Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster.

abstract：:Fossil evidence links human ancestry with populations that evolved from modern gracile morphology in Africa 130,000-160,000 years ago. Yet fossils alone do not provide clear answers to the question of whether the ancestors of all modern Homo sapiens comprised a single African population or an amalgamation of distinct ...

journal_title：Genetics

authors： Garrigan D,Mobasher Z,Kingan SB,Wilder JA,Hammer MF

更新日期：2005-08-01 00:00:00

abstract：:In(2LR)PL is a large pericentric inversion polymorphic in populations of Drosophila melanogaster on two Indian Ocean islands. This polymorphism is puzzling: because crossing over in female heterokaryotypes produces inviable zygotes, such inversions are thought to be underdominant and should be quickly eliminated from ...

journal_title：Genetics

authors： Coyne JA,Aulard S,Berry A

更新日期：1991-11-01 00:00:00

abstract：:To identify novel genomic regions that regulate sex determination, we utilized the powerful C57BL/6J-Y(POS) (B6-Y(POS)) model of XY sex reversal where mice with autosomes from the B6 strain and a Y chromosome from a wild-derived strain, Mus domesticus poschiavinus (Y(POS)), show complete sex reversal. In B6-Y(POS), th...

journal_title：Genetics

authors： Arboleda VA,Fleming A,Barseghyan H,Délot E,Sinsheimer JS,Vilain E

更新日期：2014-07-01 00:00:00

abstract：:DNA sequence variation in a 1410-bp region including the Cu,Zn Sod locus was examined in 41 homozygous lines of Drosophila melanogaster. Fourteen lines were from Barcelona, Spain, 25 were from California populations and the other two were from laboratory stocks. Two common electromorphs, SODS and SODF, are segregating...

journal_title：Genetics

authors： Hudson RR,Bailey K,Skarecky D,Kwiatowski J,Ayala FJ

更新日期：1994-04-01 00:00:00

abstract：:Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...

journal_title：Genetics

authors： Rhee Y,Sekhon RS,Chopra S,Kaeppler S

更新日期：2010-11-01 00:00:00

abstract：:Constitutive transport of cellular materials is essential for cell survival. Although multiple small GTPase Rab proteins are required for the process, few regulators of Rabs are known. Here we report that EAT-17, a novel GTPase-activating protein (GAP), regulates RAB-6.2 function in grinder formation in Caenorhabditis...

journal_title：Genetics

authors： Straud S,Lee I,Song B,Avery L,You YJ

更新日期：2013-09-01 00:00:00

abstract：:The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection ...

journal_title：Genetics

authors： Harbison ST,Yamamoto AH,Fanara JJ,Norga KK,Mackay TF

更新日期：2004-04-01 00:00:00

abstract：:An analysis of the effects of spontaneous mutations affecting age-specific mortality was conducted using 29 lines of Drosophila melanogaster that had accumulated spontaneous mutations for 19 generations. Divergence among the lines was used to estimate the mutational variance for weekly mortality rates and the covarian...

journal_title：Genetics

authors： Pletcher SD,Houle D,Curtsinger JW

更新日期：1998-01-01 00:00:00

abstract：:This paper presents the results of a study of linkage disequilibrium between five polymorphic enzyme genes located on chromosome 3 of D. melanogaster. Three sets of chromosomes were examined: two represented samples from successive years of the same natural population, and one came from a large laboratory population. ...

journal_title：Genetics

authors： Charlesworth B,Charlesworth D

更新日期：1973-02-01 00:00:00

abstract：:The GAL4 protein of Saccharomyces cerevisiae binds to DNA upstream of each of six genes and stimulates their transcription. To locate regions of the protein responsible for these processes, we identified and characterized 88 gal4 mutations selected in vivo to reduce the ability to GAL4 protein to activate transcriptio...

journal_title：Genetics

authors： Johnston M,Dover J

更新日期：1988-09-01 00:00:00

abstract：:The Pif1 family of DNA helicases is conserved from yeast to humans. Although the helicase domains of family members are well conserved, the amino termini of these proteins are not. The Saccharomyces cerevisiae genome encodes two Pif1 family members, Rrm3p and Pif1p, that have very different functions. To determine if ...

journal_title：Genetics

authors： Bessler JB,Zakian VA

更新日期：2004-11-01 00:00:00

abstract：:We have determined the complete nucleotide sequence of the mitochondrial DNA (mtDNA) of the dogfish, Scyliorhinus canicula. The 16,697-bp-long mtDNA possesses a gene organization identical to that of the Osteichthyes, but different from that of the sea lamprey Petromyzon marinus. The main features of the mtDNA of oste...

journal_title：Genetics

authors： Delarbre C,Spruyt N,Delmarre C,Gallut C,Barriel V,Janvier P,Laudet V,Gachelin G

更新日期：1998-09-01 00:00:00

abstract：:We have characterized tandem duplications in the rII regions of phage T4. The rII deletion r1589 blocks only the function of the rIIA cistron, although it extends into the B cistron. Another rII deletion, r1236, blocks the function of the rIIB cistron and overlaps r1589. When a cross is made between r1589 and r1236, t...

journal_title：Genetics

authors： Kumagai M,Yamashita T,Honda M,Ikeda H

更新日期：1993-10-01 00:00:00

abstract：:Our previous work suggests that the Nhp6 HMGB protein stimulates RNA polymerase II transcription via the TATA-binding protein TBP and that Nhp6 functions in the same functional pathway as the Gcn5 histone acetyltransferase. In this report we examine the genetic relationship between Nhp6 and Gcn5 with the Mot1 and Ccr4...

journal_title：Genetics

authors： Biswas D,Yu Y,Mitra D,Stillman DJ

更新日期：2006-02-01 00:00:00

abstract：:Determining parentage is a fundamental problem in biology and in applications such as identifying pedigrees. Difficulties inferring parentage derive from extensive inbreeding within the population, whether natural or planned; using an insufficient number of hypervariable loci; and from allele mismatches caused by muta...

journal_title：Genetics

authors： Berry DA,Seltzer JD,Xie C,Wright DL,Jones ES,Sebastian S,Smith JS

更新日期：2003-09-01 00:00:00

abstract：:Cells expend a large amount of energy to maintain their DNA sequence. DNA repair pathways, cell cycle checkpoint activation, proofreading polymerases, and chromatin structure are ways in which the cell minimizes changes to the genome. During replication, the DNA-damage tolerance pathway allows the replication forks to...

journal_title：Genetics

authors： Thurston AK,Radebaugh CA,Almeida AR,Argueso JL,Stargell LA

更新日期：2018-12-01 00:00:00

abstract：:Combined with a system for identifying each of the chromosomes in a genome, visualizing the location of individual genetic loci by fluorescence in situ hybridization (FISH) would aid in assembling physical and genetic maps. Previously, large genomic clones have been successfully used as FISH probes onto somatic chromo...

journal_title：Genetics

authors： Lamb JC,Danilova T,Bauer MJ,Meyer JM,Holland JJ,Jensen MD,Birchler JA

更新日期：2007-03-01 00:00:00

abstract：:We have found that temperature can have a striking effect upon protein export in Escherichia coli, suggesting that there is a cold-sensitive step in the protein export pathway. Cs mutations comprise the largest class of mutations affecting the membrane-localized Sec proteins SecD, SecE, SecF and SecY. Although some of...

journal_title：Genetics

authors： Pogliano KJ,Beckwith J

更新日期：1993-04-01 00:00:00

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00

abstract：:A genotype probability index (GPI) is proposed to indicate the information content of genotype probabilities derived from a segregation analysis. Typically, some individuals are genotyped at a marker locus or a quantitative trait locus, and segregation analysis is used to make genotype inferences about ungenotyped rel...

journal_title：Genetics

authors： Kinghorn BP

更新日期：1997-02-01 00:00:00

abstract：:We have studied the natural variation at microsatellite loci in two African and five non-African populations of Drosophila melanogaster. Ten dinucleotide simple sequence loci were cloned from chromosomally mapped P1 clones and typed for single individuals from isofemale lines of the respective populations. We find tha...

journal_title：Genetics

authors： Schlötterer C,Vogl C,Tautz D

更新日期：1997-05-01 00:00:00

abstract：:We formalize the use of allele frequency and geographic information for the construction of gene trees at the intraspecific level and extend the concept of evolutionary parsimony to molecular variance parsimony. The central principle is to consider a particular gene tree as a variable to be optimized in the estimation...

journal_title：Genetics

authors： Excoffier L,Smouse PE

更新日期：1994-01-01 00:00:00

abstract：:Repair of double-strand breaks (DSBs) in chromosomal DNA by nonhomologous end-joining (NHEJ) is not well characterized in the yeast Saccharomyces cerevisiae. Here we demonstrate that several genes associated with NHEJ perform essential functions in the repair of endonuclease-induced DSBs in vivo. Galactose-induced exp...

journal_title：Genetics

authors： Lewis LK,Westmoreland JW,Resnick MA

更新日期：1999-08-01 00:00:00

abstract：:Injury triggers regeneration of axons and dendrites. Research has identified factors required for axonal regeneration outside the CNS, but little is known about regeneration triggered by dendrotomy. Here, we study neuronal plasticity triggered by dendrotomy and determine the fate of complex PVD arbors following laser ...

journal_title：Genetics

authors： Oren-Suissa M,Gattegno T,Kravtsov V,Podbilewicz B

更新日期：2017-05-01 00:00:00

abstract：:The yeast pheromone/filamentous growth MAPK pathway mediates both mating and invasive-growth responses. The interface between this MAPK module and the transcriptional machinery consists of a network of two MAPKs, Fus3 and Kss1; two regulators, Rst1 and Rst2 (a.k.a. Dig1 and Dig2); and two transcription factors, Ste12 ...

journal_title：Genetics

authors： Breitkreutz A,Boucher L,Breitkreutz BJ,Sultan M,Jurisica I,Tyers M

更新日期：2003-11-01 00:00:00

abstract：:Lethal and sterility mutations were accumulated in a cage population which was initiated with lethal- and sterility-free second chromosomes of D. melanogaster. It took about 2,000 days for the frequencies of these genes to reach equilibrium levels, i.e., 18% lethal and 9% male-sterile chromosomes. Two other cage popul...

journal_title：Genetics

authors： Lee WH,Watanabe TK

更新日期：1977-07-01 00:00:00

abstract：:We describe a method for co-estimating r = C/mu (where C is the per-site recombination rate and mu is the per-site neutral mutation rate) and Theta = 4N(e)mu (where N(e) is the effective population size) from a population sample of molecular data. The technique is Metropolis-Hastings sampling: we explore a large numbe...

journal_title：Genetics

authors： Kuhner MK,Yamato J,Felsenstein J

更新日期：2000-11-01 00:00:00

abstract：:A model emphasizing the possible genetic role of tandem duplications of reverse repeats has been developed as an extension of Crick's (1971) general model for the chromosomes of higher organisms. Although developed initially (1) to explain why random differences in the control regions of individual gene loci might con...

journal_title：Genetics

authors： Wallace B,Kass TL

更新日期：1974-07-01 00:00:00

abstract：:A correlation between diversity levels and rates of recombination is predicted both by models of positive selection, such as hitchhiking associated with the rapid fixation of advantageous mutations, and by models of purifying selection against strongly deleterious mutations (commonly referred to as "background selecti...

journal_title：Genetics

authors： Andolfatto P,Przeworski M

更新日期：2001-06-01 00:00:00

abstract：:Comparison of population differentiation in neutral marker genes and in genes coding quantitative traits by means of F(ST) and Q(ST) indexes has become commonplace practice. While the properties and estimation of F(ST) have been the subject of much interest, little is known about the precision and possible bias in Q(S...

journal_title：Genetics

authors： O'Hara RB,Merilä J

更新日期：2005-11-01 00:00:00