Abstract：
:Over 100 regulatory mutations linked to the histidine (his) operon of S. typhimurium have been isolated. They all map in a region estimated to be several hundred base pairs in length located at one end of the his operon ("the hisO region"). The mutations are located at sixteen recombinationally separable sites or are deletions encompassing several sites. Data obtained from pairs of reciprocal three-point tests show that "constitutive" (high enzyme levels) and "promoter-like" (low enzyme levels) hisO mutations are interspersed on the genetic map. In a few crosses, recombination was not observed to occur between markers shown to occupy different sites based on behavior in other recombination tests.
journal_name
Geneticsjournal_title
Geneticsauthors
Ely B,Fankhauser DB,Hartman PEsubject
Has Abstractpub_date
1974-10-01 00:00:00pages
607-31issue
2eissn
0016-6731issn
1943-2631journal_volume
78pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Comparison of population differentiation in neutral marker genes and in genes coding quantitative traits by means of F(ST) and Q(ST) indexes has become commonplace practice. While the properties and estimation of F(ST) have been the subject of much interest, little is known about the precision and possible bias in Q(S...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.044545
更新日期：2005-11-01 00:00:00
abstract：:Progress in understanding the evolution of variation at the MHC has been slowed by an inability to assess the relative roles of mutation vs. intragenic recombination in contributing to observed polymorphism. Recent theoretical advances now permit a quantitative treatment of the problem, with the result that the amount...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behin...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.166.2.807
更新日期：2004-02-01 00:00:00
abstract：:Mitochondrial DNAs (mtDNAs) from 167 American Indians including 87 Amerind-speakers (Amerinds) and 80 Nadene-speakers (Nadene) were surveyed for sequence variation by detailed restriction analysis. All Native American mtDNAs clustered into one of four distinct lineages, defined by the restriction site variants: HincII...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Active endogenous transposable elements, useful tools for gene isolation, have not been reported from any legume species. An active transposable element was suggested to reside in the W4 locus that governs flower color in soybean. Through biochemical and molecular analyses of several revertants of the w4-m allele, we ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.107904
更新日期：2010-01-01 00:00:00
abstract：:Genetic screens in Drosophila melanogaster and other organisms have been pursued to filter the genome for genetic functions important for memory formation. Such screens have employed primarily chemical or transposon-mediated mutagenesis and have identified numerous mutants including classical memory mutants, dunce and...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.173575
更新日期：2015-04-01 00:00:00
abstract：:Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:Segregation distorter (SD) chromosomes are preferentially transmitted to offspring from heterozygous SD/SD(+) males owing to the induced dysfunction of the SD(+)-bearing sperm. This phenomenon involves at least two major loci: the Sd locus whose presence is necessary for distortion to occur and the Rsp locus which act...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1983-04-01 00:00:00
abstract：:Catfish is the major aquaculture species in the United States. The hybrid catfish produced by crossing channel catfish females with blue catfish males exhibit a number of desirable production traits, but their mass production has been difficult. To introduce desirable genes from blue catfish into channel catfish throu...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：:We studied the control of pharyngeal excitation in Caenorhabditis elegans. By laser ablating subsets of the pharyngeal nervous system, we found that the MC neuron type is necessary and probably sufficient for rapid pharyngeal pumping. Electropharyngeograms showed that MC transmits excitatory postsynaptic potentials, s...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.064063
更新日期：2007-03-01 00:00:00
abstract：:Two sets of overlapping experiments were conducted to examine recombination and spontaneous mutation events within clusters of resistance genes in lettuce. Multiple generations were screened for recombinants using PCR-based markers flanking Dm3. The Dm3 region is not highly recombinagenic, exhibiting a recombination f...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-02-01 00:00:00
abstract：:Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Evolutionary forces shape patterns of genetic diversity within populations and contribute to phenotypic variation. In particular, recurrent positive selection has attracted significant interest in both theoretical and empirical studies. However, most existing theoretical models of recurrent positive selection cannot e...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.156935
更新日期：2014-05-01 00:00:00
abstract：:Hormonal, genetic, and environmental factors play major roles in the complex etiology of breast cancer. When treated continuously with 17beta-estradiol (E2), the ACI rat exhibits a genetically conferred propensity to develop mammary cancer. The susceptibility of the ACI rat to E2-induced mammary cancer appears to segr...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.033878
更新日期：2004-12-01 00:00:00
abstract：:Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.084384
更新日期：2008-06-01 00:00:00
abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.087361
更新日期：2008-12-01 00:00:00
abstract：:High-throughput sequencing and bioinformatic techniques have enhanced classical genetic analysis and are essential methods for geneticists. Tsukamoto and colleagues use numerous genomic and bioinformatics methods to explore the role of ribonucleoprotein complexes in regulating oocyte meiotic maturation, which is the t...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301139
更新日期：2018-07-01 00:00:00
abstract：:Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, de...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.112.149104
更新日期：2013-05-01 00:00:00
abstract：:The reproductive success of individual fire ant queens (Solenopsis invicta) previously has been shown to be strongly influenced by their genotype at a single enzyme-encoding gene, designated Pgm-3. This paper presents evidence that a second, tightly linked gene, designated Gp-9, is under similarly strong selection in ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:Polycomb group response elements (PREs) play an essential role in gene regulation by the Polycomb group (PcG) repressor proteins in Drosophila. PREs are required for the recruitment and maintenance of repression by the PcG proteins. PREs are made up of binding sites for multiple DNA-binding proteins, but it is still u...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.153247
更新日期：2013-10-01 00:00:00
abstract：:The yellow fever mosquito Aedes aegypti has been the subject of extensive genetic research due to its medical importance and the ease with which it can be manipulated in the laboratory. A molecular genetic linkage map was constructed using 148 amplified fragment length polymorphism (AFLP) and six single-strand conform...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.055178
更新日期：2006-07-01 00:00:00
abstract：:Allozyme and inversion data from natural populations of Drosophila melanogaster from the eastern United States were analyzed to determine whether the clines at allozyme loci are due to nonrandom associations with common cosmopolitan inversions. All inversions show strong clines. Clines were large and significant for h...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:A major challenge in undergraduate life science curricula is the continual evaluation and development of courses that reflect the constantly shifting face of contemporary biological research. Synthetic biology offers an excellent framework within which students may participate in cutting-edge interdisciplinary researc...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.096784
更新日期：2009-01-01 00:00:00
abstract：:Temporally spaced genetic data allow for more accurate inference of population genetic parameters and hypothesis testing on the recent action of natural selection. In this work, we develop a novel likelihood-based method for jointly estimating selection coefficient and allele age from time series data of allele freque...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303400
更新日期：2020-10-01 00:00:00
abstract：:When individuals' fitnesses depend on the genetic composition of the population in which they are found, selection is then frequency dependent. Frequency-dependent selection (FDS) is often invoked as a heuristic explanation for the maintenance of large numbers of alleles at a locus. The pairwise interaction model is a...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.073072
更新日期：2007-07-01 00:00:00
abstract：:The centromere is essential for proper segregation and inheritance of genetic information. Centromeres are generally regulated to occur exactly once per chromosome; failure to do so leads to chromosome loss or damage and loss of linked genetic material. The mechanism for faithful regulation of centromere activity and ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：:Several eukaryotic homologs of the Escherichia coli RecQ DNA helicase have been found. These include the human BLM gene, whose mutation results in Bloom syndrome, and the human WRN gene, whose mutation leads to Werner syndrome resembling premature aging. We cloned a Drosophila melanogaster homolog of the RECQ helicase...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:A method for the estimation of population dynamic history from sequence data is described and used to investigate the past population dynamics of HIV-1 subtypes A and B. Using both gag and env gene alignments the effective population size of each subtype is estimated and found to be surprisingly small. This may be a r...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:doublesex (dsx) is unusual among the known sex-determination genes of Drosophila melanogaster in that functional homologs are found in distantly related species. In flies, dsx occupies a position near the bottom of the sex determination hierarchy. It is expressed in male- and female-specific forms and these proteins f...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
