The Triplo-lethal locus of Drosophila: reexamination of mutants and discovery of a second-site suppressor.

Abstract:

:In the genome of Drosophila melanogaster there is a single locus, Triplo-lethal (Tpl), that causes lethality when present in either one or three copies in an otherwise diploid animal. Previous attempts to mutagenize Tpl produced alleles that were viable over a chromosome bearing a duplication of Tpl, but were not lethal in combination with a wild-type chromosome, as deficiencies for Tpl are. These mutations were interpreted as hypomorphic alleles of Tpl. In this work, we show that these alleles are not mutations at Tpl; rather, they are dominant mutations in a tightly linked, but cytologically distant, locus that we have named Suppressor-of-Tpl (Sul(Tpl)). Su(Tpl) mutations suppress the lethality associated with three copies of the Triplo-lethal locus and are recessive lethal. We have mapped Su(Tpl) to the approximate map position 3-46.5, within the cytological region 76B-76D.

journal_name

Genetics

journal_title

Genetics

authors

Dorer DR,Ezekiel DH,Christensen AC

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

1037-42

issue

3

eissn

0016-6731

issn

1943-2631

journal_volume

141

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Chromosomal transmission bias in laboratory hybrids between wild strains of the two European subspecies of house mice.

    abstract::Laboratory crosses between wild strains of the two European house mouse subspecies Mus musculus domesticus (2n = 34) and M. m. musculus (2n = 40) were performed to analyze the selective processes involved in the non-introgression of centromeric regions of Robertsonian (Rb) fusions in the Danish hybrid zone. The chromo...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Lenormand T,Fel-Clair F,Manolakou K,Alibert P,Britton-Davidian J

    更新日期:1997-11-01 00:00:00

  • MNR2 regulates intracellular magnesium storage in Saccharomyces cerevisiae.

    abstract::Magnesium (Mg) is an essential enzyme cofactor and a key structural component of biological molecules, but relatively little is known about the molecular components required for Mg homeostasis in eukaryotic cells. The yeast genome encodes four characterized members of the CorA Mg transporter superfamily located in the...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.109.106419

    authors: Pisat NP,Pandey A,Macdiarmid CW

    更新日期:2009-11-01 00:00:00

  • Extended Region of Nodulation Genes in Rhizobium meliloti 1021. II. Nucleotide Sequence, Transcription Start Sites and Protein Products.

    abstract::We have established the DNA sequence and analyzed the transcription and translation products of a series of putative nodulation (nod) genes in Rhizobium meliloti strain 1021. Four loci have been designated nodF, nodE, nodG and nodH. The correlation of transposon insertion positions with phenotypes and open reading fra...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Fisher RF,Swanson JA,Mulligan JT,Long SR

    更新日期:1987-10-01 00:00:00

  • Allele-specific interactions between ttg and gl1 during trichome development in Arabidopsis thaliana.

    abstract::Trichome development in Arabidopsis thaliana is a well-characterized model for the study of plant cell differentiation. Two genes that play an essential role in the initiation of trichome development are GL1 and TTG. Mutations in either gene prevent the initiation of most trichomes. The GL1 gene encodes a myb-related ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Larkin JC,Walker JD,Bolognesi-Winfield AC,Gray JC,Walker AR

    更新日期:1999-04-01 00:00:00

  • A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.

    abstract::The Caenorhabditis elegans pRb ortholog, LIN-35, functions in a wide range of cellular and developmental processes. This includes a role of LIN-35 in nutrient utilization by the intestine, which it carries out redundantly with SLR-2, a zinc-finger protein. This and other redundant functions of LIN-35 were identified i...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.112.140152

    authors: Polley SR,Fay DS

    更新日期:2012-08-01 00:00:00

  • A comparison of isozyme and quantitative genetic variation in Pinus contorta ssp. latifolia by FST.

    abstract::We employed F-statistics to analyze quantitative and isozyme variation among five populations of Pinus contorta ssp. latifolia, a wind-pollinated outcrossing conifer with wide and continuous distribution in west North America. Estimates of population differentiation (FST) for six quantitative traits were compared with...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Yang RC,Yeh FC,Yanchuk AD

    更新日期:1996-03-01 00:00:00

  • Pervasive sex-linked effects on transcription regulation as revealed by expression quantitative trait loci mapping in lake whitefish species pairs (Coregonus sp., Salmonidae).

    abstract::Mapping of expression quantitative trait loci (eQTL) is a powerful means for elucidating the genetic architecture of gene regulation. Yet, eQTL mapping has not been applied toward investigating the regulation architecture of genes involved in the process of population divergence, ultimately leading to speciation event...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.086306

    authors: Derome N,Bougas B,Rogers SM,Whiteley AR,Labbe A,Laroche J,Bernatchez L

    更新日期:2008-08-01 00:00:00

  • Prion variants and species barriers among Saccharomyces Ure2 proteins.

    abstract::As hamster scrapie cannot infect mice, due to sequence differences in their PrP proteins, we find "species barriers" to transmission of the [URE3] prion in Saccharomyces cerevisiae among Ure2 proteins of S. cerevisiae, paradoxus, bayanus, cariocanus, and mikatae on the basis of differences among their Ure2p prion doma...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.108.099929

    authors: Edskes HK,McCann LM,Hebert AM,Wickner RB

    更新日期:2009-03-01 00:00:00

  • Genetic control of malate dehydrogenase isozymes in maize.

    abstract::At least six nuclear loci are responsible for the genetic control of malate dehydrogenase (L-malate: NAD oxidoreductase; EC 1.1.1.37; MDH) in coleoptiles of maize. Three independently segregating loci (Mdh1, Mdh2, Mdh3) govern the production of MDH isozymes resistant to inactivation by ascorbic acid and found largely ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Goodman MM,Stuber CW,Lee CN,Johnson FM

    更新日期:1980-01-01 00:00:00

  • The Y chromosome effect on intermale aggression in mice depends on the maternal environment.

    abstract::Two parental strains of laboratory mice, NZB and CBA/H, were chosen for their differences in attack behavior. NZB have higher scores than CBA/H. An effect of the Y chromosome on attack behavior was determined for two maternal environments. Each male was tested once in a dyadic encounter with an A/J male as a standard ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Carlier M,Roubertoux PL,Pastoret C

    更新日期:1991-09-01 00:00:00

  • A genetic linkage map of the model legume Lotus japonicus and strategies for fast mapping of new loci.

    abstract::A genetic map for the model legume Lotus japonicus has been developed. The F(2) mapping population was established from an interspecific cross between L. japonicus and L. filicaulis. A high level of DNA polymorphism between these parents was the source of markers for linkage analysis and the map is based on a framewor...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Sandal N,Krusell L,Radutoiu S,Olbryt M,Pedrosa A,Stracke S,Sato S,Kato T,Tabata S,Parniske M,Bachmair A,Ketelsen T,Stougaard J

    更新日期:2002-08-01 00:00:00

  • Cell excitability necessary for male mating behavior in Caenorhabditis elegans is coordinated by interactions between big current and ether-a-go-go family K(+) channels.

    abstract::Variations in K(+) channel composition allow for differences in cell excitability and, at an organismal level, provide flexibility to behavioral regulation. When the function of a K(+) channel is disrupted, the remaining K(+) channels might incompletely compensate, manifesting as abnormal organismal behavior. In this ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.111.137455

    authors: LeBoeuf B,Garcia LR

    更新日期:2012-03-01 00:00:00

  • Flanking duplications and deletions associated with P-induced male recombination in Drosophila.

    abstract::We studied P element-induced recombination in germline mitotic cells by examining the structure of the recombinant chromosomes. We found that most recombinants retain a mobile P element at the site of the recombination, usually with either a deletion or a duplication immediately adjacent to the P end at which the cros...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Preston CR,Sved JA,Engels WR

    更新日期:1996-12-01 00:00:00

  • Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans.

    abstract::The identity of a given cell type is determined by the expression of a set of genes sharing common cis-regulatory motifs and being regulated by shared transcription factors. Here, we identify cis and trans regulatory elements that drive gene expression in the bilateral sensory neuron ASJ, located in the head of the ne...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.115.176172

    authors: González-Barrios M,Fierro-González JC,Krpelanova E,Mora-Lorca JA,Pedrajas JR,Peñate X,Chavez S,Swoboda P,Jansen G,Miranda-Vizuete A

    更新日期:2015-05-01 00:00:00

  • Sequence analysis of mutations arising during prolonged starvation of Salmonella typhimurium.

    abstract::We have examined the effects of prolonged histidine deprivation on the reversion of Salmonella typhimurium histidine auxotrophs containing either hisG46, a missense mutation (CTC----CCC), or hisG428, an ochre mutation (CAA----TAA). Both of these mutants can revert to His+ via intragenic and extragenic mechanisms. Wher...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Prival MJ,Cebula TA

    更新日期:1992-10-01 00:00:00

  • Deletion of a novel F-box protein, MUS-10, in Neurospora crassa leads to altered mitochondrial morphology, instability of mtDNA and senescence.

    abstract::While mitochondria are renowned for their role in energy production, they also perform several other integral functions within the cell. Thus, it is not surprising that mitochondrial dysfunction can negatively impact cell viability. Although mitochondria have received an increasing amount of attention in recent years,...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.110.117200

    authors: Kato A,Kurashima K,Chae M,Sawada S,Hatakeyama S,Tanaka S,Inoue H

    更新日期:2010-08-01 00:00:00

  • Stem cells, their niches and the systemic environment: an aging network.

    abstract::Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity o...

    journal_title:Genetics

    pub_type: 杂志文章,评审

    doi:10.1534/genetics.108.098244

    authors: Drummond-Barbosa D

    更新日期:2008-12-01 00:00:00

  • Job Dekker: 2018 Edward Novitski Prize.

    abstract::The Genetics Society of America's (GSA) Edward Novitski Prize is awarded to researchers who have solved challenging problems in genetics through experiments that demonstrate exceptional creativity and ingenuity. Job Dekker of the University of Massachusetts Medical School has been selected for the 2018 award in recogn...

    journal_title:Genetics

    pub_type: 传,历史文章,杂志文章

    doi:10.1534/genetics.118.301641

    authors: Haloupek N

    更新日期:2018-11-01 00:00:00

  • Fine-scale genetic structure and gene dispersal in Centaurea corymbosa (Asteraceae). II. Correlated paternity within and among sibships.

    abstract::The fine-scale pattern of correlated paternity was characterized within a population of the narrow-endemic model plant species, Centaurea corymbosa, using microsatellites and natural progeny arrays. We used classical approaches to assess correlated mating within sibships and developed a new method based on pairwise ki...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.027714

    authors: Hardy OJ,González-Martínez SC,Colas B,Fréville H,Mignot A,Olivieri I

    更新日期:2004-11-01 00:00:00

  • Evidence for the involvement of serine transhydroxymethylase in serine and glycine interconversions in Salmonella typhimurium.

    abstract::Salmonella typhimurium can normally use glycine as a serine source to support the growth of serine auxotrophs. This reaction was presumed to occur by the reversible activity of the enzyme, serine transhydroxymethylase (E. C. 2. 1. 2. 1; L-serine: tetrahydrofolic-5, 10 transhydroxymethylase), which is responsible for g...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Stauffer GV,Brenchley JE

    更新日期:1974-06-01 00:00:00

  • Tetrazolium oxidase polymorphism in rainbow trout.

    abstract::Tetrazolium oxidase from the blood and liver of rainbow trout was found to be genetically polymorphic. The inheritance pattern of the liver enzyme was compatible only with a one locus-two allele hypothesis. The enzymes in the blood while having an electrophoretically identical polymorphism could differ genotypically f...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Cederbaum SD,Yoshida A

    更新日期:1972-10-01 00:00:00

  • Impact of amplified fragment length polymorphism size homoplasy on the estimation of population genetic diversity and the detection of selective loci.

    abstract::AFLP markers are becoming one of the most popular tools for genetic analysis in the fields of evolutionary genetics and ecology and conservation of genetic resources. The technique combines a high-information content and fidelity with the possibility of carrying out genomewide scans. However, a potential problem with ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.083246

    authors: Caballero A,Quesada H,Rolán-Alvarez E

    更新日期:2008-05-01 00:00:00

  • Noncell- and cell-autonomous G-protein-signaling converges with Ca2+/mitogen-activated protein kinase signaling to regulate str-2 receptor gene expression in Caenorhabditis elegans.

    abstract::In the sensory system of C. elegans, the candidate odorant receptor gene str-2 is strongly expressed in one of the two AWC neurons and weakly in both ASI neurons. Asymmetric AWC expression results from suppression of str-2 expression by a Ca2+/MAPK signaling pathway in one of the AWC neurons early in development. Here...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.106.058750

    authors: Lans H,Jansen G

    更新日期:2006-07-01 00:00:00

  • Two genetic elements regulate murine beta-glucuronidase synthesis following transcript accumulation.

    abstract::Mutant alleles of two genetic regulatory elements, which underlie a three- to sixfold reduction in beta-glucuronidase (GUS) activity levels, distinguish mice of the H haplotype from those of the other two common GUS haplotypes, A and B. Both elements are tightly linked to the GUS structural gene over which they exert ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Wawrzyniak CJ,Meredith SA,Ganschow RE

    更新日期:1989-01-01 00:00:00

  • The isolation and characterization of nrc-1 and nrc-2, two genes encoding protein kinases that control growth and development in Neurospora crassa.

    abstract::Using an insertional mutagenesis approach, a series of Neurospora crassa mutants affected in the ability to control entry into the conidiation developmental program were isolated. One such mutant, GTH16-T4, was found to lack normal vegetative hyphae and to undergo constitutive conidiation. The affected gene has been n...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kothe GO,Free SJ

    更新日期:1998-05-01 00:00:00

  • A genome-wide survey of hybrid incompatibility factors by the introgression of marked segments of Drosophila mauritiana chromosomes into Drosophila simulans.

    abstract::In hybrids between Drosophila simulans and D. mauritiana, males are sterile and females are fertile, in compliance with HALDANE's rule. The genetic basis of this phenomenon was investigated by introgression of segments of the mauritiana genome into a simulans background. A total of 87 positions throughout the mauritia...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: True JR,Weir BS,Laurie CC

    更新日期:1996-03-01 00:00:00

  • Male Phenotypes and Mating Efficiency in CAENORHABDITIS ELEGANS.

    abstract::Mating behavior in adult male nematodes can be assayed by mating efficiency, i.e., the number of cross progeny sired by males under standard conditions. Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnorm...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hodgkin J

    更新日期:1983-01-01 00:00:00

  • Shaping of Drosophila Neural Cell Lineages Through Coordination of Cell Proliferation and Cell Fate by the BTB-ZF Transcription Factor Tramtrack-69.

    abstract::Cell diversity in multicellular organisms relies on coordination between cell proliferation and the acquisition of cell identity. The equilibrium between these two processes is essential to assure the correct number of determined cells at a given time at a given place. Using genetic approaches and correlative microsco...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.119.302234

    authors: Simon F,Ramat A,Louvet-Vallée S,Lacoste J,Burg A,Audibert A,Gho M

    更新日期:2019-07-01 00:00:00

  • Mutations and Chromosomal Rearrangements Affecting the Expression of Snail, a Gene Involved in Embryonic Patterning in DROSOPHILA MELANOGASTER.

    abstract::Mutants at the snail locus are zygotically acting embryonic lethals that affect dorsoventral patterning. A comparison of seven mutant alleles shows considerable variation in expressivity and a graded effect along the dorsoventral axis: more extreme alleles result in the abnormal development of the dorsally derived ect...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Grau Y,Carteret C,Simpson P

    更新日期:1984-10-01 00:00:00

  • Genetics of yeast hexokinase.

    abstract::Two independent isolates of Saccharomyces cerevisiae lacking hexokinase activity (EC 2.7.1.1) are described. Both mutant strains grow on glucose but are unable to grow on fructose, and contain two mutant genes hxk1 and hxk2 each. The mutations are recessive and noncomplementing. Genetic analysis suggests that these tw...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Lobo Z,Maitra PK

    更新日期:1977-08-01 00:00:00