Abstract：
:The contribution of mismatch repair to genetic recombination in T4 phage has been evaluated by three independent approaches: (1) testing for non-additivity of recombinant frequencies; (2) measurements of double exchange frequencies in three-factor crosses: (3) comparisons of recombination abilities of mutations occupying the same site. Quantitative agreement among the results of these approaches suggests that within distances much less than the mean length of hybrid regions, mismatch repair accounts perfectly for high negative interference as measured in three-factor crosses and as manifested by non-additivity in two-factor crosses. The mismatch repair mechanism readily recognizes only particular mismatches, the repair frequency being dependent on the base sequence in both strands of the mismatched region.
journal_name
Geneticsjournal_title
Geneticsauthors
Shcherbakov VP,Plugina LA,Kudryashova EA,Efremova OI,Sizova ST,Toompuu OGsubject
Has Abstractpub_date
1982-12-01 00:00:00pages
627-37issue
4eissn
0016-6731issn
1943-2631journal_volume
102pub_type
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