstract：:The Yanomama Indians are a South American tribe distributed over an irregular area approximately 200 X 300 miles. The gene frequencies observed at 12 loci in 47 villages within this area have been analyzed for the occurrence of clines. Apparently significant clines are observed for alleles of the Rh, MNSs, Kidd, Gm, I...

journal_title：Genetics

authors： Ward RH,Neel JV

更新日期：1976-01-01 00:00:00

abstract：:The heterotrimeric G protein Gq regulates neuronal activity through distinct downstream effector pathways. In addition to the canonical Gq effector phospholipase Cβ, the small GTPase Rho was recently identified as a conserved effector of Gq. To identify additional molecules important for Gq signaling in neurons, we pe...

journal_title：Genetics

authors： Coleman B,Topalidou I,Ailion M

更新日期：2018-06-01 00:00:00

abstract：:Mendelian loci that control the expression levels of transcripts are called expression quantitative trait loci (eQTL). When mapping eQTL, we often deal with thousands of expression traits simultaneously, which complicates the statistical model and data analysis. Two simple approaches may be taken in eQTL analysis: (1)...

journal_title：Genetics

authors： Jia Z,Xu S

更新日期：2007-05-01 00:00:00

abstract：:A genetic linkage map was constructed in a backcross family of the red flour beetle, Tribolium castaneum, based largely on sequences from bacterial artificial chromosome (BAC) ends and untranslated regions from random cDNA's. In most cases, dimorphisms were detected using heteroduplex or single-strand conformational p...

journal_title：Genetics

authors： Lorenzen MD,Doyungan Z,Savard J,Snow K,Crumly LR,Shippy TD,Stuart JJ,Brown SJ,Beeman RW

更新日期：2005-06-01 00:00:00

abstract：:The Drosophila melanogaster Gart gene encodes three enzymatic activities in the pathway for purine de novo synthesis. Alternative processing of the primary transcript leads to the synthesis of two overlapping polypeptides. The coding sequence for both polypeptides is interrupted by an intron that contains a functional...

journal_title：Genetics

authors： Henikoff S,Eghtedarzadeh MK

更新日期：1987-12-01 00:00:00

abstract：:COTRANS is a program for analyzing cotransduction data. It calculates distances from pairwise cotransduction frequencies, computes crossovers required to obtain each observed recombinant class, and applies rules to draw conclusions about order. The rules are based on the correlation between the frequency of the classe...

journal_title：Genetics

authors： Berlyn MB,Letovsky S

更新日期：1992-05-01 00:00:00

abstract：:The genetic basis of stochastic variation within a defined environment, and the consequences of such micro-environmental variance for fitness are poorly understood . Using a multigenerational breeding design in Drosophila serrata, we demonstrated that the micro-environmental variance in a set of morphological wing tra...

journal_title：Genetics

authors： Sztepanacz JL,McGuigan K,Blows MW

更新日期：2017-08-01 00:00:00

abstract：:A simple two-locus gene conversion model is considered to investigate the amounts of DNA variation and linkage disequilibrium in small multigene families. The exact solutions for the expectations and variances of the amounts of variation within and between two loci are obtained. It is shown that gene conversion increa...

journal_title：Genetics

authors： Innan H

更新日期：2002-06-01 00:00:00

abstract：:The regulation of chemoreceptor (CR) gene expression by environmental signals and internal cues may contribute to the modulation of multiple physiological processes and behavior in Caenorhabditis elegans. We previously showed that KIN-29, a homolog of salt-inducible kinase, acts in sensory neurons to regulate the expr...

journal_title：Genetics

authors： van der Linden AM,Wiener S,You YJ,Kim K,Avery L,Sengupta P

更新日期：2008-11-01 00:00:00

abstract：:A genotype probability index (GPI) is proposed to indicate the information content of genotype probabilities derived from a segregation analysis. Typically, some individuals are genotyped at a marker locus or a quantitative trait locus, and segregation analysis is used to make genotype inferences about ungenotyped rel...

journal_title：Genetics

authors： Kinghorn BP

更新日期：1997-02-01 00:00:00