Molecular variation of Adh and P6 genes in an African population of Drosophila melanogaster and its relation to chromosomal inversions.

Abstract:

:Four-cutter molecular polymorphism of Adh and P6, and chromosome inversion polymorphism of chromosome II were investigated in 95 isogenic lines of an Ivory Coast population of Drosophila melanogaster, a species assumed to have recently spread throughout the world from a West African origin. The P6 gene showed little linkage disequilibrium with the In(2L)t inversion, although it is located within this inversion. This suggests that the inversion and the P6 locus have extensively exchanged genetic information through either double crossover or gene conversion. Allozymic variation in ADH was in linkage disequilibrium with In(2L)t and In(2R)NS inversions. Evidence suggests either that inversion linkage with the Fast allele is selectively maintained, or that this allele only recently appeared. Molecular polymorphism at the Adh locus in the Ivory Coast is not higher than in North American populations. New haplotypes specific to the African population were found, some of them connect the "WaS-like" haplotypes found at high frequencies in the United States to the other slow haplotypes. Their relation with In(2L)t supports the hypothesis that WaS recently recombined away from an In(2L)t chromosome which may be the cause of its divergence from the other haplotypes.

journal_name

Genetics

journal_title

Genetics

authors

Bénassi V,Aulard S,Mazeau S,Veuille M

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

789-99

issue

3

eissn

0016-6731

issn

1943-2631

journal_volume

134

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Mutants of downy mildew resistance in Lactuca sativa (lettuce).

    abstract::As part of our investigation of disease resistance in lettuce, we generated mutants that have lost resistance to Bremia lactucae, the casual fungus of downy mildew. Using a rapid and reliable screen, we identified 16 distinct mutants of Latuca sativa that have lost activity of one of four different downy mildew resist...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Okubara PA,Anderson PA,Ochoa OE,Michelmore RW

    更新日期:1994-07-01 00:00:00

  • Isolation and characterization of PEP5, a gene essential for vacuolar biogenesis in Saccharomyces cerevisiae.

    abstract::pep5 mutants of Saccharomyces cerevisiae accumulate inactive precursors to the vacuolar hydrolases. The PEP5 gene was isolated from a genomic DNA library by complementation of the pep5-8 mutation. Deletion analysis localized the complementing activity to a 3.3-kb DNA fragment. DNA sequence analysis of the PEP5 gene re...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Woolford CA,Dixon CK,Manolson MF,Wright R,Jones EW

    更新日期:1990-08-01 00:00:00

  • Mismatch Repair Incompatibilities in Diverse Yeast Populations.

    abstract::An elevated mutation rate can provide cells with a source of mutations to adapt to changing environments. We identified a negative epistatic interaction involving naturally occurring variants in the MLH1 and PMS1 mismatch repair (MMR) genes of Saccharomyces cerevisiae We hypothesized that this MMR incompatibility, cre...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.199513

    authors: Bui DT,Friedrich A,Al-Sweel N,Liti G,Schacherer J,Aquadro CF,Alani E

    更新日期:2017-04-01 00:00:00

  • Regulation of Cell-to-Cell Communication and Cell Wall Integrity by a Network of MAP Kinase Pathways and Transcription Factors in Neurospora crassa.

    abstract::Maintenance of cell integrity and cell-to-cell communication are fundamental biological processes. Filamentous fungi, such as Neurospora crassa, depend on communication to locate compatible cells, coordinate cell fusion, and establish a robust hyphal network. Two MAP kinase (MAPK) pathways are essential for communicat...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.118.300904

    authors: Fischer MS,Wu VW,Lee JE,O'Malley RC,Glass NL

    更新日期:2018-06-01 00:00:00

  • Age and Genetic Background Modify Hybrid Male Sterility in House Mice.

    abstract::Hybrid male sterility (HMS) contributes to reproductive isolation commonly observed among house mouse (Mus musculus) subspecies, both in the wild and in laboratory crosses. Incompatibilities involving specific Prdm9 alleles and certain Chromosome (Chr) X genotypes are known determinants of fertility and HMS, and previ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.120.303474

    authors: Widmayer SJ,Handel MA,Aylor DL

    更新日期:2020-10-01 00:00:00

  • High genetic diversity in the chemoreceptor superfamily of Caenorhabditis elegans.

    abstract::We investigated genetic polymorphism in the Caenorhabditis elegans srh and str chemoreceptor gene families, each of which consists of approximately 300 genes encoding seven-pass G-protein-coupled receptors. Almost one-third of the genes in each family are annotated as pseudogenes because of apparent functional defects...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.035329

    authors: Stewart MK,Clark NL,Merrihew G,Galloway EM,Thomas JH

    更新日期:2005-04-01 00:00:00

  • The neutral coalescent process for recent gene duplications and copy-number variants.

    abstract::I describe a method for simulating samples from gene families of size two under a neutral coalescent process, for the case where the duplicate gene either has fixed recently in the population or is still segregating. When a duplicate locus has recently fixed by genetic drift, diversity in the new gene is expected to b...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.074948

    authors: Thornton KR

    更新日期:2007-10-01 00:00:00

  • The genetic control of apomixis: asexual seed formation.

    abstract::Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...

    journal_title:Genetics

    pub_type: 杂志文章,评审

    doi:10.1534/genetics.114.163105

    authors: Hand ML,Koltunow AM

    更新日期:2014-06-01 00:00:00

  • The maize regulatory gene B-Peru contains a DNA rearrangement that specifies tissue-specific expression through both positive and negative promoter elements.

    abstract::The B-Peru allele of the maize b regulatory gene is unusual relative to most b alleles in that it is expressed in the aleurone layer of the seed. It is also expressed in a subset of plant vegetative tissues. Transgenic maize plants containing the B-Peru gene with the first 710 bases of upstream sequence conferred the ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Selinger DA,Lisch D,Chandler VL

    更新日期:1998-06-01 00:00:00

  • Genetics of life history in Drosophila melanogaster. I. Sib analysis of adult females.

    abstract::A sib analysis of adult life-history characters was performed on about twelve hundred females from a laboratory Drosophila melanogaster population that had been sampled from nature and cultured so as to preserve its genetic variability. The following results were found. There was no detectable trend with age in additi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Rose MR,Charlesworth B

    更新日期:1981-01-01 00:00:00

  • Adaptation at specific loci. IV. Differential mating success among glycolytic allozyme genotypes of Colias butterflies.

    abstract::Male mating success as a function of genotype is an important fitness component. It can be studied in wild populations, in species for which a given group of progeny has exactly one father, by determining genotypes of wildcaught mothers and of sufficient numbers of their progeny. Here, we study male mating success as ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Watt WB,Carter PA,Blower SM

    更新日期:1985-01-01 00:00:00

  • Analysis of conditional genetic effects and variance components in developmental genetics.

    abstract::A genetic model with additive-dominance effects and genotype x environment interactions is presented for quantitative traits with time-dependent measures. The genetic model for phenotypic means at time t conditional on phenotypic means measured at previous time (t-1) is defined. Statistical methods are proposed for an...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Zhu J

    更新日期:1995-12-01 00:00:00

  • Imputing Genotypes in Biallelic Populations from Low-Coverage Sequence Data.

    abstract::Low-coverage next-generation sequencing methodologies are routinely employed to genotype large populations. Missing data in these populations manifest both as missing markers and markers with incomplete allele recovery. False homozygous calls at heterozygous sites resulting from incomplete allele recovery confound man...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.115.182071

    authors: Fragoso CA,Heffelfinger C,Zhao H,Dellaporta SL

    更新日期:2016-02-01 00:00:00

  • A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.

    abstract::Loss of heterozygosity (LOH) can be a driving force in the evolution of mitotic/somatic diploid cells, and cellular changes that increase the rate of LOH have been proposed to facilitate this process. In the yeast Saccharomyces cerevisiae, spontaneous LOH occurs by a number of mechanisms including chromosome loss and ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.089250

    authors: Andersen MP,Nelson ZW,Hetrick ED,Gottschling DE

    更新日期:2008-07-01 00:00:00

  • The Saccharomyces cerevisiae SPT8 gene encodes a very acidic protein that is functionally related to SPT3 and TATA-binding protein.

    abstract::Mutations in the Saccharomyces cerevisiae SPT8 gene were previously isolated as suppressors of retrotransposon insertion mutations in the 5' regions of the HIS4 and LYS2 genes. Mutations in SPT8 confer phenotypes similar to those caused by particular mutations in SPT15, which encodes the TATA-binding protein (TBP). Th...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Eisenmann DM,Chapon C,Roberts SM,Dollard C,Winston F

    更新日期:1994-07-01 00:00:00

  • Mutations in SIN4 and RGR1 cause constitutive expression of MAL structural genes in Saccharomyces cerevisiae.

    abstract::Transcription of the Saccharomyces MAL structural genes is induced 40-fold by maltose and requires the MAL-activator and maltose permease. To identify additional players involved in regulating MAL gene expression, we carried out a genetic selection for MAL constitutive mutants. Strain CMY4000 containing MAL1 and integ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.029611

    authors: Wang X,Michels CA

    更新日期:2004-10-01 00:00:00

  • Regulation of odor receptor genes in trichoid sensilla of the Drosophila antenna.

    abstract::This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.110.117622

    authors: Miller CJ,Carlson JR

    更新日期:2010-09-01 00:00:00

  • Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast.

    abstract::Pontocerebellar hypoplasia type 1b (PCH1b) is an autosomal recessive disorder that causes cerebellar hypoplasia and spinal motor neuron degeneration, leading to mortality in early childhood. PCH1b is caused by mutations in the RNA exosome subunit gene, EXOSC3 The RNA exosome is an evolutionarily conserved complex, con...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.195917

    authors: Fasken MB,Losh JS,Leung SW,Brutus S,Avin B,Vaught JC,Potter-Birriel J,Craig T,Conn GL,Mills-Lujan K,Corbett AH,van Hoof A

    更新日期:2017-01-01 00:00:00

  • Improved confidence intervals in quantitative trait loci mapping by permutation bootstrapping.

    abstract::The nonparametric bootstrap approach is known to be suitable for calculating central confidence intervals for the locations of quantitative trait loci (QTL). However, the distribution of the bootstrap QTL position estimates along the chromosome is peaked at the positions of the markers and is not tailed equally. This ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bennewitz J,Reinsch N,Kalm E

    更新日期:2002-04-01 00:00:00

  • Genetic divergence under uniform selection. II. Different responses to selection for knockdown resistance to ethanol among Drosophila melanogaster populations and their replicate lines.

    abstract::We have tested the hypothesis that genetic differences among conspecific populations may result in diverse responses to selection, using natural populations of Drosophila melanogaster. Selection for ethanol tolerance in a tube measuring knockdown resistance was imposed on five West Coast populations. In 24 generations...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Cohan FM,Hoffmann AA

    更新日期:1986-09-01 00:00:00

  • A non-Mendelian MAPK-generated hereditary unit controlled by a second MAPK pathway in Podospora anserina.

    abstract::The Podospora anserina PaMpk1 MAP kinase (MAPK) signaling pathway can generate a cytoplasmic and infectious element resembling prions. When present in the cells, this C element causes the crippled growth (CG) cell degeneration. CG results from the inappropriate autocatalytic activation of the PaMpk1 MAPK pathway durin...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.112.139469

    authors: Lalucque H,Malagnac F,Brun S,Kicka S,Silar P

    更新日期:2012-06-01 00:00:00

  • Genetic and morphological study of aggregation in the cellular slime mold Polysphondylium violaceum.

    abstract::A system for genetic analysis in the cellular slime mold P. violaceum has been developed. Two growth-temperature-sensitive mutants were isolated in a haploid strain and used to select rare diploid heterozygotes arising by spontaneous fusion of the haploid cells. A recessive mutation to cycloheximide resistance in one ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Warren AJ,Warren WD,Cox EC

    更新日期:1976-05-01 00:00:00

  • Models of evolution of reproductive isolation.

    abstract::Mathematical models are presented for the evolution of postmating and premating reproductive isolation. In the case of postmating isolation it is assumed that hybrid sterility or inviability is caused by incompatibility of alleles at one or two loci, and evolution of reproductive isolation occurs by random fixation of...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Nei M,Maruyama T,Wu CI

    更新日期:1983-03-01 00:00:00

  • Regulation of cation balance in Saccharomyces cerevisiae.

    abstract::All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...

    journal_title:Genetics

    pub_type: 杂志文章,评审

    doi:10.1534/genetics.112.147207

    authors: Cyert MS,Philpott CC

    更新日期:2013-03-01 00:00:00

  • Regulation of mitotic spindle disassembly by an environmental stress-sensing pathway in budding yeast.

    abstract::Timely spindle disassembly is essential for coordination of mitotic exit with cytokinesis. In the budding yeast Saccharomyces cerevisiae, the microtubule-associated protein She1 functions in one of at least three parallel pathways that promote spindle disassembly. She1 phosphorylation by the Aurora kinase Ipl1 facilit...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.114.163238

    authors: Pigula A,Drubin DG,Barnes G

    更新日期:2014-11-01 00:00:00

  • The isolation and characterization of nrc-1 and nrc-2, two genes encoding protein kinases that control growth and development in Neurospora crassa.

    abstract::Using an insertional mutagenesis approach, a series of Neurospora crassa mutants affected in the ability to control entry into the conidiation developmental program were isolated. One such mutant, GTH16-T4, was found to lack normal vegetative hyphae and to undergo constitutive conidiation. The affected gene has been n...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kothe GO,Free SJ

    更新日期:1998-05-01 00:00:00

  • Identification of functionally related genes that stimulate early meiotic gene expression in yeast.

    abstract::Meiosis and spore formation in the yeast Saccharomyces cerevisiae are associated with increased expression of sporulation-specific genes. One of these genes, IME2, encodes a putative protein kinase that is a positive regulator of other sporulation-specific genes. We have isolated mutations that cause reduced expressio...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Su SS,Mitchell AP

    更新日期:1993-01-01 00:00:00

  • Phenotypes of mutations in the 5'-UTR of a limiting transcription factor in Aspergillus nidulans can be accounted for by translational inhibition and leaky scanning.

    abstract::The uaY gene encodes the transcriptional activator of purine catabolism genes in Aspergillus nidulans. uaY12 results in strongly defective growth on purines as nitrogen sources and in strongly diminished transcription of UaY-regulated genes. This mutation introduces an ATG codon 64 bp upstream of the uaY ATG, generati...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.099515

    authors: Oestreicher N,Scazzocchio C

    更新日期:2009-04-01 00:00:00

  • Dominance genetic variance for traits under directional selection in Drosophila serrata.

    abstract::In contrast to our growing understanding of patterns of additive genetic variance in single- and multi-trait combinations, the relative contribution of nonadditive genetic variance, particularly dominance variance, to multivariate phenotypes is largely unknown. While mechanisms for the evolution of dominance genetic v...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.115.175489

    authors: Sztepanacz JL,Blows MW

    更新日期:2015-05-01 00:00:00

  • The maize unstable factor for orange1 is a dominant epigenetic modifier of a tissue specifically silent allele of pericarp color1.

    abstract::We have characterized Unstable factor for orange1 (Ufo1), a dominant, allele-specific modifier of expression of the maize pericarp color1 (p1) gene. The p1 gene encodes an Myb-homologous transcriptional activator of genes required for biosynthesis of red phlobaphene pigments. The P1-wr allele specifies colorless kerne...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Chopra S,Cocciolone SM,Bushman S,Sangar V,McMullen MD,Peterson T

    更新日期:2003-03-01 00:00:00