Quantitative trait loci for grain yield and adaptation of durum wheat (Triticum durum Desf.) across a wide range of water availability.

abstract：:Changes in genome structure and gene expression have been documented in both resynthesized and natural allopolyploids that contain two or more divergent genomes. The underlying mechanisms for rapid and stochastic changes in gene expression are unknown. Arabidopsis suecica is a natural allotetraploid derived from the e...

journal_title：Genetics

authors： Chen M,Ha M,Lackey E,Wang J,Chen ZJ

更新日期：2008-04-01 00:00:00

abstract：:Disequilibrium pattern analysis, a general method for analyzing evolutionary events acting on pairs of tightly linked polymorphic loci, is applied to a large sample of Danish individuals typed for A and B loci of the HLA (human leukocyte antigen) system. Cases of selection on particular haplotypes are revealed from pa...

journal_title：Genetics

authors： Klitz W,Thomson G

更新日期：1987-08-01 00:00:00

abstract：:Previously a deletion in mouse chromosome 17, T(22H), was shown to behave like a t allele of the t complex distorter gene Tcd1, and this was attributed to deletion of this locus. Seven further deletions are studied here, with the aim of narrowing the critical region in which Tcd1 must lie. One deletion, T(30H), togeth...

journal_title：Genetics

authors： Lyon MF,Schimenti JC,Evans EP

更新日期：2000-06-01 00:00:00

abstract：:Transposable elements are often considered as selfish DNA sequences able to invade the genome of their host species. Their evolutive dynamics are complex, due to the interaction between their intrinsic amplification capacity, selection at the host level, transposition regulation, and genetic drift. Here, we propose mo...

journal_title：Genetics

authors： Le Rouzic A,Capy P

更新日期：2005-02-01 00:00:00

abstract：:The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient DNA polymerase γ mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, sug...

journal_title：Genetics

authors： Stumpf JD,Copeland WC

更新日期：2013-06-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. While many AMD susceptibility variants have been identified, their influence on AMD progression has not been elucidated. Using data from two large clinical trials, Age-Related Eye Disease Study (AREDS) and AREDS2, we evaluat...

journal_title：Genetics

authors： Ding Y,Liu Y,Yan Q,Fritsche LG,Cook RJ,Clemons T,Ratnapriya R,Klein ML,Abecasis GR,Swaroop A,Chew EY,Weeks DE,Chen W,AREDS2 Research Group.

更新日期：2017-05-01 00:00:00

abstract：:Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at leas...

journal_title：Genetics

authors： Vary PS,Stocker BA

更新日期：1973-02-01 00:00:00

abstract：:The three-dimensional organization of polytene chromosomes within nuclei containing rearranged X chromosomes was examined in male Drosophila melanogaster. Salivary glands of third instar larvae containing either an inverted X chromosome (YSX.YL, In(1)EN/O) or a ring X chromosome (R(1) 2/BSYy+) were fixed, embedded, an...

journal_title：Genetics

authors： Mathog D,Sedat JW

更新日期：1989-02-01 00:00:00

abstract：:Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae Within the yeast rDNA locus, Sir2 is required for efficient cohesin recruitment and maintaining the stability of the tandem a...

journal_title：Genetics

authors： Fine RD,Maqani N,Li M,Franck E,Smith JS

更新日期：2019-05-01 00:00:00

abstract：:We investigated genetic polymorphism in the Caenorhabditis elegans srh and str chemoreceptor gene families, each of which consists of approximately 300 genes encoding seven-pass G-protein-coupled receptors. Almost one-third of the genes in each family are annotated as pseudogenes because of apparent functional defects...

journal_title：Genetics

authors： Stewart MK,Clark NL,Merrihew G,Galloway EM,Thomas JH

更新日期：2005-04-01 00:00:00

abstract：:Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination ...

journal_title：Genetics

authors： Radford SJ,Sabourin MM,McMahan S,Sekelsky J

更新日期：2007-05-01 00:00:00

abstract：:Behavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, m...

journal_title：Genetics

authors： Ellis LL,Carney GE

更新日期：2011-01-01 00:00:00

abstract：:The evidence in support of two types of alternate disjunction in translocation heterozygotes from the German cockroach, Blattella germanica (L.), is reviewed. When unique cytomorphological features occur in the translocation figure, the two types of alternate disjunction are identifiable regardless of the angle of obs...

journal_title：Genetics

authors： Cochran DG

更新日期：1983-05-01 00:00:00

abstract：:We have identified a new locus involved in gibberellin (GA) signal transduction by screening for suppressors of the Arabidopsis thaliana GA biosynthetic mutant gal-3. The locus is named RGA for repressor of gal-3. Based on the recessive phenotype of the digenic rga/gal-3 mutant, the wild-type gene product of RGA is pr...

journal_title：Genetics

authors： Silverstone AL,Mak PY,Martínez EC,Sun TP

更新日期：1997-07-01 00:00:00

abstract：:Using conditional probabilities and moment-generating matrices, I derived approximate algebraic equations that give expectations of gene frequency, population mean, gene frequency variance within lines, or heterozygosity, and gene frequency variance between lines, or drift, for repeated cycles of recurrent selection i...

journal_title：Genetics

authors： Silvela L

更新日期：1980-07-01 00:00:00

abstract：:The standard approaches to estimation of quantitative genetic parameters and prediction of response to selection on quantitative traits are based on theory derived for populations undergoing random mating. Many studies demonstrate, however, that mating systems in natural populations often involve inbreeding in various...

journal_title：Genetics

authors： Shaw RG,Byers DL,Shaw FH

更新日期：1998-12-01 00:00:00

abstract：:Restriction site-associated DNA sequencing or genotyping-by-sequencing (GBS) approaches allow for rapid and cost-effective discovery and genotyping of thousands of single-nucleotide polymorphisms (SNPs) in multiple individuals. However, rigorous quality control practices are needed to avoid high levels of error and bi...

journal_title：Genetics

authors： Chen N,Van Hout CV,Gottipati S,Clark AG

更新日期：2014-11-01 00:00:00

abstract：:Mutation frequency and specificity were determined as a function of age in nuclear DNA from liver, bladder, and brain of Big Blue lacI transgenic mice aged 1.5-25 months. Mutations accumulated with age in liver and accumulated more rapidly in bladder. In the brain a small initial increase in mutation frequency was obs...

journal_title：Genetics

authors： Stuart GR,Oda Y,de Boer JG,Glickman BW

更新日期：2000-03-01 00:00:00

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00

abstract：:Dealing with physiological stress is a necessity for all organisms, and the pathways charged with this task are highly conserved in Metazoa . Accumulating evidence highlights cell-nonautonomous activation as an important mode of integrating stress responses at the organism level. Work in Caenorhabditis elegans highlig...

journal_title：Genetics

authors： Liu L,Ruediger C,Shapira M

更新日期：2018-12-01 00:00:00

abstract：:This paper describes a perturbation experiment on the frequency of the F and S Alcohol dehydrogenase (Adh) alleles of D. melanogaster. Fifty-four iso-female lines set up from three wild populations and with initial F frequencies of either 0.25, 0.50 or 0.75 were maintained on standard laboratory food medium at 22 degr...

journal_title：Genetics

authors： Wilson SR,Oakeshott JG,Gibson JB,Anderson PR

更新日期：1982-01-01 00:00:00

abstract：:The aim of many genetic studies is to locate the genomic regions (called quantitative trait loci, QTL) that contribute to variation in a quantitative trait (such as body weight). Confidence intervals for the locations of QTL are particularly important for the design of further experiments to identify the gene or genes...

journal_title：Genetics

authors： Manichaikul A,Dupuis J,Sen S,Broman KW

更新日期：2006-09-01 00:00:00

abstract：:Sequence divergence among the mitochondrial (mt) DNA of nine Lycopersicon and two closely related Solanum species was estimated using the shared fragment method. A portion of each mt genome was highlighted by probing total DNA with a series of plasmid clones containing mt-specific DNA fragments from Lycopersicon penne...

journal_title：Genetics

authors： McClean PE,Hanson MR

更新日期：1986-03-01 00:00:00

abstract：:We have isolated 15 spontaneous mutants resistant to one or several antibiotics like chloramphenicol, erythromycin and spiramycin. We have shown by several criteria that all of them result from mutations localized in the mitochondrial DNA. The mutations have been mapped by allelism tests and by two- and three-factor c...

journal_title：Genetics

authors： Netter P,Petrochilo E,Slonimski PP,Bolotin-Fukuhara M,Coen D,Deutsch J,Dujon B

更新日期：1974-12-01 00:00:00

abstract：:We have initiated an analysis of protein kinase A (PKA) in Drosophila using transgenic techniques to modulate PKA activity in specific tissues during development. We have constructed GAL4/UAS-regulated transgenes in active and mutant forms that encode PKAc, the catalytic subunit of PKA, and PKI(1-31), a competitive in...

journal_title：Genetics

authors： Kiger JA Jr,Eklund JL,Younger SH,O'Kane CJ

更新日期：1999-05-01 00:00:00

abstract：:The Drosophila melanogaster ovo gene is required for survival and differentiation of female germline cells, apparently playing a role in germline sex determination. We recovered 60 kb of genomic DNA from its genetic location at 4E1,2 on the X chromosome. A transcription unit coding for an apparently female-specific ge...

journal_title：Genetics

authors： Garfinkel MD,Lohe AR,Mahowald AP

更新日期：1992-04-01 00:00:00

abstract：:In the Brassicaceae, self-vs. nonself-recognition in self-incompatibility is controlled by sporophytic S-alleles. Haplotypes specifying both SRK (S-receptor kinase) and SLG (S-locus glycoprotein) are considered to play an important role in the recognition reactions. We compared the nucleotide sequences of SRK9(Bc) and...

journal_title：Genetics

authors： Hinata K,Watanabe M,Yamakawa S,Satta Y,Isogai A

更新日期：1995-07-01 00:00:00

abstract：:To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cre-drivers) that restrict expression to specific cell types. To addres...

journal_title：Genetics

authors： Korecki AJ,Hickmott JW,Lam SL,Dreolini L,Mathelier A,Baker O,Kuehne C,Bonaguro RJ,Smith J,Tan CV,Zhou M,Goldowitz D,Deussing JM,Stewart AF,Wasserman WW,Holt RA,Simpson EM

更新日期：2019-04-01 00:00:00

abstract：:Estimating the fixation probability of a beneficial mutation has a rich history in theoretical population genetics. Typically, to attain mathematical tractability, we assume that generation times are fixed, while the number of offspring per individual is stochastic. However, fixation probabilities are extremely sensit...

journal_title：Genetics

authors： Hubbarde JE,Wild G,Wahl LM

更新日期：2007-07-01 00:00:00

abstract：:Fifty-two wee mutants that undergo mitosis and cell division at a reduced size compared with wild type have been genetically analyzed. The mutants define two genes, wee1 and cdc2, which control the timing of mitosis. Fifty-one of the mutants map at the wee1 locus, which is unlinked to any known cdc gene. One of the we...

journal_title：Genetics

authors： Nurse P,Thuriaux P

更新日期：1980-11-01 00:00:00