Drosophila signal peptide peptidase is an essential protease for larval development.

Abstract:

:We identified the Drosophila melanogaster Signal peptide peptidase gene (Spp) that encodes a multipass transmembrane aspartyl protease. Drosophila SPP is homologous to the human signal peptide peptidase (SPP) and is distantly related to the presenilins. We show that, like human SPP, Drosophila SPP can proteolyze a model signal peptide and is sensitive to an SPP protease inhibitor and that it localizes to the endoplasmic reticulum. Expression of Drosophila SPP was first apparent at germ band extension, and in late embryos it was robust in the salivary glands, proventriculus, and tracheae. Flies bearing mutations in conserved residues or carrying deficiencies for the Spp gene had defective tracheae and died as larvae.

journal_name

Genetics

journal_title

Genetics

authors

Casso DJ,Tanda S,Biehs B,Martoglio B,Kornberg TB

doi

10.1534/genetics.104.039933

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

139-48

issue

1

eissn

0016-6731

issn

1943-2631

pii

genetics.104.039933

journal_volume

170

pub_type

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