Abstract：
:Chromatin insulators separate active from repressed chromatin domains. In yeast the RNA pol III transcription machinery bound to tRNA genes function with histone acetylases and chromatin remodelers to restrict the spread of heterochromatin. Our results collectively demonstrate that binding of TFIIIC is necessary for insulation but binding of TFIIIB along with TFIIIC likely improves the probability of complex formation at an insulator. Insulation by this transcription factor occurs in the absence of RNA polymerase III or polymerase II but requires specific histone acetylases and chromatin remodelers. This analysis identifies a minimal set of factors required for insulation.
journal_name
Geneticsjournal_title
Geneticsauthors
Valenzuela L,Dhillon N,Kamakaka RTdoi
10.1534/genetics.109.106203subject
Has Abstractpub_date
2009-09-01 00:00:00pages
131-48issue
1eissn
0016-6731issn
1943-2631pii
genetics.109.106203journal_volume
183pub_type
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