The EGL-4 PKG acts with KIN-29 salt-inducible kinase and protein kinase A to regulate chemoreceptor gene expression and sensory behaviors in Caenorhabditis elegans.

Abstract:

:The regulation of chemoreceptor (CR) gene expression by environmental signals and internal cues may contribute to the modulation of multiple physiological processes and behavior in Caenorhabditis elegans. We previously showed that KIN-29, a homolog of salt-inducible kinase, acts in sensory neurons to regulate the expression of a subset of CR genes, as well as sensory behaviors. Here we show that the cGMP-dependent protein kinase EGL-4 acts partly in parallel with KIN-29 to regulate CR gene expression. Sensory inputs inhibit both EGL-4 and KIN-29 functions, and KIN-29 function is inhibited in turn by cAMP-dependent protein kinase (PKA) activation. EGL-4 and KIN-29 regulate CR gene expression by antagonizing the gene repression functions of the class II HDAC HDA-4 and the MEF-2 transcription factor, and KIN-29, EGL-4, and PKA target distinct residues in HDA-4 to regulate its function and subcellular localization. While KIN-29 acts primarily via MEF-2/HDA-4 to regulate additional sensory signal-regulated physiological processes and behaviors, EGL-4 acts via both MEF-2-dependent and -independent pathways. Our results suggest that integration of complex sensory inputs via multiple signaling pathways allows animals to precisely regulate sensory gene expression, thereby appropriately modulating physiology and behavior.

journal_name

Genetics

journal_title

Genetics

authors

van der Linden AM,Wiener S,You YJ,Kim K,Avery L,Sengupta P

doi

10.1534/genetics.108.094771

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

1475-91

issue

3

eissn

0016-6731

issn

1943-2631

pii

genetics.108.094771

journal_volume

180

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Three routes to suppression of the neurodegenerative phenotypes caused by kinesin heavy chain mutations.

    abstract::Kinesin-1 is a motor protein that moves stepwise along microtubules by employing dimerized kinesin heavy chain (Khc) subunits that alternate cycles of microtubule binding, conformational change, and ATP hydrolysis. Mutations in the Drosophila Khc gene are known to cause distal paralysis and lethality preceded by the o...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.112.140798

    authors: Djagaeva I,Rose DJ,Lim A,Venter CE,Brendza KM,Moua P,Saxton WM

    更新日期:2012-09-01 00:00:00

  • A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae.

    abstract::Mitotic fidelity is ensured by achieving biorientation on all paired chromosomes. The key signal for proper chromosome alignment is the tension between sister chromatids created by opposing poleward force from the spindles. In the budding yeast, the tension-sensing function requires that the Shugoshin protein, Shugosh...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.117.300606

    authors: Buehl CJ,Deng X,Luo J,Buranasudja V,Hazbun T,Kuo MH

    更新日期:2018-02-01 00:00:00

  • Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway.

    abstract::Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease ataxia telangiectasia. Previously, we characterized the homolog of ATM ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.080879

    authors: Malavazi I,Lima JF,de Castro PA,Savoldi M,de Souza Goldman MH,Goldman GH

    更新日期:2008-02-01 00:00:00

  • The sister chromatid cohesion pathway suppresses multiple chromosome gain and chromosome amplification.

    abstract::Gain or loss of chromosomes resulting in aneuploidy can be important factors in cancer and adaptive evolution. Although chromosome gain is a frequent event in eukaryotes, there is limited information on its genetic control. Here we measured the rates of chromosome gain in wild-type yeast and sister chromatid cohesion ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.113.159202

    authors: Covo S,Puccia CM,Argueso JL,Gordenin DA,Resnick MA

    更新日期:2014-02-01 00:00:00

  • The number of loci that affect milk production traits in dairy cattle.

    abstract::We have used the results of an experiment mapping quantitative trait loci (QTL) affecting milk yield and composition to estimate the total number of QTL affecting these traits. We did this by estimating the number of segregating QTL within a half-sib daughter design using logic similar to that used to estimate the "fa...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.077784

    authors: Chamberlain AJ,McPartlan HC,Goddard ME

    更新日期:2007-10-01 00:00:00

  • Expression quantitative trait loci analysis of 13 genes in the rat prostate.

    abstract::Differential expression of mRNA among animal strains is one of the mechanisms for their diversity. cDNA microarray analysis of the prostates of BUF/Nac (BUF) and ACI/N (ACI) rats, which show different susceptibility to prostate cancers, found 195 differentially expressed genes. To identify loci that control differenti...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.038174

    authors: Yamashita S,Wakazono K,Nomoto T,Tsujino Y,Kuramoto T,Ushijima T

    更新日期:2005-11-01 00:00:00

  • Variance of neutral genetic variances within and between populations for a quantitative character.

    abstract::The variances of genetic variances within and between finite populations were systematically studied using a general multiple allele model with mutation in terms of identity by descent measures. We partitioned the genetic variances into components corresponding to genetic variances and covariances within and between l...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Zeng ZB,Cockerham CC

    更新日期:1991-10-01 00:00:00

  • Chromosomal patterns of microsatellite variability contrast sharply in African and non-African populations of Drosophila melanogaster.

    abstract::Levels of neutral variation are influenced by background selection and hitchhiking. The relative contribution of these evolutionary forces to the distribution of neutral variation is still the subject of ongoing debates. Using 133 microsatellites, we determined levels of variability on X chromosomes and autosomes in A...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kauer M,Zangerl B,Dieringer D,Schlötterer C

    更新日期:2002-01-01 00:00:00

  • Alterations of the portal protein, gpB, of bacteriophage lambda suppress mutations in cosQ, the site required for termination of DNA packaging.

    abstract::The cosQ site of bacteriophage lambda is required for DNA packaging termination. Previous studies have shown that cosQ mutations can be suppressed in three ways: by a local suppressor within cosQ, an increase in the length of the lambda chromosome, and missense mutations affecting the prohead's portal protein, gpB. In...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Wieczorek DJ,Didion L,Feiss M

    更新日期:2002-05-01 00:00:00

  • Molecular evolution of the duplicated Amy locus in the Drosophila melanogaster species subgroup: concerted evolution only in the coding region and an excess of nonsynonymous substitutions in speciation.

    abstract::From the analysis of restriction maps of the Amy region in eight sibling species belonging to the Drosophila melanogaster species subgroup, we herein show that the patterns of duplication of the Amy gene are almost the same in all species. This indicates that duplication occurred before speciation within this species ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shibata H,Yamazaki T

    更新日期:1995-09-01 00:00:00

  • The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7.

    abstract::We demonstrate that the previously described gene Androgen binding protein (Abp; Dlouhy and Karn, 1984) codes for the Alpha subunit of ABP and rename the locus Androgen binding protein alpha (Abpa). A study of recombinant inbred strains demonstrates that Abpa is located on chromosome 7 near Glucose phosphate isomerase...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Dlouhy SR,Taylor BA,Karn RC

    更新日期:1987-03-01 00:00:00

  • Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations.

    abstract::Microtubules are dynamic structures that must elongate, disassemble, and be cleaved into smaller pieces for proper neuronal development and function. The AAA ATPase Spastin severs microtubules along their lengths and is thought to regulate the balance between long, stable filaments and shorter fragments that seed exte...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.130831

    authors: Ozdowski EF,Gayle S,Bao H,Zhang B,Sherwood NT

    更新日期:2011-09-01 00:00:00

  • Genes regulating touch cell development in Caenorhabditis elegans.

    abstract::To identify genes regulating the development of the six touch receptor neurons, we screened the F(2) progeny of mutated animals expressing an integrated mec-2::gfp transgene that is expressed mainly in these touch cells. From 2638 mutated haploid genomes, we obtained 11 mutations representing 11 genes that affected th...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Du H,Chalfie M

    更新日期:2001-05-01 00:00:00

  • A defined zebrafish line for high-throughput genetics and genomics: NHGRI-1.

    abstract::Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced t...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.114.166769

    authors: LaFave MC,Varshney GK,Vemulapalli M,Mullikin JC,Burgess SM

    更新日期:2014-09-01 00:00:00

  • Chromosome loss followed by duplication is the major mechanism of spontaneous mating-type locus homozygosis in Candida albicans.

    abstract::Candida albicans, which is diploid, possesses a single mating-type (MTL) locus on chromosome 5, which is normally heterozygous (a/alpha). To mate, C. albicans must undergo MTL homozygosis to a/a or alpha/alpha. Three possible mechanisms may be used in this process, mitotic recombination, gene conversion, or loss of on...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.033167

    authors: Wu W,Pujol C,Lockhart SR,Soll DR

    更新日期:2005-03-01 00:00:00

  • An n locus multiallele model for gene substitution.

    abstract::We discuss the conceptual conflict between a slow series of gene substitutions as the mechanism of evolutionary change, and the apparent need for rapid and coordinated changes at many loci simultaneously in producing complex adaptations. To improve on the limitations of classical theory and accommodate the enormous am...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Koehler DO,Whitten BL,Gregg TG

    更新日期:1980-03-01 00:00:00

  • Substitution rates in Drosophila nuclear genes: implications for translational selection.

    abstract::The relationships between synonymous and nonsynonymous substitution rates and between synonymous rate and codon usage bias are important to our understanding of the roles of mutation and selection in the evolution of Drosophila genes. Previous studies used approximate estimation methods that ignore codon bias. In this...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Dunn KA,Bielawski JP,Yang Z

    更新日期:2001-01-01 00:00:00

  • Cytogenetic analysis of chromosome region 73AD of Drosophila melanogaster.

    abstract::The 73AD salivary chromosome region of Drosophila melanogaster was subjected to mutational analysis in order to (1) generate a collection of chromosome breakpoints that would allow a correlation between the genetic, cytological and molecular maps of the region and (2) define the number and gross organization of comple...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Belote JM,Hoffmann FM,McKeown M,Chorsky RL,Baker BS

    更新日期:1990-08-01 00:00:00

  • Variation in activities of amylase allozymes associated with chromosome inversions in Drosophila pseudoobscura, D. persimilis and D. miranda.

    abstract::Different electrophoretic alleles of amylase show associations with particular chromosome 3 inversions in D. pseudoobscura and D. persimilis. Relative adult amylase activities were compared in 37, 37 and 10 strains of D. pseudoobscura, D. persimilis and D. miranda, respectively. Strains carrying the same electrophoret...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Norman RA,Prakash S

    更新日期:1980-05-01 00:00:00

  • Genetic analysis of MraY inhibition by the phiX174 protein E.

    abstract::Protein E, the lysis protein of bacteriophage phiX174, is a specific inhibitor of MraY, the phospho-MurNAc-pentapeptide translocase that catalyzes the synthesis of lipid I in the conserved pathway for peptidoglycan biosynthesis. The original evidence for this inhibition was the isolation of two spontaneous E-resistanc...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.093443

    authors: Zheng Y,Struck DK,Bernhardt TG,Young R

    更新日期:2008-11-01 00:00:00

  • Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast.

    abstract::The S-M checkpoint ensures that entry into mitosis is dependent on completion of DNA replication. In the fission yeast Schizosaccharomyces pombe, the SM checkpoint mutant cdc2-3w is thought to be defective in receiving the checkpoint signal. To isolate genes that function in the checkpoint pathway, we screened an S. p...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Humphrey T,Enoch T

    更新日期:1998-04-01 00:00:00

  • The product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, specifically functions in mitochondria.

    abstract::We reported previously that the product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, belongs to a family of proteins that are involved in DNA repair and replication. The family includes S. cerevisiae proteins Rad2p and its human homolog XPGC, Rad27p and its mammalian homolog FEN-1, and Exonuclea...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Fikus MU,Mieczkowski PA,Koprowski P,Rytka J,Sledziewska-Gójska E,Ciésla Z

    更新日期:2000-01-01 00:00:00

  • Establishment of Locally Adapted Mutations Under Divergent Selection.

    abstract::We study the establishment probabilities of locally adapted mutations using a multi-type branching process framework. We find a surprisingly simple and intuitive analytical approximation for the establishment probabilities in a symmetric two-deme model under the assumption of weak (positive) selection. This is the fir...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.118.301104

    authors: Tomasini M,Peischl S

    更新日期:2018-07-01 00:00:00

  • Disruption of genetic interaction between two autosomal regions and the X chromosome causes reproductive isolation between mouse strains derived from different subspecies.

    abstract::Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.062976

    authors: Oka A,Aoto T,Totsuka Y,Takahashi R,Ueda M,Mita A,Sakurai-Yamatani N,Yamamoto H,Kuriki S,Takagi N,Moriwaki K,Shiroishi T

    更新日期:2007-01-01 00:00:00

  • Evolution of resistance in the presence of two insecticides.

    abstract::A two-locus model is used to analyze the effectiveness of a mixture of insecticides in delaying resistance, compared to the use of the insecticides singly. The effects of factors such as recombination, effective dominance, initial value of allele frequencies and initial value of linkage disequilibrium are considered. ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Mani GS

    更新日期:1985-04-01 00:00:00

  • A comparison of isozyme and quantitative genetic variation in Pinus contorta ssp. latifolia by FST.

    abstract::We employed F-statistics to analyze quantitative and isozyme variation among five populations of Pinus contorta ssp. latifolia, a wind-pollinated outcrossing conifer with wide and continuous distribution in west North America. Estimates of population differentiation (FST) for six quantitative traits were compared with...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Yang RC,Yeh FC,Yanchuk AD

    更新日期:1996-03-01 00:00:00

  • Population studies on an endemic troglobitic beetle: geographical patterns of genetic variation, gene flow and genetic structure compared with morphometric data.

    abstract::Highly specialized obligatory cave beetles endemic to the French Pyrenees offer an opportunity to investigate the relative importance of environmental conditions and ecological characteristics on the organization of genetic variability, to describe the genetic structure of populations, and to assess the extent of gene...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Crouau-Roy B

    更新日期:1989-03-01 00:00:00

  • Novel acid phosphatase in Candida glabrata suggests selective pressure and niche specialization in the phosphate signal transduction pathway.

    abstract::Evolution through natural selection suggests unnecessary genes are lost. We observed that the yeast Candida glabrata lost the gene encoding a phosphate-repressible acid phosphatase (PHO5) present in many yeasts including Saccharomyces cerevisiae. However, C. glabrata still had phosphate starvation-inducible phosphatas...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.110.120824

    authors: Orkwis BR,Davies DL,Kerwin CL,Sanglard D,Wykoff DD

    更新日期:2010-11-01 00:00:00

  • Activity, expression and function of a second Drosophila protein kinase A catalytic subunit gene.

    abstract::The DC2 gene was isolated previously on the basis of sequence similarity to DC0, the major Drosophila protein kinase A (PKA) catalytic subunit gene. We show here that the 67-kD Drosophila DC2 protein behaves as a PKA catalytic subunit in vitro. DC2 is transcribed in mesodermal anlagen of early embryos. This expression...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Meléndez A,Li W,Kalderon D

    更新日期:1995-12-01 00:00:00

  • Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans.

    abstract::The trace element iron is crucial for living organisms, since it plays essential roles in numerous cellular functions. Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically a...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.186742

    authors: Wang H,Jiang X,Wu J,Zhang L,Huang J,Zhang Y,Zou X,Liang B

    更新日期:2016-05-01 00:00:00