Abstract:
:Previous association analyses showed that variation at major regulatory genes contributes to standing variation for complex traits in Balsas teosinte, the progenitor of maize. This study expands our previous association mapping effort in teosinte by testing 123 markers in 52 candidate genes for association with 31 traits in a population of 817 individuals. Thirty-three significant associations for markers from 15 candidate genes and 10 traits survive correction for multiple testing. Our analyses suggest several new putative causative relationships between specific genes and trait variation in teosinte. For example, two ramosa genes (ra1 and ra2) associate with ear structure, and the MADS-box gene, zagl1, associates with ear shattering. Since zagl1 was previously shown to be a target of selection during maize domestication, we suggest that this gene was under selection for its effect on the loss of ear shattering, a key domestication trait. All observed effects were relatively small in terms of the percentage of phenotypic variation explained (<10%). We also detected several epistatic interactions between markers in the same gene that associate with the same trait. Candidate-gene-based association mapping appears to be a promising method for investigating the inheritance of complex traits in teosinte.
journal_name
Geneticsjournal_title
Geneticsauthors
Weber AL,Briggs WH,Rucker J,Baltazar BM,de Jesús Sánchez-Gonzalez J,Feng P,Buckler ES,Doebley Jdoi
10.1534/genetics.108.090134subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1221-32issue
2eissn
0016-6731issn
1943-2631pii
genetics.108.090134journal_volume
180pub_type
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