CBT1 interacts genetically with CBP1 and the mitochondrially encoded cytochrome b gene and is required to stabilize the mature cytochrome b mRNA of Saccharomyces cerevisiae.

abstract：:We developed a screening approach that utilizes an inverse polymerase chain reaction (PCR) to detect P element insertions in or near previously cloned genes in Drosophila melanogaster. We used this approach in a large scale genetic screen in which P elements were mobilized from sites on the X chromosome to new autosom...

journal_title：Genetics

authors： Dalby B,Pereira AJ,Goldstein LS

更新日期：1995-02-01 00:00:00

abstract：:Dosage compensation in Drosophila has been studied at the steady state RNA level for several single-copy genes; however, an important point is addressed by analyzing a repetitive, transposable element for dosage compensation. The two issues of gene-specific cis control and genomic position can be studied by determinin...

journal_title：Genetics

authors： Hiebert JC,Birchler JA

更新日期：1992-03-01 00:00:00

abstract：:The term "micro-evo-devo" refers to the combined study of the genetic and developmental bases of natural variation in populations and the evolutionary forces that have shaped this variation. It thus represents a synthesis of the fields of evolutionary developmental biology and population genetics. As has been pointed ...

journal_title：Genetics

authors： Nunes MD,Arif S,Schlötterer C,McGregor AP

更新日期：2013-11-01 00:00:00

abstract：:We have examined the in vivo requirement of two recently identified nonessential components of the budding yeast anaphase-promoting complex, Swm1p and Mnd2p, as well as that of the previously identified subunit Apc9p. swm1Delta mutants exhibit synthetic lethality or conditional synthetic lethality with other APC/C sub...

journal_title：Genetics

authors： Page AM,Aneliunas V,Lamb JR,Hieter P

更新日期：2005-07-01 00:00:00

abstract：:Heterochromatin is a specialized chromatin structure in chromosomal regions associated with repeated DNA sequences and low concentrations of genes. Formation of heterochromatin is determined in large part by enzymes that modify histones and structural proteins that bind to these modified histones in a cooperative fash...

journal_title：Genetics

authors： Mason JM,Ransom J,Konev AY

更新日期：2004-11-01 00:00:00

abstract：:Mutations affecting the self-incompatibility response of Nicotiana alata were generated by irradiation. Mutants in the M1 generation were selected on the basis of pollen tube growth through an otherwise incompatible pistil. Twelve of the 18 M1 plants obtained from the mutagenesis screen were self-compatible. Eleven se...

journal_title：Genetics

authors： Golz JF,Su V,Clarke AE,Newbigin E

更新日期：1999-07-01 00:00:00

abstract：:Over 100 regulatory mutations linked to the histidine (his) operon of S. typhimurium have been isolated. They all map in a region estimated to be several hundred base pairs in length located at one end of the his operon ("the hisO region"). The mutations are located at sixteen recombinationally separable sites or are ...

journal_title：Genetics

authors： Ely B,Fankhauser DB,Hartman PE

更新日期：1974-10-01 00:00:00

abstract：:Using conditional probabilities and moment-generating matrices, I derived approximate algebraic equations that give expectations of gene frequency, population mean, gene frequency variance within lines, or heterozygosity, and gene frequency variance between lines, or drift, for repeated cycles of recurrent selection i...

journal_title：Genetics

authors： Silvela L

更新日期：1980-07-01 00:00:00

abstract：:We have examined the number of X-linked loci specifically required only during oogenesis. Complementation analyses among female-sterile (fs) mutations obtained in two mutagenesis screens--GANS' and MOHLER's--indicate that any fs locus represented by two or more mutant alleles in GANS' collection are usually present in...

journal_title：Genetics

authors： Perrimon N,Mohler D,Engstrom L,Mahowald AP

更新日期：1986-07-01 00:00:00

abstract：:A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar "heavily ...

journal_title：Genetics

authors： Birkner M,Blath J,Eldon B

更新日期：2013-01-01 00:00:00

abstract：:Twenty-two markers located on Muller's elements D or E have been mapped by in situ hybridization in six species of the obscura group of Drosophila and in D. melanogaster. The obscura species can be grouped into a Palearctic cluster (D. subobscura, D. madeirensis and D. guanche) and a Nearctic one (D. pseudoobscura, D....

journal_title：Genetics

authors： Segarra C,Ribó G,Aguadé M

更新日期：1996-09-01 00:00:00

abstract：:Primary cilia have essential roles in transducing signals in eukaryotes. At their core is the ciliary axoneme, a microtubule-based structure that defines cilium morphology and provides a substrate for intraflagellar transport. However, the extent to which axonemal microtubules are specialized for sensory cilium functi...

journal_title：Genetics

authors： Hurd DD,Miller RM,Núñez L,Portman DS

更新日期：2010-07-01 00:00:00

abstract：:TE146 is a giant transposon of Drosophila melanogaster. It carries two copies of the white and roughest genes, normally found on the X chromosome. The structure of this transposon has been studied at the molecular level. TE146 may transpose to new chromosome positions, excise and be lost from the genome or undergo int...

journal_title：Genetics

authors： Lovering R,Harden N,Ashburner M

更新日期：1991-06-01 00:00:00

abstract：:To identify genes regulating the development of the six touch receptor neurons, we screened the F(2) progeny of mutated animals expressing an integrated mec-2::gfp transgene that is expressed mainly in these touch cells. From 2638 mutated haploid genomes, we obtained 11 mutations representing 11 genes that affected th...

journal_title：Genetics

authors： Du H,Chalfie M

更新日期：2001-05-01 00:00:00

abstract：:Notch signaling pathways can be regulated through a variety of cellular mechanisms, and genetically compromised systems provide useful platforms from which to search for the responsible modulators. The Caenorhabditis elegans gene aph-1 encodes a component of γ-secretase, which is essential for Notch signaling events t...

journal_title：Genetics

authors： Hale VA,Guiney EL,Goldberg LY,Haduong JH,Kwartler CS,Scangos KW,Goutte C

更新日期：2012-03-01 00:00:00

abstract：:Mendelian loci that control the expression levels of transcripts are called expression quantitative trait loci (eQTL). When mapping eQTL, we often deal with thousands of expression traits simultaneously, which complicates the statistical model and data analysis. Two simple approaches may be taken in eQTL analysis: (1)...

journal_title：Genetics

authors： Jia Z,Xu S

更新日期：2007-05-01 00:00:00

abstract：:A correlation between diversity levels and rates of recombination is predicted both by models of positive selection, such as hitchhiking associated with the rapid fixation of advantageous mutations, and by models of purifying selection against strongly deleterious mutations (commonly referred to as "background selecti...

journal_title：Genetics

authors： Andolfatto P,Przeworski M

更新日期：2001-06-01 00:00:00

abstract：:Gene targeting using sequence insertion vectors generally results in integration of one copy of the targeting vector generating a tandem duplication of the cognate chromosomal region of homology. However, occasionally the target locus is found to contain >1 copy of the integrated vector. The mechanism by which the lat...

journal_title：Genetics

authors： Ng P,Baker MD

更新日期：1999-03-01 00:00:00

abstract：:Microsatellites are tandemly repeated short DNA sequences that are favored as molecular-genetic markers due to their high polymorphism index. Plant genomes characterized to date exhibit taxon-specific differences in frequency, genomic location, and motif structure of microsatellites, indicating that extant microsatell...

journal_title：Genetics

authors： Mun JH,Kim DJ,Choi HK,Gish J,Debellé F,Mudge J,Denny R,Endré G,Saurat O,Dudez AM,Kiss GB,Roe B,Young ND,Cook DR

更新日期：2006-04-01 00:00:00

abstract：:Selective genotyping and phenotyping strategies are used to lower the cost of quantitative trait locus studies. Their efficiency has been studied primarily in simplified contexts--when a single locus contributes to the phenotype, and when the residual error (phenotype conditional on the genotype) is normally distribut...

journal_title：Genetics

authors： Sen S,Johannes F,Broman KW

更新日期：2009-04-01 00:00:00

abstract：:The parentals of the interspecific cross Cucurbita maxima xC. ecuadorensis had different isozyme phenotypes for 12 enzyme systems. Characterization of the systems demonstrated that the expression and intracellular distribution of the isozymes were similar to those in other plant taxa; however, a considerable number of...

journal_title：Genetics

authors： Weeden NF,Robinson RW

更新日期：1986-10-01 00:00:00

abstract：:The presence of at least ten mouse LDH-A pseudogenes was demonstrated in the genomic blot analysis, and four different processed pseudogenes have thus far been isolated and characterized. In this report, the nucleotide sequences to two different mouse lactate dehydrogenase-A processed pseudogenes, M11 and M14, were de...

journal_title：Genetics

authors： Fukasawa KM,Tanimura M,Sakai I,Sharief FS,Chung FZ,Li SS

更新日期：1987-01-01 00:00:00

abstract：:The uaY gene encodes the transcriptional activator of purine catabolism genes in Aspergillus nidulans. uaY12 results in strongly defective growth on purines as nitrogen sources and in strongly diminished transcription of UaY-regulated genes. This mutation introduces an ATG codon 64 bp upstream of the uaY ATG, generati...

journal_title：Genetics

authors： Oestreicher N,Scazzocchio C

更新日期：2009-04-01 00:00:00

abstract：:Crossovers (COs) between homologous chromosomes are critical for meiotic chromosome segregation and form in the context of the synaptonemal complex (SC), a meiosis-specific structure that assembles between aligned homologs. During Caenorhabditis elegans meiosis, central region components of the SC (SYP proteins) are e...

journal_title：Genetics

authors： Cahoon CK,Helm JM,Libuda DE

更新日期：2019-10-01 00:00:00

abstract：:Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are...

journal_title：Genetics

authors： Thomas PE,Hutton JJ,Taylor BA

更新日期：1973-08-01 00:00:00

abstract：:Within the context of a conservation program the management of subdivided populations implies a compromise between the control of the global genetic diversity, the avoidance of high inbreeding levels, and, sometimes, the maintenance of a certain degree of differentiation between subpopulations. We present a dynamic an...

journal_title：Genetics

authors： Fernández J,Toro MA,Caballero A

更新日期：2008-05-01 00:00:00

abstract：:Sixteen inbred or partially inbred strains of rabbits were investigated for electrophoretic and quantitative variations of alpha-1-antitrypsin (A-1-AT). We found interindividual differences in the electrophoretic A-1-AT patterns as well as quantitative differences in the concentrations of A-1-AT and the serum trypsin-...

journal_title：Genetics

authors： Kueppers F,Lee CC,Fox RR,Mills JK

更新日期：1984-04-01 00:00:00

abstract：:When a local colonization in a new niche occurs, the new derived population should be subject to different selective pressures from that in the original parental population; consequently it is likely that many loci will be subject to directional selection. In such a quick adaptation event through environmental changes...

journal_title：Genetics

authors： Innan H,Kim Y

更新日期：2008-07-01 00:00:00

abstract：:As hamster scrapie cannot infect mice, due to sequence differences in their PrP proteins, we find "species barriers" to transmission of the [URE3] prion in Saccharomyces cerevisiae among Ure2 proteins of S. cerevisiae, paradoxus, bayanus, cariocanus, and mikatae on the basis of differences among their Ure2p prion doma...

journal_title：Genetics

authors： Edskes HK,McCann LM,Hebert AM,Wickner RB

更新日期：2009-03-01 00:00:00

abstract：:Distance- as well as marker-dependence of genetic recombination of bacteriophage T4 was studied in crosses between rIIB mutants with known base sequences. The notion of a "basic recombination," which is the recombination within distances shorter than hybrid DNA length in the absence of mismatch repair and any marker e...

journal_title：Genetics

authors： Shcherbakov VP,Plugina LA

更新日期：1991-08-01 00:00:00