Abstract：
:The prune gene of Drosophila melanogaster is predicted to encode a phosphodiesterase. Null alleles of prune are viable but cause an eye-color phenotype. The abnormal wing discs gene encodes a nucleoside diphosphate kinase. Killer of prune is a missense mutation in the abnormal wing discs gene. Although it has no phenotype by itself even when homozygous, Killer of prune when heterozygous causes lethality in the absence of prune gene function. A screen for suppressors of transgenic Killer of prune led to the recovery of three mutations, all of which are in the same gene. As heterozygotes these mutations are dominant suppressors of the prune-Killer of prune lethal interaction; as homozygotes these mutations cause early larval lethality and the absence of imaginal discs. These alleles are loss-of-function mutations in CG10065, a gene that is predicted to encode a protein with several zinc finger domains and glutathione S-transferase activity.
journal_name
Geneticsjournal_title
Geneticsauthors
Provost E,Hersperger G,Timmons L,Ho WQ,Hersperger E,Alcazar R,Shearn Adoi
10.1534/genetics.105.044669keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
207-19issue
1eissn
0016-6731issn
1943-2631pii
genetics.105.044669journal_volume
172pub_type
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