Components of selection in X chromosome lines of Drosophila melanogaster: sex ratio modification by meiotic drive and viability selection.

abstract：:An association was found earlier between the Ep(1) gene locus coding for an endopeptidase and the endosperm color gene Y(1) on chromosome 6 of Zea mays. By employing primary trisomics we have unequivocally placed the Ep(1) gene on chromosome 6, closely linked to the Y(1) locus. Additionally we describe new alleles at ...

journal_title：Genetics

authors： Nielsen G,Scandalios JG

更新日期：1974-08-01 00:00:00

abstract：:Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of type II topoisomera...

journal_title：Genetics

authors： Hohl AM,Thompson M,Soshnev AA,Wu J,Morris J,Hsieh TS,Wu CT,Geyer PK

更新日期：2012-11-01 00:00:00

abstract：:The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...

journal_title：Genetics

authors： Malpica JM,Vassallo JM,Frías A,Fuentes-Bol F

更新日期：1987-01-01 00:00:00

abstract：:The agouti locus on mouse chromosome 2 encodes a secreted cysteine-rich protein of 131 amino acids that acts as a molecular switch to instruct the melanocyte to make either yellow pigment (phaeomelanin) or black pigment (eumelanin). Mutations that up-regulate agouti expression are dominant to those causing decreased e...

journal_title：Genetics

authors： Hustad CM,Perry WL,Siracusa LD,Rasberry C,Cobb L,Cattanach BM,Kovatch R,Copeland NG,Jenkins NA

更新日期：1995-05-01 00:00:00

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00

abstract：:Host variation in Toll-like receptors and other innate immune signaling molecules alters infection susceptibility. However, only a portion of the variability observed in the innate immune response is accounted for by known genes in these pathways. Thus, the identification of additional genes that regulate the response...

journal_title：Genetics

authors： Alper S,Warg LA,De Arras L,Flatley BR,Davidson EJ,Adams J,Smith K,Wohlford-Lenane CL,McCray PB Jr,Pedersen BS,Schwartz DA,Yang IV

更新日期：2016-09-01 00:00:00

abstract：:Drosophila adult leg development provides an ideal model system for characterizing the molecular mechanisms of hormone-triggered morphogenesis. A pulse of the steroid hormone ecdysone at the onset of metamorphosis triggers the rapid transformation of a flat leg imaginal disc into an immature adult leg, largely through...

journal_title：Genetics

authors： Ward RE,Evans J,Thummel CS

更新日期：2003-11-01 00:00:00

abstract：:In Arabidopsis thaliana, significant efforts to determine the extent of genomic variation between phenotypically divergent accessions are under way, but virtually nothing is known about variation at the transcription level. We used microarrays to examine variation in transcript abundance among three inbred lines and t...

journal_title：Genetics

authors： Vuylsteke M,van Eeuwijk F,Van Hummelen P,Kuiper M,Zabeau M

更新日期：2005-11-01 00:00:00

abstract：:Centromere H3 proteins (CenH3's) are variants of histone H3 specialized for packaging centromere DNA. Unlike canonical H3, which is among the most conserved of eukaryotic proteins, CenH3's are rapidly evolving, raising questions about orthology and conservation of function across species. To gain insight on CenH3 evol...

journal_title：Genetics

authors： Baker RE,Rogers K

更新日期：2006-11-01 00:00:00

abstract：:Sex-specific differences in dispersal, survival, reproductive success, and natural selection differentially affect the effective population size (N(e)) of genomic regions with different modes of inheritance such as sex chromosomes and mitochondrial DNA. In papionin monkeys (macaques, baboons, geladas, mandrills, drill...

journal_title：Genetics

authors： Evans BJ,Pin L,Melnick DJ,Wright SI

更新日期：2010-07-01 00:00:00

abstract：:Great interest was aroused by reports, based on microsatellite markers, of high levels of statistically significant long-range and nonsyntenic linkage disequilibrium (LD) in livestock. Simulation studies showed that this could result from population family structure. In contrast, recent SNP-based studies of livestock ...

journal_title：Genetics

authors： Lipkin E,Straus K,Stein RT,Bagnato A,Schiavini F,Fontanesi L,Russo V,Medugorac I,Foerster M,Sölkner J,Dolezal M,Medrano JF,Friedmann A,Soller M

更新日期：2009-02-01 00:00:00

abstract：:Determining parentage is a fundamental problem in biology and in applications such as identifying pedigrees. Difficulties inferring parentage derive from extensive inbreeding within the population, whether natural or planned; using an insufficient number of hypervariable loci; and from allele mismatches caused by muta...

journal_title：Genetics

authors： Berry DA,Seltzer JD,Xie C,Wright DL,Jones ES,Sebastian S,Smith JS

更新日期：2003-09-01 00:00:00

abstract：:Obtaining accurate estimates of the genetic covariance matrix Sigma(G) for multivariate data is a fundamental task in quantitative genetics and important for both evolutionary biologists and plant or animal breeders. Classical methods for estimating Sigma(G) are well known to suffer from substantial sampling errors; i...

journal_title：Genetics

authors： Meyer K,Kirkpatrick M

更新日期：2010-07-01 00:00:00

abstract：:The biological basis of exercise behavior is increasingly relevant for maintaining healthy lifestyles. Various quantitative genetic studies and selection experiments have conclusively demonstrated substantial heritability for exercise behavior in both humans and laboratory rodents. In the "High Runner" selection exper...

journal_title：Genetics

authors： Hillis DA,Yadgary L,Weinstock GM,Pardo-Manuel de Villena F,Pomp D,Fowler AS,Xu S,Chan F,Garland T Jr

更新日期：2020-11-01 00:00:00

abstract：:Satellite DNA is an enigmatic component of genomic DNA with unclear function that has been regarded as "junk." Yet, persistence of these tandem highly repetitive sequences in heterochromatic regions of most eukaryotic chromosomes attests to their importance in the genome. We explored the Anopheles gambiae genome for t...

journal_title：Genetics

authors： Krzywinski J,Sangaré D,Besansky NJ

更新日期：2005-01-01 00:00:00

abstract：:The pattern of mutational covariance among traits plays a central, but largely untested, role in many theories in evolutionary genetics. Here we estimate the pattern of phenotypic, environmental, and mutational correlations for a set of life-history, behavioral, and morphological traits using 67 self-fertilizing lines...

journal_title：Genetics

authors： Estes S,Ajie BC,Lynch M,Phillips PC

更新日期：2005-06-01 00:00:00

abstract：:The island model with stochastically variable migration rate and immigrant gene frequency is investigated. It is supposed that the migration rate and the immigrant gene frequency are independent of each other in each generation, and each of them is independently and identically distributed in every generation. The tre...

journal_title：Genetics

authors： Nagylaki T

更新日期：1979-01-01 00:00:00

abstract：:Simple meiotic gene conversion tracts produced in wild-type females were compared with those from two meiotic mutants, mei-9 and mei-218. The positions and lengths of conversion tracts were determined by denaturing gradient gels and DNA sequencing. Conversion tracts in wild type averaged 885 base pairs in length, were...

journal_title：Genetics

authors： Curtis D,Bender W

更新日期：1991-04-01 00:00:00

abstract：:Haploid Saccharomyces can change mating type through HO-endonuclease cleavage of an expressor locus, MAT, followed by gene conversion using one of two repository loci, HML or HMR, as donor. The mating type of a cell dictates which repository locus is used as donor, with a cells using HML and alpha cells using HMR. Thi...

journal_title：Genetics

authors： Houston P,Simon PJ,Broach JR

更新日期：2004-03-01 00:00:00

abstract：:The sojourn times until fixation of an overdominant allele were investigated based on the diffusion equation. Furthermore, the rate of accumulation of mutations, or the substitution rate, was predicted from the mean extinction time of a common overdominant allele. The substitution rate calculated theoretically agreed ...

journal_title：Genetics

authors： Ohashi J,Tokunaga K

更新日期：2000-06-01 00:00:00

abstract：:In a subdivided population, the interaction between natural selection and stochastic change in allele frequency is affected by the occurrence of local extinction and subsequent recolonization. The relative importance of selection can be diminished by this additional source of stochastic change in allele frequency. Res...

journal_title：Genetics

authors： Cherry JL

更新日期：2004-02-01 00:00:00

abstract：:Kinesin-1 is a motor protein that moves stepwise along microtubules by employing dimerized kinesin heavy chain (Khc) subunits that alternate cycles of microtubule binding, conformational change, and ATP hydrolysis. Mutations in the Drosophila Khc gene are known to cause distal paralysis and lethality preceded by the o...

journal_title：Genetics

authors： Djagaeva I,Rose DJ,Lim A,Venter CE,Brendza KM,Moua P,Saxton WM

更新日期：2012-09-01 00:00:00

abstract：:Self-incompatibility (SI) is a genetic system found in some hermaphrodite plants. Recognition of pollen by pistils expressing cognate specificities at two linked genes leads to rejection of self pollen and pollen from close relatives, i.e., to avoidance of self-fertilization and inbred matings, and thus increased outc...

journal_title：Genetics

authors： Gervais CE,Castric V,Ressayre A,Billiard S

更新日期：2011-07-01 00:00:00

abstract：:In Drosophila melanogaster, the endogenous retrovirus gypsy is repressed by the functional alleles (restrictive) of an as-yet-uncloned heterochromatic gene called flamenco. Using gypsy-lacZ transcriptional fusions, we show here that this repression takes place not only in the follicle cells of restrictive ovaries, as ...

journal_title：Genetics

authors： Sarot E,Payen-Groschêne G,Bucheton A,Pélisson A

更新日期：2004-03-01 00:00:00

abstract：:From the analysis of restriction maps of the Amy region in eight sibling species belonging to the Drosophila melanogaster species subgroup, we herein show that the patterns of duplication of the Amy gene are almost the same in all species. This indicates that duplication occurred before speciation within this species ...

journal_title：Genetics

authors： Shibata H,Yamazaki T

更新日期：1995-09-01 00:00:00

abstract：:We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associa...

journal_title：Genetics

authors： Smith LA,Peixoto AA,Kramer EM,Villella A,Hall JC

更新日期：1998-07-01 00:00:00

abstract：:A flight test box was developed and used in the isolation and initial characterization of Drosophila melanogaster mutants defective in flight behavior. Forty-eight mutants were isolated from F(1) progeny of ethyl methanesulfonate-treated males. Genetic mapping and complementation tests show that the mutations reside a...

journal_title：Genetics

authors： Homyk T,Sheppard DE

更新日期：1977-09-01 00:00:00

abstract：:Interchromosomal duplications are especially important for the study of X-linked genes. Males inheriting a mutation in a vital X-linked gene cannot survive unless there is a wild-type copy of the gene duplicated elsewhere in the genome. Rescuing the lethality of an X-linked mutation with a duplication allows the mutat...

journal_title：Genetics

authors： Cook RK,Deal ME,Deal JA,Garton RD,Brown CA,Ward ME,Andrade RS,Spana EP,Kaufman TC,Cook KR

更新日期：2010-12-01 00:00:00

abstract：:Mutations in the SPT10 and SPT21 genes were originally isolated as suppressors of Ty and LTR (delta) insertion mutations in Saccharomyces cerevisiae, and the genes were shown to be required for normal transcription at a number of loci in yeast. Now we have cloned, sequenced, mapped and mutagenized SPT10 and SPT21. Sin...

journal_title：Genetics

authors： Natsoulis G,Winston F,Boeke JD

更新日期：1994-01-01 00:00:00

abstract：:Restorer-of-fertility (Rf) alleles for S-type cytoplasmic male sterility (CMS-S) are prevalent in Mexican races of maize and teosinte. Forty-five Rf alleles from 26 races of maize and 6 Rf alleles from different accessions of teosinte were found to be homozygous viable, consistent with the hypothesis that they are nat...

journal_title：Genetics

authors： Gabay-Laughnan S,Chase CD,Ortega VM,Zhao L

更新日期：2004-02-01 00:00:00