Abstract:
:137Cs-gamma irradiation of bacteriophage T4 induces large deletions plus a variety of types of point mutations. All mutations arise with single-hit kinetics, and all by a misrepair process. The estimated point mutation rate is 1.5 X 10(-9) per locus per rad.
journal_name
Geneticsjournal_title
Geneticsauthors
Conkling MA,Grunau JA,Drake JWkeywords:
subject
Has Abstractpub_date
1976-04-01 00:00:00pages
565-75issue
4eissn
0016-6731issn
1943-2631journal_volume
82pub_type
杂志文章相关文献
GENETICS文献大全abstract::Maize (Zea mays L.) serves as model plant for heterosis research and is the crop where hybrid breeding was pioneered. We analyzed genomic and phenotypic data of 1254 hybrids of a typical maize hybrid breeding program based on the important Dent × Flint heterotic pattern. Our main objectives were to investigate genome ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.165860
更新日期:2014-08-01 00:00:00
abstract::In eukaryotic cells, checkpoint pathways arrest cell-cycle progression if a particular event has failed to complete appropriately or if an important intracellular structure is defective or damaged. Saccharomyces cerevisiae strains that lack the SFP1 gene fail to arrest at the G2 DNA-damage checkpoint in response to ge...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) si...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.086298
更新日期:2008-04-01 00:00:00
abstract::Bayesian posterior distributions are obtained for the time to the most recent common ancestor (MRCA) for a nonrecombining segment of DNA (such as the nonpseudoautosomal arm of the Y chromosome or the mitochondrial genome) for two individuals given that they match at k out of n scored markers. We argue that the distrib...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::To identify novel genomic regions that regulate sex determination, we utilized the powerful C57BL/6J-Y(POS) (B6-Y(POS)) model of XY sex reversal where mice with autosomes from the B6 strain and a Y chromosome from a wild-derived strain, Mus domesticus poschiavinus (Y(POS)), show complete sex reversal. In B6-Y(POS), th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.160259
更新日期:2014-07-01 00:00:00
abstract::Key steps of essential metabolic pathways are housed in plant peroxisomes. We conducted a microscopy-based screen for anomalous distribution of peroxisomally targeted fluorescence in Arabidopsis thaliana This screen uncovered 34 novel alleles in 15 genes affecting oil body mobilization, fatty acid β-oxidation, the gly...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.193169
更新日期:2016-11-01 00:00:00
abstract::All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.112.147207
更新日期:2013-03-01 00:00:00
abstract::A BC1 population of the self-compatible tomato Lycopersicon esculentum and its wild self-incompatible relative L. hirsutum f. typicum was used for restriction fragment length polymorphism linkage analysis and quantitative trait loci (QTL) mapping of reproductive behavior and floral traits. The self-incompatibility loc...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::We describe 83 recessive autosomal male-sterile mutations, generated by single P element mutagenesis in Drosophila melanogaster. Each mutation has been localized to a lettered subdivision of the polytene map. Reversion analyses, as well as complementation tests using available chromosomal deficiencies, indicate that t...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::In order to learn more about other proteins that may be involved in repression of HML and HMR in Saccharomyces cerevisiae, extragenic suppressor mutations were identified that could restore repression in cells defective in SIR4, a gene required for function of the silencer elements flanking HML and HMR. These suppress...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.064063
更新日期:2007-03-01 00:00:00
abstract::We demonstrate that the previously described gene Androgen binding protein (Abp; Dlouhy and Karn, 1984) codes for the Alpha subunit of ABP and rename the locus Androgen binding protein alpha (Abpa). A study of recombinant inbred strains demonstrates that Abpa is located on chromosome 7 near Glucose phosphate isomerase...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screeni...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::F1 hybrids between mouse inbred strains PWD and C57BL/6 represent the most thoroughly genetically defined model of hybrid sterility in vertebrates. Hybrid male sterility can be fully reconstituted from three components of this model, the Prdm9 gene, intersubspecific homeology of Mus musculus musculus and Mus musculus ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302554
更新日期:2019-11-01 00:00:00
abstract::When a local colonization in a new niche occurs, the new derived population should be subject to different selective pressures from that in the original parental population; consequently it is likely that many loci will be subject to directional selection. In such a quick adaptation event through environmental changes...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.086835
更新日期:2008-07-01 00:00:00
abstract::The initiation of postembryonic cell divisions by the gonadal precursors of C. elegans requires the activity of gon-2. gon-2 encodes a predicted cation channel (GON-2) of the TRPM subfamily of TRP proteins and is likely to mediate the influx of Ca(2+) and/or Mg(2+). We report here that mutations in gem-4 (gon-2 extrag...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with Caenorhabditis elegans nematodes was conducted in which independently evolving lines were initiated from a low-fitness mitochondrial electron transport chain (ETC) mutant, gas-1 Following 60 generations o...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.301935
更新日期:2019-03-01 00:00:00
abstract::In eucaryotes a cell cycle control called a checkpoint ensures that mitosis occurs only after chromosomes are completely replicated and any damage is repaired. The function of this checkpoint in budding yeast requires the RAD9 gene. Here we examine the role of the RAD9 gene in the arrest of the 12 cell division cycle ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::The island model with stochastically variable migration rate and immigrant gene frequency is investigated. It is supposed that the migration rate and the immigrant gene frequency are independent of each other in each generation, and each of them is independently and identically distributed in every generation. The tre...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::The ade6-M26 mutation of Schizosaccharomyces pombe has previously been reported to stimulate ade6 intragenic meiotic recombination. We report here that the ade6-M26 mutation is a single G----T nucleotide change, that M26 stimulated recombination within ade6 but not at other distinct loci, and that M26 stimulated meiot...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::The time of the pre-meiotic S-period was determined by (32)P incorporation in synchronously germinating zygospores of Chlamydomonas reinhardi at six and one-half to seven hours after the beginning of germination. Phenethyl alcohol treatment caused death of zygospores at a period one hour before the S-period, and also ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1973-01-01 00:00:00
abstract::The fission yeast Schizosaccharomyces pombe has never been found to give rise to viable cells totally lacking mitochondrial DNA (rho(o)). This paper describes the isolation of rho(o) strains of S. pombe by very long term incubation of cells in liquid medium containing glucose, potassium acetate and ethidium bromide. O...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Several eukaryotic homologs of the Escherichia coli RecQ DNA helicase have been found. These include the human BLM gene, whose mutation results in Bloom syndrome, and the human WRN gene, whose mutation leads to Werner syndrome resembling premature aging. We cloned a Drosophila melanogaster homolog of the RECQ helicase...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::Cytoplasmic male sterility (CMS), the maternally inherited failure to produce functional pollen, has been used in the breeding of sugar beet (Beta vulgaris ssp. vulgaris). At least three different sources of CMS can be distinguished from one another as well as from normal fertile cytoplasm by polymorphisms in their mi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.076380
更新日期:2007-11-01 00:00:00
abstract::The genetic basis of stochastic variation within a defined environment, and the consequences of such micro-environmental variance for fitness are poorly understood . Using a multigenerational breeding design in Drosophila serrata, we demonstrated that the micro-environmental variance in a set of morphological wing tra...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.199075
更新日期:2017-08-01 00:00:00
abstract::Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.114.163105
更新日期:2014-06-01 00:00:00
abstract::We studied thorax formation in Drosophila melanogaster using a misexpression screen with EP lines and thoracic Gal4 drivers that provide a genetically sensitized background. We identified 191 interacting lines showing alterations of thoracic bristles (number and/or location), thorax and scutellum malformations, lethal...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Quantitative traits whose phenotypic values change over time are called longitudinal traits. Genetic analyses of longitudinal traits can be conducted using any of the following approaches: (1) treating the phenotypic values at different time points as repeated measurements of the same trait and analyzing the trait und...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.054775
更新日期:2006-08-01 00:00:00
abstract::Synthetics play an important role in quantitative genetic research and plant breeding, but few studies have investigated the application of genomic prediction (GP) to these populations. Synthetics are generated by intermating a small number of parents ([Formula: see text] and thereby possess unique genetic properties,...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.193243
更新日期:2017-01-01 00:00:00
abstract::Aspergillus nidulans is an important experimental organism, and it is a model organism for the genus Aspergillus that includes serious pathogens as well as commercially important organisms. Gene targeting by homologous recombination during transformation is possible in A. nidulans, but the frequency of correct gene ta...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.105.052563
更新日期:2006-03-01 00:00:00