Abstract：
:We have studied the natural variation at microsatellite loci in two African and five non-African populations of Drosophila melanogaster. Ten dinucleotide simple sequence loci were cloned from chromosomally mapped P1 clones and typed for single individuals from isofemale lines of the respective populations. We find that the African populations harbor the largest degree of diversity, while the non-African populations show a lower diversity. This supports previous results that D. melanogaster originated in Africa and spread across the rest of the world in historic times. Using genetic distance measures, we find also a distinct population subdivision between the non-African populations. Most interestingly, we find for some loci in some populations a strongly reduced variability, which cannot be explained by bottleneck effects. Employing a conservative test based on the variance in repeat number, we find that at least one locus in one population deviates significantly from the expectations of mutation-drift equilibrium. We suggest that this may be due to a recent selective sweep in this chromosomal region that may have been caused by a linked locus that was involved in local adaptation of the population.
journal_name
Geneticsjournal_title
Geneticsauthors
Schlötterer C,Vogl C,Tautz Dsubject
Has Abstractpub_date
1997-05-01 00:00:00pages
309-20issue
1eissn
0016-6731issn
1943-2631journal_volume
146pub_type
杂志文章相关文献
GENETICS文献大全abstract：:The Drosophila gene exuperantia (exu) is a maternal effect gene which is needed for proper localization of the bcd RNA during the formation of oocytes. We have extended the characterization of the exu phenotype and find that the gene functions in the male as well as the female germline. Six of seven exu alleles are ma...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and mapped two of the mu...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.092775
更新日期：2008-12-01 00:00:00
abstract：:It is well known that an allele causing increased recombination is expected to proliferate as a result of genetic drift in a finite population undergoing selection, without requiring other mechanisms. This is supported by recent simulations apparently demonstrating that, in small populations, drift is more important t...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the widely conserved histone variant CENP-A. Mutations in kinetochore proteins of the fission yeast Schizosaccharomyces pom...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.300183
更新日期：2017-10-01 00:00:00
abstract：:Mutants resistant to selenomethionine were isolated, and their properties studied. Mapping studies indicate that the mutation sites are located near the eth-1(r) locus in linkage group I, about ten map units away from the mating type locus. The sites of new mutation are either allelic to or very close to eth-1(r). The...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-08-01 00:00:00
abstract：:This paper draws attention to the formal parallelism that exists between chromosomal-loss mosaicism and mutagenically induced mosaicism in Drosophila and suggests that, although the underlying processes by which these two types of genetic mosaics are generated are very different, the more refined methodology employed ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-08-01 00:00:00
abstract：:We report the results of a genetic screen designed to identify transcriptional coregulators of yeast heat-shock factor (HSF). This sequence-specific activator is required to stimulate both basal and induced transcription; however, the identity of factors that collaborate with HSF in governing noninduced heat-shock gen...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.052738
更新日期：2006-04-01 00:00:00
abstract：:Three hundred and fifteen kilobases of DNA from the rosy-Ace region on chromosome 3R of D. melanogaster have previously been cloned and extensively characterized. We describe the isolation of nine new deficiency mutants that break within the 315-kb interval. The position of these breakpoints on the DNA map was determi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:While mitochondria are renowned for their role in energy production, they also perform several other integral functions within the cell. Thus, it is not surprising that mitochondrial dysfunction can negatively impact cell viability. Although mitochondria have received an increasing amount of attention in recent years,...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.117200
更新日期：2010-08-01 00:00:00
abstract：:Among a large number of homologous gene clusters in C. elegans, two gene families that appear to undergo concerted evolution were studied in detail. Both gene families are nematode specific and encode small secreted proteins of unknown function. For both families in three Caenorhabditis species, concerted groups of ge...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.052746
更新日期：2006-04-01 00:00:00
abstract：:Genetic studies of multidimensional phenotypes can potentially link genetic variation, gene expression, and physiological data to create multi-scale models of complex traits. The challenge of reducing these data to specific hypotheses has become increasingly acute with the advent of genome-scale data resources. Multi-...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.198051
更新日期：2017-06-01 00:00:00
abstract：:Homolog recombination and unequal sister chromatid recombination were monitored in rad1-1/rad1-1 diploid yeast cells deficient for excision repair, and in control cells, RAD1/rad1-1, after exposure to UV irradiation. In a rad1-1/rad1-1 diploid, UV irradiation stimulated much more sister chromatid recombination relativ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:In a subdivided population, the interaction between natural selection and stochastic change in allele frequency is affected by the occurrence of local extinction and subsequent recolonization. The relative importance of selection can be diminished by this additional source of stochastic change in allele frequency. Res...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.166.2.1105
更新日期：2004-02-01 00:00:00
abstract：:We have identified a new locus involved in gibberellin (GA) signal transduction by screening for suppressors of the Arabidopsis thaliana GA biosynthetic mutant gal-3. The locus is named RGA for repressor of gal-3. Based on the recessive phenotype of the digenic rga/gal-3 mutant, the wild-type gene product of RGA is pr...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:The primary structures of peptides may be adapted for efficient synthesis as well as proper function. Here, the Saccharomyces cerevisiae genome sequence, DNA microarray expression data, tRNA gene numbers, and functional categorizations of proteins are employed to determine whether the amino acid composition of peptide...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:Combined with a system for identifying each of the chromosomes in a genome, visualizing the location of individual genetic loci by fluorescence in situ hybridization (FISH) would aid in assembling physical and genetic maps. Previously, large genomic clones have been successfully used as FISH probes onto somatic chromo...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.065573
更新日期：2007-03-01 00:00:00
abstract：:We have studied a genome-wide set of single-nucleotide polymorphism (SNP) allele frequency measures for African-American, East Asian, and European-American samples. For this analysis we derived a simple, closed mathematical formulation for the spectrum of expected allele frequencies when the sampled populations have e...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.166.1.351
更新日期：2004-01-01 00:00:00
abstract：:A wheat (Triticum aestivum L. emend Thell) disomic addition line (2n = 6x = 44), SH1-152-2, with a pair of Elytrigia pontica (Podp.) Holub 2n = 10x = 70 [syn. Agropyron elongatum (Host) P.B.] chromosomes controlling blue aleurone color was crossed with a short-statured spring wheat ;Sonora 64' (T. aestivum). Isoline p...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：:Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae Within the yeast rDNA locus, Sir2 is required for efficient cohesin recruitment and maintaining the stability of the tandem a...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302047
更新日期：2019-05-01 00:00:00
abstract：:DNA sequence analysis and genetic mapping of loci from mating-type-specific chromosomes of the smut fungus Microbotryum violaceum demonstrated that the nonrecombining mating-type-specific region in this species comprises approximately 25% ( approximately 1 Mb) of the chromosome length. Divergence between homologous ma...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.103192
更新日期：2009-08-01 00:00:00
abstract：:Bacteriophage T4 cytosine-containing DNA is cleaved at a single site by the restriction endonuclease, Bam H1. The site lies within the late region of the T4 genome, close to, or within, gene 8, one of the structural genes of the phage particle baseplate. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
abstract：:The morphogenetic pathway of bacteriophage phi X 174 was investigated in rep mutant hosts that specifically block stage III single-stranded DNA synthesis. The defects conferred by the mutant rep protein most likely affect the formation or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:The specification of floral organ identity in the higher dicots depends on the function of a limited set of homeotic genes, many of them members of the MADS-box gene family. Two such genes, APETALA3 (AP3) and PISTILLATA (PI), are required for petal and stamen identity in Arabidopsis; their orthologs in Antirrhinum exh...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:The distribution of fitness effects of new mutations (DFE) is important for addressing several questions in genetics, including the nature of quantitative variation and the evolutionary fate of small populations. Properties of the DFE can be inferred by comparing the distributions of the frequencies of segregating nuc...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.080663
更新日期：2007-12-01 00:00:00
abstract：:To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cre-drivers) that restrict expression to specific cell types. To addres...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.301984
更新日期：2019-04-01 00:00:00
abstract：:Three previously described genes, enhancer of yellow, 1, 2 and 3, are shown to cooperate with the zeste gene in the control of white gene expression. The mutations e(y)1u1, e(y)3u1, and to a lesser extent e(y)2u1, enhance the effect of the zeste null allele zv77h. Different combinations of e(y)1u1, e(y)2u1 and e(y)3u1...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:Smg1 is a key component of nonsense-mediated decay (NMD) in Caenorhabditis elegans and mammals. Here we report that two nonsense alleles of the ortholog of Smg1 do not affect NMD in Drosophila melanogaster. ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.045674
更新日期：2005-09-01 00:00:00
abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.300139
更新日期：2017-10-01 00:00:00
abstract：:Catfish is the major aquaculture species in the United States. The hybrid catfish produced by crossing channel catfish females with blue catfish males exhibit a number of desirable production traits, but their mass production has been difficult. To introduce desirable genes from blue catfish into channel catfish throu...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：:A number of fundamental processes comprise the cell division cycle, including spindle formation, chromosome segregation, and cytokinesis. Our current understanding of these processes has benefited from the isolation and analysis of mutants, with the meiotic divisions in the male germline of Drosophila being particular...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
