The SFP1 gene product of Saccharomyces cerevisiae regulates G2/M transitions during the mitotic cell cycle and DNA-damage response.

abstract：:In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked ...

journal_title：Genetics

authors： Weissman DB,Hallatschek O

更新日期：2014-04-01 00:00:00

abstract：:Transcriptional silencing involves the formation of specialized repressive chromatin structures. Previous studies have shown that the histone H3-H4 chaperone known as chromatin assembly factor 1 (CAF-1) contributes to transcriptional silencing in yeast, although the molecular basis for this was unknown. In this work w...

journal_title：Genetics

authors： Tamburini BA,Carson JJ,Linger JG,Tyler JK

更新日期：2006-06-01 00:00:00

abstract：:The genetic basis of body weight in the mouse was investigated by measuring frequency changes of microsatellite marker alleles in lines divergently selected for body weight from a base population of a cross between two inbred strains. In several regions of the genome, sharp peaks of frequency change at linked markers ...

journal_title：Genetics

authors： Keightley PD,Hardge T,May L,Bulfield G

更新日期：1996-01-01 00:00:00

abstract：:Argonaute2 (Ago2) is a rapidly evolving nuclease in the Drosophila melanogaster RNA interference (RNAi) pathway that targets viruses and transposable elements in somatic tissues. Here we reconstruct the history of Ago2 duplications across the D. obscura group and use patterns of gene expression to infer new functional...

journal_title：Genetics

authors： Lewis SH,Webster CL,Salmela H,Obbard DJ

更新日期：2016-10-01 00:00:00

abstract：:The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...

journal_title：Genetics

authors： Malpica JM,Vassallo JM,Frías A,Fuentes-Bol F

更新日期：1987-01-01 00:00:00

abstract：:The satellite DNA's from the embryos of five species of Drosophila (D. melanogaster, D. simulans, D. nasuta, D. virilis and D. hydei) have been analyzed for the presence of closed circular duplex DNA molecules, as determined by CsCl-EBr gradients. Circular DNA molecules were found in every species but D. melanogaster....

journal_title：Genetics

authors： Travaglini EC,Schultz J

更新日期：1972-11-01 00:00:00

abstract：:A novel fine structure mapping method for quantitative traits is presented. It is based on Bayesian modeling and inference, treating the number of quantitative trait loci (QTLs) as an unobserved random variable and using ideas similar to composite interval mapping to account for the effects of QTLs in other chromosome...

journal_title：Genetics

authors： Sillanpää MJ,Arjas E

更新日期：1998-03-01 00:00:00

abstract：:Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcri...

journal_title：Genetics

authors： Zhang H,Emmons SW

更新日期：2002-02-01 00:00:00

abstract：:Yeast cells subjected to a reversible thermal arrest of meiosis yielded progressively fewer spores per ascus as the arrest was extended. Dissection of two-spored asci by a newly developed method that prevents selection of false asci revealed that the spores were not a random sample of the haploid meiotic products. Mos...

journal_title：Genetics

authors： Davidow LS,Goetsch L,Byers B

更新日期：1980-03-01 00:00:00

abstract：:In contrast to our growing understanding of patterns of additive genetic variance in single- and multi-trait combinations, the relative contribution of nonadditive genetic variance, particularly dominance variance, to multivariate phenotypes is largely unknown. While mechanisms for the evolution of dominance genetic v...

journal_title：Genetics

authors： Sztepanacz JL,Blows MW

更新日期：2015-05-01 00:00:00

abstract：:We have characterized a Saccharomyces cerevisiae mutant strain that is hypersensitive to cyclosporin A (CsA) and FK506, immunosuppressants that inhibit calcineurin, a serine-threonine-specific phosphatase (PP2B). A single nuclear mutation, designated cev1 for calcineurin essential for viability, is responsible for the...

journal_title：Genetics

authors： Hemenway CS,Dolinski K,Cardenas ME,Hiller MA,Jones EW,Heitman J

更新日期：1995-11-01 00:00:00

abstract：:Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

journal_title：Genetics

authors： Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

更新日期：2008-06-01 00:00:00

abstract：:The long-term population genetics of multigene families is influenced by several biased and unbiased mechanisms of nonreciprocal exchanges (gene conversion, unequal exchanges, transposition) between member genes, often distributed on several chromosomes. These mechanisms cause fluctuations in the copy number of varian...

journal_title：Genetics

authors： Ohta T,Dover GA

更新日期：1984-10-01 00:00:00

abstract：:Our understanding of the cellular mechanisms by which animals regulate their response to starvation is limited, despite the strong relevance of the problem to major human health issues. The L1 diapause of Caenorhabditis elegans, where first-stage larvae arrest in response to a food-less environment, is an excellent sy...

journal_title：Genetics

authors： Cui M,Wang Y,Cavaleri J,Kelson T,Teng Y,Han M

更新日期：2017-02-01 00:00:00

abstract：:The timing of lethality caused by homozygosity for a null allele of the epidermal growth factor receptor (Egfrtm1Mag) in mice is strongly dependent on genetic background. Initial attempts to genetically map background modifiers using Swiss-derived, outbred CD-1 mice were unsuccessful. To investigate the genetic archit...

journal_title：Genetics

authors： Strunk KE,Amann V,Threadgill DW

更新日期：2004-08-01 00:00:00

abstract：:How the brain makes trillions of synaptic connections using a genome of only 20,000 genes is a major question in modern neuroscience. Alternative splicing is one mechanism that can increase the number of proteins produced by each gene, but its role in regulating synapse formation is poorly understood. In Drosophila, p...

journal_title：Genetics

authors： Kerwin SK,Li JSS,Noakes PG,Shin GJ,Millard SS

更新日期：2018-02-01 00:00:00

abstract：:To identify genes involved in stress resistance and heat hardening, replicate lines of Drosophila melanogaster were selected for increased resistance to knockdown by a 39 degrees heat stress. Two selective regimes were used, one with and one without prior hardening. Mean knockdown times were increased from approximate...

journal_title：Genetics

authors： McColl G,Hoffmann AA,McKechnie SW

更新日期：1996-08-01 00:00:00

abstract：:Mating behavior in adult male nematodes can be assayed by mating efficiency, i.e., the number of cross progeny sired by males under standard conditions. Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnorm...

journal_title：Genetics

authors： Hodgkin J

更新日期：1983-01-01 00:00:00

abstract：:COTRANS is a program for analyzing cotransduction data. It calculates distances from pairwise cotransduction frequencies, computes crossovers required to obtain each observed recombinant class, and applies rules to draw conclusions about order. The rules are based on the correlation between the frequency of the classe...

journal_title：Genetics

authors： Berlyn MB,Letovsky S

更新日期：1992-05-01 00:00:00

abstract：:To study the evolutionary role played by differential male and female fertility (sexual asymmetry) both between individuals and over the life span within single individuals, the terms "intrinsic male fertility" and "intrinsic female fertility" are introduced. With the help of these terms, the concept of sexual asymmet...

journal_title：Genetics

authors： Gregorius HR

更新日期：1991-11-01 00:00:00

abstract：:Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected under neutral evolution and described statistically by Kingman's...

journal_title：Genetics

authors： Dayarian A,Shraiman BI

更新日期：2014-07-01 00:00:00

abstract：:Mta is a cell surface antigen of the mouse and serves as a target for specific T killer lymphocytes. Using a killer cell assay, the antigen has been found in 72 strains of laboratory mice and, with one exception, in all tested samples of mice caught in the wild or bred from such, including Mus molossinus, Mus castaneu...

journal_title：Genetics

authors： Lindahl KF,Hausmann B

更新日期：1983-03-01 00:00:00

abstract：:Specialized insect mouthparts, such as those of Drosophila, are derived from an ancestral mandibulate state, but little is known about the developmental genetics of mandibulate mouthparts. Here, we study the metamorphic patterning of mandibulate mouthparts of the beetle Tribolium castaneum, using RNA interference to d...

journal_title：Genetics

authors： Angelini DR,Smith FW,Aspiras AC,Kikuchi M,Jockusch EL

更新日期：2012-02-01 00:00:00

abstract：:Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossi...

journal_title：Genetics

authors： Oka A,Aoto T,Totsuka Y,Takahashi R,Ueda M,Mita A,Sakurai-Yamatani N,Yamamoto H,Kuriki S,Takagi N,Moriwaki K,Shiroishi T

更新日期：2007-01-01 00:00:00

abstract：:A subset of cancers rely on telomerase-independent mechanisms to maintain their chromosome ends. The predominant "alternative lengthening of telomeres" pathway appears dependent on homology-directed repair (HDR) to maintain telomeric DNA. However, the molecular changes needed for cells to productively engage in telome...

journal_title：Genetics

authors： Hu Y,Bennett HW,Liu N,Moravec M,Williams JF,Azzalin CM,King MC

更新日期：2019-10-01 00:00:00

abstract：:The resistance of rice to its bacterial blight pathogen Xanthomonas oryzae pv. oryzae (Xoo) has both qualitative and quantitative components that were investigated using three near-isogenic line sets for four resistance (R) genes (Xa4, xa5, xa13, and Xa21) and 12 Xoo races. Our results indicate that these two resistan...

journal_title：Genetics

authors： Li ZK,Sanchez A,Angeles E,Singh S,Domingo J,Huang N,Khush GS

更新日期：2001-10-01 00:00:00

abstract：:This paper presents the results of a study of linkage disequilibrium between five polymorphic enzyme genes located on chromosome 3 of D. melanogaster. Three sets of chromosomes were examined: two represented samples from successive years of the same natural population, and one came from a large laboratory population. ...

journal_title：Genetics

authors： Charlesworth B,Charlesworth D

更新日期：1973-02-01 00:00:00

abstract：:A causal link between deficiency of the cytochrome respiratory pathway and life span was previously shown in the filamentous fungus Podospora anserina. To gain more insight into the relationship between mitochondrial function and life span, we have constructed a strain carrying a thermosensitive mutation of the gene o...

journal_title：Genetics

authors： Sellem CH,Lemaire C,Lorin S,Dujardin G,Sainsard-Chanet A

更新日期：2005-03-01 00:00:00

abstract：:The concept of haplotype blocks has been shown to be useful in genetics. Fields of application range from the detection of regions under positive selection to statistical methods that make use of dimension reduction. We propose a novel approach ("HaploBlocker") for defining and inferring haplotype blocks that focuses ...

journal_title：Genetics

authors： Pook T,Schlather M,de Los Campos G,Mayer M,Schoen CC,Simianer H

更新日期：2019-08-01 00:00:00

abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...

journal_title：Genetics

authors： Kitada K,Omura T

更新日期：1984-11-01 00:00:00