Quantitative trait loci (QTL) detection in multicross inbred designs: recovering QTL identical-by-descent status information from marker data.

abstract：:A female frog heterozygous at two unlinked loci, specifying electrophoretic forms of mannosephosphate isomerase (MPI) and malate dehydrogenase (MDH) was crossed to male frogs homozygous for different alleles at each locus. In the offspring approximately ten percent proved to be triploid according to nucleolar and chro...

journal_title：Genetics

authors： Wright DA,Huang CP,Chuoke BD

更新日期：1976-10-01 00:00:00

abstract：:To develop a catalog of regulatory sites in two major model organisms, Drosophila melanogaster and Caenorhabditis elegans, the modERN (model organism Encyclopedia of Regulatory Networks) consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecess...

journal_title：Genetics

authors： Kudron MM,Victorsen A,Gevirtzman L,Hillier LW,Fisher WW,Vafeados D,Kirkey M,Hammonds AS,Gersch J,Ammouri H,Wall ML,Moran J,Steffen D,Szynkarek M,Seabrook-Sturgis S,Jameel N,Kadaba M,Patton J,Terrell R,Corson M,Dur

更新日期：2018-03-01 00:00:00

abstract：:In Saccharomyces cerevisiae, silencers flanking the HML and HMR loci initiate the establishment of transcriptional silencing. We demonstrate that the activity of a silencer pertaining to its potency and directionality is dependent on its genomic position. The context of the HML-E silencer is more permissive to silence...

journal_title：Genetics

authors： Zou Y,Yu Q,Chiu YH,Bi X

更新日期：2006-09-01 00:00:00

abstract：:The robustness of parametric linkage mapping against model misspecification is considered in experimental breeding designs, with a focus on localization of the gene. By examining the expected LOD across the genome, it is shown that single-gene models are quite robust, even for polygenic traits. However, when the marke...

journal_title：Genetics

authors： Wright FA,Kong A

更新日期：1997-05-01 00:00:00

abstract：:The L-shaped distribution of estimated QTL effects (R(2)) has long been reported. We recently showed that a metabolic mechanism could account for this phenomenon. But other nonexclusive genetic or nongenetic causes may contribute to generate such a distribution. Using analysis and simulations of an additive genetic mo...

journal_title：Genetics

authors： Bost B,de Vienne D,Hospital F,Moreau L,Dillmann C

更新日期：2001-04-01 00:00:00

abstract：:Biosynthesis of most peptide hormones and neuropeptides requires proteolytic excision of the active peptide from inactive proprotein precursors, an activity carried out by subtilisin-like proprotein convertases (SPCs) in constitutive or regulated secretory pathways. The Drosophila amontillado (amon) gene encodes a hom...

journal_title：Genetics

authors： Rayburn LY,Gooding HC,Choksi SP,Maloney D,Kidd AR 3rd,Siekhaus DE,Bender M

更新日期：2003-01-01 00:00:00

abstract：:The micronutrient boron is essential in maintaining the structure of plant cell walls and is critical for high yields in crop species. Boron can move into plants by diffusion or by active and facilitated transport mechanisms. We recently showed that mutations in the maize boron efflux transporter ROTTEN EAR (RTE) caus...

journal_title：Genetics

authors： Chatterjee M,Liu Q,Menello C,Galli M,Gallavotti A

更新日期：2017-08-01 00:00:00

abstract：:Pontocerebellar hypoplasia type 1b (PCH1b) is an autosomal recessive disorder that causes cerebellar hypoplasia and spinal motor neuron degeneration, leading to mortality in early childhood. PCH1b is caused by mutations in the RNA exosome subunit gene, EXOSC3 The RNA exosome is an evolutionarily conserved complex, con...

journal_title：Genetics

authors： Fasken MB,Losh JS,Leung SW,Brutus S,Avin B,Vaught JC,Potter-Birriel J,Craig T,Conn GL,Mills-Lujan K,Corbett AH,van Hoof A

更新日期：2017-01-01 00:00:00

abstract：:Vertebrate retrotransposons have been used extensively for phylogenetic analyses and studies of molecular evolution. Information can be obtained from specific inserts either by comparing sequence differences that have accumulated over time in orthologous copies of that insert or by determining the presence or absence ...

journal_title：Genetics

authors： Cantrell MA,Filanoski BJ,Ingermann AR,Olsson K,DiLuglio N,Lister Z,Wichman HA

更新日期：2001-06-01 00:00:00

abstract：:The external genitalia are some of the most rapidly evolving morphological structures in insects. The posterior lobe of the male genital arch shows striking differences in both size and shape among closely related species of the Drosophila melanogaster species subgroup. Here, we dissect the genetic basis of posterior ...

journal_title：Genetics

authors： Masly JP,Dalton JE,Srivastava S,Chen L,Arbeitman MN

更新日期：2011-09-01 00:00:00

abstract：:Genetic and developmental analysis of an X-linked vital locus vnd was undertaken. Embryos hemizygous for the original allele vnd did not hatch and exhibited a disorganized ventral nervous system (VNS). The mutation maps in the region 1B6-7 to 1B9-10, a subregion of an area previously shown to be essential to normal ne...

journal_title：Genetics

authors： White K,DeCelles NL,Enlow TC

更新日期：1983-07-01 00:00:00

abstract：:In this paper we study the process of allele frequency change in finite populations with overlapping generations with the purpose of evaluating the possibility of estimating the effective size from observations of temporal frequency shifts of selectively neutral alleles. Focusing on allele frequency changes between su...

journal_title：Genetics

authors： Jorde PE,Ryman N

更新日期：1995-02-01 00:00:00

abstract：:We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. mela...

journal_title：Genetics

authors： Balakirev ES,Ayala FJ

更新日期：1996-12-01 00:00:00

abstract：:The spindle assembly checkpoint-mediated mitotic arrest depends on proteins that signal the presence of one or more unattached kinetochores and prevents the onset of anaphase in the presence of kinetochore or spindle damage. In the presence of either damage, bub2 cells initiate a preanaphase delay but do not maintain ...

journal_title：Genetics

authors： Krishnan R,Pangilinan F,Lee C,Spencer F

更新日期：2000-10-01 00:00:00

abstract：:In a previous study, a mitochondrial mutant expressing a specific enzymatic deficiency in co-enzyme QH2-cytochrome c reductase was described (TZAGO-LOFF, FOURY and AKAI 1976). Analysis of the mitochondrially translated proteins revealed the absence in the mutant of the mitochondrial product corresponding to cytochrome...

journal_title：Genetics

authors： Coruzzi G,Tzagoloff A

更新日期：1980-08-01 00:00:00

abstract：:Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...

journal_title：Genetics

authors： Rhee Y,Sekhon RS,Chopra S,Kaeppler S

更新日期：2010-11-01 00:00:00

abstract：:Genetical and biochemical studies have been performed with revertants induced in a polyaromatic mutant (No. 58) in the arom gene cluster of Neurospora crassa. In addition to complete and partial revertants able to grow on minimal at both 25 degrees and 35 degrees , temperature-sensitive revertants capable of growth on...

journal_title：Genetics

authors： Case ME,Giles NH

更新日期：1974-04-01 00:00:00

abstract：:Four crosses were made between inbred Cannabis sativa plants with pure cannabidiol (CBD) and pure Delta-9-tetrahydrocannabinol (THC) chemotypes. All the plants belonging to the F(1)'s were analyzed by gas chromatography for cannabinoid composition and constantly found to have a mixed CBD-THC chemotype. Ten individual ...

journal_title：Genetics

authors： de Meijer EP,Bagatta M,Carboni A,Crucitti P,Moliterni VM,Ranalli P,Mandolino G

更新日期：2003-01-01 00:00:00

abstract：:Fifty-eight isochromosomal lines sampled from two natural populations of Drosophila pseudoobscura in California and one from Bogota, Colombia, were examined using four-cutter restriction mapping. A 4.6-kb region of the xanthine dehydrogenase locus was probed and 66 of 135 restriction sites scored were polymorphic. Thi...

journal_title：Genetics

authors： Riley MA,Hallas ME,Lewontin RC

更新日期：1989-10-01 00:00:00

abstract：:Early embryogenesis in Drosophila melanogaster is controlled by maternal gene products, which are deposited in the egg during oogenesis. It is not well understood how maternal gene expression is controlled during germline development. pipsqueak (psq) is a complex locus that encodes several nuclear protein variants con...

journal_title：Genetics

authors： Grillo M,Furriols M,Casanova J,Luschnig S

更新日期：2011-02-01 00:00:00

abstract：:Yeast DNA fragments that confer multiple drug resistance when amplified were isolated. Cells containing a yeast genomic library cloned in the high copy autonomously replicating vector, YEp24, were plated on medium containing cycloheximide. Five out of 100 cycloheximide-resistant colonies were cross-resistant to the un...

journal_title：Genetics

authors： Leppert G,McDevitt R,Falco SC,Van Dyk TK,Ficke MB,Golin J

更新日期：1990-05-01 00:00:00

abstract：:We previously identified Caenorhabditis elegans mutants in which certain of the six vulval precursor cells adopt fates normally expressed by other vulval precursor cells. These mutants define genes that appear to function in the response to an intercellular signal that induces vulval development. The multivulva (Muv) ...

journal_title：Genetics

authors： Ferguson EL,Horvitz HR

更新日期：1989-09-01 00:00:00

abstract：:Actin is a major component of the cytoskeleton and one of the most abundant proteins found in eukaryotic cells. Comparative sequence analysis shows that this essential gene has been highly conserved throughout eukaryotic evolution making it useful for phylogenetic analysis. Complete cDNA clones for the actin-encoding ...

journal_title：Genetics

authors： Fletcher LD,McDowell JM,Tidwell RR,Meagher RB,Dykstra CC

更新日期：1994-07-01 00:00:00

abstract：:Key steps of essential metabolic pathways are housed in plant peroxisomes. We conducted a microscopy-based screen for anomalous distribution of peroxisomally targeted fluorescence in Arabidopsis thaliana This screen uncovered 34 novel alleles in 15 genes affecting oil body mobilization, fatty acid β-oxidation, the gly...

journal_title：Genetics

authors： Rinaldi MA,Patel AB,Park J,Lee K,Strader LC,Bartel B

更新日期：2016-11-01 00:00:00

abstract：:We describe a fast hierarchical Bayesian method for mapping quantitative trait loci by haplotype-based association, applicable when haplotypes are not observed directly but are inferred from multiple marker genotypes. The method avoids the use of a Monte Carlo Markov chain by employing priors for which the likelihood ...

journal_title：Genetics

authors： Durrant C,Mott R

更新日期：2010-03-01 00:00:00

abstract：:Conditional lethal mutant systems developed in T-even bacteriophages T2, T4 and T6 have been used to study the partial exclusion which characterizes mixed infections of these phages. In bacteria mixedly infected with T2 and T4, the dominant phage (T4) acts against localized exclusion sensitivity determinants in the ge...

journal_title：Genetics

authors： Russell RL,Huskey RJ

更新日期：1974-12-01 00:00:00

abstract：:Since the publication of the first comprehensive linkage map for the laboratory mouse, the architecture of recombination as a basic biological process has become amenable to investigation in mammalian model organisms. Here we take advantage of high-density genotyping and the unique pedigree structure of the incipient ...

journal_title：Genetics

authors： Liu EY,Morgan AP,Chesler EJ,Wang W,Churchill GA,Pardo-Manuel de Villena F

更新日期：2014-05-01 00:00:00

abstract：:Grain yield is a major goal for the improvement of durum wheat, particularly in drought-prone areas. In this study, the genetic basis of grain yield (GY), heading date (HD), and plant height (PH) was investigated in a durum wheat population of 249 recombinant inbred lines evaluated in 16 environments (10 rainfed and 6...

journal_title：Genetics

authors： Maccaferri M,Sanguineti MC,Corneti S,Ortega JL,Salem MB,Bort J,DeAmbrogio E,del Moral LF,Demontis A,El-Ahmed A,Maalouf F,Machlab H,Martos V,Moragues M,Motawaj J,Nachit M,Nserallah N,Ouabbou H,Royo C,Slama A,Tubero

更新日期：2008-01-01 00:00:00

abstract：:The initiation of postembryonic cell divisions by the gonadal precursors of C. elegans requires the activity of gon-2. gon-2 encodes a predicted cation channel (GON-2) of the TRPM subfamily of TRP proteins and is likely to mediate the influx of Ca(2+) and/or Mg(2+). We report here that mutations in gem-4 (gon-2 extrag...

journal_title：Genetics

authors： Church DL,Lambie EJ

更新日期：2003-10-01 00:00:00

abstract：:The evidence in support of two types of alternate disjunction in translocation heterozygotes from the German cockroach, Blattella germanica (L.), is reviewed. When unique cytomorphological features occur in the translocation figure, the two types of alternate disjunction are identifiable regardless of the angle of obs...

journal_title：Genetics

authors： Cochran DG

更新日期：1983-05-01 00:00:00