Abstract：
:When individuals' fitnesses depend on the genetic composition of the population in which they are found, selection is then frequency dependent. Frequency-dependent selection (FDS) is often invoked as a heuristic explanation for the maintenance of large numbers of alleles at a locus. The pairwise interaction model is a general model of FDS via intraspecific competition at the genotypic level. Here we use a parameter-space approach to investigate the full potential for the maintenance of multiallelic equilibria under the pairwise interaction model. We find that FDS maintains full polymorphism more often than classic constant-selection models and produces more skewed equilibrium allele frequencies. Fitness sets with some degree of rare advantage maintained full polymorphism most often, but a wide variety of nonobvious fitness patterns were also found to have positive potential for polymorphism. An example is put forth suggesting possible explanations for multiallelic polymorphisms maintained despite positive FDS on individual alleles.
journal_name
Geneticsjournal_title
Geneticsauthors
Trotter MV,Spencer HGdoi
10.1534/genetics.107.073072subject
Has Abstractpub_date
2007-07-01 00:00:00pages
1729-40issue
3eissn
0016-6731issn
1943-2631pii
genetics.107.073072journal_volume
176pub_type
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