Abstract：
:Mitochondria of Neurospora crassa contain a cyanide-resistant alternative respiratory pathway in addition to the cytochrome pathway. The alternative oxidase is present only when electron flow through the cytochrome chain is restricted. Both genomic and cDNA copies for the alternative oxidase gene have been isolated and analyzed. The sequence of the predicted protein is homologous to that of other species. The mRNA for the alternative oxidase is scarce in wild-type cultures grown under normal conditions, but it is abundant in cultures grown in the presence of chloramphenicol, an inhibitor of mitochondrial protein synthesis, or in mutants deficient in mitochondrial cytochromes. Thus, induction of alternative oxidase appears to be at the transcriptional level. Restriction fragment length polymorphism mapping of the isolated gene demonstrated that it is located in a position corresponding to the aod-1 locus. Sequence analysis of mutant aod-1 alleles reveals mutations affecting the coding sequence of the alternative oxidase. The level of aod-1 mRNA in an aod-2 mutant strain that had been grown in the presence of chloramphenicol was reduced several fold relative to wild-type, supporting the hypothesis that the product of aod-2 is required for optimal expression of aod-1.
journal_name
Geneticsjournal_title
Geneticsauthors
Li Q,Ritzel RG,McLean LL,McIntosh L,Ko T,Bertrand H,Nargang FEsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
129-40issue
1eissn
0016-6731issn
1943-2631journal_volume
142pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Telomere position effects on transcription (TPE, or telomeric silencing) are nucleated by association of nonhistone silencing factors with the telomere and propagated in subtelomeric regions through association of silencing factors with the specifically modified histones H3 and H4. However, the function of histone H2A...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:In many organisms, female and male meiosis display extensive sexual dimorphism in the temporal meiotic program, the number and location of recombination events, sex chromosome segregation, and checkpoint function. We show here that both meiotic prophase timing and germ-line apoptosis, one output of checkpoint signalin...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.110338
更新日期：2010-03-01 00:00:00
abstract：:Presynaptic association of homologous chromosomes is a prerequisite to the sequence of events that lead to chiasma formation. This association of homologous chromosomes, as entire units, occurs with probability a, and chiasma formation occurs independently in opposite chromosome arms with probability c. a and c have b...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
abstract：:Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the sam...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
abstract：:Equilibria are determined for the two-locus model in a partially selfing population when one locus is neutral and the other locus is heterotic. At an equilibrium point, the frequency of heterozygotes at the neutral locus is greater than that expected from one-locus theory, even if the heterotic locus is on a different...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:A recent sperm-typing study by Jeffreys and Neumann suggested that recombination rates in different individuals at the DNA2 recombination hotspot appeared to be highly dependent on their genotype at a particular A/G SNP, FG11. Specifically, individuals who carried at least one copy of the A allele at this SNP exhibite...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.039271
更新日期：2006-03-01 00:00:00
abstract：:The long-term population genetics of multigene families is influenced by several biased and unbiased mechanisms of nonreciprocal exchanges (gene conversion, unequal exchanges, transposition) between member genes, often distributed on several chromosomes. These mechanisms cause fluctuations in the copy number of varian...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：:Mutant alleles of two genetic regulatory elements, which underlie a three- to sixfold reduction in beta-glucuronidase (GUS) activity levels, distinguish mice of the H haplotype from those of the other two common GUS haplotypes, A and B. Both elements are tightly linked to the GUS structural gene over which they exert ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Directed open reading frame (ORF) disruption and a serial selection technique in Escherichia coli and the extremely thermophilic archaeon Sulfolobus solfataricus allowed the identification of otherwise cryptic crucial and noncrucial viral open reading frames in the genome of the archaeal virus SSV1. It showed that the...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：:Adherence, an important virulence factor, is mediated by the EPA (Epithelial Adhesin) genes in the opportunistic pathogen Candida glabrata Expression of adhesin-encoding genes requires tight regulation to respond to harsh environmental conditions within the host. The majority of EPA genes are localized in subtelomeric...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301202
更新日期：2018-09-01 00:00:00
abstract：:Many genes that affect axon pathfinding and cell migration have been identified. Mechanisms by which these genes and the molecules they encode interact with one another in pathways and networks to control developmental events are unclear. Rac GTPases, the cytoskeletal signaling molecule Enabled, and NIK kinase have al...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.046359
更新日期：2006-02-01 00:00:00
abstract：:The forest tent caterpillar is polymorphic for two melanic genes affecting wing color of moths. These are the first genetically determined morphological traits reported for the genus. Dark (D) is a sex-limited, autosomal dominant with a phenotype of dark brown males. Frequencies in population samples varied from 8 to ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen in C. elegans that has identified six factors required for RNAi inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.198812
更新日期：2017-07-01 00:00:00
abstract：:Two replications of a complete diallel cross experiment were performed among four partially inbred lines of mice. These inbred lines originated from a random-bred ICR strain and were produced by 12 generations of full sibbing (F congruent to 92%). Individual body weight was recorded for each animal at 12, 21, 42 and 5...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-10-01 00:00:00
abstract：:In this article we define and characterize the smellblind gene (sbl). We show that two mutants, sbl and olfDx9, both isolated by virtue of their olfactory phenotypes and analyzed extensively by others with respect to courtship behavior, contain mutations at a single locus. Meiotic recombination, duplication, and defic...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
abstract：:Gametes are produced in plants through mitotic divisions in the haploid gametophytes. We investigated the role of EXPORTIN1 (XPO1) genes during the development of both female and male gametophytes of Arabidopsis. Exportins exclude target proteins from the nucleus and are also part of a complex recruited at the kinetoc...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.094896
更新日期：2008-11-01 00:00:00
abstract：:In most species, size homeostasis appears to be exerted in late G1 phase as cells commit to division, called Start in yeast and the Restriction Point in metazoans. This size threshold couples cell growth to division, and, thereby, establishes long-term size homeostasis. Our former investigations have shown that hundre...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301872
更新日期：2019-02-01 00:00:00
abstract：:Remarkably complex patterns of aneuploidy have been observed in the genomes of many eukaryotic cell types, ranging from brewing yeasts to tumor cells. Such aberrant karyotypes are generally thought to take shape progressively over many generations, but evidence also suggests that genomes may undergo faster modes of ev...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303536
更新日期：2020-09-01 00:00:00
abstract：:Sex-specific differences in dispersal, survival, reproductive success, and natural selection differentially affect the effective population size (N(e)) of genomic regions with different modes of inheritance such as sex chromosomes and mitochondrial DNA. In papionin monkeys (macaques, baboons, geladas, mandrills, drill...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.116228
更新日期：2010-07-01 00:00:00
abstract：:Significant correlations between allelic frequencies and environmental variables in a number of insect species have been demonstrated by multivariate techniques. Since many environmental variables show a strong relationship to geographic location and since gene flow between populations can also produce patterns of gen...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-05-01 00:00:00
abstract：:Several adhesins are induced by pheromones during mating in Saccharomyces cerevisiae, including Aga1p, Aga2p, Sag1p (Agalpha1p), and Fig2p. These four proteins all participate in or influence a well-studied agglutinin interaction mediated by Aga1p-Aga2p complexes and Sag1p; however, they also play redundant and essent...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.100073
更新日期：2009-05-01 00:00:00
abstract：:Studies in the fly, Drosophila melanogaster, have revealed that several signaling pathways are important for the regulation of growth. Among these, the insulin receptor/phosphoinositide 3-kinase (PI3K) pathway is remarkable in that it affects growth and final size without disturbing pattern formation. We have used a s...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.045021
更新日期：2005-10-01 00:00:00
abstract：:We describe allelic variation at 28 gene loci in natural populations of D. willistoni. Seventy samples were studied from localities extending from Mexico and Florida, through Central America, the West Indies, and tropical South America, down to South Brazil. At least several hundred, and often several thousand, genome...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:The transcription factors WHITE COLLAR-1 (WC-1) and WHITE COLLAR-2 (WC-2) interact to form a heterodimeric complex (WCC) that is essential for most of the light-mediated processes in Neurospora crassa. WCC also plays a distinct non-light-related role as the transcriptional activator in the FREQUENCY (FRQ)/WCC feedback...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:High-throughput sequencing and bioinformatic techniques have enhanced classical genetic analysis and are essential methods for geneticists. Tsukamoto and colleagues use numerous genomic and bioinformatics methods to explore the role of ribonucleoprotein complexes in regulating oocyte meiotic maturation, which is the t...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301139
更新日期：2018-07-01 00:00:00
abstract：:Transposable elements are often considered as selfish DNA sequences able to invade the genome of their host species. Their evolutive dynamics are complex, due to the interaction between their intrinsic amplification capacity, selection at the host level, transposition regulation, and genetic drift. Here, we propose mo...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.031211
更新日期：2005-02-01 00:00:00
abstract：:A genotype probability index (GPI) is proposed to indicate the information content of genotype probabilities derived from a segregation analysis. Typically, some individuals are genotyped at a marker locus or a quantitative trait locus, and segregation analysis is used to make genotype inferences about ungenotyped rel...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:A multivariate quantitative genetic model is analyzed that is based on the assumption that the genetic variation at a locus j primarily influences an underlying physiological variable yj, while influence on the genotypic values is determined by a kind of "developmental function" which is not changed by mutations at th...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:We have identified a new locus involved in gibberellin (GA) signal transduction by screening for suppressors of the Arabidopsis thaliana GA biosynthetic mutant gal-3. The locus is named RGA for repressor of gal-3. Based on the recessive phenotype of the digenic rga/gal-3 mutant, the wild-type gene product of RGA is pr...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:Mutants of Neurospora crassa have been isolated that lack the repressible alkaline phosphatase, but, unlike nuc-1 and nuc-2 mutants, are able to make the repressible acid phosphatase and the repressible phosphate permease under conditions of derepression (phosphate deprivation). The new mutants, called pho-2, map in L...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-10-01 00:00:00
