Analysis of conditional genetic effects and variance components in developmental genetics.

Abstract:

:A genetic model with additive-dominance effects and genotype x environment interactions is presented for quantitative traits with time-dependent measures. The genetic model for phenotypic means at time t conditional on phenotypic means measured at previous time (t-1) is defined. Statistical methods are proposed for analyzing conditional genetic effects and conditional genetic variance components. Conditional variances can be estimated by minimum norm quadratic unbiased estimation (MINQUE) method. An adjusted unbiased prediction (AUP) procedure is suggested for predicting conditional genetic effects. A worked example from cotton fruiting data is given for comparison of unconditional and conditional genetic variances and additive effects.

journal_name

Genetics

journal_title

Genetics

authors

Zhu J

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

1633-9

issue

4

eissn

0016-6731

issn

1943-2631

journal_volume

141

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.

    abstract::To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Smit M,Segers K,Carrascosa LG,Shay T,Baraldi F,Gyapay G,Snowder G,Georges M,Cockett N,Charlier C

    更新日期:2003-01-01 00:00:00

  • Regulation of mating and meiosis in yeast by the mating-type region.

    abstract::A supposed sporulation-deficient mutation of Saccharomyces cerevisiae is found to affect mating in haploids and in diploids, and to be inseparable from the mating-type locus by recombination. The mutation is regarded as a defective a allele and is designated a*. This is confirmed by its dominance relations in diploids...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kassir Y,Simchen G

    更新日期:1976-02-01 00:00:00

  • The three-dimensional organization of polytene nuclei in male Drosophila melanogaster with compound XY or ring X chromosomes.

    abstract::The three-dimensional organization of polytene chromosomes within nuclei containing rearranged X chromosomes was examined in male Drosophila melanogaster. Salivary glands of third instar larvae containing either an inverted X chromosome (YSX.YL, In(1)EN/O) or a ring X chromosome (R(1) 2/BSYy+) were fixed, embedded, an...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Mathog D,Sedat JW

    更新日期:1989-02-01 00:00:00

  • Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.

    abstract::Immature spermatids from Caenorhabditis elegans are stimulated by an external activation signal to reorganize their membranes and cytoskeleton to form crawling spermatozoa. This rapid maturation, termed spermiogenesis, occurs without any new gene expression. To better understand this signal transduction pathway, we is...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Muhlrad PJ,Ward S

    更新日期:2002-05-01 00:00:00

  • Incorporation of competitive effects in forest tree or animal breeding programs.

    abstract::Competition among domesticated plants or animals can have a dramatic negative impact on yield of a stand or farm. The usual quantitative genetic model ignores these competitive interactions and could result in seriously incorrect breeding decisions and acerbate animal well-being. A general solution to this problem is ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.035956

    authors: Muir WM

    更新日期:2005-07-01 00:00:00

  • The Inheritance of Enzyme Variants for Tyrosine Aminotransferase, Nadp-Dependent Malate Dehydrogenase, Nadp-Dependent Isocitrate Dehydrogenase, and Tetrazolium Oxidase in TETRAHYMENA PYRIFORMIS, Syngen 1.

    abstract::The isozymic patterns of tyrosine aminotransferase, NADP malate dehydrogenase, NADP isocitrate dehydrogenase, and tetrazolium oxidase were examined by starch-gel electrophoresis in Tetrahymena pyriformis, syngen 1. The genetics of the alleles controlling these enzymes was studied through a breeding program. Each enzym...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Borden D,Miller ET,Nanney DL,Whitt GS

    更新日期:1973-08-01 00:00:00

  • Multiple mechanisms for degradation of bacteriophage T4 soc mRNA.

    abstract::The dmd gene of bacteriophage T4 is required for regulation of mRNA stability in a stage-dependent manner during infection. When this gene is mutated, late genes are globally silenced because of rapid degradation of mRNAs. To investigate the mechanism of such mRNA degradation, we analyzed the late gene soc transcripts...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kai T,Yonesaki T

    更新日期:2002-01-01 00:00:00

  • Molecular analysis of the neurogenic locus mastermind of Drosophila melanogaster.

    abstract::The neurogenic loci comprise a small group of genes which are required for proper division between the neural and epidermal pathways of differentiation within the neuroectoderm. Loss of neurogenic gene function results in the misrouting of prospective epidermal cells into neuroblasts. A molecular analysis of the neuro...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Yedvobnick B,Smoller D,Young P,Mills D

    更新日期:1988-03-01 00:00:00

  • Dosage effects on gene expression in a maize ploidy series.

    abstract::Previous studies on gene expression in aneuploids revealed numerous trans-acting dosage effects. Segmental aneuploidy of each varied chromosomal region exhibited predominantly inverse effects on several target genes. Here, dosage regulation was examined in a maize (Zea mays L.) ploidy series where the complete genomic...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Guo M,Davis D,Birchler JA

    更新日期:1996-04-01 00:00:00

  • A spontaneous chromosomal amplification of the ADH2 gene in Saccharomyces cerevisiae.

    abstract::A spontaneous antimycin A-resistant mutant carrying approximately four extra copies of ADH2 on chromosome XII was isolated from yeast strain 315-1D which lacks a functional copy of ADH1 and thus is antimycin A-sensitive. The additional copies of the normally glucose-repressed ADH2 are expressed during growth on glucos...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Paquin CE,Dorsey M,Crable S,Sprinkel K,Sondej M,Williamson VM

    更新日期:1992-02-01 00:00:00

  • A study of linkage disequilibrium in populations of Drosophila melanogaster.

    abstract::This paper presents the results of a study of linkage disequilibrium between five polymorphic enzyme genes located on chromosome 3 of D. melanogaster. Three sets of chromosomes were examined: two represented samples from successive years of the same natural population, and one came from a large laboratory population. ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Charlesworth B,Charlesworth D

    更新日期:1973-02-01 00:00:00

  • Specificity of insertion by the translocatable tetracycline-resistance element Tn10.

    abstract::Genetic analysis of 131 independent transpositions of the tetracycline-resistance element Tn10 from a single site in phage P22 into the histidine operon of Salmonella typhimurium reveals that Tn10 insertions are not randomly distributed along this chromosomal target. The insertions occur in 22 different "clusters"; in...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kleckner N,Steele DA,Reichardt K,Botstein D

    更新日期:1979-08-01 00:00:00

  • Genepool variation in genus Glycine subgenus Soja revealed by polymorphic nuclear and chloroplast microsatellites.

    abstract::A combination of nuclear and chloroplast simple sequence repeats (SSRs) have been used to investigate the levels and pattern of variability detected in Glycine max and G. soja genotypes. Based on the analysis of 700 soybean genotypes with 115 restriction fragment length polymorphism (RFLP) probes, 12 accessions were i...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Powell W,Morgante M,Doyle JJ,McNicol JW,Tingey SV,Rafalski AJ

    更新日期:1996-10-01 00:00:00

  • Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway.

    abstract::Hydroxyurea (HU) has been used for the treatment of multiple diseases, such as cancer. The therapeutic effect is generally believed to be due to the suppression of ribonucleotide reductase (RNR), which slows DNA polymerase movement at replication forks and induces an S phase cell cycle arrest in proliferating cells. A...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.191536

    authors: Xu YJ,Singh A,Alter GM

    更新日期:2016-11-01 00:00:00

  • Localized remodeling of the Escherichia coli chromosome: the patchwork of segments refractory and tolerant to inversion near the replication terminus.

    abstract::The behavior of chromosomal inversions in Escherichia coli depends upon the region they affect. Regions flanking the replication terminus have been termed nondivisible zones (NDZ) because inversions ending in the region were either deleterious or not feasible. This regional phenomenon is further analyzed here. Thirty ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Guijo MI,Patte J,del Mar Campos M,Louarn JM,Rebollo JE

    更新日期:2001-04-01 00:00:00

  • Regulation of sex determination in mice by a non-coding genomic region.

    abstract::To identify novel genomic regions that regulate sex determination, we utilized the powerful C57BL/6J-Y(POS) (B6-Y(POS)) model of XY sex reversal where mice with autosomes from the B6 strain and a Y chromosome from a wild-derived strain, Mus domesticus poschiavinus (Y(POS)), show complete sex reversal. In B6-Y(POS), th...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.113.160259

    authors: Arboleda VA,Fleming A,Barseghyan H,Délot E,Sinsheimer JS,Vilain E

    更新日期:2014-07-01 00:00:00

  • Concerted evolution of two novel protein families in Caenorhabditis species.

    abstract::Among a large number of homologous gene clusters in C. elegans, two gene families that appear to undergo concerted evolution were studied in detail. Both gene families are nematode specific and encode small secreted proteins of unknown function. For both families in three Caenorhabditis species, concerted groups of ge...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.052746

    authors: Thomas JH

    更新日期:2006-04-01 00:00:00

  • Female fertility and mating type effects on effective population size and evolution in filamentous fungi.

    abstract::The idealized individual in many fungal species is a haploid self-sterile hermaphrodite that may be propagated by asexually produced spores or that may reproduce sexually. In field populations, polymorphism occurs for female-sterile/hermaphrodite status, and female-sterile mutants, which function only as males during ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Leslie JF,Klein KK

    更新日期:1996-10-01 00:00:00

  • Localized mutagenesis for the isolation of temperature-sensitive mutants of Escherichia coli affected in protein synthesis.

    abstract::Two variations of the method of localized mutagenesis were used to introduce mutations into the 72 min region of the Escherichia coli chromosome. Twenty temperature-sensitive mutants, with linkage to markers in this region, have been examined. Each strain showed an inhibition of growth in liquid medium at 44 degrees, ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Champney WS

    更新日期:1979-02-01 00:00:00

  • Testing for equality of evolutionary rates.

    abstract::A likelihood ratio test is presented for comparing rates of evolutionary change in the paths of descent leading to two species. The test is compared to previous relative rate tests based on variances of estimated numbers of base substitutions. The likelihood approach allows for different transversion and transition ra...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Muse SV,Weir BS

    更新日期:1992-09-01 00:00:00

  • The sister chromatid cohesion pathway suppresses multiple chromosome gain and chromosome amplification.

    abstract::Gain or loss of chromosomes resulting in aneuploidy can be important factors in cancer and adaptive evolution. Although chromosome gain is a frequent event in eukaryotes, there is limited information on its genetic control. Here we measured the rates of chromosome gain in wild-type yeast and sister chromatid cohesion ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.113.159202

    authors: Covo S,Puccia CM,Argueso JL,Gordenin DA,Resnick MA

    更新日期:2014-02-01 00:00:00

  • Aspects of the ultraviolet photobiology of some T-even bacteriophages.

    abstract::Bacteriophage T4 DNA metabolism is largely insulated from that of its host, although some host functions assist in the repair of T4 DNA damage. Environmental factors sometimes affect survival and mutagenesis after ultraviolet (UV) irradiation of T4, and can affect mutagenesis in many organisms. We therefore tested the...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Smith LA,Drake JW

    更新日期:1998-04-01 00:00:00

  • Molecular variation in chloroplast DNA regions in ancestral species of wheat.

    abstract::Restriction map variation in two 5-6-kb chloroplast DNA regions of five diploid Aegilops species in the section Sitopsis and two wild tetraploid wheats, Triticum dicoccoides and Triticum araraticum, was investigated with a battery of four-cutter restriction enzymes. A single accession each of Triticum durum, Triticum ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Miyashita NT,Mori N,Tsunewaki K

    更新日期:1994-07-01 00:00:00

  • Identification of residues in fission yeast and human p34cdc2 required for S-M checkpoint control.

    abstract::In fission yeast, regulation of p34cdc2 plays an important role in the checkpoint coupling mitosis to completion of DNA replication. The cdc2 mutations cdc2-3w (C67Y) and cdc2-4w (C67F) abolish checkpoint control without seriously affecting normal cell proliferation. However the molecular basis of this phenotype is no...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Basi G,Enoch T

    更新日期:1996-12-01 00:00:00

  • Natural variation in the Pto pathogen resistance gene within species of wild tomato (Lycopersicon). I. Functional analysis of Pto alleles.

    abstract::Disease resistance to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst) in the cultivated tomato, Lycopersicon esculentum, and the closely related L. pimpinellifolium is triggered by the physical interaction between plant disease resistance protein, Pto, and the pathogen avirulence protein, AvrPto. To inves...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.039339

    authors: Rose LE,Langley CH,Bernal AJ,Michelmore RW

    更新日期:2005-09-01 00:00:00

  • Proliferating cell nuclear antigen and ASF1 modulate silent chromatin in Saccharomyces cerevisiae via lysine 56 on histone H3.

    abstract::The formation and stability of epigenetically regulated chromatin is influenced by DNA replication and factors that modulate post-translational modifications on histones. Here we describe evidence that PCNA can affect silencing in Saccharomyces cerevisiae by facilitating deposition of H3 K56ac onto chromosomes. We pro...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.084525

    authors: Miller A,Yang B,Foster T,Kirchmaier AL

    更新日期:2008-06-01 00:00:00

  • Neurospora strains harboring mitochondrial disease-associated mutations in iron-sulfur subunits of complex I.

    abstract::We subjected the genes encoding the 19.3-, 21.3c-, and 51-kDa iron-sulfur subunits of respiratory chain complex I from Neurospora crassa to site-directed mutagenesis to mimic mutations in human complex I subunits associated with mitochondrial diseases. The V135M substitution was introduced into the 19.3-kDa cDNA, the ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.041517

    authors: Duarte M,Schulte U,Ushakova AV,Videira A

    更新日期:2005-09-01 00:00:00

  • Comments on mutagenesis risk estimation.

    abstract::Several hypotheses and concepts have tended to oversimplify the problem of mutagenesis and can be misleading when used for genetic risk estimation. These include: (1) the hypothesis that radiation-induced mutation frequency depends primarily on the DNA content per haploid genome, (2) the extension of this concept to c...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Russell WL

    更新日期:1979-05-01 00:00:00

  • Differentiation of Muller's chromosomal elements D and E in the obscura group of Drosophila.

    abstract::Twenty-two markers located on Muller's elements D or E have been mapped by in situ hybridization in six species of the obscura group of Drosophila and in D. melanogaster. The obscura species can be grouped into a Palearctic cluster (D. subobscura, D. madeirensis and D. guanche) and a Nearctic one (D. pseudoobscura, D....

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Segarra C,Ribó G,Aguadé M

    更新日期:1996-09-01 00:00:00

  • Integrity and function of the Saccharomyces cerevisiae spindle pole body depends on connections between the membrane proteins Ndc1, Rtn1, and Yop1.

    abstract::The nuclear envelope in Saccharomyces cerevisiae harbors two essential macromolecular protein assemblies: the nuclear pore complexes (NPCs) that enable nucleocytoplasmic transport, and the spindle pole bodies (SPBs) that mediate chromosome segregation. Previously, based on metazoan and budding yeast studies, we report...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.112.141465

    authors: Casey AK,Dawson TR,Chen J,Friederichs JM,Jaspersen SL,Wente SR

    更新日期:2012-10-01 00:00:00