Abstract:
:We have characterized tandem duplications in the rII regions of phage T4. The rII deletion r1589 blocks only the function of the rIIA cistron, although it extends into the B cistron. Another rII deletion, r1236, blocks the function of the rIIB cistron and overlaps r1589. When a cross is made between r1589 and r1236, true rII+ progeny cannot form. Instead, anomalous phenotypically rII+ phages are detected carrying an rII region from each parent. Analyses of nucleotide sequences of the recombination junctions indicate that recombination takes place between short regions of homology (from 2 to 10 bp). Open reading frames of the recombinants deduced from the nucleotide sequences reveal that they contain a normal rIIA cistron and one of a variety of fused, duplicated rIIB cistrons. The T4 uvsX and uvsY genes, which participate in homologous recombination, are involved in this duplication formation. T4 DNA topoisomerase is encoded by genes 39, 52 and 60. Mutations in 52 and 60 reduced the frequency of such duplications, but mutations in gene 39 and some in gene 52 did not. Hence, the effects of topoisomerase mutations are allele-specific. Models are proposed in which these proteins are involved in tandem duplication.
journal_name
Geneticsjournal_title
Geneticsauthors
Kumagai M,Yamashita T,Honda M,Ikeda Hsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
255-64issue
2eissn
0016-6731issn
1943-2631journal_volume
135pub_type
杂志文章相关文献
GENETICS文献大全abstract::To study the interdependence of Gcr1p and Rap1p, we prepared a series of synthetic regulatory sequences that contained various numbers and combinations of CT-boxes (Gcr1p-binding sites) and RPG-boxes (Rap1p-binding sites). The ability of the synthetic oligonucleotides to function as regulatory sequences was tested usi...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::The spatial model of Levene (1953) was examined in a finite population and compared to a temporal model. The spatial model was much more effective in retaining genetic variation in a finite population. Furthermore, the haploid spatial model was more effective in retaining genetic variation than the analogous diploid a...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1978-06-01 00:00:00
abstract::The effect of nonhomologous DNA sequences at one or both sides of short genetic intervals on recombination within that interval was investigated, using an interplasmidic recombination system in Escherichia coli K-12. The recombining plasmids were derivatives of pBR322 and pACYC184, which share a 1330-nucleotide sequen...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::Paramecium has long been a model eukaryote. The sequence of the Paramecium tetraurelia genome reveals a history of three successive whole-genome duplications (WGDs), and the sequences of P. biaurelia and P. sexaurelia suggest that these WGDs are shared by all members of the aurelia species complex. Here, we present th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163287
更新日期:2014-08-01 00:00:00
abstract::Genes expressed in testes are critical to male reproductive success, affecting spermatogenesis, sperm competition, and sperm-egg interaction. Comparing the evolution of testis proteins at different taxonomic levels can reveal which genes and functional classes are targets of natural and sexual selection and whether th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.085902
更新日期:2008-08-01 00:00:00
abstract::We develop a maximum penalized-likelihood (MPL) method to estimate the fitnesses of amino acids and the distribution of selection coefficients (S = 2Ns) in protein-coding genes from phylogenetic data. This improves on a previous maximum-likelihood method. Various penalty functions are used to penalize extreme estimate...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.162263
更新日期:2014-05-01 00:00:00
abstract::Differences in mating behaviors evolve early during speciation, eventually contributing to reproductive barriers between species. Knowledge of the genetic and genomic basis of these behaviors is therefore integral to a causal understanding of speciation. Acoustic behaviors are often part of the mating ritual in animal...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.118.301706
更新日期:2019-03-01 00:00:00
abstract::Genomic prediction methods based on multiple markers have potential to include nonadditive effects in prediction and analysis of complex traits. However, most developments assume a Hardy-Weinberg equilibrium (HWE). Statistical approaches for genomic selection that account for dominance and epistasis in a general conte...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.199406
更新日期:2017-07-01 00:00:00
abstract::Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.117.300139
更新日期:2017-10-01 00:00:00
abstract::A model is presented showing that natural selection operating at the individual level can adequately explain the evolution of multiple mating behavior by honey bee queens. Group selection need not be invoked. The fitness of a given female genotype is a function of the number of sex alleles in the population, the numbe...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::In this article we define and characterize the smellblind gene (sbl). We show that two mutants, sbl and olfDx9, both isolated by virtue of their olfactory phenotypes and analyzed extensively by others with respect to courtship behavior, contain mutations at a single locus. Meiotic recombination, duplication, and defic...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) are secreted signaling molecules that control important developmental events in many different organisms. Previous studies have shown that BMPs are expressed at the earliest stages of skeletal development, and are required for formation of specific skeletal features, strongly suggest...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Populations of several co-existing species of Simocephalus were examined electrophoretically at 11 enzyme loci. The prevailing pattern was one of extensive allelic substitution between species and low levels of polymorphism (0-10%) within species. Genetic identity values between species were very low (10-50%). These r...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::Two large, stable populations (Texas and Japan) of Drosophila melanogaster were surveyed at 21 allozyme loci on the second and third chromosomes and for chromosomal gene arrangements on those two chromosomes. Over 220 independent gametes were sampled from each population. The types and frequencies of the surveyed gene...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1974-11-01 00:00:00
abstract::Distributive disjunction is defined as the first division meiotic segregation of either nonhomologous chromosomes that lack homologs or homologous chromosomes that have not recombined. To determine if chromosomes from the yeast Saccharomyces cerevisiae were capable of distributive disjunction, we constructed a strain ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::Protein serine/threonine phosphatase type 1 (PP1) has been found in all eukaryotes examined to date and is involved in the regulation of many cellular functions, including glycogen metabolism, muscle contraction, and mitosis. In Drosophila, four genes code for the catalytic subunit of PP1 (PP1c), three of which belong...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.069914
更新日期:2007-05-01 00:00:00
abstract::I have studied nucleotide polymorphism and linkage disequilibrium using multilocus data from 77 fragments, with an average length of fragments of 550 bp, in the deciduous tree Populus tremula (Salicaceae). The frequency spectrum across loci showed a modest excess of mutations segregating at low frequency and a marked ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.090431
更新日期:2008-09-01 00:00:00
abstract::Brassica self-incompatibility (SI) is controlled by SLG and SRK expressed in the stigma and by SP11/SCR expressed in the anther. We determined the sequences of the S domains of 36 SRK alleles, 13 SLG alleles, and 14 SP11 alleles from Brassica oleracea and B. rapa. We found three S haplotypes lacking SLG genes in B. ra...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::Following the advent of a gene targeting technique in Drosophila, different methods have been developed to modify the Drosophila genome. The initial demonstration of gene targeting in flies used an ends-in method, which generates a duplication of the target locus. The duplicated locus can then be efficiently reduced t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.030882
更新日期:2004-11-01 00:00:00
abstract::With the rise of both the number and the complexity of traits of interest, control of the false discovery rate (FDR) in genetic association studies has become an increasingly appealing and accepted target for multiple comparison adjustment. While a number of robust FDR-controlling strategies exist, the nature of this ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.193987
更新日期:2017-01-01 00:00:00
abstract::Numerous loci in host organisms are involved in parasite recognition, such as major histocompatibility complex (MHC) genes in vertebrates or genes involved in gene-for-gene (GFG) relationships in plants. Diversity is commonly observed at such loci and at corresponding loci encoding antigenic molecules in parasites. Mu...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.074393
更新日期:2007-11-01 00:00:00
abstract::We have established the DNA sequence and analyzed the transcription and translation products of a series of putative nodulation (nod) genes in Rhizobium meliloti strain 1021. Four loci have been designated nodF, nodE, nodG and nodH. The correlation of transposon insertion positions with phenotypes and open reading fra...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::A genotype probability index (GPI) is proposed to indicate the information content of genotype probabilities derived from a segregation analysis. Typically, some individuals are genotyped at a marker locus or a quantitative trait locus, and segregation analysis is used to make genotype inferences about ungenotyped rel...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::Two protocols are presented that allow the selection of mutations mapping to micronuclear chromosome 5 in Tetrahymena thermophilia. One protocol involves crossing mutagenized diploid cells directly to a strain nullisomic for chromosome 5 and screening the monosomic progeny for a mutant phenotype. The second protocol f...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Hotspots regulate the position and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are suicidal and are somehow resurrected elsewhere in the genome. After the DNA sequence-dependent activation of hotspots was discovered in fission yeast, nearly two decades elapsed before the key real...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.134130
更新日期:2011-11-01 00:00:00
abstract::Grain yield is a major goal for the improvement of durum wheat, particularly in drought-prone areas. In this study, the genetic basis of grain yield (GY), heading date (HD), and plant height (PH) was investigated in a durum wheat population of 249 recombinant inbred lines evaluated in 16 environments (10 rainfed and 6...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.077297
更新日期:2008-01-01 00:00:00
abstract::Data are presented concerning the gene arrangements in both arms of the X-chromosome of Drosophila robusta in eight altitudinal transects. The major change appears to be the increase of gene arrangement XL-1 (and decrease in XL, sometimes also XL-2) with increasing altitude. In each transect only one combination of XL...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract::Positive selection in genes and genomes can point to the evolutionary basis for differences among species and among races within a species. The detection of positive selection can also help identify functionally important protein regions and thus guide protein engineering. Many existing tests for positive selection ar...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.074732
更新日期:2007-08-01 00:00:00
abstract::Mapping quantitative trait loci in plants is usually conducted using a population derived from a cross between two inbred lines. The power of such QTL detection and the parameter estimates depend largely on the choice of the two parental lines. Thus, the QTL detected in such populations represent only a small part of ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.028993
更新日期:2004-11-01 00:00:00
abstract::The formation of the Aspergillus nidulans fruiting body is affected by a number of genetic and environmental factors. Here, the nsdC (never in sexual development) gene-encoding a putative transcription factor carrying a novel type of zinc-finger DNA-binding domain consisting of two C(2)H(2)'s and a C(2)HC motif that a...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.101667
更新日期:2009-07-01 00:00:00