Abstract：
:Heteroduplexes with single base pair mismatches of known sequence were prepared by annealing separated strands of bacteriophage lambda DNA and used to transfect Escherichia coli. A series of transition (G:T and A:C) and transversion (G:A and C:T) mismatches located throughout most of the bacteriophage lambda cI gene has been examined. The results suggest that the transition mismatches are generally better repaired than the transversion mismatches and that, at least for the transversion mismatches studied, repair efficiency increases with increasing G:C content in the neighboring nucleotide sequence. This specificity of the E. coli mismatch repair system can account, in part, for the similar frequencies of base substitution mutations throughout the E. coli genome.
journal_name
Geneticsjournal_title
Geneticsauthors
Jones M,Wagner R,Radman Msubject
Has Abstractpub_date
1987-04-01 00:00:00pages
605-10issue
4eissn
0016-6731issn
1943-2631journal_volume
115pub_type
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