Bipartite structure of the 5S ribosomal gene family in a Drosophila melanogaster strain, and its evolutionary implications.

abstract：:The results from a simulation model of selection, mutation and genetic drift in a geographically subdivided population are presented. The infinite-alleles mutation model of Kimura and Crow (1964) is asumed, and both advantageous and deleterious mutations are considered. It is shown that the average frequency of an all...

journal_title：Genetics

authors： Slatkin M

更新日期：1981-10-01 00:00:00

abstract：:A consensus microsatellite-based linkage map of the turbot (Scophthalmus maximus) was constructed from two unrelated families. The mapping panel was derived from a gynogenetic family of 96 haploid embryos and a biparental diploid family of 85 full-sib progeny with known linkage phase. A total of 242 microsatellites we...

journal_title：Genetics

authors： Bouza C,Hermida M,Pardo BG,Fernández C,Fortes GG,Castro J,Sánchez L,Presa P,Pérez M,Sanjuán A,de Carlos A,Alvarez-Dios JA,Ezcurra S,Cal RM,Piferrer F,Martínez P

更新日期：2007-12-01 00:00:00

abstract：:A lethal locus (l(2)br7;35B6-10), near Adh on chromosome arm 2L of D. melanogaster, is identified with Plunkett's dominant suppressor of Hairless (H). Of eight new alleles, seven act as dominant suppressors of H, the eighth is a dominant enhancer of H. One of the suppressor alleles is both a leaky lethal and a weak s...

journal_title：Genetics

authors： Ashburner M

更新日期：1982-07-01 00:00:00

abstract：:Protein E, the lysis protein of bacteriophage phiX174, is a specific inhibitor of MraY, the phospho-MurNAc-pentapeptide translocase that catalyzes the synthesis of lipid I in the conserved pathway for peptidoglycan biosynthesis. The original evidence for this inhibition was the isolation of two spontaneous E-resistanc...

journal_title：Genetics

authors： Zheng Y,Struck DK,Bernhardt TG,Young R

更新日期：2008-11-01 00:00:00

abstract：:We report the identification of bang senseless (bss), a Drosophila melanogaster mutant exhibiting seizure-like behaviors, as an allele of the paralytic (para) voltage-gated Na(+) (Na(V)) channel gene. Mutants are more prone to seizure episodes than normal flies because of a lowered seizure threshold. The bss phenotype...

journal_title：Genetics

authors： Parker L,Padilla M,Du Y,Dong K,Tanouye MA

更新日期：2011-02-01 00:00:00

abstract：:The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencin...

journal_title：Genetics

authors： Kirby A,Kang HM,Wade CM,Cotsapas C,Kostem E,Han B,Furlotte N,Kang EY,Rivas M,Bogue MA,Frazer KA,Johnson FM,Beilharz EJ,Cox DR,Eskin E,Daly MJ

更新日期：2010-07-01 00:00:00

abstract：:Understanding variation in allele frequencies across populations is a central goal of population genetics. Classical models for the distribution of allele frequencies, using forward simulation, coalescent theory, or the diffusion approximation, have been applied extensively for demographic inference, medical study des...

journal_title：Genetics

authors： Jouganous J,Long W,Ragsdale AP,Gravel S

更新日期：2017-07-01 00:00:00

abstract：:Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activi...

journal_title：Genetics

authors： Allen AT,Maher KN,Wani KA,Betts KE,Chase DL

更新日期：2011-07-01 00:00:00

abstract：:The shibire locus of Drosophila melanogaster encodes dynamin, a GTPase required for the fission of endocytic vesicles from plasma membrane. Biochemical studies indicate that mammalian dynamin is part of a complex containing multiple dynamin subunits and other polypeptides. To gain insight into sequences of dynamin cri...

journal_title：Genetics

authors： Grant D,Unadkat S,Katzen A,Krishnan KS,Ramaswami M

更新日期：1998-06-01 00:00:00

abstract：:Data for Apis mellifera indicate that the P-3 proteins and one esterase enzyme are controlled by two genes, P-3 and Est, with two alleles each. The frequency of the P-3 alleles is different in the two subspecies (adansonii and ligustica), that for P-3(F) in Italian bees being 46.9% and in African 0.5%. The frequency o...

journal_title：Genetics

authors： Mestriner MA,Contel EP

更新日期：1972-12-01 00:00:00

abstract：:Hybrid sterility is a common form of reproductive isolation between nascent species. Although hybrid sterility is routinely documented and genetically dissected in speciation studies, its developmental basis is rarely examined, especially in generations beyond the F1 generation. To identify phenotypic and genetic dete...

journal_title：Genetics

authors： Schwahn DJ,Wang RJ,White MA,Payseur BA

更新日期：2018-12-01 00:00:00

abstract：:Genetic adaptation to external stimuli occurs through the combined action of mutation and selection. A central problem in genetics is to identify loci responsive to specific selective constraints. Many tests have been proposed to identify the genomic signatures of natural selection by quantifying the skew in the site ...

journal_title：Genetics

authors： Ronen R,Udpa N,Halperin E,Bafna V

更新日期：2013-09-01 00:00:00

abstract：:The sexual dimorphism of aggression has led to a search for its Y chromosomal correlates. We have previously confirmed that initiation of attack behavior against a conspecific male is Y-dependent in two strains of laboratory mice (NZB and CBA/H). We provide evidence that the non-pseudoautosomal region of the Y is not ...

journal_title：Genetics

authors： Roubertoux PL,Carlier M,Degrelle H,Haas-Dupertuis MC,Phillips J,Moutier R

更新日期：1994-01-01 00:00:00

abstract：:Frequent nonhomologous recombination has been previously postulated to explain the 1045-bp insertion in one mitochondrial sperm-transmitted haplotype of Mytilus galloprovincialis. Such recombination would lead to the disruption of gene order and so the existence of a specific mechanism for maintaining the same gene or...

journal_title：Genetics

authors： Burzyński A

更新日期：2007-02-01 00:00:00

abstract：:Mutation of a CCG sequence in the 5'-untranslated region of the mitochondrially encoded cytochrome b mRNA in Saccharomyces cerevisiae results in destabilization of the message and respiratory deficiency of the mutant strain. This phenotype mimics that of a mutation in the nuclear CBP1 gene. Here it is shown that overe...

journal_title：Genetics

authors： Ellis TP,Schonauer MS,Dieckmann CL

更新日期：2005-11-01 00:00:00

abstract：:Spontaneous tandem chromosomal duplications are common in populations of Escherichia coli and Salmonella typhimurium. They range in frequency for a given locus from 10(-2) to 10(-4) and probably form by RecA-dependent unequal sister strand exchanges between repetitive sequences in direct order. Certain duplications ha...

journal_title：Genetics

authors： Haack KR,Roth JR

更新日期：1995-12-01 00:00:00

abstract：:Progress in understanding the evolution of variation at the MHC has been slowed by an inability to assess the relative roles of mutation vs. intragenic recombination in contributing to observed polymorphism. Recent theoretical advances now permit a quantitative treatment of the problem, with the result that the amount...

journal_title：Genetics

authors： Richman AD,Herrera LG,Nash D

更新日期：2003-05-01 00:00:00

abstract：:We propose a simple algorithm for estimating the number of nucleotide differences between a pair of RNA or DNA sequences through comparison of their RNAse A mismatch cleavage patterns. In the RNAse A mismatch cleavage technique two or more sample sequences are hybridized to the same RNA probe, the hybrids are partiall...

journal_title：Genetics

authors： Rzhetsky A,Dopazo J,Snyder E,Dangler CA,Ayala FJ

更新日期：1996-12-01 00:00:00

abstract：:The ability of a virus population to colonize a novel host is predicted to depend on the equilibrium frequency of potential colonists (i.e., genotypes capable of infecting the novel host) in the source population. In this study, we investigated the determinants of the equilibrium frequency of potential colonists in th...

journal_title：Genetics

authors： Ferris MT,Joyce P,Burch CL

更新日期：2007-06-01 00:00:00

abstract：:Bacteriophages are the most abundant biological entities in our biosphere, characterized by their hyperplasticity, mosaic composition, and the many unknown functions (ORFans) encoded by their immense genetic repertoire. These genes are potentially maintained by the bacteriophage to allow efficient propagation on hosts...

journal_title：Genetics

authors： Ang D,Georgopoulos C

更新日期：2012-03-01 00:00:00

abstract：:The nuclear envelope in Saccharomyces cerevisiae harbors two essential macromolecular protein assemblies: the nuclear pore complexes (NPCs) that enable nucleocytoplasmic transport, and the spindle pole bodies (SPBs) that mediate chromosome segregation. Previously, based on metazoan and budding yeast studies, we report...

journal_title：Genetics

authors： Casey AK,Dawson TR,Chen J,Friederichs JM,Jaspersen SL,Wente SR

更新日期：2012-10-01 00:00:00

abstract：:Some populations of maize's closest relatives, the annual teosintes of Mexico, are unreceptive to maize pollen. When present in the pistil (silk and ovary) a number of maize genes discriminate against or exclude pollen not carrying the same allele. An analogous gene Tcb1-s was found in some teosinte populations but no...

journal_title：Genetics

authors： Kermicle JL

更新日期：2006-01-01 00:00:00

abstract：:Natural selection favors alleles that increase the number of offspring produced by their carriers. But in a world that is inherently uncertain within generations, selection also favors alleles that reduce the variance in the number of offspring produced. If previous studies have established this principle, they have l...

journal_title：Genetics

authors： Mullon C,Reuter M,Lehmann L

更新日期：2014-01-01 00:00:00

abstract：:The Pif1 family of DNA helicases is conserved from yeast to humans. Although the helicase domains of family members are well conserved, the amino termini of these proteins are not. The Saccharomyces cerevisiae genome encodes two Pif1 family members, Rrm3p and Pif1p, that have very different functions. To determine if ...

journal_title：Genetics

authors： Bessler JB,Zakian VA

更新日期：2004-11-01 00:00:00

abstract：:We describe here a new variant of transposon Tn10 especially adapted for transposon analysis of cloned yeast genes; it can equally well be used for analysis of prokaryotic genes. We have applied this element to analysis of the LEU2, RAD50, and CDC48 genes of Saccharomyces cerevisiae. This transposon, nicknamed mini-Tn...

journal_title：Genetics

authors： Huisman O,Raymond W,Froehlich KU,Errada P,Kleckner N,Botstein D,Hoyt MA

更新日期：1987-06-01 00:00:00

abstract：:Previous association analyses showed that variation at major regulatory genes contributes to standing variation for complex traits in Balsas teosinte, the progenitor of maize. This study expands our previous association mapping effort in teosinte by testing 123 markers in 52 candidate genes for association with 31 tra...

journal_title：Genetics

authors： Weber AL,Briggs WH,Rucker J,Baltazar BM,de Jesús Sánchez-Gonzalez J,Feng P,Buckler ES,Doebley J

更新日期：2008-10-01 00:00:00

abstract：:Nonallelic gene conversion has been proposed as a major force in homogenizing the sequences of paralogous genes. In this work, we investigate the extent and characteristics of gene conversion among gene families in nine species of the genus Drosophila. We carried out a genome-wide study of 2855 gene families (includin...

journal_title：Genetics

authors： Casola C,Ganote CL,Hahn MW

更新日期：2010-05-01 00:00:00

abstract：:The mitochondrial genotype of all F(1) female offspring (426 individuals) of a single Drosophila mauritiana female, heteroplasmic for two types of mtDNA (a short and a long genome), was established. All descendants were heteroplasmic. The earliest eggs laid by this female show the cytoplasmic genetic structure of ovar...

journal_title：Genetics

authors： Solignac M,Génermont J,Monnerot M,Mounolou JC

更新日期：1987-12-01 00:00:00

abstract：:Adaptive introgression is common in nature and can be driven by selection acting on multiple, linked genes. We explore the effects of polygenic selection on introgression under the infinitesimal model with linkage. This model assumes that the introgressing block has an effectively infinite number of loci, each with an...

journal_title：Genetics

authors： Sachdeva H,Barton NH

更新日期：2018-08-01 00:00:00

abstract：:An article by Singh and colleagues in this issue of GENETICS quantifies variation in recombination rate across a small region of the Drosophila melanogaster genome, providing an opportunity for instructors of genetics to introduce or reinforce important concepts such as recombination and recombination rate variation, ...

journal_title：Genetics

authors： Heil CS,Noor MA

更新日期：2013-06-01 00:00:00