Natural selection and age-structured populations.

abstract：:This FlyBook chapter summarizes the history and the current state of our understanding of the Wingless signaling pathway. Wingless, the fly homolog of the mammalian Wnt oncoproteins, plays a central role in pattern generation during development. Much of what we know about the pathway was learned from genetic and molec...

journal_title：Genetics

authors： Bejsovec A

更新日期：2018-04-01 00:00:00

abstract：:The Sex-Ratio (SR) phenomenon is associated with the X chromosome of many species of Drosophila. Males carrying SR transmit predominantly sperm bearing the X chromosome. SR, therefore, has a very significant advantage in segregation. This paper provides an experimental analysis of the role of virility selection in pre...

journal_title：Genetics

authors： Wu CI

更新日期：1983-11-01 00:00:00

abstract：:The cosQ site of bacteriophage lambda is required for DNA packaging termination. Previous studies have shown that cosQ mutations can be suppressed in three ways: by a local suppressor within cosQ, an increase in the length of the lambda chromosome, and missense mutations affecting the prohead's portal protein, gpB. In...

journal_title：Genetics

authors： Wieczorek DJ,Didion L,Feiss M

更新日期：2002-05-01 00:00:00

abstract：:We study levels of X-linked vs. autosomal diversity using a model developed to analyze the hitchhiking effect. Repeated bouts of hitchhiking are thought to lower X-linked diversity for two reasons: first, because sojourn times of beneficial mutations are shorter on the X, and second, because adaptive substitutions may...

journal_title：Genetics

authors： Betancourt AJ,Kim Y,Orr HA

更新日期：2004-12-01 00:00:00

abstract：:Two Podospora mutants carrying mutations modE and modF were persumed to be quiescent defective, because, when grown under glucose limitation, they differed from the wild-type strain in an excess of dry weight production and a reduction of cell survival. New insight on the action of modE and modF mutations was provided...

journal_title：Genetics

authors： Durrens P,Bernet J

更新日期：1985-01-01 00:00:00

abstract：:Accounting for gene-environment (G×E) interactions in complex trait association studies can facilitate our understanding of genetic heterogeneity under different environmental exposures, improve the ability to discover susceptible genes that exhibit little marginal effect, provide insight into the biological mechanism...

journal_title：Genetics

authors： Zhao G,Marceau R,Zhang D,Tzeng JY

更新日期：2015-03-01 00:00:00

abstract：:HO endonuclease-induced double-strand breaks (DSBs) within a direct duplication of Escherichia coli lacZ genes are repaired either by gene conversion or by single-strand annealing (SSA), with > 80% being SSA. Previously it was demonstrated that the RAD52 gene is required for DSB-induced SSA. In the present study, the ...

journal_title：Genetics

authors： Ivanov EL,Sugawara N,Fishman-Lobell J,Haber JE

更新日期：1996-03-01 00:00:00

abstract：:Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments on accumulation of mutations on protected second chromosomes. A model of equal mutant effects gives a poor fit to the data ...

journal_title：Genetics

authors： Keightley PD

更新日期：1994-12-01 00:00:00

abstract：:Backcross populations are often used to study quantitative trait loci (QTL) after they are initially discovered in balanced populations, such as F(2), BC(1), or recombinant inbreds. While the latter are more powerful for mapping marker loci, the former have the reduced background genetic variation necessary for more p...

journal_title：Genetics

authors： Butruille DV,Guries RP,Osborn TC

更新日期：1999-10-01 00:00:00

abstract：:Genes expressed in testes are critical to male reproductive success, affecting spermatogenesis, sperm competition, and sperm-egg interaction. Comparing the evolution of testis proteins at different taxonomic levels can reveal which genes and functional classes are targets of natural and sexual selection and whether th...

journal_title：Genetics

authors： Turner LM,Chuong EB,Hoekstra HE

更新日期：2008-08-01 00:00:00

abstract：:Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossi...

journal_title：Genetics

authors： Oka A,Aoto T,Totsuka Y,Takahashi R,Ueda M,Mita A,Sakurai-Yamatani N,Yamamoto H,Kuriki S,Takagi N,Moriwaki K,Shiroishi T

更新日期：2007-01-01 00:00:00

abstract：:In California, Drosophila simulans females from some populations (type W) produce relatively few adult progeny when crossed to males from some other populations (type R), but the productivity of the reciprocal cross is comparable to within-population controls. These two incompatibility types are widespread in North Am...

journal_title：Genetics

authors： Hoffmann AA,Turelli M

更新日期：1988-06-01 00:00:00

abstract：:AFLP markers are becoming one of the most popular tools for genetic analysis in the fields of evolutionary genetics and ecology and conservation of genetic resources. The technique combines a high-information content and fidelity with the possibility of carrying out genomewide scans. However, a potential problem with ...

journal_title：Genetics

authors： Caballero A,Quesada H,Rolán-Alvarez E

更新日期：2008-05-01 00:00:00

abstract：:To study the functions of DNA topoisomerase I and Hpr1 protein, a suppressor mutant of the temperature-sensitive growth of an hpr1 top1-5ts double mutant was isolated. The isolated triple mutant showed cold-sensitive growth. By complementation of this phenotype, the suppressor gene was cloned. DNA sequencing showed it...

journal_title：Genetics

authors： Uemura H,Pandit S,Jigami Y,Sternglanz R

更新日期：1996-04-01 00:00:00

abstract：:SNAP receptor (SNARE) and Sec1/Munc18 (SM) proteins are required for all intracellular membrane fusion events. SNAREs are widely believed to drive the fusion process, but the function of SM proteins remains unclear. To shed light on this, we screened for dominant-negative mutants of yeast Sec1 by random mutagenesis of...

journal_title：Genetics

authors： Boyd A,Ciufo LF,Barclay JW,Graham ME,Haynes LP,Doherty MK,Riesen M,Burgoyne RD,Morgan A

更新日期：2008-09-01 00:00:00

abstract：:The B-Peru allele of the maize b regulatory gene is unusual relative to most b alleles in that it is expressed in the aleurone layer of the seed. It is also expressed in a subset of plant vegetative tissues. Transgenic maize plants containing the B-Peru gene with the first 710 bases of upstream sequence conferred the ...

journal_title：Genetics

authors： Selinger DA,Lisch D,Chandler VL

更新日期：1998-06-01 00:00:00

abstract：:The Caenorhabditis elegans pRb ortholog, LIN-35, functions in a wide range of cellular and developmental processes. This includes a role of LIN-35 in nutrient utilization by the intestine, which it carries out redundantly with SLR-2, a zinc-finger protein. This and other redundant functions of LIN-35 were identified i...

journal_title：Genetics

authors： Polley SR,Fay DS

更新日期：2012-08-01 00:00:00

abstract：:Following transformation of a Drosophila melanogaster true M strain with an autonomous P element, six lines were established and monitored for their molecular and phenotypic properties during a 4-yr period. The number of P elements increased with time in all the lines but the rate of increase differed among lines. Fur...

journal_title：Genetics

authors： Daniels SB,Clark SH,Kidwell MG,Chovnick A

更新日期：1987-04-01 00:00:00

abstract：:There is increasing evidence that certain Vacuolar protein sorting (Vps) proteins, factors that mediate vesicular protein trafficking, have additional roles in regulating transcription factors at the endosome. We found that yeast mutants lacking the phosphatidylinositol 3-phosphate [PI(3)P] kinase Vps34 or its associa...

journal_title：Genetics

authors： Gaur NA,Hasek J,Brickner DG,Qiu H,Zhang F,Wong CM,Malcova I,Vasicova P,Brickner JH,Hinnebusch AG

更新日期：2013-03-01 00:00:00

abstract：:When individuals' fitnesses depend on the genetic composition of the population in which they are found, selection is then frequency dependent. Frequency-dependent selection (FDS) is often invoked as a heuristic explanation for the maintenance of large numbers of alleles at a locus. The pairwise interaction model is a...

journal_title：Genetics

authors： Trotter MV,Spencer HG

更新日期：2007-07-01 00:00:00

abstract：:Quantitative traits whose phenotypic values change over time are called longitudinal traits. Genetic analyses of longitudinal traits can be conducted using any of the following approaches: (1) treating the phenotypic values at different time points as repeated measurements of the same trait and analyzing the trait und...

journal_title：Genetics

authors： Yang R,Tian Q,Xu S

更新日期：2006-08-01 00:00:00

abstract：:The effective population size (N(e)) is notoriously difficult to accurately estimate in wild populations as it is influenced by a number of parameters that are difficult to delineate in natural systems. The different methods that are used to estimate N(e) are affected variously by different processes at the population...

journal_title：Genetics

authors： Serbezov D,Jorde PE,Bernatchez L,Olsen EM,Vøllestad LA

更新日期：2012-06-01 00:00:00

abstract：:The recessive mutation, hop1-1, was isolated by use of a screen designed to detect mutations defective in homologous chromosomal pairing during meiosis in Saccharomyces cerevisiae. Mutants in HOP1 displayed decreased levels of meiotic crossing over and intragenic recombination between markers on homologous chromosomes...

journal_title：Genetics

authors： Hollingsworth NM,Byers B

更新日期：1989-03-01 00:00:00

abstract：:Regulatory networks provide control over complex cell behavior in all kingdoms of life. Here we describe a statistical model, based on representing proteins as collections of domains or motifs, which predicts unknown molecular interactions within these biological networks. Using known protein-protein interactions of S...

journal_title：Genetics

authors： Gomez SM,Lo SH,Rzhetsky A

更新日期：2001-11-01 00:00:00

abstract：:The RNA polymerase II (Pol-II) holoenzyme, responsible for messenger RNA production, typically consists of 10-12 subunits. Our laboratory previously demonstrated that maternally deposited, long, noncoding, template RNAs are essential for programmed genome rearrangements in the ciliate Oxytricha trifallax. Here we show...

journal_title：Genetics

authors： Khurana JS,Wang X,Chen X,Perlman DH,Landweber LF

更新日期：2014-07-01 00:00:00

abstract：:Polyploidy has occurred throughout the evolutionary history of all eukaryotes and is extremely common in plants. Reunification of the evolutionarily divergent genomes in allopolyploids creates regulatory incompatibilities that must be reconciled. Here we report genomewide gene expression analysis of Arabidopsis synthe...

journal_title：Genetics

authors： Wang J,Tian L,Lee HS,Wei NE,Jiang H,Watson B,Madlung A,Osborn TC,Doerge RW,Comai L,Chen ZJ

更新日期：2006-01-01 00:00:00

abstract：:Maintenance of proper neuronal excitability is vital to nervous system function and normal behavior. A subset of Drosophila mutants that exhibit altered behavior also exhibit defective motor neuron excitability, which can be monitored with electrophysiological methods. One such mutant is the P-element insertion mutant...

journal_title：Genetics

authors： Schweers BA,Walters KJ,Stern M

更新日期：2002-07-01 00:00:00

abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...

journal_title：Genetics

authors： Kitada K,Omura T

更新日期：1984-11-01 00:00:00

abstract：:The vacuolar hydrolase protease B in Saccharomyces cerevisiae is synthesized as an inactive precursor (Prb1p). The precursor undergoes post-translational modifications while transiting the secretory pathway. In addition to N- and O-linked glycosylations, four proteolytic cleavages occur during the maturation of Prb1p....

journal_title：Genetics

authors： Naik RR,Jones EW

更新日期：1998-07-01 00:00:00

abstract：:Many data sets one could use for population genetics contain artifactual sites, i.e., sequencing errors. Here, we first explore the impact of such errors on several common summary statistics, assuming that sequencing errors are mostly singletons. We thus show that in the presence of those errors, estimators of can be ...

journal_title：Genetics

authors： Achaz G

更新日期：2008-07-01 00:00:00