Abstract:
:Extensive length polymorphism and heteroplasmy (multiple forms within an individual) of the D-loop region are observed in mitochondrial DNA of the white sturgeon (Acipenser transmontanus). The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers of a perfect 82-bp direct repeat. We propose a model for the replicative origin of length differences, involving a competitive equilibrium between the heavy strand and the D-loop strand. This model suggests that frequent misalignment in the repeat region prior to elongation, facilitated by a stable secondary structure in the displaced strand, can explain both the polymorphism and heteroplasmy in this species.
journal_name
Geneticsjournal_title
Geneticsauthors
Buroker NE,Brown JR,Gilbert TA,O'Hara PJ,Beckenbach AT,Thomas WK,Smith MJsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
157-63issue
1eissn
0016-6731issn
1943-2631journal_volume
124pub_type
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