Linkage disequilibrium in natural populations of Drosophila melanogaster.

abstract：:The transcription factors Adr1 and Cat8 act in concert to regulate the expression of numerous yeast genes after the diauxic shift. Their activities are regulated by Snf1, the yeast homolog of the AMP-activated protein kinase of higher eukaryotes. Cat8 is regulated directly by Snf1, but how Snf1 regulates Adr1 is unkno...

journal_title：Genetics

authors： Ratnakumar S,Kacherovsky N,Arms E,Young ET

更新日期：2009-07-01 00:00:00

abstract：:Motile and immotile (or primary) cilia are microtubule-based structures that mediate multiple cellular functions, including the transduction of environmental cues, developmental signaling, cellular motility, and modulation of fluid flow. Although their core architectures are similar, motile and primary cilia exhibit m...

journal_title：Genetics

authors： Kazatskaya A,Kuhns S,Lambacher NJ,Kennedy JE,Brear AG,McManus GJ,Sengupta P,Blacque OE

更新日期：2017-12-01 00:00:00

abstract：:A series of clear mutants of the temperate phage 16-3 of Rhizobium meliloti were isolated that included various point and deletion mutants of the C cistron, coding for the phage repressor. It was observed that recombinant genotypes, such as c(+) and ti (temperature-sensitive allele), which form turbid plaques, can be ...

journal_title：Genetics

authors： Orosz L

更新日期：1980-02-01 00:00:00

abstract：:A BC1 population of the self-compatible tomato Lycopersicon esculentum and its wild self-incompatible relative L. hirsutum f. typicum was used for restriction fragment length polymorphism linkage analysis and quantitative trait loci (QTL) mapping of reproductive behavior and floral traits. The self-incompatibility loc...

journal_title：Genetics

authors： Bernacchi D,Tanksley SD

更新日期：1997-10-01 00:00:00

abstract：:The classic diallel takes a set of parents and produces offspring from all possible mating pairs. Phenotype values among the offspring can then be related back to their respective parentage. When the parents are diploid, sexed, and inbred, the diallel can characterize aggregate effects of genetic background on a pheno...

journal_title：Genetics

authors： Lenarcic AB,Svenson KL,Churchill GA,Valdar W

更新日期：2012-02-01 00:00:00

abstract：:The three-dimensional (3D) organization of chromosomes can influence transcription. However, the frequency and magnitude of these effects remain debated. To determine how changes in chromosome positioning affect transcription across thousands of genes with minimal perturbation, we characterized nuclear organization an...

journal_title：Genetics

authors： Di Stefano M,Di Giovanni F,Pozharskaia V,Gomar-Alba M,Baù D,Carey LB,Marti-Renom MA,Mendoza M

更新日期：2020-03-01 00:00:00

abstract：:Sensory cues regulate several aspects of behavior and development in Caenorhabditis elegans, including entry into and exit from an alternative developmental stage called the dauer larva. Three parallel pathways, including a TGF-beta-like pathway, regulate dauer formation. The mechanisms by which the activities of thes...

journal_title：Genetics

authors： Daniels SA,Ailion M,Thomas JH,Sengupta P

更新日期：2000-09-01 00:00:00

abstract：:Seven hundred and three second chromosomes were extracted from a Raleigh, North Carolina population of Drosophila melanogaster in 1970. Additionally, four hundred and eighty-nine third chromosomes were extracted from a large cage population founded from the flies in the 1970 Raleigh collection. The alpha glycerol-3-ph...

journal_title：Genetics

authors： Muki T,Watanabe TK,Yamaguchi O

更新日期：1974-08-01 00:00:00

abstract：:A number of fundamental processes comprise the cell division cycle, including spindle formation, chromosome segregation, and cytokinesis. Our current understanding of these processes has benefited from the isolation and analysis of mutants, with the meiotic divisions in the male germline of Drosophila being particular...

journal_title：Genetics

authors： Afshar K,Gönczy P,DiNardo S,Wasserman SA

更新日期：2001-03-01 00:00:00

abstract：:The regulation of chemoreceptor (CR) gene expression by environmental signals and internal cues may contribute to the modulation of multiple physiological processes and behavior in Caenorhabditis elegans. We previously showed that KIN-29, a homolog of salt-inducible kinase, acts in sensory neurons to regulate the expr...

journal_title：Genetics

authors： van der Linden AM,Wiener S,You YJ,Kim K,Avery L,Sengupta P

更新日期：2008-11-01 00:00:00

abstract：:Previous mathematical analyses of mutation-selection balance for metric traits assume that selection acts on the relevant loci only through the character(s) under study. Thus, they implicitly assume that all of the relevant mutation and selection parameters are estimable. A more realistic analysis must recognize that ...

journal_title：Genetics

authors： Turelli M

更新日期：1985-09-01 00:00:00

abstract：:The conserved histone variant H2A.Z fulfills many functions by being an integral part of the nucleosomes placed at specific regions of the genome. Telomeres cap natural ends of chromosomes to prevent their recognition as double-strand breaks. At yeast telomeres, H2A.Z prevents the spreading of silent chromatin into pr...

journal_title：Genetics

authors： Rong YS

更新日期：2008-12-01 00:00:00

abstract：:The gastrulation defective (gd) locus encodes a novel serine protease that is involved in specifying the dorsal-ventral axis during embryonic development. Mutant alleles of gd have been classified into three complementation groups, two of which exhibit strong interallelic (intragenic) complementation. To understand th...

journal_title：Genetics

authors： Ponomareff G,Giordano H,DeLotto Y,DeLotto R

更新日期：2001-10-01 00:00:00

abstract：:The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient DNA polymerase γ mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, sug...

journal_title：Genetics

authors： Stumpf JD,Copeland WC

更新日期：2013-06-01 00:00:00

abstract：:Two-dimensional paper chromatography was performed on methanol extracts of leaves of hexaploid bread wheat, Triticum aestivum L. em. Thell. cultivar Chinese Spring, and of the available nullisomic-tetrasomic compensating lines, the tetrasomic lines and the ditelocentric lines. The chromatograms had 27 spots identified...

journal_title：Genetics

authors： Neuman PR,Waines JG,Hilu KW,Barnhart D

更新日期：1983-02-01 00:00:00

abstract：:The phenomenon of chromosome, or genomic, imprinting indicates the relevance of parental origin in determining functional differences between alleles, homologous chromosomes, or haploid sets. In mealybug males (Homoptera, Coccoidea), the haploid set of paternal origin undergoes heterochromatization at midcleavage and ...

journal_title：Genetics

authors： Bongiorni S,Cintio O,Prantera G

更新日期：1999-04-01 00:00:00

abstract：:Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activi...

journal_title：Genetics

authors： Allen AT,Maher KN,Wani KA,Betts KE,Chase DL

更新日期：2011-07-01 00:00:00

abstract：:We compared allele sequences of two loci near the Arabidopsis lyrata self-incompatibility (S) loci with sequences of A. thaliana orthologs and found high numbers of shared polymorphisms, even excluding singletons and sites likely to be highly mutable. This suggests maintenance of entire S-haplotypes for long evolution...

journal_title：Genetics

authors： Charlesworth D,Kamau E,Hagenblad J,Tang C

更新日期：2006-04-01 00:00:00

abstract：:Very few mutations derived from Mutator maize lines have been studied at the molecular level. The variety of Mu elements that can induce mutations, the relative frequency of mutant induction by insertion of a given class of Mu elements or by a Mu-induced genomic rearrangement, a possible intragenic insertion site spec...

journal_title：Genetics

authors： Brown WE,Robertson DS,Bennetzen JL

更新日期：1989-06-01 00:00:00

abstract：:A causal link between deficiency of the cytochrome respiratory pathway and life span was previously shown in the filamentous fungus Podospora anserina. To gain more insight into the relationship between mitochondrial function and life span, we have constructed a strain carrying a thermosensitive mutation of the gene o...

journal_title：Genetics

authors： Sellem CH,Lemaire C,Lorin S,Dujardin G,Sainsard-Chanet A

更新日期：2005-03-01 00:00:00

abstract：:In contrast to our growing understanding of patterns of additive genetic variance in single- and multi-trait combinations, the relative contribution of nonadditive genetic variance, particularly dominance variance, to multivariate phenotypes is largely unknown. While mechanisms for the evolution of dominance genetic v...

journal_title：Genetics

authors： Sztepanacz JL,Blows MW

更新日期：2015-05-01 00:00:00

abstract：:A unique aspect of meiosis is the segregation of homologous chromosomes at the meiosis I division. The pairing of homologous chromosomes is a critical aspect of meiotic prophase I that aids proper disjunction at anaphase I. We have used a site-specific recombination assay in Saccharomyces cerevisiae to examine allelic...

journal_title：Genetics

authors： Lui DY,Peoples-Holst TL,Mell JC,Wu HY,Dean EW,Burgess SM

更新日期：2006-07-01 00:00:00

abstract：:We studied P element-induced recombination in germline mitotic cells by examining the structure of the recombinant chromosomes. We found that most recombinants retain a mobile P element at the site of the recombination, usually with either a deletion or a duplication immediately adjacent to the P end at which the cros...

journal_title：Genetics

authors： Preston CR,Sved JA,Engels WR

更新日期：1996-12-01 00:00:00

abstract：:During segmentation of vertebrate embryos, somites form in accordance with a periodic pattern established by the segmentation clock. In the zebrafish (Danio rerio), the segmentation clock includes six hairy/enhancer of split-related (her/hes) genes, five of which oscillate due to negative autofeedback. The nonoscillat...

journal_title：Genetics

authors： Schwendinger-Schreck J,Kang Y,Holley SA

更新日期：2014-06-01 00:00:00

abstract：:We tested the hypothesis that the time course of the evolution of antifungal drug resistance depends on the ploidy of the fungus. The experiments were designed to measure the initial response to the selection imposed by the antifungal drug fluconazole up to and including the fixation of the first resistance mutation i...

journal_title：Genetics

authors： Anderson JB,Sirjusingh C,Ricker N

更新日期：2004-12-01 00:00:00

abstract：:In a subdivided population, the interaction between natural selection and stochastic change in allele frequency is affected by the occurrence of local extinction and subsequent recolonization. The relative importance of selection can be diminished by this additional source of stochastic change in allele frequency. Res...

journal_title：Genetics

authors： Cherry JL

更新日期：2004-02-01 00:00:00

abstract：:The Sex-Ratio (SR) phenomenon is associated with the X chromosome of many species of Drosophila. Males carrying SR transmit predominantly sperm bearing the X chromosome. SR, therefore, has a very significant advantage in segregation. This paper provides an experimental analysis of the role of virility selection in pre...

journal_title：Genetics

authors： Wu CI

更新日期：1983-11-01 00:00:00

abstract：:We consider resequencing studies of associated loci and the problem of prioritizing sequence variants for functional follow-up. Working within the multivariate linear regression framework helps us to account for the joint effects of multiple genes; and adopting a Bayesian approach leads to posterior probabilities that...

journal_title：Genetics

authors： Stell L,Sabatti C

更新日期：2016-02-01 00:00:00

abstract：:Genetic material sequenced from ancient samples is revolutionizing our understanding of the recent evolutionary past. However, ancient DNA is often degraded, resulting in low coverage, error-prone sequencing. Several solutions exist to this problem, ranging from simple approach, such as selecting a read at random for ...

journal_title：Genetics

authors： Schraiber JG

更新日期：2018-01-01 00:00:00

abstract：:Naturally transformable bacteria acquire chromosomal DNA from related species at lower frequencies than from cognate DNA sources. To determine how genome location affects heterogamic transformation in bacteria, we inserted an nptI marker into random chromosome locations in 19 different strains of the Acinetobacter gen...

journal_title：Genetics

authors： Ray JL,Harms K,Wikmark OG,Starikova I,Johnsen PJ,Nielsen KM

更新日期：2009-08-01 00:00:00