Gene conversion in Drosophila and the effects of the meiotic mutants mei-9 and mei-218.

Abstract:

:Simple meiotic gene conversion tracts produced in wild-type females were compared with those from two meiotic mutants, mei-9 and mei-218. The positions and lengths of conversion tracts were determined by denaturing gradient gels and DNA sequencing. Conversion tracts in wild type averaged 885 base pairs in length, were continuous, and displayed no obvious hot spots of initiation. Some unusual conversion events were found in the mei-218 and mei-9 samples, although most events were indistinguishable from wild-type tracts in their length and continuity.

journal_name

Genetics

journal_title

Genetics

authors

Curtis D,Bender W

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

739-46

issue

4

eissn

0016-6731

issn

1943-2631

journal_volume

127

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Extragenic suppressors of Schizosaccharomyces pombe rad9 mutations uncouple radioresistance and hydroxyurea sensitivity from cell cycle checkpoint control.

    abstract::Schizosaccharomyces pombe cells that contain a mutation within rad9 are sensitive to ionizing radiation, UV light and hydroxyurea, relative to wild-type strains. In addition, the mutants are moderately hypomutable by UV and unable to delay initiation of mitosis after treatment with radiation or hydroxyurea. Three radi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Lieberman HB

    更新日期:1995-09-01 00:00:00

  • Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae.

    abstract::Mating type interconversion in Saccharomyces cerevisiae occurs by transposition of copies of the a or alpha mating type cassettes from inactive loci, HML and HMR, to an active locus, MAT. The lack of expression of the a and alpha genes at the silent loci results from repression by trans-acting regulators encoded by SI...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Rine J,Herskowitz I

    更新日期:1987-05-01 00:00:00

  • An implanted recombination hot spot stimulates recombination and enhances sister chromatid cohesion of heterologous YACs during yeast meiosis.

    abstract::Heterologous yeast artificial chromosomes (YACs) do not recombine with each other and missegregate in 25% of meiosis I events. Recombination hot spots in the yeast Saccharomyces cerevisiae have previously been shown to be associated with sites of meiosis-induced double-strand breaks (DSBs). A 6-kb fragment containing ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Sears DD,Hieter P,Simchen G

    更新日期:1994-12-01 00:00:00

  • Synaptic adjustment of inversion loops in Neurospora crassa.

    abstract::Heterozygotes for three long inversions on chromosome 1 were analyzed by serial reconstruction from electron micrographs. Measurements of loop lengths at different meiotic prophase substages revealed that the homologous synapsis of the inverted region was gradually replaced by nonhomologous synapsis as loops were elim...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bojko M

    更新日期:1990-03-01 00:00:00

  • On the components of segregation distortion in Drosophila melanogaster. IV. Construction and analysis of free duplications for the Responder locus.

    abstract::Male Drosophila heterozygous for an SD-bearing second chromosome and a normal homolog preferentially transmit the SD chromosome to their offspring. The distorted transmission involves the induced dysfunction of the sperm that receive the SD+ chromosome. The loci on the SD chromosome responsible for causing distortion ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Brittnacher JG,Ganetzky B

    更新日期:1989-04-01 00:00:00

  • Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family.

    abstract::To understand the role of Los1p in pre-tRNA splicing, we sought los1 multicopy suppressors. We found SOL1 that suppresses both point and null LOS1 mutations. Since, when fused to the Ga14p DNA-binding domain, Los1p activates transcription, we tested whether Los1p regulates SOL1. We found that las1 mutants have deplete...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shen WC,Stanford DR,Hopper AK

    更新日期:1996-06-01 00:00:00

  • The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing and sister-chromatid cohesion during meiosis.

    abstract::The fission yeast Schizosaccharomyces pombe does not form tripartite synaptonemal complexes during meiotic prophase, but axial core-like structures (linear elements). To probe the relationship between meiotic recombination and the structure, pairing, and segregation of meiotic chromosomes, we genetically and cytologic...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Molnar M,Bähler J,Sipiczki M,Kohli J

    更新日期:1995-09-01 00:00:00

  • The role of breeding and genetics in animal production improvement in the developing countries.

    abstract::Availability of animal protein for human consumption is very low in the developing countries mainly because of low productivity of existing livestock; ways and means to improve productivity through breeding are discussed and some basic issues requiring further research pointed out. ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Rendel J

    更新日期:1974-09-01 00:00:00

  • Variation Associated with an AEGILOPS UMBELLULATA Chromosome Segment Incorporated in Wheat. II. Peroxidase and Leucine Aminopeptidase Isozymes.

    abstract::Zymograms were analyzed of a number of Triticum aestivum derivatives which incorporated a segment of the Aegilops umbellulata chromosome bearing resistance to leaf rust. Evidence has been presented which suggests that genes involved in the production of two peroxidases and a single peptidase are located on the short a...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Macdonald T,Smith HH

    更新日期:1972-09-01 00:00:00

  • Conserved WCPL and CX4C domains mediate several mating adhesin interactions in Saccharomyces cerevisiae.

    abstract::Several adhesins are induced by pheromones during mating in Saccharomyces cerevisiae, including Aga1p, Aga2p, Sag1p (Agalpha1p), and Fig2p. These four proteins all participate in or influence a well-studied agglutinin interaction mediated by Aga1p-Aga2p complexes and Sag1p; however, they also play redundant and essent...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.100073

    authors: Huang G,Dougherty SD,Erdman SE

    更新日期:2009-05-01 00:00:00

  • Genetic variation in a heterogeneous environment. V. Spatial heterogeneity in finite populations.

    abstract::The spatial model of Levene (1953) was examined in a finite population and compared to a temporal model. The spatial model was much more effective in retaining genetic variation in a finite population. Furthermore, the haploid spatial model was more effective in retaining genetic variation than the analogous diploid a...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hedrick PW

    更新日期:1978-06-01 00:00:00

  • The Saccharomyces cerevisiae recombination enhancer biases recombination during interchromosomal mating-type switching but not in interchromosomal homologous recombination.

    abstract::Haploid Saccharomyces can change mating type through HO-endonuclease cleavage of an expressor locus, MAT, followed by gene conversion using one of two repository loci, HML or HMR, as donor. The mating type of a cell dictates which repository locus is used as donor, with a cells using HML and alpha cells using HMR. Thi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.166.3.1187

    authors: Houston P,Simon PJ,Broach JR

    更新日期:2004-03-01 00:00:00

  • The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.

    abstract::Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras/Map kinase signaling through the recruitment of csw/ptp-2/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (insulin receptor-like) signaling, it is shown t...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.055822

    authors: Hopper NA

    更新日期:2006-05-01 00:00:00

  • Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping.

    abstract::Rodent inbred line crosses are widely used to map genetic loci associated with complex traits. This approach has proven to be powerful for detecting quantitative trait loci (QTL); however, the resolution of QTL locations, typically approximately 20 cM, means that hundreds of genes are implicated as potential candidate...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.033993

    authors: Li R,Lyons MA,Wittenburg H,Paigen B,Churchill GA

    更新日期:2005-03-01 00:00:00

  • Joint effects of natural selection and recombination on gene flow between Drosophila ananassae populations.

    abstract::We estimated DNA sequence variation in a 5.7-kb fragment of the furrowed (fw) gene region within and between four populations of Drosophila ananassae; fw is located in a chromosomal region of very low recombination. We analyzed gene flow between these four populations along a latitudinal transect on the Indian subcont...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Chen Y,Marsh BJ,Stephan W

    更新日期:2000-07-01 00:00:00

  • Challenges of detecting directional selection after a bottleneck: lessons from Sorghum bicolor.

    abstract::Multilocus surveys of sequence variation can be used to identify targets of directional selection, which are expected to have reduced levels of variation. Following a population bottleneck, the signal of directional selection may be hard to detect because many loci may have low variation by chance and the frequency sp...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.054312

    authors: Hamblin MT,Casa AM,Sun H,Murray SC,Paterson AH,Aquadro CF,Kresovich S

    更新日期:2006-06-01 00:00:00

  • Response to selection at two temperatures for fast and slow growth from five to nine weeks of age in poultry.

    abstract::Cornell Control White Leghorn chicks were grown in a common environment to five weeks of age and selected for fast and slow gain in body weight from five to nine weeks of age at two temperatures, 21.1 degrees (cold) and 32.2 degrees (hot), during which time a constant 50% relative humidity was maintained. All lines we...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bohren BB,Carson JR,Rogler JC

    更新日期:1981-02-01 00:00:00

  • Testing for neutrality in samples with sequencing errors.

    abstract::Many data sets one could use for population genetics contain artifactual sites, i.e., sequencing errors. Here, we first explore the impact of such errors on several common summary statistics, assuming that sequencing errors are mostly singletons. We thus show that in the presence of those errors, estimators of can be ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.082198

    authors: Achaz G

    更新日期:2008-07-01 00:00:00

  • Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis.

    abstract::Drosophila adult leg development provides an ideal model system for characterizing the molecular mechanisms of hormone-triggered morphogenesis. A pulse of the steroid hormone ecdysone at the onset of metamorphosis triggers the rapid transformation of a flat leg imaginal disc into an immature adult leg, largely through...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ward RE,Evans J,Thummel CS

    更新日期:2003-11-01 00:00:00

  • Gene conversion between direct noncoding repeats promotes genetic and phenotypic diversity at a regulatory locus of Zea mays (L.).

    abstract::While evolution of coding sequences has been intensively studied, diversification of noncoding regulatory regions remains poorly understood. In this study, we investigated the molecular evolution of an enhancer region located 5 kb upstream of the transcription start site of the maize pericarp color1 (p1) gene. The p1 ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.053942

    authors: Zhang F,Peterson T

    更新日期:2006-10-01 00:00:00

  • A "FLP-Out" system for controlled gene expression in Caenorhabditis elegans.

    abstract::We present a two-part system for conditional FLP-out of FRT-flanked sequences in Caenorhabditis elegans to control gene activity in a spatially and/or temporally regulated manner. Using reporters, we assess the system for efficacy and demonstrate its use as a cell lineage marking tool. In addition, we construct and te...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.090274

    authors: Voutev R,Hubbard EJ

    更新日期:2008-09-01 00:00:00

  • Identification of quantitative trait loci and environmental interactions for accumulation and remobilization of water-soluble carbohydrates in wheat (Triticum aestivum L.) stems.

    abstract::Genetic analyses of nine traits associated with stem water-soluble carbohydrate (SWSC) accumulation and remobilization at grain-filling period under drought stress (DS) and well-watered (WW) conditions were undertaken using doubled haploid lines (DHLs) derived from two Chinese common wheat cultivars. Some significantl...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.068361

    authors: Yang DL,Jing RL,Chang XP,Li W

    更新日期:2007-05-01 00:00:00

  • The RAD52 recombinational repair pathway is essential in pol30 (PCNA) mutants that accumulate small single-stranded DNA fragments during DNA synthesis.

    abstract::To identify in vivo pathways that compensate for impaired proliferating cell nuclear antigen (PCNA or Pol30p in yeast) activity, we performed a synthetic lethal screen with the yeast pol30-104 mutation. We identified nine mutations that display synthetic lethality with pol30-104; three mutations affected the structura...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Merrill BJ,Holm C

    更新日期:1998-02-01 00:00:00

  • Nonallelic gene conversion in the genus Drosophila.

    abstract::Nonallelic gene conversion has been proposed as a major force in homogenizing the sequences of paralogous genes. In this work, we investigate the extent and characteristics of gene conversion among gene families in nine species of the genus Drosophila. We carried out a genome-wide study of 2855 gene families (includin...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.110.115444

    authors: Casola C,Ganote CL,Hahn MW

    更新日期:2010-05-01 00:00:00

  • Quantitative trait loci mapping and the genetic basis of heterosis in maize and rice.

    abstract::Despite its importance to agriculture, the genetic basis of heterosis is still not well understood. The main competing hypotheses include dominance, overdominance, and epistasis. NC design III is an experimental design that has been used for estimating the average degree of dominance of quantitative trait loci (QTL) a...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.082867

    authors: Garcia AA,Wang S,Melchinger AE,Zeng ZB

    更新日期:2008-11-01 00:00:00

  • Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster.

    abstract::To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant to globally ab...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.112.142042

    authors: Chen A,Ng F,Lebestky T,Grygoruk A,Djapri C,Lawal HO,Zaveri HA,Mehanzel F,Najibi R,Seidman G,Murphy NP,Kelly RL,Ackerson LC,Maidment NT,Jackson FR,Krantz DE

    更新日期:2013-01-01 00:00:00

  • Extragenic bypass suppressors of mutations in the essential gene BLD2 promote assembly of basal bodies with abnormal microtubules in Chlamydomonas reinhardtii.

    abstract::bld2-1 mutant Chlamydomonas reinhardtii strains assemble basal bodies with singlet microtubules; bld2-1 cells display flagellar assembly defects as well as positioning defects of the mitotic spindle and cleavage furrow. To further understand the role of the BLD2 gene, we have isolated three new bld2 alleles and three ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Preble AM,Giddings TH Jr,Dutcher SK

    更新日期:2001-01-01 00:00:00

  • The brood pattern of mitomycin-c-induced translocations in Drosophila melanogaster males: the effect of time.

    abstract::Translocations between the two large autosomes were scored in the progeny of males that had been fed mitomycin-C. The frequencies were the same in spermatogonia sampled after 12 and 25 days and in spermatozoa stored for the same periods in untreated females. ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shukla PT,Auerbach C

    更新日期:1979-10-01 00:00:00

  • Genetic variability at the esterase-6 locus in natural populations of Drosophila simulans in relation to environmental heterogeneity.

    abstract::The allozymic variation at at the esterase-6 locus examined in fourteen samples of natural populations of Drosophila simulans collected in two different localities. The samples were collected from different species of fruits in the two localities and from banana baits located some meters apart from the fruits. The ana...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: de Albuquerque CM,Napp M

    更新日期:1981-06-01 00:00:00

  • Assembly of the mitochondrial membrane system: nuclear suppression of a cytochrome b mutation in yeast mitochondrial DNA.

    abstract::In a previous study, a mitochondrial mutant expressing a specific enzymatic deficiency in co-enzyme QH2-cytochrome c reductase was described (TZAGO-LOFF, FOURY and AKAI 1976). Analysis of the mitochondrially translated proteins revealed the absence in the mutant of the mitochondrial product corresponding to cytochrome...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Coruzzi G,Tzagoloff A

    更新日期:1980-08-01 00:00:00