Structure, expression and phylogenetic analysis of the gene encoding actin I in Pneumocystis carinii.

abstract：:Signaling by the second messenger inositol 1,4,5-trisphosphate is thought to affect several developmental and physiological processes. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene of Drosophila exhibit delays in molting while stronger alleles are also larval lethal. In a freshly generated set of EM...

journal_title：Genetics

authors： Joshi R,Venkatesh K,Srinivas R,Nair S,Hasan G

更新日期：2004-01-01 00:00:00

abstract：:The idea of trait-based linkage analysis in half-sibs is extended by comparing the frequency of parental marker haplotypes in animals with different phenotypes. This article first presents the likelihood of observing different classes of paternal haplotypes in a half-sib family, where only family members of a certain ...

journal_title：Genetics

authors： Reinsch N

更新日期：2002-09-01 00:00:00

abstract：:In multicellular organisms, genetic programs guide cells to adopt cell fates as tissues are formed during development, maintained in adults, and repaired after injury. Here we explore how a small molecule in the environment can switch a genetic program from one fate to another. Wild-type Caenorhabditis elegans XX adul...

journal_title：Genetics

authors： Sorokin EP,Gasch AP,Kimble J

更新日期：2014-10-01 00:00:00

abstract：:The plant mitochondrial genome is composed of a set of molecules of various sizes that generate each other through recombination between repeated sequences. Molecular observations indicate that these different molecules are present in an equilibrium state. Different compositions of molecules have been observed within ...

journal_title：Genetics

authors： Albert B,Godelle B,Atlan A,De Paepe R,Gouyon PH

更新日期：1996-09-01 00:00:00

abstract：:The three-dimensional organization of polytene chromosomes within nuclei containing rearranged X chromosomes was examined in male Drosophila melanogaster. Salivary glands of third instar larvae containing either an inverted X chromosome (YSX.YL, In(1)EN/O) or a ring X chromosome (R(1) 2/BSYy+) were fixed, embedded, an...

journal_title：Genetics

authors： Mathog D,Sedat JW

更新日期：1989-02-01 00:00:00

abstract：:Ribosome biogenesis is tightly regulated through stress-sensing pathways that impact genome stability, aging and senescence. In Saccharomyces cerevisiae, ribosomal RNAs are transcribed from rDNA located on the right arm of chromosome XII. Numerous studies reveal that rDNA decondenses into a puff-like structure during ...

journal_title：Genetics

authors： Shen D,Skibbens RV

更新日期：2020-03-01 00:00:00

abstract：:In Neurospora crassa, DNA sequence duplications are detected and altered efficiently during the sexual cycle by a process known as RIP (repeat-induced point mutation). Affected sequences are subjected to multiple GC-to-AT mutations. To explore the pattern in which base changes are laid down by RIP we examined two sets...

journal_title：Genetics

authors： Watters MK,Randall TA,Margolin BS,Selker EU,Stadler DR

更新日期：1999-10-01 00:00:00

abstract：:Cse4p is an essential histone H3 variant in Saccharomyces cerevisiae that defines centromere identity and is required for proper segregation of chromosomes. In this study, we investigated phenotypic consequences of Cse4p mislocalization and increased dosage of histone H3 and Cse4p, and established a direct link betwee...

journal_title：Genetics

authors： Au WC,Crisp MJ,DeLuca SZ,Rando OJ,Basrai MA

更新日期：2008-05-01 00:00:00

abstract：:A laboratory strain of Drosophila pseudoobscura (L116) is studied that, when crossed to sex-ratio homozygous females, produces sons that exhibit varying levels of the male sex-ratio (msr) phenotype. The msr phenotype occurs only in sex-ratio males and is due to the production of a high frequency of nullo-XY sperm. The...

journal_title：Genetics

authors： Cobbs G

更新日期：1986-06-01 00:00:00

abstract：:The Yanomama Indians are a South American tribe distributed over an irregular area approximately 200 X 300 miles. The gene frequencies observed at 12 loci in 47 villages within this area have been analyzed for the occurrence of clines. Apparently significant clines are observed for alleles of the Rh, MNSs, Kidd, Gm, I...

journal_title：Genetics

authors： Ward RH,Neel JV

更新日期：1976-01-01 00:00:00

abstract：:Strong deviation of allele frequencies from Mendelian inheritance favoring Mus spretus-derived alleles has been described previously for X-linked loci in four mouse interspecific crosses. We reanalyzed data for three of these crosses focusing on the location of the gene(s) controlling deviation on the X chromosome and...

journal_title：Genetics

authors： Montagutelli X,Turner R,Nadeau JH

更新日期：1996-08-01 00:00:00

abstract：:Previous models suggested that regulation of telomere length in Saccharomyces cerevisiae by Tel1(ATM) and Mec1(ATR) would parallel the established pathways regulating the DNA damage response. Here, we provide evidence that telomere length regulation differs from the DNA damage response in both the Tel1 and Mec1 pathwa...

journal_title：Genetics

authors： Keener R,Connelly CJ,Greider CW

更新日期：2019-12-01 00:00:00

abstract：:The developmental gene optomotor-blind (omb) encodes a T-box-containing transcription factor that has multiple roles in Drosophila development. Previous genetic analyses established that omb plays a key role in establishing the abdominal pigmentation pattern of Drosophila melanogaster. In this report we examine patter...

journal_title：Genetics

authors： Brisson JA,Templeton AR,Duncan I

更新日期：2004-12-01 00:00:00

abstract：:The trace element iron is crucial for living organisms, since it plays essential roles in numerous cellular functions. Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically a...

journal_title：Genetics

authors： Wang H,Jiang X,Wu J,Zhang L,Huang J,Zhang Y,Zou X,Liang B

更新日期：2016-05-01 00:00:00

abstract：:We report the identification of bang senseless (bss), a Drosophila melanogaster mutant exhibiting seizure-like behaviors, as an allele of the paralytic (para) voltage-gated Na(+) (Na(V)) channel gene. Mutants are more prone to seizure episodes than normal flies because of a lowered seizure threshold. The bss phenotype...

journal_title：Genetics

authors： Parker L,Padilla M,Du Y,Dong K,Tanouye MA

更新日期：2011-02-01 00:00:00

abstract：:Two large, stable populations (Texas and Japan) of Drosophila melanogaster were surveyed at 21 allozyme loci on the second and third chromosomes and for chromosomal gene arrangements on those two chromosomes. Over 220 independent gametes were sampled from each population. The types and frequencies of the surveyed gene...

journal_title：Genetics

authors： Langley CH,Tobari YN,Kojima KI

更新日期：1974-11-01 00:00:00

abstract：:Theoretically, one of the most general benefits of sex is given by its function in facilitating selection against deleterious mutations. This advantage of sex may be deterministic if deleterious mutations affect the fitness of an individual in a synergistic way, i.e., if mutations increase each others' negative fitnes...

journal_title：Genetics

authors： de Visser JA,Hoekstra RF,van den Ende H

更新日期：1997-03-01 00:00:00

abstract：:The RAD54 gene, which encodes a protein in the SWI2/SNF2 family, plays an important role in recombination and DNA repair in Saccharomyces cerevisiae. The yeast genome project revealed a homologue of RAD54, RDH54/TID1. Properties of the rdh54/tid1 mutant and the rad54 rdh54/tid1 double mutant are shown for mitosis and ...

journal_title：Genetics

authors： Shinohara M,Shita-Yamaguchi E,Buerstedde JM,Shinagawa H,Ogawa H,Shinohara A

更新日期：1997-12-01 00:00:00

abstract：:We have examined the stability of the tandemly repeated genes that encode the ribosomal RNA in Coprinus cinereus. These genes are contained within two linked HindIII fragments in a 3.0-Mb chromosome. We monitored the size of these fragments in both mitotic and meiotic segregants using the contour-clamped homogeneous e...

journal_title：Genetics

authors： Pukkila PJ,Skrzynia C

更新日期：1993-02-01 00:00:00

abstract：:A system for genetic analysis in the cellular slime mold P. violaceum has been developed. Two growth-temperature-sensitive mutants were isolated in a haploid strain and used to select rare diploid heterozygotes arising by spontaneous fusion of the haploid cells. A recessive mutation to cycloheximide resistance in one ...

journal_title：Genetics

authors： Warren AJ,Warren WD,Cox EC

更新日期：1976-05-01 00:00:00

abstract：:We examined linkage relationships for RecBC-mediated recombination in lytic cycle crosses of lambda phages bearing two cohesive end sites (cos) oriented in the same direction. The relationships obtained imply that a given recombinant tends to be packaged from the cos site that is the nearer one to the right of the exc...

journal_title：Genetics

authors： Stahl FW,Kobayashi I,Thaler D,Stahl MM

更新日期：1986-06-01 00:00:00

abstract：:There are many types of DNA damage that are repaired by a multiplicity of different repair pathways. All damage and repair occur in the context of chromatin, and histone modifications are involved in many repair processes. We have analyzed the roles of H2A and its modifications in repair by mutagenizing modifiable res...

journal_title：Genetics

authors： Moore JD,Yazgan O,Ataian Y,Krebs JE

更新日期：2007-05-01 00:00:00

abstract：:Drosophila melanogaster males dosage compensate by twofold upregulation of the expression of genes on their single X chromosome. This process requires at least five proteins and two noncoding RNAs, roX1 and roX2, which paint the male X chromosome. We used a deletion analysis to search for functional RNA domains within...

journal_title：Genetics

authors： Stuckenholz C,Meller VH,Kuroda MI

更新日期：2003-07-01 00:00:00

abstract：:Understanding how variation in reproductive success is related to demography is a critical component in understanding the life history of an organism. Parentage analysis using molecular markers can be used to estimate the reproductive success of different groups of individuals in natural populations. Previous models h...

journal_title：Genetics

authors： Jones B,Grossman GD,Walsh DC,Porter BA,Avise JC,Fiumera AC

更新日期：2007-08-01 00:00:00

abstract：:Fifty-two wee mutants that undergo mitosis and cell division at a reduced size compared with wild type have been genetically analyzed. The mutants define two genes, wee1 and cdc2, which control the timing of mitosis. Fifty-one of the mutants map at the wee1 locus, which is unlinked to any known cdc gene. One of the we...

journal_title：Genetics

authors： Nurse P,Thuriaux P

更新日期：1980-11-01 00:00:00

abstract：:The distribution of fitness effects (DFE) of new mutations is of fundamental importance in evolutionary genetics. Recently, methods have been developed for inferring the DFE that use information from the allele frequency distributions of putatively neutral and selected nucleotide polymorphic variants in a population s...

journal_title：Genetics

authors： Schneider A,Charlesworth B,Eyre-Walker A,Keightley PD

更新日期：2011-12-01 00:00:00

abstract：:A model emphasizing the possible genetic role of tandem duplications of reverse repeats has been developed as an extension of Crick's (1971) general model for the chromosomes of higher organisms. Although developed initially (1) to explain why random differences in the control regions of individual gene loci might con...

journal_title：Genetics

authors： Wallace B,Kass TL

更新日期：1974-07-01 00:00:00

abstract：:The mutational origin and subsequent evolution of de novo genes, which are hypothesized to be genes of recent origin that are not obviously related to ancestral coding sequence, are poorly understood. However, accumulating evidence suggests that such genes may often function in male reproduction. Here we use testis-de...

journal_title：Genetics

authors： Begun DJ,Lindfors HA,Kern AD,Jones CD

更新日期：2007-06-01 00:00:00

abstract：:Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at leas...

journal_title：Genetics

authors： Vary PS,Stocker BA

更新日期：1973-02-01 00:00:00

abstract：:In vivo haploid induction (HI) triggered by pollination with special intraspecific genotypes, called inducers, is unique to Zea maysL. within the plant kingdom and has revolutionized maize breeding during the last decade. However, the molecular mechanisms underlying HI in maize are still unclear. To investigate the ge...

journal_title：Genetics

authors： Hu H,Schrag TA,Peis R,Unterseer S,Schipprack W,Chen S,Lai J,Yan J,Prasanna BM,Nair SK,Chaikam V,Rotarenco V,Shatskaya OA,Zavalishina A,Scholten S,Schön CC,Melchinger AE

更新日期：2016-04-01 00:00:00