Abstract:
:A supposed sporulation-deficient mutation of Saccharomyces cerevisiae is found to affect mating in haploids and in diploids, and to be inseparable from the mating-type locus by recombination. The mutation is regarded as a defective a allele and is designated a*. This is confirmed by its dominance relations in diploids, triploids, and tetraploids. Tetrad analysis of tetraploids and of their sporulating diploid progeny suggests the existence of an additional locus, RME, which regulates sporulation in yeast strains that can mate. Thus the recessive homozygous constitution rme/rm- enables the diploids a*/alpha, a/a*, and alpha/alpha to go through meiosis. Haploids carrying rme show apparent premeiotic DNA replication in sporulation conditions. This new regulatory locus is linked to the centromere of the mating-type chromosome, and its two alleles, rme and RME, are found among standard laboratory strains.
journal_name
Geneticsjournal_title
Geneticsauthors
Kassir Y,Simchen Gsubject
Has Abstractpub_date
1976-02-01 00:00:00pages
187-206issue
2eissn
0016-6731issn
1943-2631journal_volume
82pub_type
杂志文章相关文献
GENETICS文献大全abstract::It is well known that most new mutations that affect fitness exert deleterious effects and that natural populations are often composed of subpopulations (demes) connected by gene flow. To gain a better understanding of the joint effects of purifying selection and population structure, we focus on a scenario where an a...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.178558
更新日期:2015-12-01 00:00:00
abstract::The identity of a given cell type is determined by the expression of a set of genes sharing common cis-regulatory motifs and being regulated by shared transcription factors. Here, we identify cis and trans regulatory elements that drive gene expression in the bilateral sensory neuron ASJ, located in the head of the ne...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.176172
更新日期:2015-05-01 00:00:00
abstract::Mating behavior in adult male nematodes can be assayed by mating efficiency, i.e., the number of cross progeny sired by males under standard conditions. Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnorm...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Putzig (Pzg) was originally identified as being an integral component of the TRF2/DREF complex in Drosophila melanogaster, thereby regulating the transcriptional activation of replication-related genes. In a DREF-independent manner, Pzg was shown to mediate Notch target gene activation. This function of Pzg entails an...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.127795
更新日期:2011-05-01 00:00:00
abstract::Isogenic lines, in which chromosomes sampled from natural populations of C. melanogaster are substituted into a common genetic background, were used to detect and partially characterize autosomal factors that affect the activities of the two pentose phosphate pathway enzymes, glucose 6-phosphate dehydrogenase (G6PD) a...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::The DC2 gene was isolated previously on the basis of sequence similarity to DC0, the major Drosophila protein kinase A (PKA) catalytic subunit gene. We show here that the 67-kD Drosophila DC2 protein behaves as a PKA catalytic subunit in vitro. DC2 is transcribed in mesodermal anlagen of early embryos. This expression...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::We have isolated and characterized deletions arising within a P transposon, P[hswa], in the presence of P transposase. P[hswa] carries white-apricot (wa) sequences, including a complete copia element, under the control of an hsp70 promoter, and resembles the original wa allele in eye color phenotype. In the presence o...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with Caenorhabditis elegans nematodes was conducted in which independently evolving lines were initiated from a low-fitness mitochondrial electron transport chain (ETC) mutant, gas-1 Following 60 generations o...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.301935
更新日期:2019-03-01 00:00:00
abstract::Satellite DNA is an enigmatic component of genomic DNA with unclear function that has been regarded as "junk." Yet, persistence of these tandem highly repetitive sequences in heterochromatic regions of most eukaryotic chromosomes attests to their importance in the genome. We explored the Anopheles gambiae genome for t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.034264
更新日期:2005-01-01 00:00:00
abstract::We have characterized tandem duplications in the rII regions of phage T4. The rII deletion r1589 blocks only the function of the rIIA cistron, although it extends into the B cistron. Another rII deletion, r1236, blocks the function of the rIIB cistron and overlaps r1589. When a cross is made between r1589 and r1236, t...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.070235
更新日期:2007-07-01 00:00:00
abstract::An AluI family of highly reiterated nontranscribed sequences has been found in the genome of the honeybee Apis mellifera. This repeated sequence is shown to be present at approximately 23,000 copies per haploid genome constituting about 2% of the total genomic DNA. The nucleotide sequence of 10 monomers was determined...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) si...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.086298
更新日期:2008-04-01 00:00:00
abstract::Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of type II topoisomera...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.144006
更新日期:2012-11-01 00:00:00
abstract::The regulation of chemoreceptor (CR) gene expression by environmental signals and internal cues may contribute to the modulation of multiple physiological processes and behavior in Caenorhabditis elegans. We previously showed that KIN-29, a homolog of salt-inducible kinase, acts in sensory neurons to regulate the expr...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.094771
更新日期:2008-11-01 00:00:00
abstract::Plants with mutations in one of three maize genes, mop1, rmr1, and rmr2, are defective in paramutation, an allele-specific interaction that leads to meiotically heritable chromatin changes. Experiments reported here demonstrate that these genes are required to maintain the transcriptional silencing of two different tr...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.058669
更新日期:2006-07-01 00:00:00
abstract::How many genes contribute to reproductive isolation between closely related species? We determined the number of genes located in the 9D-12B region of the Drosophila mauritiana X chromosome that cause hybrid male sterility in a D. simulans background. Previous low resolution studies suggested that a single hybrid ster...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::Mutants of Neurospora crassa have been isolated that lack the repressible alkaline phosphatase, but, unlike nuc-1 and nuc-2 mutants, are able to make the repressible acid phosphatase and the repressible phosphate permease under conditions of derepression (phosphate deprivation). The new mutants, called pho-2, map in L...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-10-01 00:00:00
abstract::Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.115766
更新日期:2010-06-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) are secreted signaling molecules that control important developmental events in many different organisms. Previous studies have shown that BMPs are expressed at the earliest stages of skeletal development, and are required for formation of specific skeletal features, strongly suggest...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Combined with a system for identifying each of the chromosomes in a genome, visualizing the location of individual genetic loci by fluorescence in situ hybridization (FISH) would aid in assembling physical and genetic maps. Previously, large genomic clones have been successfully used as FISH probes onto somatic chromo...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.065573
更新日期:2007-03-01 00:00:00
abstract::The larval cuticle protein (Lcp) cluster in Drosophila melanogaster contains four functional genes and a closely related pseudogene. A 630-bp fragment including the larval cuticle pseudogene locus (Lcp psi) was nucleotide sequenced in 10 strains of D. melanogaster and a 458-bp Lcp psi fragment from D. simulans was als...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::Individual inbreeding and historical demography can be estimated by analyzing runs of homozygosity (ROH), which are indicative of chromosomal segments of identity by descent (IBD). Such analyses have so far been rare in natural populations due to limited genomic resources. We analyzed ROH in whole genome sequences fro...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.198861
更新日期:2017-03-01 00:00:00
abstract::The extent of conservation of synteny and gene order in the Lepidoptera has been investigated previously only by comparing a small subset of linkage groups between the moth Bombyx mori and the butterfly Heliconius melpomene. Here we report the mapping of 64 additional conserved genes in H. melpomene, which contributed...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.073122
更新日期:2007-09-01 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are an important family of signaling molecules with the unusual property that they are able to transduce their signals using the same downstream pathways. This has led to an unresolved debate as to whether individual receptors are interchangeable, or if each receptor can mediate specif...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.098475
更新日期:2009-04-01 00:00:00
abstract::In Drosophila there exist several examples of gene expression that can be modified by an interaction between alleles; this effect is known as transvection. The inference that alleles interact comes from the observations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrangements ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Race-cultivar specialization during the interaction of the basidiomycete smut pathogen Ustilago hordei with its barley host was described in the 1940s. Subsequent genetic analyses revealed the presence of dominant avirulence genes in the pathogen that conform to the gene-for-gene theory. This pathosystem therefore pre...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.166.1.99
更新日期:2004-01-01 00:00:00
abstract::Regulatory networks provide control over complex cell behavior in all kingdoms of life. Here we describe a statistical model, based on representing proteins as collections of domains or motifs, which predicts unknown molecular interactions within these biological networks. Using known protein-protein interactions of S...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract::We reported previously that the product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, belongs to a family of proteins that are involved in DNA repair and replication. The family includes S. cerevisiae proteins Rad2p and its human homolog XPGC, Rad27p and its mammalian homolog FEN-1, and Exonuclea...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::The TATA-binding protein (TBP) is composed of a highly conserved core domain sufficient for TATA-element binding and preinitiation complex formation as well as a highly divergent N-terminal region that is dispensable for yeast cell viability. In vitro, removal of the N-terminal region domain enhances TBP-TATA associat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00