Epistatic control of non-Mendelian inheritance in mouse interspecific crosses.

Abstract:

:Strong deviation of allele frequencies from Mendelian inheritance favoring Mus spretus-derived alleles has been described previously for X-linked loci in four mouse interspecific crosses. We reanalyzed data for three of these crosses focusing on the location of the gene(s) controlling deviation on the X chromosome and the genetic basis for incomplete deviation. At least two loci control deviation on the X chromosome, one near Xist (the candidate gene controlling X inactivation) and the other more centromerically located. In all three crosses, strong epistasis was found between loci near Xist and marker loci on the central portion of chromosome 2. The mechanism for this deviation from Mendelian expectations is not yet known but it is probably based on lethality of embryos carrying particular combinations of alleles rather than true segregation distortion during oogenesis in F1 hybrid females.

journal_name

Genetics

journal_title

Genetics

authors

Montagutelli X,Turner R,Nadeau JH

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

1739-52

issue

4

eissn

0016-6731

issn

1943-2631

journal_volume

143

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Focused genetic recombination of bacteriophage t4 initiated by double-strand breaks.

    abstract::A model system for studying double-strand-break (DSB)-induced genetic recombination in vivo based on the ets1 segCDelta strain of bacteriophage T4 was developed. The ets1, a 66-bp DNA fragment of phage T2L containing the cleavage site for the T4 SegC site-specific endonuclease, was inserted into the proximal part of t...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shcherbakov V,Granovsky I,Plugina L,Shcherbakova T,Sizova S,Pyatkov K,Shlyapnikov M,Shubina O

    更新日期:2002-10-01 00:00:00

  • Regulation of syrM and nodD3 in Rhizobium meliloti.

    abstract::The early steps of symbiotic nodule formation by Rhizobium on plants require coordinate expression of several nod gene operons, which is accomplished by the activating protein NodD. Three different NodD proteins are encoded by Sym plasmid genes in Rhizobium meliloti, the alfalfa symbiont. NodD1 and NodD2 activate nod ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Swanson JA,Mulligan JT,Long SR

    更新日期:1993-06-01 00:00:00

  • Inheritance of the 2 micrometer m DNA plasmid from Saccharomyces.

    abstract::A variety of Saccharomyces strains were examined for the presence of 2micro DNA and, if present, for the pattern of fragments produced by its digestion with site-specific (restriction) endonucleases. Two strains were found that did not contain detectable levels of 2micro DNA, and two strains contained 2micro DNA molec...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Livingston DM

    更新日期:1977-05-01 00:00:00

  • Selfish genes, pleiotropy and the origin of recombination.

    abstract::If multiple linked polymorphisms are under natural selection, then conflicts arise and the efficiency of natural selection is hindered relative to the case of no linkage. This simple interaction between linkage and natural selection creates an opportunity for mutations that raise the level of recombination to increase...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hey J

    更新日期:1998-08-01 00:00:00

  • Mapping quantitative trait loci for milk production and health of dairy cattle in a large outbred pedigree.

    abstract::Quantitative trait loci (QTL) affecting milk production and health of dairy cattle were mapped in a very large Holstein granddaughter design. The analysis included 1794 sons of 14 sires and 206 genetic markers distributed across all 29 autosomes and flanking an estimated 2497 autosomal cM using Kosambi's mapping funct...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Zhang Q,Boichard D,Hoeschele I,Ernst C,Eggen A,Murkve B,Pfister-Genskow M,Witte LA,Grignola FE,Uimari P,Thaller G,Bishop MD

    更新日期:1998-08-01 00:00:00

  • Analysis of a mutant exhibiting conditional sorting to dense core secretory granules in Tetrahymena thermophila.

    abstract::The formation of dense core granules (DCGs) requires both the sorting of granule contents from other secretory proteins and a postsorting maturation process. The Tetrahymena thermophila strain SB281 fails to synthesize DCGs, and previous analysis suggested that the defect lay at or near the sorting step. Because this ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bowman GR,Turkewitz AP

    更新日期:2001-12-01 00:00:00

  • The homozygosity test after a change in population size.

    abstract::The homozygosity of a population will be influenced by any recent change in the population size. The "homozygosity test" of the neutral mutation hypothesis might also be influenced by a population change. A computer simulation method is described that establishes the significance levels of observed homozygosities afte...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Watterson GA

    更新日期:1986-04-01 00:00:00

  • Clines with variable migration.

    abstract::The consequences of a discontinuity in the migration rate and of a geographical barrier in the habitat are studied in a diffusion model of migration and selection. The treatment is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is supposed further that...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Nagylaki T

    更新日期:1976-08-01 00:00:00

  • Two alternative transcripts coding for alcohol dehydrogenase accumulate with different developmental specificities in different species of picture-winged Drosophila.

    abstract::Two alternate transcripts of the single copy Alcohol dehydrogenase (Adh) gene accumulate with developmental specificity in all of 12 species of Hawaiian picture-winged Drosophila which have been examined. Relative to the paradigm species D. affinidisjuncta, the Adh transcript normally restricted to larvae is found to ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Rowan RG,Dickinson WJ

    更新日期:1986-10-01 00:00:00

  • Spontaneous mutation in Escherichia coli containing the dnaE911 DNA polymerase antimutator allele.

    abstract::We have previously isolated mutants of Escherichia coli that replicate their DNA with increased fidelity. These mutants have a mutation in the dnaE gene, encoding the alpha subunit of DNA polymerase III. They were isolated in a mismatch-repair-defective mutL background, in which mutations can be considered to represen...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Oller AR,Schaaper RM

    更新日期:1994-10-01 00:00:00

  • Artificial and epigenetic regulation of the I factor, a nonviral retrotransposon of Drosophila melanogaster.

    abstract::The I factor (IF) is a LINE-like transposable element from Drosophila melanogaster. IF is silenced in most strains, but under special circumstances its transposition can be induced and correlates with the appearance of a syndrome of female sterility called hybrid dysgenesis. To elucidate the relationship between IF ex...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Gauthier E,Tatout C,Pinon H

    更新日期:2000-12-01 00:00:00

  • Needs and targets for the multi sex combs gene product in Drosophila melanogaster.

    abstract::We have analyzed the requirements for the multi sex combs (mxc) gene during development to gain further insight into the mechanisms and developmental processes that depend on the important trans-regulators forming the Polycomb group (PcG) in Drosophila melanogaster. mxc is allelic with the tumor suppressor locus letha...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Saget O,Forquignon F,Santamaria P,Randsholt NB

    更新日期:1998-08-01 00:00:00

  • Gene deletions by ends-in targeting in Drosophila melanogaster.

    abstract::Following the advent of a gene targeting technique in Drosophila, different methods have been developed to modify the Drosophila genome. The initial demonstration of gene targeting in flies used an ends-in method, which generates a duplication of the target locus. The duplicated locus can then be efficiently reduced t...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.030882

    authors: Xie HB,Golic KG

    更新日期:2004-11-01 00:00:00

  • Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster.

    abstract::This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screeni...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Eberl DF,Hilliker AJ

    更新日期:1988-01-01 00:00:00

  • GIT1, a gene encoding a novel transporter for glycerophosphoinositol in Saccharomyces cerevisiae.

    abstract::Phosphatidylinositol catabolism in Saccharomyces cerevisiae cells cultured in media containing inositol results in the release of glycerophosphoinositol (GroPIns) into the medium. As the extracellular concentration of inositol decreases with growth, the released GroPIns is transported back into the cell. Exploiting th...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Patton-Vogt JL,Henry SA

    更新日期:1998-08-01 00:00:00

  • Temporal allele frequency change and estimation of effective size in populations with overlapping generations.

    abstract::In this paper we study the process of allele frequency change in finite populations with overlapping generations with the purpose of evaluating the possibility of estimating the effective size from observations of temporal frequency shifts of selectively neutral alleles. Focusing on allele frequency changes between su...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Jorde PE,Ryman N

    更新日期:1995-02-01 00:00:00

  • Intragenic Suppression at the b2 Locus in ASCOBOLUS IMMERSUS. II. Characteristics of the Mutations in Groups A and E.

    abstract::The present report is a study of 60 intragenic suppressors located in the A or E group of the b2 spore-color locus of Ascobolus immersus. The frameshift nature of the suppressors was shown by 19 combinations of plus and minus suppressor mutations. The location of the mutation sites on the genetic map of group A was de...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Leblon G

    更新日期:1979-08-01 00:00:00

  • Normal female germ cell differentiation requires the female X chromosome to autosome ratio and expression of sex-lethal in Drosophila melanogaster.

    abstract::In somatic cells of Drosophila, the ratio of X chromosomes to autosomes (X:A ratio) determines sex and dosage compensation. The present paper addresses the question of whether germ cells also use the X:A ratio for sex determination and dosage compensation. Triploid female embryos were generated which, through the loss...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Schüpbach T

    更新日期:1985-03-01 00:00:00

  • Epistasis for fitness-related quantitative traits in Arabidopsis thaliana grown in the field and in the greenhouse.

    abstract::The extent to which epistasis contributes to adaptation, population differentiation, and speciation is a long-standing and important problem in evolutionary genetics. Using recombinant inbred (RI) lines of Arabidopsis thaliana grown under natural field conditions, we have examined the genetic architecture of fitness-c...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.046078

    authors: Malmberg RL,Held S,Waits A,Mauricio R

    更新日期:2005-12-01 00:00:00

  • A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae.

    abstract::Transcriptional silencing in the budding yeast Saccharomyces cerevisiae may be linked to DNA replication and cell cycle progression. In this study, we have surveyed the effect of 41 mutations in genes with a role in replication, the cell cycle, and DNA repair on silencing at HMR. Mutations in PCNA (POL30), RF-C (CDC44...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ehrenhofer-Murray AE,Kamakaka RT,Rine J

    更新日期:1999-11-01 00:00:00

  • Co-segregation of intermale aggression with the pseudoautosomal region of the Y chromosome in mice.

    abstract::The sexual dimorphism of aggression has led to a search for its Y chromosomal correlates. We have previously confirmed that initiation of attack behavior against a conspecific male is Y-dependent in two strains of laboratory mice (NZB and CBA/H). We provide evidence that the non-pseudoautosomal region of the Y is not ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Roubertoux PL,Carlier M,Degrelle H,Haas-Dupertuis MC,Phillips J,Moutier R

    更新日期:1994-01-01 00:00:00

  • Multiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein.

    abstract::The TATA-binding protein (TBP) is composed of a highly conserved core domain sufficient for TATA-element binding and preinitiation complex formation as well as a highly divergent N-terminal region that is dispensable for yeast cell viability. In vitro, removal of the N-terminal region domain enhances TBP-TATA associat...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Lee M,Struhl K

    更新日期:2001-05-01 00:00:00

  • Distinct steps in yeast spore morphogenesis require distinct SMK1 MAP kinase thresholds.

    abstract::The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Wagner M,Briza P,Pierce M,Winter E

    更新日期:1999-04-01 00:00:00

  • Isozyme allelic frequencies related to selection and gene-flow hypotheses.

    abstract::Significant correlations between allelic frequencies and environmental variables in a number of insect species have been demonstrated by multivariate techniques. Since many environmental variables show a strong relationship to geographic location and since gene flow between populations can also produce patterns of gen...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Schaffer HE,Johnson FM

    更新日期:1974-05-01 00:00:00

  • Identification of an alternative oxidase induction motif in the promoter region of the aod-1 gene in Neurospora crassa.

    abstract::The nuclear aod-1 gene of Neurospora crassa encodes the alternative oxidase and is induced when the standard cytochrome-mediated respiratory chain of mitochondria is inhibited. To study elements of the pathway responsible for alternative oxidase induction, we generated a series of mutations in the region upstream from...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.068635

    authors: Chae MS,Lin CC,Kessler KE,Nargang CE,Tanton LL,Hahn LB,Nargang FE

    更新日期:2007-04-01 00:00:00

  • High intake of dietary sugar enhances bisphenol A (BPA) disruption and reveals ribosome-mediated pathways of toxicity.

    abstract::Bisphenol A (BPA) is an organic compound to which human populations are ubiquitously exposed. Epidemiological data suggest BPA exposure might be associated with higher rates of diabetes and reproductive anomalies. Health concerns also include transgenerational consequences, but these mechanisms are crudely defined. Si...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.114.163170

    authors: Branco AT,Lemos B

    更新日期:2014-05-01 00:00:00

  • Maize adaptation to temperate climate: relationship between population structure and polymorphism in the Dwarf8 gene.

    abstract::To investigate the genetic basis of maize adaptation to temperate climate, collections of 375 inbred lines and 275 landraces, representative of American and European diversity, were evaluated for flowering time under short- and long-day conditions. The inbred line collection was genotyped for 55 genomewide simple sequ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.048603

    authors: Camus-Kulandaivelu L,Veyrieras JB,Madur D,Combes V,Fourmann M,Barraud S,Dubreuil P,Gouesnard B,Manicacci D,Charcosset A

    更新日期:2006-04-01 00:00:00

  • Comparative effects of pollen and seed migration on the cytonuclear structure of plant populations. I. Maternal cytoplasmic inheritance.

    abstract::We explicitly solve and analyze a series of deterministic continent-island models to delimit the effects of pollen and seed migration on cytonuclear frequencies and disequilibria in random-mating, mixed-mating and self-fertilized populations. Given the critical assumption of maternal cytoplasmic inheritance, five majo...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Asmussen MA,Schnabel A

    更新日期:1991-07-01 00:00:00

  • Synaptonemal complex and recombination nodules in wild-type Drosophila melanogaster females.

    abstract::Electron microscope serial section reconstruction analysis of all zygotene-pachytene nuclei of meiotic cells from three wild-type germaria (a subunit of the ovary containing the early meiotic stages arrayed in temporal developmental sequence) of Drosophila melanogaster females corroborates and extends earlier observat...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Carpenter AT

    更新日期:1979-06-01 00:00:00

  • Spe3, which encodes spermidine synthase, is required for full repression through NRE(DIT) in Saccharomyces cerevisiae.

    abstract::We previously identified a transcriptional regulatory element, which we call NRE(DIT), that is required for repression of the sporulation-specific genes, DIT1 and DIT2, during vegetative growth of Saccharomyces cerevisiae. Repression through this element is dependent on the Ssn6-Tup1 corepressor. In this study, we sho...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Friesen H,Tanny JC,Segall J

    更新日期:1998-09-01 00:00:00