Disequilibrium pattern analysis. II. Application to Danish HLA A and B locus data.

abstract：:As a genetic mutation is passed down across generations, it distinguishes those genomes that have inherited it from those that have not, providing a glimpse of the genealogical tree relating the genomes to each other at that site. Statistical summaries of genetic variation therefore also describe the underlying geneal...

journal_title：Genetics

authors： Ralph P,Thornton K,Kelleher J

更新日期：2020-07-01 00:00:00

abstract：:Two protocols are presented that allow the selection of mutations mapping to micronuclear chromosome 5 in Tetrahymena thermophilia. One protocol involves crossing mutagenized diploid cells directly to a strain nullisomic for chromosome 5 and screening the monosomic progeny for a mutant phenotype. The second protocol f...

journal_title：Genetics

authors： Altschuler MI,Bruns PJ

更新日期：1984-03-01 00:00:00

abstract：:We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling thos...

journal_title：Genetics

authors： Roux F,Colomé-Tatché M,Edelist C,Wardenaar R,Guerche P,Hospital F,Colot V,Jansen RC,Johannes F

更新日期：2011-08-01 00:00:00

abstract：:Two closely related bacteriophage, varphiCr30 and varphiCr35, are the first bacteriophage shown to mediate generalized transduction in Caulobacter crescentus. Unlike most other transducing phage, they are virulent and do not form any sort of lysogenic relationship with their host. However, they are rather inefficient ...

journal_title：Genetics

authors： Ely B,Johnson RC

更新日期：1977-11-01 00:00:00

abstract：:To assess the reliability of genetic markers it is important to compare inferences that are based on them to a priori expectations. In this article we present an analysis of microsatellite variation within and among populations of island foxes (Urocyon littoralis) on California's Channel Islands. We first show that mi...

journal_title：Genetics

authors： Goldstein DB,Roemer GW,Smith DA,Reich DE,Bergman A,Wayne RK

更新日期：1999-02-01 00:00:00

abstract：:Evolutionary models appropriate for analyzing nucleotide sequences that are subject to constraints on secondary structure are developed. The models consider the evolution of pairs of nucleotides, and they incorporate the effects of base-pairing constraints on nucleotide substitution rates by introducing a new paramete...

journal_title：Genetics

authors： Muse SV

更新日期：1995-03-01 00:00:00

abstract：:The Triplo-lethal locus (Tpl) is unique in its dosage sensitivity; no other locus in Drosophila has been identified that is lethal when present in three doses. Tpl is also haplo-lethal, and its function is still a mystery. Previous workers have found it nearly impossible to mutationally inactive Tpl other than by comp...

journal_title：Genetics

authors： Dorer DR,Christensen AC

更新日期：1990-08-01 00:00:00

abstract：:Haploid Saccharomyces can change mating type through HO-endonuclease cleavage of an expressor locus, MAT, followed by gene conversion using one of two repository loci, HML or HMR, as donor. The mating type of a cell dictates which repository locus is used as donor, with a cells using HML and alpha cells using HMR. Thi...

journal_title：Genetics

authors： Houston P,Simon PJ,Broach JR

更新日期：2004-03-01 00:00:00

abstract：:Yip1p is the first identified Rab-interacting membrane protein and the founder member of the YIP1 family, with both orthologs and paralogs found in all eukaryotic genomes. The exact role of Yip1p is unclear; YIP1 is an essential gene and defective alleles severely disrupt membrane transport and inhibit ER vesicle budd...

journal_title：Genetics

authors： Chen CZ,Calero M,DeRegis CJ,Heidtman M,Barlowe C,Collins RN

更新日期：2004-12-01 00:00:00

abstract：:Schizosaccharomyces pombe cells that contain a mutation within rad9 are sensitive to ionizing radiation, UV light and hydroxyurea, relative to wild-type strains. In addition, the mutants are moderately hypomutable by UV and unable to delay initiation of mitosis after treatment with radiation or hydroxyurea. Three radi...

journal_title：Genetics

authors： Lieberman HB

更新日期：1995-09-01 00:00:00

abstract：:Understanding the initiation of meiosis and the relationship of this event with other key cytogenetic processes are major goals in studying the genetic control of meiosis in higher plants. Our genetic and structural analysis of two mutant alleles of the ameiotic1 gene (am1 and am1-praI) suggest that this locus plays a...

journal_title：Genetics

authors： Golubovskaya I,Grebennikova ZK,Avalkina NA,Sheridan WF

更新日期：1993-12-01 00:00:00

abstract：:Recessive mutant alleles at the autosomal dpy-21 locus of C. elegans cause a dumpy phenotype in XX animals but not in XO animals. This dumpy phenotype is characteristic of X chromosome aneuploids with higher than normal X to autosome ratios and is proposed to result from overexpression of X-linked genes. We have isola...

journal_title：Genetics

authors： Meneely PM,Wood WB

更新日期：1984-01-01 00:00:00

abstract：:The experimental population genetics of Y-chromosome drive in Drosophila melanogaster is approximated by studying the behavior of T(Y;2),SD lines. These exhibit "pseudo-Y" drive through the effective coupling of the Y chromosome to the second chromosome meiotic drive locus, Segregation distorter (SD). T(Y;2),SD males ...

journal_title：Genetics

authors： Lyttle TW

更新日期：1977-06-01 00:00:00

abstract：:We explicitly solve and analyze a series of deterministic continent-island models to delimit the effects of pollen and seed migration on cytonuclear frequencies and disequilibria in random-mating, mixed-mating and self-fertilized populations. Given the critical assumption of maternal cytoplasmic inheritance, five majo...

journal_title：Genetics

authors： Asmussen MA,Schnabel A

更新日期：1991-07-01 00:00:00

abstract：:Rodent inbred line crosses are widely used to map genetic loci associated with complex traits. This approach has proven to be powerful for detecting quantitative trait loci (QTL); however, the resolution of QTL locations, typically approximately 20 cM, means that hundreds of genes are implicated as potential candidate...

journal_title：Genetics

authors： Li R,Lyons MA,Wittenburg H,Paigen B,Churchill GA

更新日期：2005-03-01 00:00:00

abstract：:Aspergillus nidulans is an important experimental organism, and it is a model organism for the genus Aspergillus that includes serious pathogens as well as commercially important organisms. Gene targeting by homologous recombination during transformation is possible in A. nidulans, but the frequency of correct gene ta...

journal_title：Genetics

authors： Nayak T,Szewczyk E,Oakley CE,Osmani A,Ukil L,Murray SL,Hynes MJ,Osmani SA,Oakley BR

更新日期：2006-03-01 00:00:00

abstract：:Initial events in double-strand break repair by homologous recombination in vivo involve homology searching, 3' strand invasion, and new DNA synthesis. While studies in yeast have contributed much to our knowledge of these processes, in comparison, little is known of the early events in the integrated mammalian system...

journal_title：Genetics

authors： Si W,Mundia MM,Magwood AC,Mark AL,McCulloch RD,Baker MD

更新日期：2010-06-01 00:00:00

abstract：:Cell differentiation in yeast species is controlled by a reversible, programmed DNA-rearrangement process called mating-type switching. Switching is achieved by two functionally similar but structurally distinct processes in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe In ...

journal_title：Genetics

authors： Hanson SJ,Wolfe KH

更新日期：2017-05-01 00:00:00

abstract：:Cornell Control White Leghorn chicks were grown in a common environment to five weeks of age and selected for fast and slow gain in body weight from five to nine weeks of age at two temperatures, 21.1 degrees (cold) and 32.2 degrees (hot), during which time a constant 50% relative humidity was maintained. All lines we...

journal_title：Genetics

authors： Bohren BB,Carson JR,Rogler JC

更新日期：1981-02-01 00:00:00

abstract：:The recent progress in sequencing technologies makes possible large-scale medical sequencing efforts to assess the importance of rare variants in complex diseases. The results of such efforts depend heavily on the use of efficient study designs and analytical methods. We introduce here a unified framework for associat...

journal_title：Genetics

authors： Ionita-Laza I,Ottman R

更新日期：2011-11-01 00:00:00

abstract：:We describe here a family of P elements that we refer to as type I repressors. These elements are identified by their repressor functions and their lack of any deletion within the first two-thirds of the canonical P sequence. Elements belonging to this repressor class were isolated from P strains and were made in vitr...

journal_title：Genetics

authors： Gloor GB,Preston CR,Johnson-Schlitz DM,Nassif NA,Phillis RW,Benz WK,Robertson HM,Engels WR

更新日期：1993-09-01 00:00:00

abstract：:Adaptation from de novo mutation can produce so-called soft selective sweeps, where adaptive alleles of independent mutational origin sweep through the population at the same time. Population genetic theory predicts that such soft sweeps should be likely if the product of the population size and the mutation rate towa...

journal_title：Genetics

authors： Wilson BA,Petrov DA,Messer PW

更新日期：2014-10-01 00:00:00

abstract：:The ability of a virus population to colonize a novel host is predicted to depend on the equilibrium frequency of potential colonists (i.e., genotypes capable of infecting the novel host) in the source population. In this study, we investigated the determinants of the equilibrium frequency of potential colonists in th...

journal_title：Genetics

authors： Ferris MT,Joyce P,Burch CL

更新日期：2007-06-01 00:00:00

abstract：:A lethal locus (l(2)br7;35B6-10), near Adh on chromosome arm 2L of D. melanogaster, is identified with Plunkett's dominant suppressor of Hairless (H). Of eight new alleles, seven act as dominant suppressors of H, the eighth is a dominant enhancer of H. One of the suppressor alleles is both a leaky lethal and a weak s...

journal_title：Genetics

authors： Ashburner M

更新日期：1982-07-01 00:00:00

abstract：:The Saccharomyces cerevisiae mitochondrial endonuclease I-SceI creates a double-strand break as the initiating step in the gene conversional transfer of the omega+ intron to omega- DNA. We have expressed a galactose-inducible synthetic I-SceI gene in the nucleus of yeast that also carries the I-SceI recognition site o...

journal_title：Genetics

authors： Plessis A,Perrin A,Haber JE,Dujon B

更新日期：1992-03-01 00:00:00

abstract：:Genic heterozygosity and variation were studied in the permanent translocation heterozygotes Oenothera biennis I, Oe. biennis II, Oe. biennis III, Oe. strigosa, Oe. parviflora I, Oe. parviflora II, and in the related bivalent formers Oe. argillicola and Oe. hookeri. From variation at 20 enzyme loci, we find that trans...

journal_title：Genetics

authors： Levy M,Levin DA

更新日期：1975-03-01 00:00:00

abstract：:Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behin...

journal_title：Genetics

authors： Myster SH,Wang F,Cavallo R,Christian W,Bhotika S,Anderson CT,Peifer M

更新日期：2004-02-01 00:00:00

abstract：:Position-effect control at the silent mat2-mat3 interval and at centromeres and telomeres in fission yeast is suggested to be mediated through the assembly of heterochromatin-like structures. Therefore, trans-acting genes that affect silencing may encode either chromatin proteins, factors that modify them, or factors ...

journal_title：Genetics

authors： Grewal SI,Bonaduce MJ,Klar AJ

更新日期：1998-10-01 00:00:00

abstract：:In California, Drosophila simulans females from some populations (type W) produce relatively few adult progeny when crossed to males from some other populations (type R), but the productivity of the reciprocal cross is comparable to within-population controls. These two incompatibility types are widespread in North Am...

journal_title：Genetics

authors： Hoffmann AA,Turelli M

更新日期：1988-06-01 00:00:00

abstract：:Here I show that the mean codon usage bias of a genome, and of the lowly expressed genes in a genome, is largely similar across eukaryotes ranging from unicellular protists to vertebrates. Conversely, this bias in housekeeping genes and in highly expressed genes has a remarkable inverse relationship with species gener...

journal_title：Genetics

authors： Subramanian S

更新日期：2008-04-01 00:00:00