Altered dosage and mislocalization of histone H3 and Cse4p lead to chromosome loss in Saccharomyces cerevisiae.

abstract：:The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the post...

journal_title：Genetics

authors： Hayashi S,Kondo T

更新日期：2018-06-01 00:00:00

abstract：:The sexual dimorphism of aggression has led to a search for its Y chromosomal correlates. We have previously confirmed that initiation of attack behavior against a conspecific male is Y-dependent in two strains of laboratory mice (NZB and CBA/H). We provide evidence that the non-pseudoautosomal region of the Y is not ...

journal_title：Genetics

authors： Roubertoux PL,Carlier M,Degrelle H,Haas-Dupertuis MC,Phillips J,Moutier R

更新日期：1994-01-01 00:00:00

abstract：:We have analyzed the 2E1-3A1 area of the X chromosome with special attention to loci related to embryogenesis. Published maps indicate that this chromosomal segment contains ten bands. Our genetic analysis has identified 11 complementation groups: one recessive visible (prune), two female steriles and eight lethals. O...

journal_title：Genetics

authors： Perrimon N,Engstrom L,Mahowald AP

更新日期：1984-11-01 00:00:00

abstract：:Stress caused by the increased salinity of irrigated fields impairs plant growth and is one of the major constraints that limits crop productivity in many important agricultural areas. As a contribution to solving such agronomic problems, we have carried out a large-scale screening for Arabidopsis thaliana mutants ind...

journal_title：Genetics

authors： Quesada V,Ponce MR,Micol JL

更新日期：2000-01-01 00:00:00

abstract：:Sexual isolating mechanisms that act before fertilization are often considered the most important genetic barriers leading to speciation in animals. While recent progress has been made toward understanding the genetic basis of the postzygotic isolating mechanisms of hybrid sterility and inviability, little is known ab...

journal_title：Genetics

authors： Moehring AJ,Li J,Schug MD,Smith SG,deAngelis M,Mackay TF,Coyne JA

更新日期：2004-07-01 00:00:00

abstract：:Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-function phenotypes, which cannot differentiate between separation-of-...

journal_title：Genetics

authors： Lubin JW,Rao T,Mandell EK,Wuttke DS,Lundblad V

更新日期：2013-03-01 00:00:00

abstract：:The sequentially Markov coalescent is a simplified genealogical process that aims to capture the essential features of the full coalescent model with recombination, while being scalable in the number of loci. In this article, the sequentially Markov framework is applied to the conditional sampling distribution (CSD), ...

journal_title：Genetics

authors： Paul JS,Steinrücken M,Song YS

更新日期：2011-04-01 00:00:00

abstract：:The 73AD salivary chromosome region of Drosophila melanogaster was subjected to mutational analysis in order to (1) generate a collection of chromosome breakpoints that would allow a correlation between the genetic, cytological and molecular maps of the region and (2) define the number and gross organization of comple...

journal_title：Genetics

authors： Belote JM,Hoffmann FM,McKeown M,Chorsky RL,Baker BS

更新日期：1990-08-01 00:00:00

abstract：:Biosynthesis of most peptide hormones and neuropeptides requires proteolytic excision of the active peptide from inactive proprotein precursors, an activity carried out by subtilisin-like proprotein convertases (SPCs) in constitutive or regulated secretory pathways. The Drosophila amontillado (amon) gene encodes a hom...

journal_title：Genetics

authors： Rayburn LY,Gooding HC,Choksi SP,Maloney D,Kidd AR 3rd,Siekhaus DE,Bender M

更新日期：2003-01-01 00:00:00

abstract：:Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments on accumulation of mutations on protected second chromosomes. A model of equal mutant effects gives a poor fit to the data ...

journal_title：Genetics

authors： Keightley PD

更新日期：1994-12-01 00:00:00

abstract：:In many plant species, exposure to a prolonged period of cold during the winter promotes flowering in the spring, a process termed vernalization. In Arabidopsis thaliana, the vernalization requirement of winter-annual ecotypes is caused by the MADS-box gene FLOWERING LOCUS C (FLC), which is a repressor of flowering. D...

journal_title：Genetics

authors： Reeves PA,He Y,Schmitz RJ,Amasino RM,Panella LW,Richards CM

更新日期：2007-05-01 00:00:00

abstract：:Associative overdominance, the fitness difference between heterozygotes and homozygotes at a neutral locus, is classically described using two categories of models: linkage disequilibrium in small populations or identity disequilibrium in infinite, partially selfing populations. In both cases, only equilibrium situati...

journal_title：Genetics

authors： Bierne N,Tsitrone A,David P

更新日期：2000-08-01 00:00:00

abstract：:The SUF13 and SUF14 genes were identified among extragenic suppressors of +1 frameshift mutations. SUF13 is synonymous with MBF1, a single-copy nonessential gene coding for a POLII transcription factor. The suf13-1 mutation is a two-nucleotide deletion in the SUF13/MBF1 coding region. A suf13::TRP1 null mutant suppres...

journal_title：Genetics

authors： Hendrick JL,Wilson PG,Edelman II,Sandbaken MG,Ursic D,Culbertson MR

更新日期：2001-03-01 00:00:00

abstract：:Much recent work in the theoretical study of adaptation has focused on the so-called strong selection-weak mutation (SSWM) limit, wherein adaptation is due to new mutations of definite selective advantage. This work, in turn, has focused on the first step (substitution) during adaptive evolution. Here we extend this t...

journal_title：Genetics

authors： Unckless RL,Orr HA

更新日期：2009-11-01 00:00:00

abstract：:Methodology for mapping quantitative trait loci (QTL) has focused primarily on treating the QTL as a fixed effect. These methods differ from the usual models of genetic variation that treat genetic effects as random. Computationally expensive methods that allow QTL to be treated as random have been explicitly develope...

journal_title：Genetics

authors： Zimmer D,Mayer M,Reinsch N

更新日期：2011-01-01 00:00:00

abstract：:Automated image acquisition, a custom analysis algorithm, and a distributed computing resource were used to add time as a third dimension to a quantitative trait locus (QTL) map for plant root gravitropism, a model growth response to an environmental cue. Digital images of Arabidopsis thaliana seedling roots from two ...

journal_title：Genetics

authors： Moore CR,Johnson LS,Kwak IY,Livny M,Broman KW,Spalding EP

更新日期：2013-11-01 00:00:00

abstract：:A general method is proposed for calculating approximate thresholds of interval mapping tests for quantitative trait loci (QTL) detection. Simulation results show that this method, when applied to backcross and F2 populations, gives good approximations and is useful for any situation. Programs which calculate these th...

journal_title：Genetics

authors： Rebaï A,Goffinet B,Mangin B

更新日期：1994-09-01 00:00:00

abstract：:We propose a new method for calculating probabilities for pedigree genetic data that incorporates crossover interference using the chi-square models. Applications include relationship inference, genetic map construction, and linkage analysis. The method is based on importance sampling of unobserved inheritance pattern...

journal_title：Genetics

authors： Browning S

更新日期：2003-08-01 00:00:00

abstract：:The plant mitochondrial genome is composed of a set of molecules of various sizes that generate each other through recombination between repeated sequences. Molecular observations indicate that these different molecules are present in an equilibrium state. Different compositions of molecules have been observed within ...

journal_title：Genetics

authors： Albert B,Godelle B,Atlan A,De Paepe R,Gouyon PH

更新日期：1996-09-01 00:00:00

abstract：:The r-X1 deficiency in maize induces nondisjunction at the second mitotic division during embryo sac formation. However, it was not known if this deficiency also induces nondisjunction during the microspore divisions. Microsporogenesis in plants lacking or containing this deficiency was compared using two approaches. ...

journal_title：Genetics

authors： Zhao ZY,Weber DF

更新日期：1988-08-01 00:00:00

abstract：:In contrast to our growing understanding of patterns of additive genetic variance in single- and multi-trait combinations, the relative contribution of nonadditive genetic variance, particularly dominance variance, to multivariate phenotypes is largely unknown. While mechanisms for the evolution of dominance genetic v...

journal_title：Genetics

authors： Sztepanacz JL,Blows MW

更新日期：2015-05-01 00:00:00

abstract：:The DNA-binding protein encoded by the zeste gene of Drosophila activates transcription and mediates interchromosomal interactions such as transvection. The mutant protein encoded by the zeste1 (z1) allele retains the ability to support transvection, but represses white. Similar to transvection, repression requires Ze...

journal_title：Genetics

authors： Rosen C,Dorsett D,Jack J

更新日期：1998-04-01 00:00:00

abstract：:Regulatory networks provide control over complex cell behavior in all kingdoms of life. Here we describe a statistical model, based on representing proteins as collections of domains or motifs, which predicts unknown molecular interactions within these biological networks. Using known protein-protein interactions of S...

journal_title：Genetics

authors： Gomez SM,Lo SH,Rzhetsky A

更新日期：2001-11-01 00:00:00

abstract：:Interactions with bacteria play a major role in immune responses, ecology, and evolution of all animals, but they have been neglected until recently in the case of C. elegans. We report a genetic investigation of the interaction of C. elegans with the nematode-specific pathogen Microbacterium nematophilum, which colon...

journal_title：Genetics

authors： Gravato-Nobre MJ,Nicholas HR,Nijland R,O'Rourke D,Whittington DE,Yook KJ,Hodgkin J

更新日期：2005-11-01 00:00:00

abstract：:Interactions between Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs and CRISPR-associated (Cas) proteins form an RNA-guided adaptive immune system in prokaryotes. The adaptive immune system utilizes segments of the genetic material of invasive foreign elements in the CRISPR locus. The loci are ...

journal_title：Genetics

authors： Fu BX,Wainberg M,Kundaje A,Fire AZ

更新日期：2017-08-01 00:00:00

abstract：:Over 100 regulatory mutations linked to the histidine (his) operon of S. typhimurium have been isolated. They all map in a region estimated to be several hundred base pairs in length located at one end of the his operon ("the hisO region"). The mutations are located at sixteen recombinationally separable sites or are ...

journal_title：Genetics

authors： Ely B,Fankhauser DB,Hartman PE

更新日期：1974-10-01 00:00:00

abstract：:The effect of genetic hitchhiking on neutral variation is analyzed in subdivided populations with differentiated demes. After fixation of a favorable mutation, the consequences on particular subpopulations can be radically different. In the subpopulation where the mutation first appeared by mutation, variation at link...

journal_title：Genetics

authors： Santiago E,Caballero A

更新日期：2005-01-01 00:00:00

abstract：:Remarkably complex patterns of aneuploidy have been observed in the genomes of many eukaryotic cell types, ranging from brewing yeasts to tumor cells. Such aberrant karyotypes are generally thought to take shape progressively over many generations, but evidence also suggests that genomes may undergo faster modes of ev...

journal_title：Genetics

authors： Heasley LR,Watson RA,Argueso JL

更新日期：2020-09-01 00:00:00

abstract：:Maintenance of proper neuronal excitability is vital to nervous system function and normal behavior. A subset of Drosophila mutants that exhibit altered behavior also exhibit defective motor neuron excitability, which can be monitored with electrophysiological methods. One such mutant is the P-element insertion mutant...

journal_title：Genetics

authors： Schweers BA,Walters KJ,Stern M

更新日期：2002-07-01 00:00:00

abstract：:Properties of identity relation between genes are discussed, and a derivation of recurrent equations of identity coefficients in a random mating, diploid dioecious population is presented. Computations are run by repeated matrix multiplication. Results show that for effective population size (Ne) larger than 16 and no...

journal_title：Genetics

authors： Chevalet C,Gillois M,Nassar RF

更新日期：1977-07-01 00:00:00