Interallelic complementation at the suppressor of forked locus of Drosophila reveals complementation between suppressor of forked proteins mutated in different regions.

abstract：:Signaling by receptor tyrosine kinases (RTKs) is critical for a multitude of developmental decisions and processes. Among the molecules known to transduce the RTK-generated signal is the nonreceptor protein tyrosine phosphatase Corkscrew (Csw). Previously, Csw has been demonstrated to function throughout the Drosophil...

journal_title：Genetics

authors： Firth L,Manchester J,Lorenzen JA,Baron M,Perkins LA

更新日期：2000-10-01 00:00:00

abstract：:In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination often leads to loss of heterozygosity (LOH). Most previous studies of mitotic recombination in Saccharomyces cerevisiae have focused on a single chromosome or a single region of one chromosome at which LOH events can be selected. I...

journal_title：Genetics

authors： St Charles J,Hazkani-Covo E,Yin Y,Andersen SL,Dietrich FS,Greenwell PW,Malc E,Mieczkowski P,Petes TD

更新日期：2012-04-01 00:00:00

abstract：:Seven hundred and three second chromosomes were extracted from a Raleigh, North Carolina population of Drosophila melanogaster in 1970. Additionally, four hundred and eighty-nine third chromosomes were extracted from a large cage population founded from the flies in the 1970 Raleigh collection. The alpha glycerol-3-ph...

journal_title：Genetics

authors： Muki T,Watanabe TK,Yamaguchi O

更新日期：1974-08-01 00:00:00

abstract：:Intrachromosomal gene conversion is the non-reciprocal transfer of information between a pair of repeated genes on a single chromosome. This process produces eventual sequence homogeneity within a family of repeated genes. An evolutionary model for a single chromosome lineage was formulated and analyzed. Expressions w...

journal_title：Genetics

authors： Nagylaki T,Petes TD

更新日期：1982-02-01 00:00:00

abstract：:IS1 is one of the smallest transposable elements found in bacteria (768 bp). It contains eight overlapping open-reading-frames (ORFs) greater than 50 codons, designated insA to insG and insB'. To determine which of the ORFs actually code for proteins involved in transposition, we have introduced amber codons into each...

journal_title：Genetics

authors： Jakowec M,Prentki P,Chandler M,Galas DJ

更新日期：1988-09-01 00:00:00

abstract：:DNA sequence analysis and genetic mapping of loci from mating-type-specific chromosomes of the smut fungus Microbotryum violaceum demonstrated that the nonrecombining mating-type-specific region in this species comprises approximately 25% ( approximately 1 Mb) of the chromosome length. Divergence between homologous ma...

journal_title：Genetics

authors： Votintseva AA,Filatov DA

更新日期：2009-08-01 00:00:00

abstract：:Estimating the fixation probability of a beneficial mutation has a rich history in theoretical population genetics. Typically, to attain mathematical tractability, we assume that generation times are fixed, while the number of offspring per individual is stochastic. However, fixation probabilities are extremely sensit...

journal_title：Genetics

authors： Hubbarde JE,Wild G,Wahl LM

更新日期：2007-07-01 00:00:00

abstract：:During meiosis, the stable pairing of the homologous chromosomes is mediated by the assembly of the synaptonemal complex (SC). Its tripartite structure is well conserved in Metazoa and consists of two lateral elements (LEs) and a central region (CR) that in turn is formed by several transverse filaments (TFs) and a ce...

journal_title：Genetics

authors： Fraune J,Brochier-Armanet C,Alsheimer M,Benavente R

更新日期：2013-11-01 00:00:00

abstract：:A model emphasizing the possible genetic role of tandem duplications of reverse repeats has been developed as an extension of Crick's (1971) general model for the chromosomes of higher organisms. Although developed initially (1) to explain why random differences in the control regions of individual gene loci might con...

journal_title：Genetics

authors： Wallace B,Kass TL

更新日期：1974-07-01 00:00:00

abstract：:The MITF protein is a member of the MYC family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors and is most closely related to the TFE3, TFEC, and TFEB proteins. In the mouse, MITF is required for the development of several different cell types, including the retinal pigment epithelial (RPE) c...

journal_title：Genetics

authors： Hallsson JH,Haflidadóttir BS,Stivers C,Odenwald W,Arnheiter H,Pignoni F,Steingrímsson E

更新日期：2004-05-01 00:00:00

abstract：:Lethal and sterility mutations were accumulated in a cage population which was initiated with lethal- and sterility-free second chromosomes of D. melanogaster. It took about 2,000 days for the frequencies of these genes to reach equilibrium levels, i.e., 18% lethal and 9% male-sterile chromosomes. Two other cage popul...

journal_title：Genetics

authors： Lee WH,Watanabe TK

更新日期：1977-07-01 00:00:00

abstract：:Genic variation in natural populations of Drosophila simulans was surveyed using allozymic and two-dimensional electrophoretic techniques. Consistent with some previous reports, allozymic heterozygosity appeared lower than in the sibling species D. melanogaster (0.07 vs. 0.16). No variation was detected by two-dimensi...

journal_title：Genetics

authors： Ohnishi S,Leigh Brown AJ,Voelker RA,Langley CH

更新日期：1982-01-01 00:00:00

abstract：:Hybrid matings between the sexual species Poeciliopsis monacha and Poeciliopsis lucida produced a series of diploid all-female lineages of P. monacha-lucida that inhabit the Río Fuerte of northwestern Mexico. Restriction site analyses of mitochondrial DNA (mtDNA) clearly revealed that P. monacha was the maternal ances...

journal_title：Genetics

authors： Quattro JM,Avise JC,Vrijenhoek RC

更新日期：1991-02-01 00:00:00

abstract：:We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. mela...

journal_title：Genetics

authors： Balakirev ES,Ayala FJ

更新日期：1996-12-01 00:00:00

abstract：:Constitutive transport of cellular materials is essential for cell survival. Although multiple small GTPase Rab proteins are required for the process, few regulators of Rabs are known. Here we report that EAT-17, a novel GTPase-activating protein (GAP), regulates RAB-6.2 function in grinder formation in Caenorhabditis...

journal_title：Genetics

authors： Straud S,Lee I,Song B,Avery L,You YJ

更新日期：2013-09-01 00:00:00

abstract：:Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the sam...

journal_title：Genetics

authors： Lewontin RC

更新日期：1988-11-01 00:00:00

abstract：:A multi-locus model for complete positive assortative mating is discussed. For a two-locus model, if the gene frequencies for the two loci are different, as they are likely to be, it is shown that in equilibrium the population is not composed of only two homozygous types, as is usually thought. The limiting distributi...

journal_title：Genetics

authors： Ghai GL

更新日期：1973-12-01 00:00:00

abstract：:We discuss the conceptual conflict between a slow series of gene substitutions as the mechanism of evolutionary change, and the apparent need for rapid and coordinated changes at many loci simultaneously in producing complex adaptations. To improve on the limitations of classical theory and accommodate the enormous am...

journal_title：Genetics

authors： Koehler DO,Whitten BL,Gregg TG

更新日期：1980-03-01 00:00:00

abstract：:We study the mechanisms that guide the formation and maintenance of the highly ordered actin-myosin cytoskeleton in striated muscle. The UNC-82 kinase of Caenorhabditis elegans is orthologous to mammalian kinases ARK5/NUAK1 and SNARK/NUAK2. UNC-82 localizes to the M-line, and is required for proper organization of thi...

journal_title：Genetics

authors： Schiller NR,Duchesneau CD,Lane LS,Reedy AR,Manzon ER,Hoppe PE

更新日期：2017-03-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is an extensive organelle in neurons with important roles at synapses including the regulation of cytosolic Ca2+, neurotransmission, lipid metabolism, and membrane trafficking. Despite intriguing evidence for these crucial functions, how the presynaptic ER influences synaptic physiology ...

journal_title：Genetics

authors： Kikuma K,Li X,Kim D,Sutter D,Dickman DK

更新日期：2017-11-01 00:00:00

abstract：:Sex-specific differences in dispersal, survival, reproductive success, and natural selection differentially affect the effective population size (N(e)) of genomic regions with different modes of inheritance such as sex chromosomes and mitochondrial DNA. In papionin monkeys (macaques, baboons, geladas, mandrills, drill...

journal_title：Genetics

authors： Evans BJ,Pin L,Melnick DJ,Wright SI

更新日期：2010-07-01 00:00:00

abstract：:Data for Apis mellifera indicate that the P-3 proteins and one esterase enzyme are controlled by two genes, P-3 and Est, with two alleles each. The frequency of the P-3 alleles is different in the two subspecies (adansonii and ligustica), that for P-3(F) in Italian bees being 46.9% and in African 0.5%. The frequency o...

journal_title：Genetics

authors： Mestriner MA,Contel EP

更新日期：1972-12-01 00:00:00

abstract：:The external genitalia are some of the most rapidly evolving morphological structures in insects. The posterior lobe of the male genital arch shows striking differences in both size and shape among closely related species of the Drosophila melanogaster species subgroup. Here, we dissect the genetic basis of posterior ...

journal_title：Genetics

authors： Masly JP,Dalton JE,Srivastava S,Chen L,Arbeitman MN

更新日期：2011-09-01 00:00:00

abstract：:Great interest was aroused by reports, based on microsatellite markers, of high levels of statistically significant long-range and nonsyntenic linkage disequilibrium (LD) in livestock. Simulation studies showed that this could result from population family structure. In contrast, recent SNP-based studies of livestock ...

journal_title：Genetics

authors： Lipkin E,Straus K,Stein RT,Bagnato A,Schiavini F,Fontanesi L,Russo V,Medugorac I,Foerster M,Sölkner J,Dolezal M,Medrano JF,Friedmann A,Soller M

更新日期：2009-02-01 00:00:00

abstract：:To study the interdependence of Gcr1p and Rap1p, we prepared a series of synthetic regulatory sequences that contained various numbers and combinations of CT-boxes (Gcr1p-binding sites) and RPG-boxes (Rap1p-binding sites). The ability of the synthetic oligonucleotides to function as regulatory sequences was tested usi...

journal_title：Genetics

authors： Uemura H,Koshio M,Inoue Y,Lopez MC,Baker HV

更新日期：1997-10-01 00:00:00

abstract：:We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) w...

journal_title：Genetics

authors： Niculita-Hirzel H,Stöck M,Perrin N

更新日期：2008-07-01 00:00:00

abstract：:We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. ...

journal_title：Genetics

authors： Fearnhead P

更新日期：2006-11-01 00:00:00

abstract：:The purpose of this study was to characterize two mutator stocks of yeast which were induced and selected on the basis of high spontaneous reversion rates of the suppressible "ochre" nonsense allele lys1-1. In the mutator stock VA-3, a single mutation, designated mut1-1, is responsible for the increase in the reversio...

journal_title：Genetics

authors： Gottlieb DJ,von Borstel RC

更新日期：1976-08-01 00:00:00

abstract：:The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex of Saccharomyces cerevisiae is a multifunctional coactivator complex that has been shown to regulate transcription by distinct mechanisms. Previous results have shown that the Spt3 and Spt8 components of SAGA regulate initiation of transcription of particular genes by ...

journal_title：Genetics

authors： Laprade L,Rose D,Winston F

更新日期：2007-12-01 00:00:00

abstract：:Interactions with bacteria play a major role in immune responses, ecology, and evolution of all animals, but they have been neglected until recently in the case of C. elegans. We report a genetic investigation of the interaction of C. elegans with the nematode-specific pathogen Microbacterium nematophilum, which colon...

journal_title：Genetics

authors： Gravato-Nobre MJ,Nicholas HR,Nijland R,O'Rourke D,Whittington DE,Yook KJ,Hodgkin J

更新日期：2005-11-01 00:00:00